메뉴 건너뛰기




Volumn 89, Issue , 2008, Pages 223-232

The genetics of Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; ANIMAL; CLASSIFICATION; GENETIC LINKAGE; GENETICS; HUMAN; REVIEW;

EID: 66049109678     PISSN: 00729752     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0072-9752(07)01221-3     Document Type: Review
Times cited : (2)

References (61)
  • 1
    • 33748182901 scopus 로고    scopus 로고
    • Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer's disease
    • Adighibe O., Arepalli S., Duckworth J., et al. Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer's disease. Neurobiol Aging 27 (2005) 1431-1434
    • (2005) Neurobiol Aging , vol.27 , pp. 1431-1434
    • Adighibe, O.1    Arepalli, S.2    Duckworth, J.3
  • 2
    • 0035479323 scopus 로고    scopus 로고
    • Systematic genetic study of Alzheimer disease in Latin America: mutation frequencies of the amyloid beta precursor protein and presenilin genes in Colombia
    • Arango D., Cruts M., Torres O., et al. Systematic genetic study of Alzheimer disease in Latin America: mutation frequencies of the amyloid beta precursor protein and presenilin genes in Colombia. Am J Med Genet 103 (2001) 138-143
    • (2001) Am J Med Genet , vol.103 , pp. 138-143
    • Arango, D.1    Cruts, M.2    Torres, O.3
  • 3
    • 0033593027 scopus 로고    scopus 로고
    • Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease
    • Bales K.R., Verina T., Cummins D.J., et al. Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 96 (1999) 15233-15238
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 15233-15238
    • Bales, K.R.1    Verina, T.2    Cummins, D.J.3
  • 4
    • 0032829336 scopus 로고    scopus 로고
    • Apolipoprotein E and beta-amyloid levels in the hippocampus and frontal cortex of Alzheimer's disease subjects are disease-related and apolipoprotein E genotype dependent
    • Beffert U., Cohn J.S., Petit-Turcotte C., et al. Apolipoprotein E and beta-amyloid levels in the hippocampus and frontal cortex of Alzheimer's disease subjects are disease-related and apolipoprotein E genotype dependent. Brain Res 843 (1999) 87-94
    • (1999) Brain Res , vol.843 , pp. 87-94
    • Beffert, U.1    Cohn, J.S.2    Petit-Turcotte, C.3
  • 6
    • 1842507631 scopus 로고    scopus 로고
    • Alzheimer's disease: One disorder, too many genes?
    • Spec No 1:
    • Bertram L., and Tanzi R.E. Alzheimer's disease: One disorder, too many genes?. Hum Mol Genet 13 (2004) R135-R141 Spec No 1:
    • (2004) Hum Mol Genet , vol.13
    • Bertram, L.1    Tanzi, R.E.2
  • 7
    • 0842282469 scopus 로고    scopus 로고
    • PEN2 is not a genetic risk factor for Alzheimer's disease in a large family sample
    • Bertram L., Menon R., Mullin K., et al. PEN2 is not a genetic risk factor for Alzheimer's disease in a large family sample. Neurology 62 (2004) 304-306
    • (2004) Neurology , vol.62 , pp. 304-306
    • Bertram, L.1    Menon, R.2    Mullin, K.3
  • 8
    • 33845892752 scopus 로고    scopus 로고
    • Systematic Meta-Analyses of Alzheimer Disease Genetic Association Studies: The AlzGene Database
    • Bertram L., McQueen M.B., Mullin K., et al. Systematic Meta-Analyses of Alzheimer Disease Genetic Association Studies: The AlzGene Database. Nat Genet 39 (2007) 17-23
    • (2007) Nat Genet , vol.39 , pp. 17-23
    • Bertram, L.1    McQueen, M.B.2    Mullin, K.3
  • 9
    • 17744410836 scopus 로고    scopus 로고
    • Apoe-4 and age at onset of Alzheimer's disease: the NIMH genetics initiative
    • Blacker D., Haines J.L., Rodes L., et al. Apoe-4 and age at onset of Alzheimer's disease: the NIMH genetics initiative. Neurology 48 (1997) 139-147
    • (1997) Neurology , vol.48 , pp. 139-147
    • Blacker, D.1    Haines, J.L.2    Rodes, L.3
  • 10
    • 12244296117 scopus 로고    scopus 로고
    • Results of a high-resolution genome screen of 437 Alzheimer's Disease families
    • Blacker D., Bertram L., Saunders A.J., et al. Results of a high-resolution genome screen of 437 Alzheimer's Disease families. Hum Mol Genet 12 (2003) 23-32
    • (2003) Hum Mol Genet , vol.12 , pp. 23-32
    • Blacker, D.1    Bertram, L.2    Saunders, A.J.3
  • 11
    • 33750588301 scopus 로고    scopus 로고
    • Genetic risk and transcriptional variability of amyloid precursor protein in Alzheimer's disease
    • Brouwers N., Sleegers K., Engelborghs S., et al. Genetic risk and transcriptional variability of amyloid precursor protein in Alzheimer's disease. Brain 129 (2006) 2984-2991
    • (2006) Brain , vol.129 , pp. 2984-2991
    • Brouwers, N.1    Sleegers, K.2    Engelborghs, S.3
  • 12
    • 0034770853 scopus 로고    scopus 로고
    • Categorizing genetic tests to identify their ethical, legal, and social implications
    • Burke W., Pinsky L.E., Press N.A., et al. Categorizing genetic tests to identify their ethical, legal, and social implications. Am J Med Genet 106 (2001) 233-240
    • (2001) Am J Med Genet , vol.106 , pp. 233-240
    • Burke, W.1    Pinsky, L.E.2    Press, N.A.3
  • 13
    • 0028305380 scopus 로고
    • Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease
    • Corder E.H., Saunders A.M., Risch N.J., et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet 7 (1994) 180-184
    • (1994) Nat Genet , vol.7 , pp. 180-184
    • Corder, E.H.1    Saunders, A.M.2    Risch, N.J.3
  • 14
    • 0033926434 scopus 로고    scopus 로고
    • The number of trait loci in late-onset Alzheimer disease
    • Daw E.W., Payami H., Nemens E.J., et al. The number of trait loci in late-onset Alzheimer disease. Am J Hum Genet 66 (2000) 196-204
    • (2000) Am J Hum Genet , vol.66 , pp. 196-204
    • Daw, E.W.1    Payami, H.2    Nemens, E.J.3
  • 15
    • 0030823158 scopus 로고    scopus 로고
    • Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium
    • Farrer L.A., Cupples L.A., Haines J.L., et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA 278 (1997) 1349-1356
    • (1997) JAMA , vol.278 , pp. 1349-1356
    • Farrer, L.A.1    Cupples, L.A.2    Haines, J.L.3
  • 16
    • 0037348113 scopus 로고    scopus 로고
    • The future of genetic association studies in Alzheimer disease
    • Finckh U. The future of genetic association studies in Alzheimer disease. J Neural Transm 110 (2003) 253-266
    • (2003) J Neural Transm , vol.110 , pp. 253-266
    • Finckh, U.1
  • 17
    • 32244435907 scopus 로고    scopus 로고
    • Role of genes and environments for explaining Alzheimer disease
    • Gatz M., Reynolds C.A., Fratiglioni L., et al. Role of genes and environments for explaining Alzheimer disease. Arch Gen Psychiatry 63 (2006) 168-174
    • (2006) Arch Gen Psychiatry , vol.63 , pp. 168-174
    • Gatz, M.1    Reynolds, C.A.2    Fratiglioni, L.3
  • 18
    • 0026088977 scopus 로고
    • Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
    • Goate A., Chartier-Harlin M.C., Mullan M., et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349 (1991) 704-706
    • (1991) Nature , vol.349 , pp. 704-706
    • Goate, A.1    Chartier-Harlin, M.C.2    Mullan, M.3
  • 19
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
    • Hardy J., and Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297 (2002) 353-356
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 20
    • 0037442235 scopus 로고    scopus 로고
    • Genetic associations in large versus small studies: an empirical assessment
    • Ioannidis J.P., Trikalinos T.A., Ntzani E.E., et al. Genetic associations in large versus small studies: an empirical assessment. Lancet 361 (2003) 567-571
    • (2003) Lancet , vol.361 , pp. 567-571
    • Ioannidis, J.P.1    Trikalinos, T.A.2    Ntzani, E.E.3
  • 21
    • 4444364883 scopus 로고    scopus 로고
    • Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein
    • Irizarry M.C., Deng A., Lleo A., et al. Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein. J Neurochem 90 (2004) 1132-1143
    • (2004) J Neurochem , vol.90 , pp. 1132-1143
    • Irizarry, M.C.1    Deng, A.2    Lleo, A.3
  • 22
    • 0034606897 scopus 로고    scopus 로고
    • Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls. International Studies of Infarct Survival (ISIS) Collaborators
    • Keavney B., McKenzie C., Parish S., et al. Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls. International Studies of Infarct Survival (ISIS) Collaborators. Lancet 355 (2000) 434-442
    • (2000) Lancet , vol.355 , pp. 434-442
    • Keavney, B.1    McKenzie, C.2    Parish, S.3
  • 23
    • 0029087026 scopus 로고
    • Candidate gene for the chromosome 1 familial Alzheimer's disease locus
    • Levy-Lahad E., Wasco W., Poorkaj P., et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269 (1995) 973-977
    • (1995) Science , vol.269 , pp. 973-977
    • Levy-Lahad, E.1    Wasco, W.2    Poorkaj, P.3
  • 24
    • 26444569232 scopus 로고    scopus 로고
    • Serum cholesterol and risk of Alzheimer disease: A community-based cohort study
    • Li G., Shofer J.B., Kukull W.A., et al. Serum cholesterol and risk of Alzheimer disease: A community-based cohort study. Neurology 65 (2005) 1045-1050
    • (2005) Neurology , vol.65 , pp. 1045-1050
    • Li, G.1    Shofer, J.B.2    Kukull, W.A.3
  • 25
    • 0036845601 scopus 로고    scopus 로고
    • Frequency of mutations in the presenilin and amyloid precursor protein genes in early-onset Alzheimer disease in Spain
    • Lleo A., Blesa R., Queralt R., et al. Frequency of mutations in the presenilin and amyloid precursor protein genes in early-onset Alzheimer disease in Spain. Arch Neurol 59 (2002) 1759-1763
    • (2002) Arch Neurol , vol.59 , pp. 1759-1763
    • Lleo, A.1    Blesa, R.2    Queralt, R.3
  • 26
    • 0037312921 scopus 로고    scopus 로고
    • Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease
    • Lohmueller K.E., Pearce C.L., Pike M., et al. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 33 (2003) 177-182
    • (2003) Nat Genet , vol.33 , pp. 177-182
    • Lohmueller, K.E.1    Pearce, C.L.2    Pike, M.3
  • 27
    • 33645808672 scopus 로고    scopus 로고
    • Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer's disease
    • Mahley R.W., Weisgraber K.H., Huang Y., et al. Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proc Natl Acad Sci USA 103 (2006) 5644-5651
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 5644-5651
    • Mahley, R.W.1    Weisgraber, K.H.2    Huang, Y.3
  • 28
    • 0031820439 scopus 로고    scopus 로고
    • APOE genotype predicts when-not whether-one is predisposed to develop Alzheimer disease
    • Meyer M.R., Tschanz J.T., Norton M.C., et al. APOE genotype predicts when-not whether-one is predisposed to develop Alzheimer disease. Nat Genet 19 (1998) 321-322
    • (1998) Nat Genet , vol.19 , pp. 321-322
    • Meyer, M.R.1    Tschanz, J.T.2    Norton, M.C.3
  • 29
    • 0027024651 scopus 로고
    • A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the alpha 1-antichymotrypsin gene
    • Mullan M., Houlden H., Windelspecht M., et al. A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the alpha 1-antichymotrypsin gene. Nat Genet 2 (1992) 340-342
    • (1992) Nat Genet , vol.2 , pp. 340-342
    • Mullan, M.1    Houlden, H.2    Windelspecht, M.3
  • 30
    • 0028878371 scopus 로고
    • Apoe genotype and familial Alzheimer's disease: a possible influence on age of onset in APP717 Val-->Ile mutated families
    • Nacmias B., Latorraca S., Piersanti P., et al. Apoe genotype and familial Alzheimer's disease: a possible influence on age of onset in APP717 Val-->Ile mutated families. Neurosci Lett 183 (1995) 1-3
    • (1995) Neurosci Lett , vol.183 , pp. 1-3
    • Nacmias, B.1    Latorraca, S.2    Piersanti, P.3
  • 31
    • 2642517835 scopus 로고    scopus 로고
    • The tau R406W mutation causes progressive presenile dementia with bitemporal atrophy
    • Ostojic J., Elfgren C., Passant U., et al. The tau R406W mutation causes progressive presenile dementia with bitemporal atrophy. Dement Geriatr Cogn Disord 17 (2004) 298-301
    • (2004) Dement Geriatr Cogn Disord , vol.17 , pp. 298-301
    • Ostojic, J.1    Elfgren, C.2    Passant, U.3
  • 32
    • 0032521394 scopus 로고    scopus 로고
    • Incidence and risk of dementia. The Rotterdam Study
    • Ott A., Breteler M.M., van Harskamp F., et al. Incidence and risk of dementia. The Rotterdam Study. Am J Epidemiol 147 (1998) 574-580
    • (1998) Am J Epidemiol , vol.147 , pp. 574-580
    • Ott, A.1    Breteler, M.M.2    van Harskamp, F.3
  • 33
    • 0025735884 scopus 로고
    • Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage
    • Pericak-Vance M.A., Bebout J.L., Gaskell P.C., et al. Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage. Am J Hum Genet 48 (1991) 1034-1050
    • (1991) Am J Hum Genet , vol.48 , pp. 1034-1050
    • Pericak-Vance, M.A.1    Bebout, J.L.2    Gaskell, P.C.3
  • 34
    • 0035807776 scopus 로고    scopus 로고
    • A new locus on chromosome 19 linked with late-onset Alzheimer's disease
    • Poduslo S.E., and Yin X. A new locus on chromosome 19 linked with late-onset Alzheimer's disease. Neuroreport 12 (2001) 3759-3761
    • (2001) Neuroreport , vol.12 , pp. 3759-3761
    • Poduslo, S.E.1    Yin, X.2
  • 35
    • 0034515763 scopus 로고    scopus 로고
    • Apolipoprotein E and Alzheimer's disease. A role in amyloid catabolism
    • Poirier J. Apolipoprotein E and Alzheimer's disease. A role in amyloid catabolism. Ann N Y Acad Sci 924 (2000) 81-90
    • (2000) Ann N Y Acad Sci , vol.924 , pp. 81-90
    • Poirier, J.1
  • 36
    • 0242353016 scopus 로고    scopus 로고
    • Tau (MAPT) mutation Arg406Trp presenting clinically with Alzheimer disease does not share a common founder in Western Europe
    • Rademakers R., Dermaut B., Peters K., et al. Tau (MAPT) mutation Arg406Trp presenting clinically with Alzheimer disease does not share a common founder in Western Europe. Hum Mutat 22 (2003) 409-411
    • (2003) Hum Mutat , vol.22 , pp. 409-411
    • Rademakers, R.1    Dermaut, B.2    Peters, K.3
  • 37
    • 25444507964 scopus 로고    scopus 로고
    • Linkage and association studies identify a novel locus for Alzheimer disease at 7q36 in a dutch population-based sample
    • Rademakers R., Cruts M., Sleegers K., et al. Linkage and association studies identify a novel locus for Alzheimer disease at 7q36 in a dutch population-based sample. Am J Hum Genet 77 (2005) 643-652
    • (2005) Am J Hum Genet , vol.77 , pp. 643-652
    • Rademakers, R.1    Cruts, M.2    Sleegers, K.3
  • 38
    • 26944475934 scopus 로고    scopus 로고
    • Molecular diagnosis of autosomal dominant early onset Alzheimer's disease: an update
    • Raux G., Guyant-Marechal L., Martin C., et al. Molecular diagnosis of autosomal dominant early onset Alzheimer's disease: an update. J Med Genet 42 (2005) 793-795
    • (2005) J Med Genet , vol.42 , pp. 793-795
    • Raux, G.1    Guyant-Marechal, L.2    Martin, C.3
  • 39
    • 2442489033 scopus 로고    scopus 로고
    • Relation of plasma lipids to Alzheimer disease and vascular dementia
    • Reitz C., Tang M.X., Luchsinger J., et al. Relation of plasma lipids to Alzheimer disease and vascular dementia. Arch Neurol 61 (2004) 705-714
    • (2004) Arch Neurol , vol.61 , pp. 705-714
    • Reitz, C.1    Tang, M.X.2    Luchsinger, J.3
  • 40
    • 0029741063 scopus 로고    scopus 로고
    • The future of genetic studies of complex human diseases
    • Risch N., and Merikangas K. The future of genetic studies of complex human diseases. Science 273 (1996) 1516-1517
    • (1996) Science , vol.273 , pp. 1516-1517
    • Risch, N.1    Merikangas, K.2
  • 41
    • 0038240721 scopus 로고    scopus 로고
    • Causative and susceptibility genes for Alzheimer's disease: a review
    • Rocchi A., Pellegrini S., Siciliano G., et al. Causative and susceptibility genes for Alzheimer's disease: a review. Brain Res Bull 61 (2003) 1-24
    • (2003) Brain Res Bull , vol.61 , pp. 1-24
    • Rocchi, A.1    Pellegrini, S.2    Siciliano, G.3
  • 42
    • 0029101491 scopus 로고
    • Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
    • Rogaev E.I., Sherrington R., Rogaeva E.A., et al. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376 (1995) 775-778
    • (1995) Nature , vol.376 , pp. 775-778
    • Rogaev, E.I.1    Sherrington, R.2    Rogaeva, E.A.3
  • 43
    • 0041320789 scopus 로고    scopus 로고
    • Frontotemporal dementia in The Netherlands: patient characteristics and prevalence estimates from a population-based study
    • Rosso S.M., Donker Kaat L., Baks T., et al. Frontotemporal dementia in The Netherlands: patient characteristics and prevalence estimates from a population-based study. Brain 126 (2003) 2016-2022
    • (2003) Brain , vol.126 , pp. 2016-2022
    • Rosso, S.M.1    Donker Kaat, L.2    Baks, T.3
  • 44
    • 29444442794 scopus 로고    scopus 로고
    • APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy
    • Rovelet-Lecrux A., Hannequin D., Raux G., et al. APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat Genet 38 (2006) 24-26
    • (2006) Nat Genet , vol.38 , pp. 24-26
    • Rovelet-Lecrux, A.1    Hannequin, D.2    Raux, G.3
  • 45
    • 0024342769 scopus 로고
    • Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease
    • Rumble B., Retallack R., Hilbich C., et al. Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease. N Engl J Med 320 (1989) 1446-1452
    • (1989) N Engl J Med , vol.320 , pp. 1446-1452
    • Rumble, B.1    Retallack, R.2    Hilbich, C.3
  • 46
    • 25144453307 scopus 로고    scopus 로고
    • PEN-2 gene mutation in a familial Alzheimer's disease case
    • Sala Frigerio C., Piscopo P., Calabrese E., et al. PEN-2 gene mutation in a familial Alzheimer's disease case. J Neurol 252 (2005) 1033-1036
    • (2005) J Neurol , vol.252 , pp. 1033-1036
    • Sala Frigerio, C.1    Piscopo, P.2    Calabrese, E.3
  • 47
    • 0027327267 scopus 로고
    • Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease
    • Saunders A.M., Strittmatter W.J., Schmechel D., et al. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43 (1993) 1467-1472
    • (1993) Neurology , vol.43 , pp. 1467-1472
    • Saunders, A.M.1    Strittmatter, W.J.2    Schmechel, D.3
  • 48
    • 0026471656 scopus 로고
    • Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14
    • Schellenberg G.D., Bird T.D., Wijsman E.M., et al. Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. Science 258 (1992) 668-671
    • (1992) Science , vol.258 , pp. 668-671
    • Schellenberg, G.D.1    Bird, T.D.2    Wijsman, E.M.3
  • 49
    • 0029004341 scopus 로고
    • Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
    • Sherrington R., Rogaev E.I., Liang Y., et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375 (1995) 754-760
    • (1995) Nature , vol.375 , pp. 754-760
    • Sherrington, R.1    Rogaev, E.I.2    Liang, Y.3
  • 50
    • 0036548070 scopus 로고    scopus 로고
    • γ-Secretase, notch, Aβ and Alzheimer's disease: where do the presenilins fit in?
    • Sisodia S.S., and St George-Hyslop P.H. γ-Secretase, notch, Aβ and Alzheimer's disease: where do the presenilins fit in?. Nat Rev Neurosci 3 (2002) 281-290
    • (2002) Nat Rev Neurosci , vol.3 , pp. 281-290
    • Sisodia, S.S.1    St George-Hyslop, P.H.2
  • 51
    • 33750579333 scopus 로고    scopus 로고
    • APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy
    • Sleegers K., Brouwers N., Gijselinck I., et al. APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy. Brain 129 (2006) 2977-2983
    • (2006) Brain , vol.129 , pp. 2977-2983
    • Sleegers, K.1    Brouwers, N.2    Gijselinck, I.3
  • 52
    • 0027032695 scopus 로고
    • Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14
    • St George-Hyslop P., Haines J., Rogaev E., et al. Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14. Nat Genet 2 (1992) 330-334
    • (1992) Nat Genet , vol.2 , pp. 330-334
    • St George-Hyslop, P.1    Haines, J.2    Rogaev, E.3
  • 53
    • 0027407565 scopus 로고
    • Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
    • Strittmatter W.J., Saunders A.M., Schmechel D., et al. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 90 (1993) 1977-1981
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 1977-1981
    • Strittmatter, W.J.1    Saunders, A.M.2    Schmechel, D.3
  • 54
    • 0032697036 scopus 로고    scopus 로고
    • A genetic dichotomy model for the inheritance of Alzheimer's disease and common age-related disorders
    • Tanzi R.E. A genetic dichotomy model for the inheritance of Alzheimer's disease and common age-related disorders. J Clin Invest 104 (1999) 1175-1179
    • (1999) J Clin Invest , vol.104 , pp. 1175-1179
    • Tanzi, R.E.1
  • 55
    • 13944276825 scopus 로고    scopus 로고
    • Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective
    • Tanzi R.E., and Ertram L. Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective. Cell 120 (2005) 545-555
    • (2005) Cell , vol.120 , pp. 545-555
    • Tanzi, R.E.1    Ertram, L.2
  • 56
    • 0023109592 scopus 로고
    • Amyloid beta protein gene: cdna, mrna distribution, and genetic linkage near the Alzheimer locus
    • Tanzi R.E., Gusella J.F., Watkins P.C., et al. Amyloid beta protein gene: cdna, mrna distribution, and genetic linkage near the Alzheimer locus. Science 235 (1987) 880-884
    • (1987) Science , vol.235 , pp. 880-884
    • Tanzi, R.E.1    Gusella, J.F.2    Watkins, P.C.3
  • 57
    • 33646886350 scopus 로고    scopus 로고
    • Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease
    • Theuns J., Brouwers N., Engelborghs S., et al. Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease. Am J Hum Genet 78 (2006) 936-946
    • (2006) Am J Hum Genet , vol.78 , pp. 936-946
    • Theuns, J.1    Brouwers, N.2    Engelborghs, S.3
  • 58
    • 0027031612 scopus 로고
    • Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3
    • Van Broeckhoven C., Backhovens H., Cruts M., et al. Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3. Nat Genet 2 (1992) 335-339
    • (1992) Nat Genet , vol.2 , pp. 335-339
    • Van Broeckhoven, C.1    Backhovens, H.2    Cruts, M.3
  • 59
    • 4143140828 scopus 로고    scopus 로고
    • Evidence for a novel late-onset Alzheimer disease locus on chromosome 19p13.2
    • Wijsman E.M., Daw E.W., Yu C.E., et al. Evidence for a novel late-onset Alzheimer disease locus on chromosome 19p13.2. Am J Hum Genet 75 (2004) 398-409
    • (2004) Am J Hum Genet , vol.75 , pp. 398-409
    • Wijsman, E.M.1    Daw, E.W.2    Yu, C.E.3
  • 60
    • 0021827420 scopus 로고
    • Alzheimer's disease in Down's syndrome: Clinicopathologic studies
    • Wisniewski K.E., Dalton A.J., McLachlan C., et al. Alzheimer's disease in Down's syndrome: Clinicopathologic studies. Neurology 35 (1985) 957-961
    • (1985) Neurology , vol.35 , pp. 957-961
    • Wisniewski, K.E.1    Dalton, A.J.2    McLachlan, C.3
  • 61
    • 0030028429 scopus 로고    scopus 로고
    • Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease. Alzheimer's Disease Collaborative Group
    • Wragg M., Hutton M., Talbot C., et al. Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease. Alzheimer's Disease Collaborative Group. Lancet 347 (1996) 509-512
    • (1996) Lancet , vol.347 , pp. 509-512
    • Wragg, M.1    Hutton, M.2    Talbot, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.