Endothelin rather than 20-HETE contributes to loss of pial arteriolar dilation during focal cerebral ischemia with and without polymeric hemoglobin transfusion

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 296, Issue 5, 2009, Pages

  Cao, Suyi ^a   Wang, Liang Chao ^a   Kwansa, Herman ^a   Roman, Richard J ^b   Harder, David R ^b   Koehler, Raymond C ^a,c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Blood substitutes; BQ610; Hemoglobin based oxygen carrier; HET0016; Rat; Stroke

Indexed keywords

20 HYDROXYICOSATETRAENOIC ACID; BQ 610; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; HEMOGLOBIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTERY DIAMETER; ARTERY DILATATION; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; EXCHANGE BLOOD TRANSFUSION; LEUKOCYTE ADHERENCE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PIA ARTERY; PRIORITY JOURNAL; RAT;

AMIDINES; ANIMALS; ARTERIOLES; BLOOD SUBSTITUTES; BLOOD TRANSFUSION; BRAIN ISCHEMIA; ENDOTHELINS; HEMOGLOBINS; HYDROXYEICOSATETRAENOIC ACIDS; MALE; MODELS, ANIMAL; OLIGOPEPTIDES; PIA MATER; POLYMERS; RATS; RATS, WISTAR; RECEPTOR, ENDOTHELIN A; REGIONAL BLOOD FLOW; VASODILATION;

EID: 66149101990     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00003.2009     Document Type: Article

References (37)

1. Atochin DN, Wang A, Liu VW, Critchlow JD, Dantas AP, Looft-Wilson R, Murata T, Salomone S, Shin HK, Ayata C, Moskowitz MA, Michel T, Sessa WC, Huang PL. The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo. J Clin Invest 117: 1961-1967, 2007. (Pubitemid 47036330)
2. Barone FC, Globus MYT, Price WJ, White RF, Storer BL, Feuerstein GZ, Busto R, Ohlstein EH. Endothelin levels increase in rat focal and global ischemia. J Cereb Blood Flow Metab 14: 337-342, 1994. (Pubitemid 24064447)
3. Cole DJ, Schell RM, Przybelski RJ, Drummond JC, Bradley K. Focal cerebral ischemia in rats: effect of hemodilution with α-α cross-linked hemoglobin on CBF. J Cereb Blood Flow Metab 12: 971-976, 1992.
4. Dunn KM, Renic M, Flasch AK, Harder DR, Falck JR, Roman RJ. Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 295: H2455-H2465, 2008.
5. Gebremedhin D, Lange AR, Lowry TF, Taheri MR, Birks EK, Hudetz AG, Narayanan J, Falck JR, Okamoto H, Roman RJ, Nithipatikom K, Campbell WB, Harder DR. Production of 20-HETE and its role in autoregulation of cerebral blood flow. Circ Res 87: 60-65, 2000. (Pubitemid 30456936)
6. + channel currents in rat cerebral arterial muscle cells. Am J Physiol Heart Circ Physiol 294: H107-H120, 2008.
7. Gulati A, Sen AP, Sharma AC, Singh G. Role of ET and NO in resuscitative effect of diaspirin cross-linked hemoglobin after hemorrhage in rat. Am J Physiol Heart Circ Physiol 273: H827-H836, 1997. (Pubitemid 27392238)
8. Gulati A, Sharma AC, Singh G. Role of endothelin in the cardiovascular effects of diaspirin cross-linked hemoglobin. Crit Care Med 24: 137-147, 1996. (Pubitemid 26153242)
9. Gulati A, Singh G, Rebello S, Sharma AC. Effect of diaspirin crosslinked and stroma-reduced hemoglobin on mean arterial pressure and endothelin-1 concentration in rats. Life Sci 56: 1433-1442, 1995.
10. Harder DR, Narayanan J, Birks EK, Liard JF, Imig JD, Lombard JH, Lange AR, Roman RJ. Identification of a putative microvascular oxygen sensor. Circ Res 79: 54-61, 1996. (Pubitemid 26196317)
11. Legos JJ, Lenhard SC, Haimbach RE, Schaeffer TR, Bentley RG, McVey MJ, Chandra S, Irving EA, Andrew AP, Barone FC. SB 234551 selective ET(A) receptor antagonism: perfusion/diffusion MRI used to define treatable stroke model, time to treatment and mechanism of protection. Exp Neurol 212: 53-62, 2008.
12. Lehmberg J, Putz C, Furst M, Beck J, Baethmann A, Uhl E. Impact of the endothelin-A receptor antagonist BQ 610 on microcirculation in global cerebral ischemia and reperfusion. Brain Res 961: 277-286, 2003. (Pubitemid 36071589)
13. Matheson B, Kwansa HE, Bucci E, Rebel A, Koehler RC. Vascular response to infusions of a nonextravasating hemoglobin polymer. J Appl Physiol 93: 1479-1486, 2002.
14. Mito T, Nemoto M, Kwansa H, Sampei K, Habeeb M, Murphy SJ, Bucci E, Koehler RC. Decreased damage from transient focal cerebral ischemia by transfusion of zero-link hemoglobin polymers in mouse. Stroke 40: 278-284, 2009.
15. Miyata N, Seki T, Tanaka Y, Omura T, Taniguchi K, Doi M, Bandou K, Kametani S, Sato M, Okuyama S, Cambj-Sapunar L, Harder DR, Roman RJ. Beneficial effects of a new 20-hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4-morpholin-4-yl) phenyl-N′-hydroxyimido formamide], on hemorrhagic and ischemic stroke. J Pharmacol Exp Ther 314: 77-85, 2005. (Pubitemid 41058243)
16. Morikawa E, Rosenblatt S, Moskowitz MA. L-Arginine dilates rat pial arterioles by nitric oxide-dependent mechanisms and increases blood flow during focal cerebral ischemia. Br J Pharmacol 107: 905-907, 1992.
17. Omura T, Tanaka Y, Miyata N, Koizumi C, Sakurai T, Fukasawa M, Hachiuma K, Minagawa T, Susumu T, Yoshida S, Nakaike S, Okuyama S, Harder DR, Roman RJ. Effect of a new inhibitor of the synthesis of 20-HETE on cerebral ischemia reperfusion injury. Stroke 37: 1307-1313, 2006. (Pubitemid 43731881)
18. Patel TR, Galbraith S, Graham DI, Hallak H, Doherty AM, McCulloch J. Endothelin receptor antagonist increases cerebral perfusion and reduces ischaemic damage in feline focal cerebral ischaemia. J Cereb Blood Flow Metab 16: 950-958, 1996. (Pubitemid 26292062)
19. Patel TR, Galbraith S, McAuley MA, McCulloch J. Endothelin-mediated vascular tone following focal cerebral ischaemia in the cat. J Cereb Blood Flow Metab 16: 679-687, 1996. (Pubitemid 26227078)
20. Poloyac SM, Zhang Y, Bies RR, Kochanek PM, Graham SH. Protective effect of the 20-HETE inhibitor HET0016 on brain damage after temporary focal ischemia. J Cereb Blood Flow Metab 26: 1551-1561, 2006.
21. Qin X, Kwansa H, Bucci E, Dore S, Boehning D, Shugar D, Koehler RC. Role of heme oxygenase-2 in pial arteriolar response to acetylcholine in mice with and without transfusion of cell-free hemoglobin polymers. Am J Physiol Regul Integr Comp Physiol 295: R498-R504, 2008.
22. Qin X, Kwansa H, Bucci E, Roman RJ, Koehler RC. Role of 20-HETE in the pial arteriolar constrictor response to decreased hematocrit after exchange transfusion of cell-free polymeric hemoglobin. J Appl Physiol 100: 336-342, 2006. (Pubitemid 43671126)
23. Rebel A, Cao S, Kwansa H, Dore S, Bucci E, Koehler RC. Dependence of acetylcholine and ADP dilation of pial arterioles on heme oxygenase after transfusion of cell-free polymeric hemoglobin. Am J Physiol Heart Circ Physiol 290: H1027-H1037, 2006.
24. Rebel A, Ulatowski JA, Joung K, Bucci E, Traystman RJ, Koehler RC. Regional cerebral blood flow in cats with cross-linked hemoglobin transfusion during focal cerebral ischemia. Am J Physiol Heart Circ Physiol 282: H832-H841, 2002. (Pubitemid 34654917)
25. Rebel A, Ulatowski JA, Kwansa H, Bucci E, Koehler RC. Cerebrovascular response to decreased hematocrit: effect of cell-free hemoglobin, plasma viscosity, and CO2. Am J Physiol Heart Circ Physiol 285: H1600-H1608, 2003. (Pubitemid 37169515)
26. Renic M, Klaus JA, Omura T, Kawashima N, Onishi M, Miyata N, Koehler RC, Harder DR, Roman RJ. Effect of 20-HETE inhibition on infarct volume and cerebral blood flow after transient middle cerebral artery occlusion. J Cereb Blood Flow Metab 29: 629-639, 2008.
27. Rikitake Y, Kim HH, Huang Z, Seto M, Yano K, Asano T, Moskowitz MA, Liao JK. Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke 36: 2251-2257, 2005. (Pubitemid 41429255)
28. Sampei K, Ulatowski JA, Asano Y, Kwansa H, Bucci E, Koehler RC. Role of nitric oxide scavenging in vascular response to cell-free hemoglobin transfusion. Am J Physiol Heart Circ Physiol 289: H1191-H1201, 2005. (Pubitemid 41208963)
29. Saxena R, Wijnhoud AD, Carton H, Hacke W, Kaste M, Przybelski RJ, Stern KN, Koudstaal PJ. Controlled safety study of a hemoglobin-based oxygen carrier, DCLHb, in acute ischemic stroke. Stroke 30: 993-996, 1999. (Pubitemid 29211616)
30. Saxena R, Wijnhoud AD, Man in 't Veld AJ, van den Meiracker AH, Boomsma F, Przybelski RJ, Koudstaal PJ. Effect of diaspirin crosslinked hemoglobin on endothelin-1 and blood pressure in acute ischemic stroke in man. J Hypertens 16: 1459-1465, 1998.
31. Shin HK, Salomone S, Potts EM, Lee SW, Millican E, Noma K, Huang PL, Boas DA, Liao JK, Moskowitz MA, Ayata C. Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms. J Cereb Blood Flow Metab 27: 998-1009, 2007. (Pubitemid 46659030)
32. Tatlisumak T, Carano RAD, Takano K, Opgenorth TJ, Sotak CH, Fisher M. A novel endothelin antagonist, A-12772, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion. Stroke 29: 850-858, 1998.
33. Ulatowski JA, Nishikawa T, Matheson-Urbaitis B, Bucci E, Traystman RJ, Koehler RC. Regional blood flow alterations after bovine fumaryl ββ-crosslinked hemoglobin transfusion and nitric oxide synthase inhibition. Crit Care Med 24: 558-565, 1996. (Pubitemid 26133787)
34. Yamaguchi S, Kobayashi S, Yamashita K, Kitani M. Pial arterial pressure contribution to early ischemic brain edema. J Cereb Blood Flow Metab 9: 597-602, 1989. (Pubitemid 19239478)
35. Zhang Y, Belayev L, Zhao W, Irving EA, Busto R, Ginsberg MD. A selective endothelin ET(A) receptor antagonist, SB 234551, improves cerebral perfusion following permanent focal cerebral ischemia in rats. Brain Res 1045: 150-156, 2005. (Pubitemid 40725231)
36. Zhang Z, Chen TY, Kirsch JR, Toung TJ, Traystman RJ, Koehler RC, Hurn PD, Bhardwaj A. Kappa-opioid receptor selectivity for ischemic neuroprotection with BRL 52537 in rats. Anesth Analg 97: 1776-1783, 2003. (Pubitemid 37475138)
37. Ziv I, Fleminger G, Djaldetti R, Achiron A, Melamed E, Sokolovsky M. Increased plasma endothelin-1 in acute ischemic stroke. Stroke 23: 1014-1016, 1992.