The human cytomegalovirus-encoded chemokine receptor US28 promotes angiogenesis and tumor formation via cyclooxygenase-2

Cancer Research

Volumn 69, Issue 7, 2009, Pages 2861-2869

  Maussang, David ^a   Langemeijer, Ellen ^a   Fitzsimons, Carlos P ^a   Stigter van Walsům, Marijke ^b   Dijkman, Remco ^c   Borg, Martin K ^c   Slinger, Erik ^a   Schreiber, Andreas ^d   Michel, Detlef ^d   Tensen, Cornelia P ^c   Van Dongen, Guus A M S ^b   Leurs, Rob ^a   Smit, Martine J ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELECOXIB; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR US28; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN; CYCLOOXYGENASE 2 INHIBITOR; PYRAZOLE DERIVATIVE; SULFONAMIDE; US28 RECEPTOR, CYTOMEGALOVIRUS; VASCULOTROPIN A; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL STRAIN 3T3; CONTROLLED STUDY; CYTOMEGALOVIRUS; DRUG EFFECT; EMBRYO; ENZYME ACTIVATION; ENZYME RELEASE; FEMALE; GENE EXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR; TUMOR VASCULARIZATION; UPREGULATION; VIRUS CARCINOGENESIS; VIRUS INDUCTION; ANIMAL; BIOSYNTHESIS; CELL LINE; DNA MICROARRAY; ENZYME INDUCTION; EXPERIMENTAL NEOPLASM; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; VASCULARIZATION; VIRUS CELL TRANSFORMATION;

ANIMALS; CELL LINE; CELL TRANSFORMATION, VIRAL; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYTOMEGALOVIRUS; ENZYME INDUCTION; HUMANS; MICE; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; NF-KAPPA B; NIH 3T3 CELLS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PYRAZOLES; RECEPTORS, CHEMOKINE; SULFONAMIDES; TRANSCRIPTION, GENETIC; TRANSFECTION; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VIRAL PROTEINS;

EID: 66149091169     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-2487     Document Type: Article

References (47)

1. Rosenkilde MM, Smit MJ, Waldhoer M. Structure, function and physiological, consequences of virally encoded chemokine seven transmembrane receptors. BrJ Pharmacol 2008:153 Suppl l:S154-66.
2. Flore O, Raffi S, Ely S, O'LearyJJ, HyjekEM, Cesarman E. Transformation of primary human, endothelial cells by Kaposi's sarcoma-associated herpesvirus. Nature 1998;394:588-592.
3. Ganem D. KSHV and Kaposi's sarcoma: The end of the beginning? Cell 1997;91:157-160.
4. Young LS1 Rickinson AB. Epstein-Barr virus: 40 years on. Nat Rev Cancer 2004;4:757-768.
5. Damania B. Oncogenic 7-herpesvlruses: comparison of viral proteins involved in tumorigenesis. Nat Rev Microbiol 2004;2:656-668.
6. Cinatl J Jr., Vogel JU, Kotchetkov R, Wilhelm Doerr H. Oncomodulatory signals by regulatory proteins encoded by human cytomegalovirus: a novel role for viral, infection in tumor progression. FEMS Microbiol Rev 2004;28:59-77.
7. Harkins L, Volk AL, Samanta M, et al. Specific localisation of human cytomegalovirus nucleic acids and proteins in. human colorectal, cancer. Lancet 2002; 360:1557-1563.
8. Sabatier J, Uro-Coste E, Pommepuy I, et al. Detection of human cytomegalovirus genome and gene products in central nervous system tumours. Br J Cancer 2005:92: 747-50.
9. Soderberg-Naucler C. HCMV microinfections in inflammatory diseases and cancer. J Clin. Virol 2008;41: 21.8-23.
10. Michaelis M, Kotchetkov R, Vogel JU, Doerr HW, Cinatl J, Jr. Cytomegalovirus infection blocks apoptosis in cancer cells. Cell Mol Life Sci 2004;61:1307-16.
11. Balkwill F. Cancer and the chemokine network. Nat Rev Cancer 2004;4:540-50.
12. Bais C, Santomasso B, Coso O, et al. G-protein-coupled receptor of Kaposi's sarcoma-associated her-pesvirus is a viral oncogene and angiogenesis activator. Nature 1998;391:86-9.
13. Yang TY, Chen SC, Leach MW et al. Transgenic expression of the chemokine receptor encoded by human herpesvirus 8 induces an angioprollferative disease resembling Kaposi's sarcoma. J Exp Med 2000; 191:445-54.
14. Maussang D, Verzijl D, van Walsům. M1 et al. Human cytomegalovirus-encoded chemokine receptor US28 promotes tumorigenesis. Proc Natl. Acad Sei U S A 2006:103:13068-73.
15. Casarosa P, Bakker RA Verzijl D, et al. Constitutive signaling of the human cytomegalovirus-encoded che- mokine receptor US28. J Biol Chem 2001;276:1133-7.
16. Boomker JM, Verschuuren EA, Blinker MG, de LeIj LF, The TH, Harmsen MC. Kinetics of US28 gene expression during active human cytomegalovirus infection, in lung-transplant recipients. J Infect Dis 2006;193: 1552-1556.
17. Russo G, Zegar C, Giordano A. Advantages and limitations of microarray technology in human cancer. Oncogene 2003;22:6497-6507.
18. Moses AV, Jarvis MA, Raggo C, et al. Kaposi's sarcoma-associated herpesvirus-induced up-regulation of the c-kit proto-oncogene, as identified by gene expression, profiling is essential for the transformation, of endothelial cells. J Vird 2002;76:8383-8399.
19. Schlee M Holzel M Bernard S et al. C-myc activation impairs the NF-KB and the interferon response: implications for the pathogenesis of Burkitt's lymphoma. Int J Cancer 2007;120:1387-1395.
20. Zhu H, Cong JP, Mamtora G, Gingeras T, Shenk T. Cellular gene expression altered by human, cytomegalo- virus: global monitoring with oligonucleotide arrays. Proc Natl Acad Sei U S A 1998:95:14470-14475.
21. Smyth GK. Limma: linear models for microarray data. In: Gentleman. R, Carey V, Huber W Irizarry R, Dudolt S, editors. Bioinformatics and Computational Biology Solutions using R and Bioconductor. New York: Springen 2005. p. 397-420.
22. Edgar R, Domrachev M, Lash AE. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 2002;30: 207-10.
23. Dennis G, Jr., Sherman BT, Hosack DA, et al. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 2003;4:P3.
24. Hosack DA, Dennis G, Jr., Sherman BT, Lane HC, Lempicki RA. Identifying biological themes within lists of genes with EASE. Genome Biol 2003;4;R70.
25. Iniguez MA, Martinez-Martinez S, Punzón C, Redondo JM, Fresno M. An essential role of the nuclear factor of activated T cells in the regulation, of the expression of the cyclooxygenase-2 gene in human T lymphocytes. J Biol Chem 2000;275:23627-23635.
26. Casarosa P, Menge WM, Minisini R1 et al. Identifica- tion of the first nonpeptidergic inverse agonist for a constltutively active viral-encoded G protein-coupled receptor. J Biol Chem 2003;278:5172-5178.
27. Kanehisa M, Goto S. KEGG: kyoto encydopedia of genes and genomes. Nucleic Acids Res 2000;28:27-30.
28. Higgins ME, Claremont M, Major JE, Sander C, Lash AE. CancerGenes: a gene selection, resource for cancer genome projects. Nucleic Acids Res 2007;35: D721-6.
29. Turini ME, DuBoIs RN. Cyclooxygen.ase-2: a therapeutic target. Annu Rev Med 2002;53:35-57.
30. Dorsam RT, Gutkind JS. G-protein-coupled receptors and cancer. Nat Rev Cancer 2007;7:79-94.
31. Smith WI, DeWitt DL, Garavlto RM. Cyclooxyge- nases: structural, cellular, and molecular biology. Annu Rev Biochem 2000:69:145-82.
32. Zhu H, Cong JP, Yu D, Bresnahan WA, Shenk TE. Inhibition of cyclooxygenase 2 blocks human cytomeg- alovirus replication. Proc Natl Acad Sei U S A 2002:99: 3932-3937.
33. Ragel BT, Jensen RL, Gillespie DL, Prescott SM, Couldwell WT. Celecoxib inhibits meningioma tumor growth in a mouse xenograft model. Cancer 2007; 1.09: 588-597.
34. Dhillon AS, Hagan S, Rath O, Kolch W. MAP kinase signalling pathways in cancer. Oncogene 2007; 26:3279-3290.
35. Roberts PJ, Der CJ. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 2007;26:3291-3310.
36. Scian MJ, Carchman EH, Mohanraj L, et al. Wild-type p53 and p73 negatively regulate expression of proliferation related genes. Oncogene 2008;27:2583-2593.
37. Toledo F, Wahl GM. Regulating the p53 pathway: in vitro hypotheses, in vivo Veritas. Nat Rev Cancer 2006; 6:909-923.
38. Hanahan. D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
39. Shelby BD, Nelson A, Morris C. 7-herpesvirus neoplasia: a growing role for COX-2. Microsc Res Tech 2005;68:120-129.
40. Pereg D1 Lishner M. Non-steroidal anti-inflammatory drugs for the prevention and treatment of cancer. J Intern Med 2005;258:115-23.
41. Howes LG. Selective COX-2 inhibitors, NSAIDs and cardiovascular events - is celecoxib the safest choice? Ther Clin Risk Manag 2007:3:831-845.
42. Cui W, Yu CH, Hu KQ. In vitro and in vivo effects and mechanisms of celecoxfb-induced growth inhibition of human, hepatocellular carcinoma cells. Clin. Cancer Res 2005;! 1:821.3-21.
43. Zhang X, Chen ZG, Choe MS, et al. Tumor growth inhibition by simultaneously blocking epidermal growth factor receptor and cyclooxygenase-2 in a xenograft model. Clin. Cancer Res 2005;11:6261-6269.
44. Grosch S, Maier TJ, Schiffmann S, Geisslinger G. Cyclooxygenase-2 (COX-2)-independen.t anticarcino- genic effects of selective COX-2 inhibitors. J Natl. Cancer Inst 2006;98:736-747.
45. Patel MT, Subbaramalah K, Du B, et al. Celecoxib inhibits prostate cancer growth: evidence of a cyclo- oxygenase-2-independent mechanism Clin Cancer Res 2005;11:1999-2007.
46. Subhashini J, Mahipal SV, Reddanna P. Anti-proliferative and apoptotic effects of celecoxib on human chronic myeloid leukemia in vitro. Cancer Lett 2005;224: 31-43.
47. Melnychuk RM, Streblow DN, Smith PP1 Hirsch AJ1 Pancheva D1 Nelson JA. Human cytomegalovirus- encoded G protein-coupled receptor US28 mediates smooth muscle cell migration through Goi.12. J Virol 2004;78:8382-8391.