Air pollution and cardiac remodeling: A role for RhoA/Rho-kinase

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 296, Issue 5, 2009, Pages

  Ying, Zhekang ^a   Yue, Peibin ^a   Xu, Xiaohua ^b   Zhong, Mianhua ^c   Sun, Qinghua ^a,b   Mikolaj, Michael ^a   Wang, Aixia ^a   Brook, Robert D ^d   Chen, Lung Chi ^c   Rajagopalan, Sanjay ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Angiotensin II; Hypertension; Vasoconstrictors

Indexed keywords

ANGIOTENSIN II; COLLAGEN; FASUDIL; GUANINE NUCLEOTIDE; MATRIX METALLOPROTEINASE; PLACEBO; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

AIR POLLUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL REACTIVITY; CARDIOVASCULAR FUNCTION; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE REMODELING; HYPERTENSION; MALE; MOUSE; NONHUMAN; PARTICULATE MATTER; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANGIOTENSIN II; ANIMALS; ATMOSPHERE EXPOSURE CHAMBERS; BLOOD PRESSURE; CARDIOMEGALY; COLLAGEN; DISEASE MODELS, ANIMAL; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HYPERTENSION; INFUSION PUMPS; INHALATION EXPOSURE; INJECTIONS, INTRAPERITONEAL; MALE; MATRIX METALLOPROTEINASES, SECRETED; MICE; MICE, INBRED C57BL; MYOCARDIUM; PARTICULATE MATTER; PROTEIN KINASE INHIBITORS; RHO GTP-BINDING PROTEINS; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION; VASOCONSTRICTION; VASODILATION; VENTRICULAR REMODELING;

EID: 66149093377     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01270.2008     Document Type: Article

References (58)

1. Amara N, Bachoual R, Desmard M, Golda S, Guichard C, Lanone S, Aubier M, Ogier-Denis E, Boczkowski J. Diesel exhaust particles induce matrix metalloprotease-1 in human lung epithelial cells via a NADP(H) oxidase/NOX4 redox-dependent mechanism. Am J Physiol Lung Cell Mol Physiol 293: L170-L181, 2007. (Pubitemid 47080725)
2. Aoki H, Izumo S, Sadoshima J. Angiotensin II activates RhoA in cardiac myocytes: a critical role of RhoA in angiotensin II-induced premyofibril formation. Circ Res 82: 666-676, 1998. (Pubitemid 28160707)
3. Becher R, Bucht A, Ovrevik J, Hongslo JK, Dahlman HJ, Samuelsen JT, Schwarze PE. Involvement of NADPH oxidase and iNOS in rodent pulmonary cytokine responses to urban air and mineral particles. Inhal Toxicol 19: 645-655, 2007. (Pubitemid 46788946)
4. Brilla CG, Rupp H, Funck R, Maisch B. The renin-angiotensin-aldosterone system and myocardial collagen matrix remodelling in congestive heart failure. Eur Heart J 16, Suppl O: 107-109, 1995. (Pubitemid 26082358)
5. Brook RD. Is air pollution a cause of cardiovascular disease? Updated review and controversies. Rev Environ Health 22: 115-137, 2007.
6. Brook RD, Brook JR, Urch B, Vincent R, Rajagopalan S, Silverman F. Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults. Circulation 105: 1534-1536, 2002. (Pubitemid 34297626)
7. Brook RD, Franklin B, Cascio W, Hong Y, Howard G, Lipsett M, Luepker R, Mittleman M, Samet J, Smith SC Jr, Tager I. Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association. Circulation 109: 2655-2671, 2004. (Pubitemid 38720571)
8. Browatzki M, Larsen D, Pfeiffer CA, Gehrke SG, Schmidt J, Kranzhofer A, Katus HA, Kranzhofer R. Angiotensin II stimulates matrix metalloproteinase secretion in human vascular smooth muscle cells via nuclear factor-kappaB and activator protein 1 in a redox-sensitive manner. J Vasc Res 42: 415-423, 2005. (Pubitemid 41368960)
9. Charron F, Tsimiklis G, Arcand M, Robitaille L, Liang Q, Molkentin JD, Meloche S, Nemer M. Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA. Genes Dev 15: 2702-2719, 2001. (Pubitemid 32988880)
10. Chen LC, Hwang JS. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice. IV. Characterization of acute and chronic effects of ambient air fine particulate matter exposures on heart-rate variability. Inhal Toxicol 17: 209-216, 2005.
11. Dominici F, Peng RD, Bell ML, Pham L, McDermott A, Zeger SL, Samet JM. Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. JAMA 295: 1127-1134, 2006. (Pubitemid 43352341)
12. Flamant M, Placier S, Dubroca C, Esposito B, Lopes I, Chatziantoniou C, Tedgui A, Dussaule JC, Lehoux S. Role of matrix metalloproteinases in early hypertensive vascular remodeling. Hypertension 50: 212-218, 2007. (Pubitemid 46986043)
13. Griendling KK. NADPH oxidases: new regulators of old functions. Antioxidants Redox Signal 8: 1443-1445, 2006.
14. Gurgueira SA, Lawrence J, Coull B, Murthy GG, Gonzalez-Flecha B. Rapid increases in the steady-state concentration of reactive oxygen species in the lungs and heart after particulate air pollution inhalation. Environ Health Perspect 110: 749-755., 2002.
15. Harrabi I, Rondeau V, Dartigues JF, Tessier JF, Filleul L. Effects of particulate air pollution on systolic blood pressure: a population-based approach. Environ Res 101: 89-93, 2006.
16. Hartz AM, Bauer B, Block ML, Hong JS, Miller DS. Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein upregulation at the blood-brain barrier. FASEB J 22: 2723-2733, 2008.
17. Hattori T, Shimokawa H, Higashi M, Hiroki J, Mukai Y, Tsutsui H, Kaibuchi K, Takeshita A. Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice. Circulation 109: 2234-2239, 2004. (Pubitemid 38625402)
18. Higashi Y, Sasaki S, Nakagawa K, Matsuura H, Oshima T, Chayama K. Endothelial function and oxidative stress in renovascular hypertension. N Engl J Med 346: 1954-1962, 2002. (Pubitemid 34651355)
19. Hilgers RH, Todd J Jr, Webb RC. Increased PDZ-RhoGEF/RhoA/Rho kinase signaling in small mesenteric arteries of angiotensin II-induced hypertensive rats. J Hypertens 25: 1687-1697, 2007.
20. Ibald-Mulli A, Stieber J, Wichmann HE, Koenig W, Peters A. Effects of air pollution on blood pressure: a population-based approach. Am J Public Health 91: 571-577, 2001. (Pubitemid 32245297)
21. Khan R, Sheppard R. Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia. Immunology 118: 10-24, 2006.
22. Kobayashi N, Horinaka S, Mita S, Nakano S, Honda T, Yoshida K, Kobayashi T, Matsuoka H. Critical role of Rho-kinase pathway for cardiac performance and remodeling in failing rat hearts. Cardiovasc Res 55: 757-767, 2002.
23. Kuwahara K, Saito Y, Nakagawa O, Kishimoto I, Harada M, Ogawa E, Miyamoto Y, Hamanaka I, Kajiyama N, Takahashi N, Izumi T, Kawakami R, Tamura N, Ogawa Y, Nakao K. The effects of the selective ROCK inhibitor, Y27632, on ET-1-induced hypertrophic response in neonatal rat cardiac myocytes-possible involvement of Rho/ ROCK pathway in cardiac muscle cell hypertrophy. FEBS Lett 452: 314-318, 1999. (Pubitemid 29301767)
24. Leask A. TGFbeta, cardiac fibroblasts, and the fibrotic response. Cardiovasc Res 74: 207-212, 2007. (Pubitemid 46533834)
25. Li Z, Carter JD, Dailey LA, Huang YC. Pollutant particles produce vasoconstriction and enhance MAPK signaling via angiotensin type I receptor. Environ Health Perspect 113: 1009-1014, 2005. (Pubitemid 41149630)
26. 2 production from NAD(P)H oxidase and mitochondria in human pulmonary artery endothelial cells. Am J Physiol Cell Physiol 291: C357-C365, 2006.
27. Loirand G, Guerin P, Pacaud P. Rho kinases in cardiovascular physiology and pathophysiology. Circ Res 98: 322-334, 2006. (Pubitemid 43755328)
28. Luchtefeld M, Grote K, Grothusen C, Bley S, Bandlow N, Selle T, Struber M, Haverich A, Bavendiek U, Drexler H, Schieffer B. Angiotensin II induces MMP-2 in a p47phox-dependent manner. Biochem Biophys Res Commun 328: 183-188, 2005. (Pubitemid 40164653)
29. Maciejczyk P, Zhong M, Li Q, Xiong J, Nadziejko C, Chen LC. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice. II. The design of a CAPs exposure system for biometric telemetry monitoring. Inhal Toxicol 17: 189-197, 2005. (Pubitemid 40516017)
30. Miller KA, Siscovick DS, Sheppard L, Shepherd K, Sullivan JH, Anderson GL, Kaufman JD. Long-term exposure to air pollution and incidence of cardiovascular events in women. N Engl J Med 356: 447-458, 2007. (Pubitemid 46193072)
31. Mills NL, Tornqvist H, Robinson SD, Gonzalez M, Darnley K, Mac- Nee W, Boon NA, Donaldson K, Blomberg A, Sandstrom T, Newby DE. Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis. Circulation 112: 3930-3936, 2005. (Pubitemid 43739491)
32. Nemmar A, Hoet PH, Vanquickenborne B, Dinsdale D, Thomeer M, Hoylaerts MF, Vanbilloen H, Mortelmans L, Nemery B. Passage of inhaled particles into the blood circulation in humans. Circulation 105: 411-414, 2002. (Pubitemid 34141694)
33. Nemmar A, Hoylaerts MF, Hoet PH, Dinsdale D, Smith T, Xu H, Vermylen J, Nemery B. Ultrafine particles affect experimental thrombosis in an in vivo hamster model. Am J Respir Crit Care Med 166: 998-1004, 2002. (Pubitemid 35193233)
34. Nohria A, Grunert ME, Rikitake Y, Noma K, Prsic A, Ganz P, Liao JK, Creager MA. Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease. Circ Res 99: 1426-1432, 2006.
35. Noma K, Oyama N, Liao JK. Physiological role of ROCKs in the cardiovascular system. Am J Physiol Cell Physiol 290: C661-C668, 2006.
36. Oka M, Homma N, Taraseviciene-Stewart L, Morris KG, Kraskauskas D, Burns N, Voelkel NF, McMurtry IF. Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats. Circ Res 100: 923-929, 2007. (Pubitemid 46555698)
37. Olson ER, Shamhart PE, Naugle JE, Meszaros JG. Angiotensin IIinduced extracellular signal-regulated kinase 1/2 activation is mediated by protein kinase Cdelta and intracellular calcium in adult rat cardiac fibroblasts. Hypertension 51: 704-711, 2008.
38. Pope CA, 3rd, Dockery DW. Health effects of fine particulate air pollution: lines that connect. J Air Waste Manag Assoc 56: 709-742, 2006.
39. Pope CA, 3rd Muhlestein JB, May HT, Renlund DG, Anderson JL, Horne BD. Ischemic heart disease events triggered by short-term exposure to fine particulate air pollution. Circulation 114: 2443-2448, 2006.
40. Rajagopalan S, Kurz S, Munzel T, Tarpey M, Freeman BA, Griendling KK, Harrison DG. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone. J Clin Invest 97: 1916-1923, 1996. (Pubitemid 26129879)
41. Rajagopalan S, Meng XP, Ramasamy S, Harrison DG, Galis ZS. Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability. J Clin Invest 98: 2572-2579, 1996. (Pubitemid 26415078)
42. Rikitake Y, Oyama N, Wang CY, Noma K, Satoh M, Kim HH, Liao JK. Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+- haploinsufficient mice. Circulation 112: 2959-2965, 2005. (Pubitemid 41612298)
43. Satoh S, Ueda Y, Koyanagi M, Kadokami T, Sugano M, Yoshikawa Y, Makino N. Chronic inhibition of Rho kinase blunts the process of left ventricular hypertrophy leading to cardiac contractile dysfunction in hypertension-induced heart failure. J Mol Cell Cardiol 35: 59-70, 2003. (Pubitemid 36286968)
44. Schulz H, Harder V, Ibald-Mulli A, Khandoga A, Koenig W, Krombach F, Radykewicz R, Stampfl A, Thorand B, Peters A. Cardiovascular effects of fine and ultrafine particles. J Aerosol Med 18: 1-22, 2005. (Pubitemid 40349943)
45. Senzaki H, Gluzband YA, Pak PH, Crow MT, Janicki JS, Kass DA. Synergistic exacerbation of diastolic stiffness from short-term tachycardia-induced cardiodepression and angiotensin II. Circ Res 82: 503-512, 1998. (Pubitemid 28117332)
46. Shimokawa H, Takeshita A. Rho-kinase is an important therapeutic target in cardiovascular medicine. Arterioscler Thromb Vasc Biol 25: 1767-1775, 2005. (Pubitemid 41243442)
47. Siomboing X, Gressier B, Dine T, Brunet C, Luyckx M, Cazin M, Cazin JC. Investigation of the inhibitory effects of HA-1077 and Y-32885 on the translocation of PKCbetaI, PKCbetaII and PKCzeta in human neutrophils. Mediators Inflamm 10: 315-321, 2001. (Pubitemid 34084411)
48. Sun Q, Wang A, Jin X, Natanzon A, Duquaine D, Brook RD, Aguinaldo JG, Fayad ZA, Fuster V, Lippmann M, Chen LC, Rajagopalan S. Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal model. JAMA 294: 3003-3010, 2005. (Pubitemid 41817662)
49. Sun Q, Yue P, Ying Z, Cardounel AJ, Brook RD, Devlin R, Hwang JS, Zweier JL, Chen LC, Rajagopalan S. Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho/ ROCK. Arterioscler Thromb Vasc Biol 28: 1760-1766, 2008.
50. Sun Q, Yue P, Ying Z, Cardounel AJ, Brook RD, Devlin R, Hwang JS, Zweier JL, Chen LC, Rajagopalan S. Air pollution exposure potentiates hypertension through reactive oxygen species mediated activation of Rho/ROCK. Arterioscler Thromb Vasc Biol 28: 1760-1766, 2008.
51. 51a.United States Environmental Protection Agency. Federal Register Environmental Documents. Air Quality Criteria for Particulate Matter (online). http://www.epa.gov/EPA-AIR/2004/October/Day-29/a24232.htm [16 March 2009].
52. Urch B, Silverman F, Corey P, Brook JR, Lukic KZ, Rajagopalan S, Brook RD. Acute blood pressure responses in healthy adults during controlled air pollution exposures. Environ Health Perspect 113: 1052-1055, 2005. (Pubitemid 41149637)
53. von Klot S, Peters A, Aalto P, Bellander T, Berglind N, D'Ippoliti D, Elosua R, Hormann A, Kulmala M, Lanki T, Lowel H, Pekkanen J, Picciotto S, Sunyer J, Forastiere F. Ambient air pollution is associated with increased risk of hospital cardiac readmissions of myocardial infarction survivors in five European cities. Circulation 112: 3073-3079, 2005. (Pubitemid 43113438)
54. Wang YX, da Cunha V, Martin-McNulty B, Vincelette J, Li W, Choy DF, Halks-Miller M, Mahmoudi M, Schroeder M, Johns A, Light DR, Dole WP. Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice. Eur J Pharmacol 512: 215-222, 2005.
55. Wellenius GA, Schwartz J, Mittleman MA. Particulate air pollution and hospital admissions for congestive heart failure in seven United States cities. Am J Cardiol 97: 404-408, 2006. (Pubitemid 43133059)
56. Wong LS, Martins-Green M. Firsthand cigarette smoke alters fibroblast migration and survival: implications for impaired healing. Wound Repair Regen 12: 471-484, 2004. (Pubitemid 39007048)
57. Zahradka P. Novel role for osteopontin in cardiac fibrosis. Circ Res 102: 270-272, 2008.
58. Zanobetti A, Canner MJ, Stone PH, Schwartz J, Sher D, Eagan- Bengston E, Gates KA, Hartley LH, Suh H, Gold DR. Ambient pollution and blood pressure in cardiac rehabilitation patients. Circulation 110: 2184-2189, 2004. (Pubitemid 39372499)