Quantum dots and their potential biomedical applications in photosensitization for photodynamic therapy

Nanomedicine

Volumn 4, Issue 3, 2009, Pages 353-363

  Yaghini, Elnaz ^a   Seifalian, Alexander M ^a   MacRobert, Alexander J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Cancer; Energy transfer; FRET; PDT; Photodynamic therapy; Photosensitizer; Quantum dots; Singlet oxygen

Indexed keywords

NANOPARTICLE; PHOTOSENSITIZING AGENT; PHTHALOCYANINE; QUANTUM DOT; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; BIOCOMPATIBILITY; CELL DEATH; CYTOTOXICITY; DNA DAMAGE; DRUG DELIVERY SYSTEM; ENERGY TRANSFER; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; IMAGING SYSTEM; MALIGNANT NEOPLASTIC DISEASE; PATIENT SAFETY; PHOTODYNAMIC THERAPY; PHOTOSENSITIZATION; PRIORITY JOURNAL; REVIEW; ULTRAVIOLET RADIATION; CHEMISTRY; DIAGNOSTIC IMAGING; METABOLISM; METHODOLOGY; NANOMEDICINE; PHOTOCHEMOTHERAPY;

DIAGNOSTIC IMAGING; HUMANS; NANOMEDICINE; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; QUANTUM DOTS; REACTIVE OXYGEN SPECIES;

EID: 66149115270     PISSN: 17435889     EISSN: None     Source Type: Journal    
DOI: 10.2217/nnm.09.9     Document Type: Review

References (60)

1. Miyawaki A: Visualization of the spatial and temporal dynamics of intracellular signaling. Dev. Cell 4(3),295-305 (2003).
2. Schrock E, du Manoir S, Veldman T et al.: Multicolor spectral karyotyping of human chromosomes. Science 273(5274),494-497 (1996).
3. Resch-Genger U, Grabolle M, Cavaliere-Jaricot S, Nitschke R, Nann T: Quantum dots versus organic dyes as fluorescent labels. Nat. Methods 5(9),763-775 (2008).
4. Bruchez M, Moronne M, Gin P, Weiss S, Alivisatos AP: Semiconductor nanocrystals as fluorescent biological labels. Science 281 (5385),2013-2016 (1998).
5. Chan WCW, Nie SM: Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 281(5385),2016-2018 (1998).
6. Dabbousi BO, Rodriguez Viejo J, Mikulec FV et al.: (CdSe)ZnS core-shell quantum dots: synthesis and characterization of a size series of highly luminescent nanocrystallites. J. Phys. Chem. B 101(46),9463-9475 (1997).
7. Leatherdale CA, Woo WK, Mikulec FV, Bawendi MG: On the absorption cross section of CdSe nanocrystal quantum dots. J. Phys. Chem. B 106(31),7619-7622 (2002).
8. Alivisatos P: The use of nanocrystals in biological detection. Nat. Biotechnol. 22(1),47-52 (2004).
9. Jamieson T, Bakhshi R, Petrova D, Pocock R, Imani M, Seifalian AM: Biological applications of quantum dots. Biomaterials 28(31),4717-4732 (2007).
10. Zhang H, Yee D, Wang C: Quantum dots for cancer diagnosis and therapy: biological and clinical perspectives. Nanomed. 3(1),83-91 (2008).
11. Dolmans JG, Fukumura D, Jain RK: Photodynamic therapy for cancer. Nat. Rev. Cancer 3(5),380-387 (2003).
12. Ochsner M: Photophysical and photobiological processes in the photodynamic therapy of tumors. J. Photochem. Photobiol. B Biol. 39(1),1-18 (1997).
13. Hopper C: Photodynamic therapy: a clinical reality in the treatment of cancer. Lancet Oncol. 1,212-219 (2000)
14. Komerik N, Nakanishi H, MacRobert AJ, Henderson B, Speight P, Wilson M: In vivo killing of Porphyromonas gingivalis by toluidine blue-mediated photosensitization in an animal model. Antimicrob. Agents Chemother. 47(3),932-940 (2003).
15. Schuitmaker JJ, Bass P, van Leengoed LM, van der Meulen FW, Star WM, van Zandwijk N: Photodynamic therapy: a promising new modality for the treatment of cancer. J. Photochem. Photobiol. B Biol. 34(1),3-12 (1996).
16. Spikes JD: New trends in photobiology (invited review) - chlorins as photosensitizers in biology and medicine. J. Photochem. Photobiol. B Biol. 6(3),259-274 (1990).
17. Pandey RK: Recent advances in photodynamic therapy. J. Porphyrins Phthalocyanines 4(4),368-373 (2000).
18. Imahori H, Arimura M, Hanada T et al.: Photoactive three-dimensional monolayers: porphyrin-alkanethiolate-stabilized gold clusters. J. Am. Chem. Soc. 123(2),335-336 (2001).
19. Battah S, Balaratnam S, Casas A et al.: Macromolecular delivery of 5-aminolaevulinic acid for photodynamic therapy using dendrimer conjugates. Mol. Cancer Ther. 6(3),876-885 (2007).
20. Hone DC, Walker PI, Evans-Gowing R et al.: Generation of cytotoxic singlet oxygen via phthalocyanine-stabilized gold nanoparticles: a potential delivery vehicle for photodynamic therapy. Langmuir 18(8),2985-2987 (2002).
21. Roy I, Ohulchanskyy TY, Pudavar HE et al.: Ceramic-based nanoparticles entrapping water-insoluble photosensitizing anticancer drugs: a novel drug-carrier system for photodynamic therapy. J. Am. Chem. Soc. 125(26),7860-7865 (2003).
22. Wang SZ, Gao RM, Zhou FM, Selke M: Nanomaterials and singlet oxygen photosensitizers: potential applications in photodynamic therapy. J. Mat. Chem. 14(4),487-493 (2004).
23. Wieder ME, Hone DC, Cook MJ, Handsley MM, Gavrilovic J, Russell DA: Intracellular photodynamic therapy with photosensitizer-nanoparticle conjugates: cancer therapy using a 'Trojan horse'. Photochem. Photobiol. Sci. 5 (8),727-734 (2006).
24. Chen W: Nanoparticle self-lighting photodynamic therapy for cancer treatment. J. Biomed. Nanotechnol.4(4),369-376 (2008).
25. Juzenas P, Chen W, Sun YP et al.: Quantum dots and nanoparticles for photodynamic and radiation therapies of cancer. Adv. Drug Del. Rev.60(15),1600-1614 (2008).
26. Arya H, Kaul Z, Wadhwa R, Taira K, Hirano T, Kaul SC: Quantum dots in bio-imaging: revolution by the small. Biochem. Biophys. Res. Comm.329(4),1173-1177 (2005).
27. Kunz L, Connelly JP, Woodhams JH, MacRobert AJ: Photodynamic modification of disulfonated aluminium phthalocyanine. fluorescence in a macrophage cell line. Photochem. Photobiol. Sci.6(9),940-948 (2007).
28. Kovalev D, Fujii M: Silicon nanocrystals: photosensitizers for oxygen molecules. Adv. Mat.17(21),2531-2544 (2005).
29. Ipe BI, Lehnig M, Niemeyer CM: On the generation of free radical species from quantum dots. Small1(7),706-709 (2005).
30. Lovric J, Bazzi HS, Cuie Y, Fortin GRA, Winnik FM, Maysinger D: Differences in subcellular distribution and toxicity of green and red emitting CdTe quantum dots. J. Mol. Med.83 (5),377-385 (2005).
31. Green M, Howman E: Semiconductor quantum dots and free radical induced DNA nicking. Chem. Comm.(1),121-123 (2005).
32. Anas A, Akita H, Harashima H, Itoh T, Ishikawa M, Biju V: Photosensitized breakage and damage of DNA by CdSe-ZnS quantum dots. J. Phys. Chem B112(32),10005-19011 (2008).
33. Lovric J, Cho SJ, Winnik FM, Maysinger D: Unmodified cadmium telluride quantum dots induce reactive oxygen species formation leading to multiple organelle damage and cell death. Chem. Biol.12(11),1227-1234 (2005).
34. Chan WH, Shiao NH, Lu PZ: CdSe quantum dots induce apoptosis in human neuroblastoma, cells via mitochondrial-dependent pathways and inhibition of survival signals. Toxicol. Lett.167 (3),191-200 (2006).
35. Cho SJ, Maysinger D, Jain M, Roder B, Hackbarth S, Winnik FM: Long-term exposure to CdTe quantum dots causes functional impairments in live cells. Langmuir23(4),1974-1980 (2007).
36. Forster T: 10th Spiers memorial lecture - transfer mechanisms of electronic excitation. Disc. Faraday Soc.(27),7-17 (1959).
37. Clapp AR, Medintz IL, Mauro JM, Fisher BR, Bawendi MG, Mattoussi H: Fluorescence resonance energy transfer between quantum dot donors and dye-labeled protein acceptors. J. Am. Chem. Soc.126(1),301-310 (2004).
38. Kagan CR, Murray CB, Nirmal M, Bawendi MG: Electronic energy transfer in CdSe quantum dot solids. Phys. Rev. Lett.76,1517-1520 (1996).
39. Kagan CR, Murray CB, Bawendi MG: Longrange resonance transfer of electronic excitations in close-packed CdSe quantum-dot solids. Phys. Rev. B54(12),8633-8643 (1996).
40. Willard DM, Carillo LL, Jung J, Van Orden A: CdSe-ZnS quantum dots as resonance energy transfer donors in a model protein-protein binding assay. Nano Lett.1(9),469-474 (2001).
41. Patolsky F, Gill R, Weizmann Y, Mokari T, Banin U, Willner I: Lighting-up the dynamics of telomerization and DNA replication by CdSe-ZnS quantum dots. J. Am. Chem. Soc.125 (46),13918-13919 (2003).
42. Clapp AR, Pons T, Medintz IL et al.: Twophoton excitation of quantum-dot-based fluorescence resonance energy transfer and its applications. Adv. Mat.19(15),1921-1926 (2007).
43. Medintz EL, Trammell SA, Mattoussi H, Mauro JM: Reversible modulation of quantum dot photoluminescence using a protein-bound photochromic fluorescence resonance energy transfer acceptor. J. Am. Chem. Soc.126(1),30-31 (2004).
44. Medintz IL, Clapp AR, Melinger JS, Deschamps JR, Mattoussi H: A reagentless biosensing assembly based on quantum dot-donor Forster resonance energy transfer. Adv. Mat.17 (20),2450-2455 (2005).
45. Tran PT, Goldman ER, Anderson GP, Mauro JM, Mattoussi H: Use of luminescent CdSe-ZnS nanocrystal bioconjugates in quantum dot-based nanosensors. Phys. Status Solidi B Basic Res.229 (1),427-432 (2002).
46. Medintz IL, Clapp AR, Mattoussi H, Goldman ER, Fisher B, Mauro JM: Self-assembled nanoscale biosensors, based on quantum dot FRET donors. Nat. Mat.2(9),630-638 (2003).
47. Medintz IL, Clapp AR, Brunel FM et al.: Proteolytic activity monitored by fluorescence resonance energy transfer through quantum-dotpeptide conjugates. Nat. Mat.5(7),581-589 (2006).
48. Mamedova NN, Kotov NA, Rogach AL, Studer J: Albumin-CdTe nanoparticle bioconjugates: preparation, structure, and interunit energy transfer with antenna effect. Nano Lett.1 (6),281-286 (2001).
49. Clapp AR, Medintz IL, Fisher BR, Anderson GP, Mattoussi H: Can luminescent quantum dots be efficient energy acceptors with organic dye donors? J. Am. Chem. Soc.127(4),1242-1250 (2005).
50. Samia AC, Chen X, Burda C: Semiconductor quantum dots for photodynamic therapy. J. Am. Chem. Soc.125(51),15736-15737 (2003).
51. Dayal S, Lou YB, Samia AC, Berlin JC, Kenney ME, Burda C: Observation of non-Forstertype energy-transfer behavior in quantum dotphthalocyanine conjugates. J. Am. Chem. Soc.128 (43),13974-13975 (2006).
52. Shi LX, Hernandez B, Selke M: Singlet oxygen generation from water-soluble quantum dot-organic dye nanocomposites. J. Am. Chem. Soc.128(19),6278-6279 (2006).
53. Hsieh JM, Ho ML, Wu PW, Chou PT, Tsai TT, Chi Y: Iridium-complex modified CdSe/ZnS quantum dots; a conceptual design for bifunctionality toward imaging and photosensitization. Chem. Comm.(6),615-617 (2006).
54. Tsay JM, Trzoss M, Shi LX et al.: Singlet oxygen production by peptide-coated quantum dotphotosensitizer conjugates. J. Am. Chem. Soc.129 (21),6865-6871 (2007).
55. Ma J, Chen JY, Idowu M, Nyokong T: Generation of singlet oxygen via the composites of water-soluble thiol-capped CdTe quantum dots - sulfonated aluminum phthalocyanines. J. Phys. Chem. B112(15),4465-4469 (2008).
56. Bakalova R, Ohba H, Zhelev Z et al.: Quantum dot anti-CD conjugates: are they potential photosensitizers or potentiators of classical photosensitizing agents in photodynamic therapy of cancer? Nano Lett.4(9),1567-1573 (2004)
57. Medintz IL, Mattoussi H, Clapp AR: Potential clinical applications of quantum dots. Int. J. Nanomed.3(2),151-167 (2008).
58. Jaiswal JK, Mattoussi H, Mauro JM, Simon SM: Long-term multiple color imaging of live cells using quantum dot bioconjugates. Nat. Biotechnol.21(1),47-51 (2003).
59. Derfus AM, Chan WCW, Bhatia SN: Probing the cytotoxicity of semiconductor quantum dots. Nano Lett.4(1),11-18 (2004).
60. Collins HA, Khurana M, Moriyama EH et al.: Blood-vessel closure using photosensitizers engineered for two-photon excitation. Nat. Photonics2(7),420-424 (2008).