Contribution of the central hydrophobic residue in the PXP motif of voltage-dependent K+ channels to S6 flexibility and gating properties

Channels

Volumn 3, Issue 1, 2009, Pages 39-45

  Imbrici, Paola ^a   Grottesi, Alessandro ^b   D'Adamo, Maria Cristina ^a   Mannucci, Roberta ^a   Tucker, Stephen J ^c   Pessia, Mauro ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b CASPUR   (Italy)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Gating; KV1.1; Potassium channels; S6 helix; Shaker; V404

Indexed keywords

ISOLEUCINE; PROTEIN S6; VALINE; VOLTAGE GATED POTASSIUM CHANNEL; KCNA1 PROTEIN, HUMAN; POTASSIUM; POTASSIUM CHANNEL KV1.1;

ANIMAL CELL; ARTICLE; CHANNEL GATING; FEMALE; HYDROPHOBICITY; MEMBRANE CONDUCTANCE; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; SIMULATION; AMINO ACID SEQUENCE; ANIMAL; CELL MEMBRANE POTENTIAL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; GENETICS; HUMAN; KINETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; OOCYTE; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; STRUCTURE ACTIVITY RELATION; XENOPUS LAEVIS;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; COMPUTER SIMULATION; HUMANS; HYDROPHOBICITY; ION CHANNEL GATING; ISOLEUCINE; KINETICS; KV1.1 POTASSIUM CHANNEL; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; OOCYTES; POTASSIUM; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP; VALINE; XENOPUS LAEVIS;

EID: 66149154316     PISSN: 19336950     EISSN: 19336969     Source Type: Journal    
DOI: 10.4161/chan.3.1.7548     Document Type: Article

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