메뉴 건너뛰기




Volumn 327, Issue 2, 2003, Pages 445-452

Design of a modular immunotoxin connected by polyionic adapter peptides

Author keywords

Disulfide bond; Exotoxin; FACS; Fv fragment; Polyionic peptides

Indexed keywords

HYBRID PROTEIN; IMMUNOTOXIN; PEPTIDE;

EID: 0037459221     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(03)00141-4     Document Type: Article
Times cited : (15)

References (41)
  • 2
    • 0035524114 scopus 로고    scopus 로고
    • Improving the efficacy of antibody-based cancer therapies
    • Carter P. Improving the efficacy of antibody-based cancer therapies. Nature Rev. Cancer. 1:2001;118-129.
    • (2001) Nature Rev. Cancer , vol.1 , pp. 118-129
    • Carter, P.1
  • 3
    • 0032850677 scopus 로고    scopus 로고
    • Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
    • Cobleigh M.A., Vogel C.L., Tripathy D., Robert N.J., Scholl S., Fehrenbacher L., et al. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J. Clin. Oncol. 17:1999;2639-2648.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 2639-2648
    • Cobleigh, M.A.1    Vogel, C.L.2    Tripathy, D.3    Robert, N.J.4    Scholl, S.5    Fehrenbacher, L.6
  • 4
    • 0032447240 scopus 로고    scopus 로고
    • Clinical status and optimal use of rituximab for B-cell lymphomas
    • McLaughlin P., White C.A., Grillo-Lopez A.J., Maloney D.G. Clinical status and optimal use of rituximab for B-cell lymphomas. Oncology. 12:1998;1763-1769.
    • (1998) Oncology , vol.12 , pp. 1763-1769
    • McLaughlin, P.1    White, C.A.2    Grillo-Lopez, A.J.3    Maloney, D.G.4
  • 5
    • 0023888286 scopus 로고
    • Activity of immunotoxins constructed with modified Pseudomonas exotoxin A lacking the cell recognition domain
    • Kondo T., FitzGerald D., Chaudhary V.K., Adhya S., Pastan I. Activity of immunotoxins constructed with modified Pseudomonas exotoxin A lacking the cell recognition domain. J. Biol. Chem. 263:1988;9470-9475.
    • (1988) J. Biol. Chem. , vol.263 , pp. 9470-9475
    • Kondo, T.1    FitzGerald, D.2    Chaudhary, V.K.3    Adhya, S.4    Pastan, I.5
  • 6
    • 0026762794 scopus 로고
    • Antitumor effects of B3-PE and B3-LysPE40 in a nude mouse model of human breast cancer and the evaluation of B3-PE toxicity in monkeys
    • Pai L.H., Batra J.K., FitzGerald D.J., Willingham M.C., Pastan I. Antitumor effects of B3-PE and B3-LysPE40 in a nude mouse model of human breast cancer and the evaluation of B3-PE toxicity in monkeys. Cancer Res. 52:1992;3189-3193.
    • (1992) Cancer Res. , vol.52 , pp. 3189-3193
    • Pai, L.H.1    Batra, J.K.2    FitzGerald, D.J.3    Willingham, M.C.4    Pastan, I.5
  • 7
    • 0024349836 scopus 로고
    • A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin
    • Chaudhary V.K., Queen C., Junghans R.P., Waldmann T.A., FitzGerald D.J., Pastan I. A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin. Nature. 339:1989;394-397.
    • (1989) Nature , vol.339 , pp. 394-397
    • Chaudhary, V.K.1    Queen, C.2    Junghans, R.P.3    Waldmann, T.A.4    FitzGerald, D.J.5    Pastan, I.6
  • 8
    • 0032879545 scopus 로고    scopus 로고
    • Immunotoxins in cancer therapy
    • Kreitman R.J. Immunotoxins in cancer therapy. Curr. Opin. Immunol. 11:1999;570-578.
    • (1999) Curr. Opin. Immunol. , vol.11 , pp. 570-578
    • Kreitman, R.J.1
  • 10
    • 0028275863 scopus 로고
    • Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment
    • Reiter Y., Pai L.H., Brinkmann U., Wang Q.C., Pastan I. Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment. Cancer Res. 54:1994;2714-2718.
    • (1994) Cancer Res. , vol.54 , pp. 2714-2718
    • Reiter, Y.1    Pai, L.H.2    Brinkmann, U.3    Wang, Q.C.4    Pastan, I.5
  • 11
    • 0029569061 scopus 로고
    • Immunotoxins containing Pseudomonas exotoxin that target LeY damage human endothelial cells in an antibody-specific mode: Relevance to vascular leak syndrome
    • Kuan C.T., Pai L.H., Pastan I. Immunotoxins containing Pseudomonas exotoxin that target LeY damage human endothelial cells in an antibody-specific mode: relevance to vascular leak syndrome. Clin. Cancer Res. 1:1995;1589-1594.
    • (1995) Clin. Cancer Res. , vol.1 , pp. 1589-1594
    • Kuan, C.T.1    Pai, L.H.2    Pastan, I.3
  • 13
    • 0035661006 scopus 로고    scopus 로고
    • Artificial conjugation of proteins using polyionic fusion peptides
    • Richter S., Stubenrauch K., Lilie H., Rudolph R. Artificial conjugation of proteins using polyionic fusion peptides. Protein Eng. 14:2001;775-783.
    • (2001) Protein Eng. , vol.14 , pp. 775-783
    • Richter, S.1    Stubenrauch, K.2    Lilie, H.3    Rudolph, R.4
  • 14
    • 0035875141 scopus 로고    scopus 로고
    • Tumor cell specific targeting and gene transfer by recombinant polyoma virus like particle/antibody conjugates
    • Stubenrauch K., Gleiter S., Brinkmann U., Rudolph R., Lilie H. Tumor cell specific targeting and gene transfer by recombinant polyoma virus like particle/antibody conjugates. Biochem. J. 356:2001;867-873.
    • (2001) Biochem. J. , vol.356 , pp. 867-873
    • Stubenrauch, K.1    Gleiter, S.2    Brinkmann, U.3    Rudolph, R.4    Lilie, H.5
  • 15
    • 0023657391 scopus 로고
    • Functional domains of Pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. Coli
    • Hwang J., Fitzgerald D.J., Adhya S., Pastan I. Functional domains of Pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. Coli. Cell. 48:1987;129-136.
    • (1987) Cell , vol.48 , pp. 129-136
    • Hwang, J.1    Fitzgerald, D.J.2    Adhya, S.3    Pastan, I.4
  • 16
    • 0029942828 scopus 로고    scopus 로고
    • In vitro enzyme activation and folded stability of Pseudomonas aeruginosa exotoxin A and its C-terminal peptide
    • Beattie B.K., Merrill A.R. In vitro enzyme activation and folded stability of Pseudomonas aeruginosa exotoxin A and its C-terminal peptide. Biochemistry. 35:1996;9042-9051.
    • (1996) Biochemistry , vol.35 , pp. 9042-9051
    • Beattie, B.K.1    Merrill, A.R.2
  • 17
    • 0033025519 scopus 로고    scopus 로고
    • A fluorescence investigation of the active site of Pseudomonas aeruginosa exotoxin A
    • Beattie B.K., Merrill A.R. A fluorescence investigation of the active site of Pseudomonas aeruginosa exotoxin A. J. Biol. Chem. 274:1999;15646-15654.
    • (1999) J. Biol. Chem. , vol.274 , pp. 15646-15654
    • Beattie, B.K.1    Merrill, A.R.2
  • 18
    • 0029163551 scopus 로고
    • Phase II trial of 131 I-B1 (anti-CD20) antibody therapy with autologous stem cell transplantation for relapsed B cell lymphomas
    • Press O.W., Eary J.F., Appelbaum F.R., Martin P.J., Nelp W.B., Glenn S., et al. Phase II trial of 131 I-B1 (anti-CD20) antibody therapy with autologous stem cell transplantation for relapsed B cell lymphomas. Lancet. 346:1995;336-340.
    • (1995) Lancet , vol.346 , pp. 336-340
    • Press, O.W.1    Eary, J.F.2    Appelbaum, F.R.3    Martin, P.J.4    Nelp, W.B.5    Glenn, S.6
  • 21
    • 0036187968 scopus 로고    scopus 로고
    • Efficient and selective gene transfer into primary human brain tumors by using single-chain antibody-targeted adenoviral vectors with native tropism abolished
    • van Beusechem V.W., Grill J., Mastenbroek D.C., Wickham T.J., Roelvink P.W., Haisma H.J., et al. Efficient and selective gene transfer into primary human brain tumors by using single-chain antibody-targeted adenoviral vectors with native tropism abolished. J. Virol. 76:2002;2753-2762.
    • (2002) J. Virol. , vol.76 , pp. 2753-2762
    • Van Beusechem, V.W.1    Grill, J.2    Mastenbroek, D.C.3    Wickham, T.J.4    Roelvink, P.W.5    Haisma, H.J.6
  • 22
    • 0033639310 scopus 로고    scopus 로고
    • Specific targeting strategies of cancer gene therapy using a single-chain variable fragment (scFv) with a high affinity for CEA
    • Kuroki M., Arakawa F., Khare P.D., Kuroki M., Liao S., Matsumoto H., et al. Specific targeting strategies of cancer gene therapy using a single-chain variable fragment (scFv) with a high affinity for CEA. Anticancer Res. 20:2001;4067-4071.
    • (2001) Anticancer Res. , vol.20 , pp. 4067-4071
    • Kuroki, M.1    Arakawa, F.2    Khare, P.D.3    Kuroki, M.4    Liao, S.5    Matsumoto, H.6
  • 23
    • 0037298835 scopus 로고    scopus 로고
    • Cell-type specific targeting and gene expression using a variant of polyoma VP1 virus-like particles
    • Gleiter S., Lilie H. Cell-type specific targeting and gene expression using a variant of polyoma VP1 virus-like particles. Biol. Chem. 384:2003;247-255.
    • (2003) Biol. Chem. , vol.384 , pp. 247-255
    • Gleiter, S.1    Lilie, H.2
  • 24
    • 0035993314 scopus 로고    scopus 로고
    • Assessment of cell type specific gene transfer of polyoma virus like particles presenting a tumor specific antibody Fv fragment
    • May T., Gleiter S., Lilie H. Assessment of cell type specific gene transfer of polyoma virus like particles presenting a tumor specific antibody Fv fragment. J. Virol. Methods. 105:2002;147-155.
    • (2002) J. Virol. Methods , vol.105 , pp. 147-155
    • May, T.1    Gleiter, S.2    Lilie, H.3
  • 26
    • 0034682480 scopus 로고    scopus 로고
    • Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity
    • Tsutsumi Y., Onda M., Nagata S., Lee B., Kreitman R.J., Pastan I. Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity. Proc. Natl Acad. Sci. USA. 97:2000;8548-8553.
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 8548-8553
    • Tsutsumi, Y.1    Onda, M.2    Nagata, S.3    Lee, B.4    Kreitman, R.J.5    Pastan, I.6
  • 27
    • 0021751543 scopus 로고
    • Production of target-specific effector cells using hetero-cross-linked aggregates containing anti-target cell and anti-Fc gamma receptor antibodies
    • Karpovsky B., Titus J.A., Stephany D.A., Segal D.M. Production of target-specific effector cells using hetero-cross-linked aggregates containing anti-target cell and anti-Fc gamma receptor antibodies. J. Expt. Med. 160:1984;1686-1701.
    • (1984) J. Expt. Med. , vol.160 , pp. 1686-1701
    • Karpovsky, B.1    Titus, J.A.2    Stephany, D.A.3    Segal, D.M.4
  • 28
    • 0032579437 scopus 로고    scopus 로고
    • The first constant domain (C(H)1 and C(L)) of an antibody used as heterodimerization domain for bispecific miniantibodies
    • Muller K.M., Arndt K.M., Strittmatter W., Plückthun A. The first constant domain (C(H)1 and C(L)) of an antibody used as heterodimerization domain for bispecific miniantibodies. FEBS Letters. 422:1998;259-264.
    • (1998) FEBS Letters , vol.422 , pp. 259-264
    • Muller, K.M.1    Arndt, K.M.2    Strittmatter, W.3    Plückthun, A.4
  • 29
    • 85031206844 scopus 로고    scopus 로고
    • Reconstitution of human RNase A from separate fragments fused to two different single chain antibody fragments: On the way to binary immunotoxins
    • Dübel S. Reconstitution of human RNase A from separate fragments fused to two different single chain antibody fragments: on the way to binary immunotoxins. Tumor Targeting. 4:1999;73-81.
    • (1999) Tumor Targeting , vol.4 , pp. 73-81
    • Dübel, S.1
  • 30
    • 0026348474 scopus 로고
    • Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif
    • Carr D.W., Stofko-Hahn R.E., Fraser J.D., Bishop S.M., Acott T.S., Brennan R.D., Scott J.D. Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif. J. Biol. Chem. 266:1991;14188-14192.
    • (1991) J. Biol. Chem. , vol.266 , pp. 14188-14192
    • Carr, D.W.1    Stofko-Hahn, R.E.2    Fraser, J.D.3    Bishop, S.M.4    Acott, T.S.5    Brennan, R.D.6    Scott, J.D.7
  • 31
    • 0026528230 scopus 로고
    • Miniantibodies: Use of amphipathic helices to produce functional, flexibly linked dimeric Fv fragments with high avidity in Escherichia coli
    • Pack P., Plückthun A. Miniantibodies: use of amphipathic helices to produce functional, flexibly linked dimeric Fv fragments with high avidity in Escherichia coli. Biochemistry. 31:1992;1579-1584.
    • (1992) Biochemistry , vol.31 , pp. 1579-1584
    • Pack, P.1    Plückthun, A.2
  • 32
    • 0025771405 scopus 로고
    • ZEBRA and a Fos-GCN4 chimeric protein differ in their DNA-binding specificities for sites in the Epstein-Barr virus BZLF1 promoter
    • Taylor N., Flemington E., Kolman J.L., Baumann R.P., Speck S.H., Miller G. ZEBRA and a Fos-GCN4 chimeric protein differ in their DNA-binding specificities for sites in the Epstein-Barr virus BZLF1 promoter. J. Virol. 65:1991;4033-4041.
    • (1991) J. Virol. , vol.65 , pp. 4033-4041
    • Taylor, N.1    Flemington, E.2    Kolman, J.L.3    Baumann, R.P.4    Speck, S.H.5    Miller, G.6
  • 33
    • 0026511240 scopus 로고
    • Transformation and transactivation suppressor activity of the c-Jun leucine zipper fused to a bacterial repressor
    • Granger-Schnarr M., Benusiglio E., Schnarr M., Sassone-Corsi P. Transformation and transactivation suppressor activity of the c-Jun leucine zipper fused to a bacterial repressor. Proc. Natl Acad. Sci. USA. 89:1992;4236-4239.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 4236-4239
    • Granger-Schnarr, M.1    Benusiglio, E.2    Schnarr, M.3    Sassone-Corsi, P.4
  • 34
    • 0028134881 scopus 로고
    • A general method for facilitating heterodimeric pairing between two proteins: Application to expression of alpha and beta T-cell receptor extracellular segments
    • Chang H.C., Bao Z., Yao Y., Tse A.G., Goyarts E.C., Madsen M., et al. A general method for facilitating heterodimeric pairing between two proteins: application to expression of alpha and beta T-cell receptor extracellular segments. Proc. Natl Acad. Sci. USA. 91:1994;11408-11412.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 11408-11412
    • Chang, H.C.1    Bao, Z.2    Yao, Y.3    Tse, A.G.4    Goyarts, E.C.5    Madsen, M.6
  • 36
    • 0032996760 scopus 로고    scopus 로고
    • Engineering receptor-mediated cytotoxicity into human ribonucleases by steric blockade of inhibitor interaction
    • Suzuki M., Saxena S.K., Boix E., Prill R.J., Vasandani V.M., Ladner J.E., et al. Engineering receptor-mediated cytotoxicity into human ribonucleases by steric blockade of inhibitor interaction. Nature Biotechnol. 17:1999;265-270.
    • (1999) Nature Biotechnol. , vol.17 , pp. 265-270
    • Suzuki, M.1    Saxena, S.K.2    Boix, E.3    Prill, R.J.4    Vasandani, V.M.5    Ladner, J.E.6
  • 37
    • 0028216376 scopus 로고
    • Engineering interchain disulfide bonds into conserved framework regions of Fv fragments: Improved biochemical characteristics of recombinant immunotoxins containing disulfide-stabilized Fv
    • Reiter Y., Brinkmann U., Webber K.O., Jung S.H., Lee B., Pastan I. Engineering interchain disulfide bonds into conserved framework regions of Fv fragments: improved biochemical characteristics of recombinant immunotoxins containing disulfide-stabilized Fv. Protein Eng. 5:1994;697-704.
    • (1994) Protein Eng. , vol.5 , pp. 697-704
    • Reiter, Y.1    Brinkmann, U.2    Webber, K.O.3    Jung, S.H.4    Lee, B.5    Pastan, I.6
  • 39
    • 0028275293 scopus 로고
    • Design of interchain disulfide bonds in the framework region of the Fv fragment of the monoclonal antibody B3
    • Jung S.H., Pastan I., Lee B. Design of interchain disulfide bonds in the framework region of the Fv fragment of the monoclonal antibody B3. Proteins: Struct. Funct. Genet. 19:1994;35-47.
    • (1994) Proteins: Struct. Funct. Genet. , vol.19 , pp. 35-47
    • Jung, S.H.1    Pastan, I.2    Lee, B.3
  • 41
    • 0023158779 scopus 로고
    • Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of radiosensitivity
    • Carmichael J., DeGraff W.G., Gazdar A.F., Minna J.D., Mitchell J.B. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of radiosensitivity. Cancer Res. 47:1987;943-946.
    • (1987) Cancer Res. , vol.47 , pp. 943-946
    • Carmichael, J.1    DeGraff, W.G.2    Gazdar, A.F.3    Minna, J.D.4    Mitchell, J.B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.