Conformationally constrained analogues of diacylglycerol (DAG). 31. Modulation of the biological properties of diacylgycerol lactones (DAG-lactones) containing rigid-rod acyl groups separated from the core lactone by spacer units of different lengths

Journal of Medicinal Chemistry

Volumn 52, Issue 10, 2009, Pages 3274-3283

  Comin, Maria J ^a   Czifra, Gabriella ^b   Kedei, Noemi ^b   Telek, Andrea ^b   Lewin, Nancy E ^b   Kolusheva, Sofiya ^c   Velasquez, Julia F ^b   Kobylarz, Ryan ^b   Jelinek, Raz ^c   Blumberg, Peter M ^b   Marquez, Victor E ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMIMETIC MATERIAL; DIACYLGLYCEROL; DIACYLGLYCEROL LACTONE DERIVATIVE; LACTONE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLSERINE; PHOSPHOLIPID; PROTEIN KINASE C ALPHA; PROTEIN KINASE C DELTA; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; ARTIFICIAL MEMBRANE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CANCER CELL; CELL MEMBRANE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME KINETICS; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; NONHUMAN;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; DIGLYCERIDES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; KINETICS; LACTONES; MALE; MOLECULAR CONFORMATION; PHOSPHOLIPIDS; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTEIN BINDING; PROTEIN KINASE C; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 66249114302     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900186m     Document Type: Article

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