Kappa-Opioid Receptor Selectivity for Ischemic Neuroprotection with BRL 52537 in Rats

Anesthesia and Analgesia

Volumn 97, Issue 6, 2003, Pages 1776-1783

  Zhang, Zhizheng ^a   Chen, Tsung Ying ^b   Kirsch, Jeffrey R ^a   Toung, Thomas J K ^b   Traystman, Richard J ^a   Koehler, Raymond C ^b   Hurn, Patricia D ^a   Bhardwaj, Anish ^b,c  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3,4 DICHLOROPHENYL)ACETYL 2 (1 PYRROLIDINYL)METHYLPIPERADINE; 17,17' (DICYCLOPROPYLMETHYL) 6,6'7,7' BINORPHINAN 3,4',14,14' TETROL; BINALTORPHIMINE; BRL 52537; KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR AGONIST; KAPPA OPIATE RECEPTOR ANTAGONIST; NEUROPROTECTIVE AGENT; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN PERFUSION; CAUDATE NUCLEUS; CONTROLLED STUDY; DRUG EFFECT; DRUG SELECTIVITY; HISTOLOGY; LASER DOPPLER FLOWMETRY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PUTAMEN; RAT; RECEPTOR SENSITIVITY; REPERFUSION; TRANSIENT ISCHEMIC ATTACK; TREATMENT OUTCOME;

EID: 0344851894     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ANE.0000087800.56290.2E     Document Type: Article

References (43)

1. Zabramski JM, Spetzler RF, Selman WR, et al. Naloxone therapy during focal cerebral ischemia evaluation in a primate model. Stroke 1984;15:621-7.
2. Rogers H, Birch PJ, Harrison SM, et al. GR94839, a kappa-opioid agonist with limited access to the central nervous system, has antinociceptive activity. Br J Pharmacol 1992;106:783-9.
3. Baskin DS, Hosobuchi Y, Loh HH, et al. Dynorphin(1-13) improves survival in cats with focal cerebral ischemia. Nature 1984;312:551-2.
4. Tang AH. Protection from cerebral ischemia by U-50,488E, a specific kappa opioid analgesic agent. Life Sci 1985;37:1475-82.
5. Silvia RC, Sllizgi GR, Ludens JH, et al. Protection from ischemia-induced cerebral edema in the rat by U-50488H, a kappa opioid receptor agonist. Brain Res 1987;403:52-7.
6. Mackay KB, Kusomoto K, Graham DI, et al. Effect of kappa-1 opioid agonist CI-977 on ischemic brain damage and cerebral blood flow after middle cerebral artery occlusion in the rat. Brain Res 1993;629:10-8.
7. Kusomoto K, Mackay KB, McCulloch J. The effect of the kappa-opioid receptor agonist CI-977 in a rat model of focal cerebral ischemia. Brain Res 1992;576:147-51.
8. Baskin DS, Widmayer MA, Browning JL, et al. Evaluation of delayed treatment of focal cerebral ischemia with three selective κ-opioid agonists in cats. Stroke 1994;25:2047-54.
9. Ohno M, Yamamoto T, Ueki S. Effect of the κ-receptor agonist, U-50,488H, on cerebral-ischemia-induced impairment of working memory assessed in rats by a three-panel runway task. Eur J Pharmacol 1991;193:357-61.
10. Itoh J, Ukai M, Kameyama T. U-50,488H, a κ-receptor agonist, markedly prevents memory dysfunctions induced by transient cerebral ischemia in mice. Brain Res 1993;619:223-8.
11. Itoh J, Ukai M, Kameyama T. Dynorphine A-(1-13) potently prevents memory dysfunctions induced by transient cerebral ischemia in mice. Eur J Pharmacol 1993;234:99-104.
12. Genovese RF, Moreton JE, Tortella FC. Evaluation of neuroprotection and behavioral recovery by the kappa-opioid, PD117302 following transient forebrain ischemia. Brain Res Bull 1994;34: 111-6.
13. Pinnock RD. A highly selective κ-opioid receptor agonist, CL-977, reduces excitatory synaptic potentials in the rat locus coeruleus in vitro. Neuroscience 1992;47:87-94.
14. Wagner JJ, Caudle RM, Chavkin C. κ-Opioids decrease excitatory neurotransmission in the dentate gyrus of the guinea pig hippocampus. J Neurosci 1992;12:132-41.
15. Gannon RL, Terrian DM. U-50,488H inhibits dynorphin and glutamate release from guinea pig hippocampal mossy fiber terminals. Brain Res 1991;548:242-7.
16. Bradford HF, Crowder JM, White EJ. Inhibitory actions of opioid compounds on calcium fluxes and neurotransmitter release from mammalian cerebral cortical slices. Br J Pharmacol 1986; 88:87-93.
17. 45Ca into rat cortical synaptosomes by inhibiting N- but not L-type calcium channels. Neuropharmacology 1990;29:439-44.
18. Gross RA, Macdonald RL. Dynorphin A selectively reduces a large transient (N-type) calcium current of mouse dorsal root ganglion neurons in cell culture. Proc Natl Acad Sci U S A 1987;84:5469-73.
19. Goyagi T, Toung TJK, Kirsch JR, et al. Neuroprotective kappa opioid receptor agonist, BRL 52537 attenuates ischemia-evoked nitric oxide production in vivo in rats. Stroke 2003;34:1533-8.
20. Vecchietti V, Giordani A, Giardina G, et al. (2S)-1-(Arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective kappa opioid analgesics. J Med Chem 1991;34:397-403.
21. Vecchietti V, Clarke GD, Colle R, et al. (1S)-1-(Aminomethyl)-2-(arylacetyl)-1,2,3,4-tetrahydroisoquinoline and heterocycle-condensed tetrahydropyridine derivatives: members of a novel class of very potent kappa opioid analgesics. J Med Chem 1991;34:2624-33.
22. Vecchietti V, Clarke GD, Colle R, et al. Substituted 1-(aminomethyl)-2-(arylacetyl)-1,2,3,4-tetrahydroisoquinolines: a novel class of very potent antinociceptive agents with varying degrees for kappa and mu opioid receptors. J Med Chem 1992; 35:2970-8.
23. Giardina G, Clarke GD, Dondio G, et al. Selective kappa-opioid agonists: synthesis and structure-activity relationships of piperidines incorporating on oxo-containing acyl group. J Med Chem 1994;37:3482-91.
24. Portoghese PS, Lin CE, Farouz-Grant F, et al. Structure-activity relationship of N17′-substituted norbinaltorphimine congeners: role of the N17′-basic group in the interaction with a putative address subsite on the κ-opioid receptor. J Med Chem 1994;37: 1495-500.
25. Chang AC, Takemori AE, Portoghese PS. (2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl) -2-(1-pyrrolidinyl)ethyl] acetamide): an opioid receptor affinity label that produces selective and long lasting κ antagonism in mice. J Med Chem 1994;37:1547-9.
26. Chang AC, Takemori AE, Ojala WH, et al. κ Opioid receptor selective affinity labels: electrophilic benzeneacetamides as κ-selective opioid antagonists. J Med Chem 1994;37:4490-8.
27. Longa EZ, Weinstein PR, Carlson S, et al. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989;20:84-91.
28. Alkayed NJ, Murphy SJ, Traystman RJ, et al. Neuroprotective effects of female gonadal steroids in reproductively senescent female rats. Stroke 2000;31:161-8.
29. Bhardwaj A, Harukuni I, Murphy SJ, et al. Hypertonic saline worsens infarction volume following transient focal ischemia in rat. Stroke 2000;31:1694-701.
30. Werner C, Hoffman WE, Kochs E, et al. Captopril improves neurologic outcome from incomplete cerebral ischemia in rats. Stroke 1991;22:910-4.
31. Bederson JB, Pitts LH, Tsuji M, et al. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 1986;17:472-6.
32. Lin TN, He YY, Wu G, et al. Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats. Stroke 1993; 24:117-21.
33. Schoffelmeer AN, Hogenboom F, Mulder AH. Kappa 1- and kappa 2-opioid receptors mediating presynaptic inhibition of dopamine and acetylcholine release in rat neostriatum. Br J Pharmacol 1997;122:520-4.
34. 1-opioid receptor binding in human insular cortex. Life Sci 1999;65:857-62.
35. Alicea C, Belkowski SM, Sliker JK, et al. Characterization of kappa-opioid receptor transcripts expressed by T cells and macrophages. J Neuroimmunol 1998;91:55-62.
36. Boutin H, Dauphin F, MacKenzie ET, et al. Differential time-course decreases in nonselective μ-, δ,- and κ-opioid receptors after focal cerebral ischemia in mice. Stroke 1999;30:1271-7.
37. Kumon Y, Kim SC, Tompkins P, et al. Neuroprotective effects of postischemic administration of progesterone in spontaneously hypertensive rats with focal cerebral ischemia. J Neurosurg 2000;92:848-52.
38. Lei B, Cottrell JE, Kass IS. Neuroprotective effects of low-dose lidocaine in rat model of transient focal cerebral ischemia. Anesthesiology 2000;95:445-51.
39. Chen H, Chopp M, Welch KMA. Effect of mild hypothermia on ischemic infarct volume after middle cerebral artery occlusion in the rat. Neurology 1991;41:1133-5.
40. Morikawa E, Ginsberg MD, Dietrich WD, et al. The significance of brain temperature in focal cerebral ischemia: histopathological consequences of middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 1992;12:380-9.
41. Benamar K, Geller EB, Adler MW. Role of the nitric oxide pathway in kappa-opioid induced hypothermia in rats. J Pharmacol Exp Ther 2002;303:375-8.
42. Bhargava HN, Kumar S. Effect of multiple injections of U50, 488H, a kappa-opioid receptor agonist, on the activity of nitric oxide synthase in brain regions and spinal cord of mice. Gen Pharmacol 1997;29:397-9.
43. Toung TJK, Hurn PD, Traystman RJ, et al. Global brain water increases after experimental focal ischemia: effect of hypertonic saline. Crit Care Med 2000;30:644-9.