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Volumn 8, Issue 8, 2009, Pages 1217-1227

The centrosomal FOP protein is required for cell cycle progression and survival

Author keywords

Apoptosis; Centrosome; DT40; FOP; p53

Indexed keywords

CELL PROTEIN; FAS ANTIGEN; PROTEIN FOP; PROTEIN NOXA; PROTEIN P53; UNCLASSIFIED DRUG;

EID: 65949101469     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.8.8.8248     Document Type: Article
Times cited : (24)

References (58)
  • 1
    • 0036468420 scopus 로고    scopus 로고
    • Centrosome composition and microtubule anchoring mechanisms
    • DOI 10.1016/S0955-0674(01)00290-3
    • Bornens M. Centrosome composition and microtubule anchoring mechanisms. Curr Opin Cell Biol 2002; 14:25-34. (Pubitemid 34131653)
    • (2002) Current Opinion in Cell Biology , vol.14 , Issue.1 , pp. 25-34
    • Bornens, M.1
  • 2
    • 33847776094 scopus 로고    scopus 로고
    • Microtubule-organizing centres: A re-evaluation
    • DOI 10.1038/nrm2100, PII NRM2100
    • Luders J, Stearns T. Microtubule-organizing centres: a re-evaluation. Nat Rev Mol Cell Biol 2007; 8:161-167 (Pubitemid 46432528)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.2 , pp. 161-167
    • Luders, J.1    Stearns, T.2
  • 4
    • 8344221351 scopus 로고    scopus 로고
    • Asymmetric cell division in C. elegans: Cortical polarity and spindle positioning
    • Cowan CR, Hyman AA. Asymmetric cell division in C. elegans: cortical polarity and spindle positioning. Annu Rev Cell Dev Biol 2004; 20:427-453
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 427-453
    • Cowan, C.R.1    Hyman, A.A.2
  • 5
    • 34249087470 scopus 로고    scopus 로고
    • The centrosome in neuronal development
    • DOI 10.1016/j.tins.2007.04.001, PII S0166223607000781
    • Higginbotham HR, Gleeson JG. The centrosome in neuronal development. Trends Neurosci 2007; 30:276-283 (Pubitemid 46802834)
    • (2007) Trends in Neurosciences , vol.30 , Issue.6 , pp. 276-283
    • Higginbotham, H.R.1    Gleeson, J.G.2
  • 6
    • 33947384151 scopus 로고    scopus 로고
    • Overview of structure and function of mammalian cilia
    • DOI 10.1146/annurev.physiol.69.040705.141236
    • Satir P, Christensen ST. Overview of structure and function of mammalian cilia. Annu Rev Physiol 2007; 69:377-400. (Pubitemid 46457649)
    • (2007) Annual Review of Physiology , vol.69 , pp. 377-400
    • Satir, P.1    Christensen, S.T.2
  • 7
    • 17144377111 scopus 로고    scopus 로고
    • Cilium-generated signaling and cilia-related disorders
    • DOI 10.1038/labinvest.3700253
    • Pan J, Wang Q, Snell WJ. Cilium-generated signaling and cilia-related disorders. Lab Invest 2005; 85:452-463 (Pubitemid 40523938)
    • (2005) Laboratory Investigation , vol.85 , Issue.4 , pp. 452-463
    • Pan, J.1    Wang, Q.2    Snell, W.J.3
  • 8
    • 33746528106 scopus 로고    scopus 로고
    • Tuning in to the cell's antenna
    • Marshall WF, Nonaka S. Cilia: tuning in to the cell's antenna. Curr Biol 2006; 16:604-614
    • (2006) Curr Biol , vol.16 , pp. 604-614
    • Marshall, W.F.1    Cilia, N.S.2
  • 9
    • 33746891890 scopus 로고    scopus 로고
    • The primary cilium as the cell's antenna: Signaling at a sensory organelle
    • DOI 10.1126/science.1124534
    • Singla V, Reiter JF. The primary cilium as the cell's antenna: signaling at a sensory organelle. Science 2006; 313:629-633 (Pubitemid 44201133)
    • (2006) Science , vol.313 , Issue.5787 , pp. 629-633
    • Singla, V.1    Reiter, J.F.2
  • 11
    • 34047119626 scopus 로고    scopus 로고
    • The Centrosome Opens the Way to Mitosis
    • DOI 10.1016/j.devcel.2007.03.012, PII S1534580707001128
    • Basto R, Pines J. The centrosome opens the way to mitosis. Dev Cell 2007; 12:475-477 (Pubitemid 46523649)
    • (2007) Developmental Cell , vol.12 , Issue.4 , pp. 475-477
    • Basto, R.1    Pines, J.2
  • 12
    • 34249336078 scopus 로고    scopus 로고
    • Centrosome biogenesis and function: Centrosomics brings new understanding
    • DOI 10.1038/nrm2180, PII NRM2180
    • Bettencourt-Dias M, Glover DM. Centrosome biogenesis and function: centrosomics brings new understanding. Nat Rev Mol Cell Biol 2007; 8:451-463 (Pubitemid 46809152)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.6 , pp. 451-463
    • Bettencourt-Dias, M.1    Glover, D.M.2
  • 13
    • 33749240905 scopus 로고    scopus 로고
    • The centrosome and the DNA damage induced checkpoint
    • DOI 10.1016/j.canlet.2006.01.006, PII S0304383506000310
    • Fletcher L, Muschel RJ. The centrosome and the DNA damage induced checkpoint. Cancer Lett 2006; 243:1-8. (Pubitemid 44485329)
    • (2006) Cancer Letters , vol.243 , Issue.1 , pp. 1-8
    • Fletcher, L.1    Muschel, R.J.2
  • 14
    • 0035478337 scopus 로고    scopus 로고
    • The centrosome in vertebrates: More than a microtubule-organizing center
    • DOI 10.1016/S0962-8924(01)02085-2, PII S0962892401020852
    • Rieder CL, Faruki S, Khodjakov A. The centrosome in vertebrates: more than a microtubule-organizing center. Trends Cell Biol 2001; 11:413-419 (Pubitemid 32900603)
    • (2001) Trends in Cell Biology , vol.11 , Issue.10 , pp. 413-419
    • Rieder, C.L.1    Faruki, S.2    Khodjakov, A.3
  • 15
    • 34047244598 scopus 로고    scopus 로고
    • The centrosome and cell proliferation
    • DOI 10.1186/1747-1028-1-26
    • Srsen V, Merdes A. The centrosome and cell proliferation. Cell Div 2006; 1:26. (Pubitemid 46731031)
    • (2006) Cell Division , vol.1 , pp. 26
    • Srsen, V.1    Merdes, A.2
  • 16
    • 47749085495 scopus 로고    scopus 로고
    • Characterization of centrosomal localization and dynamics of Cdc25C phosphatase in mitosis
    • Bonnet J, Coopman P, Morris MC. Characterization of centrosomal localization and dynamics of Cdc25C phosphatase in mitosis. Cell Cycle 2008; 7:1991-1998.
    • (2008) Cell Cycle , vol.7 , pp. 1991-1998
    • Bonnet, J.1    Coopman, P.2    Morris, M.C.3
  • 17
    • 0035936898 scopus 로고    scopus 로고
    • 1 into S phase
    • DOI 10.1126/science.1056866
    • Hinchcliffe EH, Miller FJ, Cham M, Khodjakov A, Sluder G. Requirement of a centrosomal activity for cell cycle progression through G1 into S phase. Science 2001; 291:1547-1550 (Pubitemid 32179221)
    • (2001) Science , vol.291 , Issue.5508 , pp. 1547-1550
    • Hinchcliffe, E.H.1    Miller, F.J.2    Cham, M.3    Khodjakov, A.4    Sluder, G.5
  • 18
    • 0035795415 scopus 로고    scopus 로고
    • Centrosomes enhance the fidelity of cytokinesis in vertebrates and are required for cell cycle progression
    • DOI 10.1083/jcb.153.1.237
    • Khodjakov A, Rieder CL. Centrosomes enhance the fidelity of cytokinesis in vertebrates and are required for cell cycle progression. J Cell Biol 2001; 153:237-242 (Pubitemid 34280209)
    • (2001) Journal of Cell Biology , vol.153 , Issue.1 , pp. 237-242
    • Khodjakov, A.1    Rieder, C.L.2
  • 20
    • 33748102496 scopus 로고    scopus 로고
    • Inhibition of centrosome protein assembly leads to p53-dependent exit from the cell cycle
    • DOI 10.1083/jcb.200606051
    • Srsen V, Gnadt N, Dammermann A, Merdes A. Inhibition of centrosome protein assembly leads to p53-dependent exit from the cell cycle. J Cell Biol 2006; 174:625-630 (Pubitemid 44306718)
    • (2006) Journal of Cell Biology , vol.174 , Issue.5 , pp. 625-630
    • Srsen, V.1    Gnadt, N.2    Dammermann, A.3    Merdes, A.4
  • 21
    • 33846432426 scopus 로고    scopus 로고
    • Cell cycle pr ogression and de novo centriole assembly after centrosomal removal in untransformed human cells
    • Uetake Y, Loncarek J, Nordberg JJ, English CN, La Terra S, Khodjakov A, et al. Cell cycle pr ogression and de novo centriole assembly after centrosomal removal in untransformed human cells. J Cell Biol 2007; 176:173-182
    • (2007) J Cell Biol , vol.176 , pp. 173-182
    • Uetake, Y.1    Loncarek, J.2    Nordberg, J.J.3    English, C.N.4    La Terra, S.5    Khodjakov, A.6
  • 22
  • 23
    • 0033558253 scopus 로고    scopus 로고
    • The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1
    • Popovici C, Zhang B, Gregoire MJ, Jonveaux P, Lafage-Pochitaloff M, Birnbaum D, et al. The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1. Blood 1999; 93:1381-1389
    • (1999) Blood , vol.93 , pp. 1381-1389
    • Popovici, C.1    Zhang, B.2    Gregoire, M.J.3    Jonveaux, P.4    Lafage-Pochitaloff, M.5    Birnbaum, D.6
  • 25
    • 43149085967 scopus 로고    scopus 로고
    • Myeloproliferative disorder FOP-FGFR1 fusion kinase recruits phosphoinositide-3 kinase and phospholipase Cgamma at the centrosome
    • Lelievre H, Chevrier V, Tassin AM, Birnbaum D. Myeloproliferative disorder FOP-FGFR1 fusion kinase recruits phosphoinositide-3 kinase and phospholipase Cgamma at the centrosome. Mol Cancer 2008; 7:30.
    • (2008) Mol Cancer , vol.7 , pp. 30
    • Lelievre, H.1    Chevrier, V.2    Tassin, A.M.3    Birnbaum, D.4
  • 26
    • 31944450657 scopus 로고    scopus 로고
    • A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring
    • DOI 10.1091/mbc.E05-08-0810
    • Yan X, Habedanck R, Nigg EA. A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring. Mol Biol Cell 2006; 17:634-644 (Pubitemid 43191099)
    • (2006) Molecular Biology of the Cell , vol.17 , Issue.2 , pp. 634-644
    • Yan, X.1    Habedanck, R.2    Nigg, E.A.3
  • 28
    • 0033396570 scopus 로고    scopus 로고
    • Comparison of the tamoxifen regulated chimeric Cre recombinases MerCreMer and CreMer
    • Verrou C, Zhang Y, Zurn C, Schamel WW, Reth M. Comparison of the tamoxifen regulated chimeric Cre recombinases MerCreMer and CreMer. Biol Chem 1999; 380:1435-1438 (Pubitemid 30021366)
    • (1999) Biological Chemistry , vol.380 , Issue.12 , pp. 1435-1438
    • Verrou, C.1    Zhang, Y.2    Zurn, C.3    Schamel, W.W.A.4    Reth, M.5
  • 29
    • 4344685939 scopus 로고    scopus 로고
    • Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition
    • DOI 10.1128/MCB.24.17.7654-7668.2004
    • Dai MS, Zeng SX, Jin Y, Sun XX, David L, Lu H. Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. Mol Cell Biol 2004; 24:7654-7668 (Pubitemid 39121491)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.17 , pp. 7654-7668
    • Dai, M.-S.1    Zeng, S.X.2    Jin, Y.3    Sun, X.-X.4    David, L.5    Lu, H.6
  • 33
    • 0035953394 scopus 로고    scopus 로고
    • DNA microarrays identification of primary and secondary target genes regulated by p53
    • Kannan K, Amariglio N, Rechavi G, Jakob-Hirsch J, Kela I, Kaminski N, et al. DNA microarrays identification of primary and secondary target genes regulated by p53. Oncogene 2001; 20:2225-2234
    • (2001) Oncogene , vol.20 , pp. 2225-2234
    • Kannan, K.1    Amariglio, N.2    Rechavi, G.3    Jakob-Hirsch, J.4    Kela, I.5    Kaminski, N.6
  • 34
    • 20444407162 scopus 로고    scopus 로고
    • Centrosome control of the cell cycle
    • DOI 10.1016/j.tcb.2005.04.008, PII S0962892405001121
    • Doxsey S, Zimmerman W, Mikule K. Centrosome control of the cell cycle. Trends Cell Biol 2005; 15:303-311 (Pubitemid 40805326)
    • (2005) Trends in Cell Biology , vol.15 , Issue.6 , pp. 303-311
    • Doxsey, S.1    Zimmerman, W.2    Mikule, K.3
  • 35
    • 0036468701 scopus 로고    scopus 로고
    • Integration of the centrosome in cell cycle control, stress response and signal transduction pathways
    • DOI 10.1016/S0955-0674(01)00291-5
    • Lange BM. Integration of the centrosome in cell cycle control, stress response and signal transduction pathways. Curr Opin Cell Biol 2002; 14:35-43. (Pubitemid 34131654)
    • (2002) Current Opinion in Cell Biology , vol.14 , Issue.1 , pp. 35-43
    • Lange, B.M.H.1
  • 39
    • 0027451668 scopus 로고
    • P53-Dependent apoptosis modulates the cytotoxicity of anticancer agents
    • DOI 10.1016/0092-8674(93)90719-7
    • Lowe SW, Ruley HE, Jacks T, Housman DE. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 1993; 74:957-967 (Pubitemid 23289454)
    • (1993) Cell , vol.74 , Issue.6 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 40
    • 1542353401 scopus 로고    scopus 로고
    • Control of apoptosis by p53
    • DOI 10.1038/sj.onc.1207116, Apoptosis - Part 2
    • Fridman JS, Lowe SW. Control of apoptosis by p53. Oncogene 2003; 22:9030-9040 (Pubitemid 38121703)
    • (2003) Oncogene , vol.22 , Issue.56 REV. ISS. 8 , pp. 9030-9040
    • Fridman, J.S.1    Lowe, S.W.2
  • 41
    • 4444240191 scopus 로고    scopus 로고
    • The functional interactions between the p53 and MAPK signaling pathways
    • Wu GS. The functional interactions between the p53 and MAPK signaling pathways. Cancer Biol Ther 2004; 3:156-161 (Pubitemid 41350895)
    • (2004) Cancer Biology and Therapy , vol.3 , Issue.2 , pp. 156-161
    • Gen, S.W.1
  • 42
    • 0034785883 scopus 로고    scopus 로고
    • MEKK1 is essential for DT40 cell apoptosis in response to microtubule disruption
    • DOI 10.1128/MCB.21.21.7183-7190.2001
    • Kwan R, Burnside J, Kurosaki T, Cheng G. MEKK1 is essential for DT40 cell apoptosis in response to microtubule disruption. Mol Cell Biol 2001; 21:7183-7190 (Pubitemid 32953472)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.21 , pp. 7183-7190
    • Kwan, R.1    Burnside, J.2    Kurosaki, T.3    Cheng, G.4
  • 43
    • 36549024010 scopus 로고    scopus 로고
    • Cell-Cycle Progression without an Intact Microtubule Cytoskeleton
    • DOI 10.1016/j.cub.2007.10.065, PII S0960982207021975
    • Uetake Y, Sluder G. Cell cycle progression without an intact microtuble cytoskeleton. Curr Biol 2007; 17:2081-2086 (Pubitemid 350180474)
    • (2007) Current Biology , vol.17 , Issue.23 , pp. 2081-2086
    • Uetake, Y.1    Sluder, G.2
  • 44
    • 0033615982 scopus 로고    scopus 로고
    • Centriolar satellites: Molecular characterization, ATP-dependent movement toward centrioles and possible involvement in ciliogenesis
    • Kubo A, Sasaki H, Yuba-Kubo A, Tsukita S, Shiina N. Centriolar satellites: molecular characterization, ATP-dependent movement toward centrioles and possible involvement in ciliogenesis. J Cell Biol 1999; 147:969-980
    • (1999) J Cell Biol , vol.147 , pp. 969-980
    • Kubo, A.1    Sasaki, H.2    Yuba-Kubo, A.3    Tsukita, S.4    Shiina, N.5
  • 45
    • 20244381625 scopus 로고    scopus 로고
    • The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression
    • Kim JC, Badano JL, Sibold S, Esmail MA, Hill J, Hoskins BE, et al. The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression. Nat Genet 2004; 36:462-470
    • (2004) Nat Genet , vol.36 , pp. 462-470
    • Kim, J.C.1    Badano, J.L.2    Sibold, S.3    Esmail, M.A.4    Hill, J.5    Hoskins, B.E.6
  • 46
    • 0037191046 scopus 로고    scopus 로고
    • Assembly of centrosomal proteins and microtubule organization depends on PCM-1
    • DOI 10.1083/jcb.200204023
    • Dammermann A, Merdes A. Assembly of centrosomal proteins and microtubule organization depends on PCM-1. J Cell Biol 2002; 159:255-266 (Pubitemid 35283395)
    • (2002) Journal of Cell Biology , vol.159 , Issue.2 , pp. 255-266
    • Dammermann, A.1    Merdes, A.2
  • 47
    • 34047160952 scopus 로고    scopus 로고
    • A microtubule-independent role for centrosomes and aurora a in nuclear envelope breakdown
    • Portier N, Audhya A, Maddox PS, Green RA, Dammermann A, Desai, et al. A microtubule-independent role for centrosomes and aurora a in nuclear envelope breakdown. Dev Cell 2007; 12:515-529
    • (2007) Dev Cell , vol.12 , pp. 515-529
    • Portier, N.1    Audhya, A.2    Maddox, P.S.3    Green, R.A.4    Desai, D.A.5
  • 49
    • 0037322744 scopus 로고    scopus 로고
    • Active cyclin B1-Cdk1 first appears on centrosomes in prophase
    • DOI 10.1038/ncb918
    • Jackman M, Lindon C, Nigg EA, Pines J. Active cyclin B1-Cdk1 first appears on centrosomes in prophase. Nat Cell Biol 2003; 5:143-148 (Pubitemid 36204196)
    • (2003) Nature Cell Biology , vol.5 , Issue.2 , pp. 143-148
    • Jackman, M.1    Lindon, C.2    Niggt, E.A.3    Pines, J.4
  • 50
    • 34047179437 scopus 로고    scopus 로고
    • Centrosomes promote timely mitotic entry in C. elegans embryos
    • Hachet V, Canard C, Gonczy P. Centrosomes promote timely mitotic entry in C. elegans embryos. Dev Cell 2007; 12:531-541
    • (2007) Dev Cell , vol.12 , pp. 531-541
    • Hachet, V.1    Canard, C.2    Gonczy, P.3
  • 51
    • 7444229923 scopus 로고    scopus 로고
    • A centrosomal localization signal in cyclin e required for Cdk2-independent S phase entry
    • DOI 10.1126/science.1103544
    • Matsumoto Y, Maller JL. A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry. Science 2004; 306:885-888 (Pubitemid 39447000)
    • (2004) Science , vol.306 , Issue.5697 , pp. 885-888
    • Matsumoto, Y.1    Maller, J.L.2
  • 52
    • 0347363834 scopus 로고    scopus 로고
    • Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf
    • DOI 10.1038/sj.onc.1207185
    • Brummer T, Naegele H, Reth M, Misawa Y. Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf. Oncogene 2003; 22:8823-8834 (Pubitemid 38021498)
    • (2003) Oncogene , vol.22 , Issue.55 , pp. 8823-8834
    • Brummer, T.1    Naegele, H.2    Reth, M.3    Misawa, Y.4
  • 53
    • 1642272806 scopus 로고    scopus 로고
    • Binding of Free Immunoglobulin Light Chains to VpreB3 Inhibits Their Maturation and Secretion in Chicken B Cells
    • DOI 10.1074/jbc.M312169-A200
    • Rosnet O, Blanco-Betancourt C, Grivel K, Richter K, Schiff C. Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells. J Biol Chem 2004; 279:10228-10236 (Pubitemid 38372628)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.11 , pp. 10228-10236
    • Rosnet, O.1    Blanco-Betancourt, C.2    Grivel, K.3    Richter, K.4    Schiff, C.5
  • 54
    • 3042559648 scopus 로고    scopus 로고
    • Mutants IoxP vectors for selectable marker recycle and conditional knock-outs
    • DOI 10.1186/1472-6750-1-7
    • Arakawa H, Lodygin D, Buerstedde JM. Mutant loxP vectors for selectable marker recycle and conditional knock-outs. BMC Biotechnol 2001; 1:7. (Pubitemid 38846427)
    • (2001) BMC Biotechnology , vol.1 , pp. 7
    • Arakawa, H.1    Lodygin, D.2    Buerstedde, J.-M.3
  • 55
    • 0034678396 scopus 로고    scopus 로고
    • The respective contributions of the mother and daughter centrioles to centrosome activity and behavior in vertebrate cells
    • DOI 10.1083/jcb.149.2.317
    • Piel M, Meyer P, Khodjakov A, Rieder CL, Bornens M. The respective contributions of the mother and daughter centrioles to centrosome activity and behavior in vertebrate cells. J Cell Biol 2000; 149:317-330 (Pubitemid 30227150)
    • (2000) Journal of Cell Biology , vol.149 , Issue.2 , pp. 317-329
    • Piel, M.1    Meyer, P.2    Khodjakov, A.3    Rieder, C.L.4    Bornens, M.5
  • 57
    • 0033990048 scopus 로고    scopus 로고
    • Primer3 on the WWW for general users and for biologist programmers
    • Rozen S, Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 2000; 132:365-386
    • (2000) Methods Mol Biol , vol.132 , pp. 365-386
    • Rozen, S.1    Skaletsky, H.2
  • 58
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001; 29:45.
    • (2001) Nucleic Acids Res , vol.29 , pp. 45
    • Pfaffl, M.W.1


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