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Volumn 7, Issue 1, 2007, Pages 50-60

The osteoinductive properties of Nell-1 in a rat spinal fusion model

Author keywords

Demineralized bone matrix; Gene therapy; Nell 1; Rat model; Spinal fusion

Indexed keywords

BETA GALACTOSIDASE; BONE MORPHOGENETIC PROTEIN 2; EOSIN; EPIDERMAL GROWTH FACTOR; HEMATOXYLIN; NEL LIKE MOLECULE 1 PROTEIN; OSTEOGENIC PROTEIN 1; PROTEIN NELL 1; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

EID: 33845786651     PISSN: 15299430     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.spinee.2006.04.020     Document Type: Article
Times cited : (99)

References (47)
  • 2
    • 0030020988 scopus 로고    scopus 로고
    • Donor-site morbidity with use of vascularized autogenous fibular grafts
    • Vail T.P., and Urbaniak J.R. Donor-site morbidity with use of vascularized autogenous fibular grafts. J Bone Joint Surg Am 78 (1996) 204-211
    • (1996) J Bone Joint Surg Am , vol.78 , pp. 204-211
    • Vail, T.P.1    Urbaniak, J.R.2
  • 3
    • 0031882790 scopus 로고    scopus 로고
    • A comparative analysis of fusion rates and donor-site morbidity for autogeneic rib and iliac crest bone grafts in posterior cervical fusions
    • Sawin P.D., Traynelis V.C., and Menezes A.H. A comparative analysis of fusion rates and donor-site morbidity for autogeneic rib and iliac crest bone grafts in posterior cervical fusions. J Neurosurg 88 (1998) 255-265
    • (1998) J Neurosurg , vol.88 , pp. 255-265
    • Sawin, P.D.1    Traynelis, V.C.2    Menezes, A.H.3
  • 4
    • 0026398196 scopus 로고
    • Degenerative lumbar spondylolisthesis with spinal stenosis: a prospective study comparing decompression with decompression and intertransverse process arthrodesis
    • Herkowitz H.N., and Kurz L.T. Degenerative lumbar spondylolisthesis with spinal stenosis: a prospective study comparing decompression with decompression and intertransverse process arthrodesis. J Bone Joint Surg Am 73 (1991) 802-808
    • (1991) J Bone Joint Surg Am , vol.73 , pp. 802-808
    • Herkowitz, H.N.1    Kurz, L.T.2
  • 5
    • 0033838534 scopus 로고    scopus 로고
    • Biology of lumbar spine fusion and use of bone graft substitutes: present, future, and next generation
    • Boden S.D. Biology of lumbar spine fusion and use of bone graft substitutes: present, future, and next generation. Tissue Eng 6 (2000) 383-399
    • (2000) Tissue Eng , vol.6 , pp. 383-399
    • Boden, S.D.1
  • 6
    • 0031573532 scopus 로고    scopus 로고
    • 1997 Volvo Award winner in clinical studies. Degenerative lumbar spondylolisthesis with spinal stenosis: a prospective, randomized study comparing decompressive laminectomy and arthrodesis with and without spinal instrumentation
    • Fischgrund J.S., Mackay M., Herkowitz H.N., Brower R., Montgomery D.M., and Kurz L.T. 1997 Volvo Award winner in clinical studies. Degenerative lumbar spondylolisthesis with spinal stenosis: a prospective, randomized study comparing decompressive laminectomy and arthrodesis with and without spinal instrumentation. Spine 22 (1997) 2807-2812
    • (1997) Spine , vol.22 , pp. 2807-2812
    • Fischgrund, J.S.1    Mackay, M.2    Herkowitz, H.N.3    Brower, R.4    Montgomery, D.M.5    Kurz, L.T.6
  • 7
    • 0032238373 scopus 로고    scopus 로고
    • Lumbar spine fusion by local gene therapy with a cDNA encoding a novel osteoinductive protein (LMP-1)
    • Boden S.D., Titus L., Hair G., et al. Lumbar spine fusion by local gene therapy with a cDNA encoding a novel osteoinductive protein (LMP-1). Spine 23 (1998) 2486-2492
    • (1998) Spine , vol.23 , pp. 2486-2492
    • Boden, S.D.1    Titus, L.2    Hair, G.3
  • 8
    • 0029621125 scopus 로고
    • Biologic enhancement of spinal fusion
    • Boden S.D., and Schimandle J.H. Biologic enhancement of spinal fusion. Spine 20 (1995) 113S-123S
    • (1995) Spine , vol.20
    • Boden, S.D.1    Schimandle, J.H.2
  • 9
    • 0037103848 scopus 로고    scopus 로고
    • Overview of the biology of lumbar spine fusion and principles for selecting a bone graft substitute
    • Boden S.D. Overview of the biology of lumbar spine fusion and principles for selecting a bone graft substitute. Spine 27 (2002) S26-S31
    • (2002) Spine , vol.27
    • Boden, S.D.1
  • 10
    • 5344252302 scopus 로고    scopus 로고
    • Osteoinductivity of commercially available demineralized bone matrix: preparations in a spine fusion model
    • Peterson B., Whang P.G., Iglesias R., Wang J.C., and Lieberman J.R. Osteoinductivity of commercially available demineralized bone matrix: preparations in a spine fusion model. J Bone Joint Surg Am 86-A (2004) 2243-2250
    • (2004) J Bone Joint Surg Am , vol.86 -A , pp. 2243-2250
    • Peterson, B.1    Whang, P.G.2    Iglesias, R.3    Wang, J.C.4    Lieberman, J.R.5
  • 11
    • 0042423688 scopus 로고    scopus 로고
    • Comparative evaluation of the osteoinductivity of two formulations of human demineralized bone matrix
    • Takikawa S., Bauer T.W., Kambic H., and Togawa D. Comparative evaluation of the osteoinductivity of two formulations of human demineralized bone matrix. J Biomed Mater Res A 65 (2003) 37-42
    • (2003) J Biomed Mater Res A , vol.65 , pp. 37-42
    • Takikawa, S.1    Bauer, T.W.2    Kambic, H.3    Togawa, D.4
  • 12
    • 33845748346 scopus 로고    scopus 로고
    • Laurencin C, Khan Y. Bone graft substitute materials: emedicine: http://www.emedicine.com/orthoped/topic611.htm. Accessed January 5, 2006.
  • 13
    • 0026458369 scopus 로고
    • Histopathologic and morphometric study of spinal cord lesion in a chronic cord compression model using bone morphogenetic protein in rabbits
    • Saito H., Mimatsu K., Sato K., and Hashizume Y. Histopathologic and morphometric study of spinal cord lesion in a chronic cord compression model using bone morphogenetic protein in rabbits. Spine 17 (1992) 1368-1374
    • (1992) Spine , vol.17 , pp. 1368-1374
    • Saito, H.1    Mimatsu, K.2    Sato, K.3    Hashizume, Y.4
  • 14
    • 0026549477 scopus 로고
    • Ossification of the ligamentum flavum induced by bone morphogenetic protein: an experimental study in mice
    • Miyamoto S., Takaoka K., Yonenobu K., and Ono K. Ossification of the ligamentum flavum induced by bone morphogenetic protein: an experimental study in mice. J Bone Joint Surg Br 74 (1992) 279-283
    • (1992) J Bone Joint Surg Br , vol.74 , pp. 279-283
    • Miyamoto, S.1    Takaoka, K.2    Yonenobu, K.3    Ono, K.4
  • 15
    • 0030711574 scopus 로고    scopus 로고
    • Experimental chronic compression on the spinal cord of the rabbit by ectopic bone formation in the ligamentum flavum with bone morphogenetic protein
    • Mimatsu K., Kishi S., and Hashizume Y. Experimental chronic compression on the spinal cord of the rabbit by ectopic bone formation in the ligamentum flavum with bone morphogenetic protein. Spinal Cord 35 (1997) 740-746
    • (1997) Spinal Cord , vol.35 , pp. 740-746
    • Mimatsu, K.1    Kishi, S.2    Hashizume, Y.3
  • 16
    • 33845730511 scopus 로고    scopus 로고
    • Riew DK, Tungsiripat R, Wathanaapisith T, Taylor B. Bmp2 for anterior cervical surgery does it increase early postoperative swallowing difficulties? Cervial Spine Research Society Annual Meeting, San Diego, 2005.
  • 17
    • 0034277236 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein-7 in maxillary sinus floor elevation surgery in 3 patients compared to autogenous bone grafts: a clinical pilot study
    • Van den Bergh J.P., ten Bruggenkate C.M., Groeneveld H.H., Burger E.H., and Tuinzing D.B. Recombinant human bone morphogenetic protein-7 in maxillary sinus floor elevation surgery in 3 patients compared to autogenous bone grafts: a clinical pilot study. J Clin Periodontol 27 (2000) 627-636
    • (2000) J Clin Periodontol , vol.27 , pp. 627-636
    • Van den Bergh, J.P.1    ten Bruggenkate, C.M.2    Groeneveld, H.H.3    Burger, E.H.4    Tuinzing, D.B.5
  • 18
    • 33845762042 scopus 로고    scopus 로고
    • Smucker JD, Rhee JM, Singh K et al. Increased postoperative airway or swallowing complications associated with use of rhBMP-2 in anterior cervical fusion. Cervial Spine Research Society Annual Meeting, San Diego, 2005.
  • 19
    • 26244461248 scopus 로고    scopus 로고
    • A 2-year follow-up pilot study evaluating the safety and efficacy of OP-1 putty (rhBMP-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions
    • Vaccaro A.R., Patel T., Fischgrund J., et al. A 2-year follow-up pilot study evaluating the safety and efficacy of OP-1 putty (rhBMP-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions. Eur Spine J 14 (2005) 623-629
    • (2005) Eur Spine J , vol.14 , pp. 623-629
    • Vaccaro, A.R.1    Patel, T.2    Fischgrund, J.3
  • 20
    • 0032925143 scopus 로고    scopus 로고
    • Human NELL-1 expressed in unilateral coronal synostosis
    • Ting K., Vastardis H., Mulliken J.B., et al. Human NELL-1 expressed in unilateral coronal synostosis. J Bone Miner Res 14 (1999) 80-89
    • (1999) J Bone Miner Res , vol.14 , pp. 80-89
    • Ting, K.1    Vastardis, H.2    Mulliken, J.B.3
  • 21
    • 0035236997 scopus 로고    scopus 로고
    • Regulation of osteoblast formation and function
    • Aubin J.E. Regulation of osteoblast formation and function. Rev Endocr Metab Disord 2 (2001) 81-94
    • (2001) Rev Endocr Metab Disord , vol.2 , pp. 81-94
    • Aubin, J.E.1
  • 23
    • 33845762488 scopus 로고    scopus 로고
    • Jiang X, Wu B, Zhang Z, Ting K, Zhang X. Nell-1, Cbfa-1 downstream mediator, in inducing bone formation. J Dent Res 2005.
  • 24
    • 33845735246 scopus 로고    scopus 로고
    • Truong T, Zhang X, Pathmanathan D, Soo C, Ting K. Craniosynostosis-associated gene Nell-1 is regulated by Runx2. JBMR. In press.
  • 25
    • 33845776784 scopus 로고    scopus 로고
    • Partial compensation of Cbfa1 deficiency by Nell-1 overexpression
    • Miao Y.P., Ting K., Wong J., Truong T., and Zhang X. Partial compensation of Cbfa1 deficiency by Nell-1 overexpression. J Dent Res 83 (2004) 1306
    • (2004) J Dent Res , vol.83 , pp. 1306
    • Miao, Y.P.1    Ting, K.2    Wong, J.3    Truong, T.4    Zhang, X.5
  • 26
    • 0036738422 scopus 로고    scopus 로고
    • Craniosynostosis in transgenic mice overexpressing Nell-1
    • Zhang X., Kuroda S., Carpenter D., et al. Craniosynostosis in transgenic mice overexpressing Nell-1. J Clin Invest 110 (2002) 861-870
    • (2002) J Clin Invest , vol.110 , pp. 861-870
    • Zhang, X.1    Kuroda, S.2    Carpenter, D.3
  • 27
    • 21344464386 scopus 로고    scopus 로고
    • Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic differentiation and spine fusion in a rodent model
    • Zhu W., Rawlins B.A., Boachie-Adjei O., et al. Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic differentiation and spine fusion in a rodent model. J Bone Miner Res 19 (2004) 2021-2032
    • (2004) J Bone Miner Res , vol.19 , pp. 2021-2032
    • Zhu, W.1    Rawlins, B.A.2    Boachie-Adjei, O.3
  • 28
    • 0032904360 scopus 로고    scopus 로고
    • Percutaneous spinal fusion using bone morphogenetic protein-2 gene therapy
    • Alden T.D., Pittman D.D., Beres E.J., et al. Percutaneous spinal fusion using bone morphogenetic protein-2 gene therapy. J Neurosurg 90 (1999) 109-114
    • (1999) J Neurosurg , vol.90 , pp. 109-114
    • Alden, T.D.1    Pittman, D.D.2    Beres, E.J.3
  • 29
    • 0038333622 scopus 로고    scopus 로고
    • Effect of regional gene therapy with bone morphogenetic protein-2-producing bone marrow cells on spinal fusion in rats
    • Wang J.C., Kanim L.E., Yoo S., Campbell P.A., Berk A.J., and Lieberman J.R. Effect of regional gene therapy with bone morphogenetic protein-2-producing bone marrow cells on spinal fusion in rats. J Bone Joint Surg Am 85-A (2003) 905-911
    • (2003) J Bone Joint Surg Am , vol.85 -A , pp. 905-911
    • Wang, J.C.1    Kanim, L.E.2    Yoo, S.3    Campbell, P.A.4    Berk, A.J.5    Lieberman, J.R.6
  • 30
    • 0029058803 scopus 로고
    • Possible orthopaedic applications of gene therapy
    • Evans C.H., and Robbins P.D. Possible orthopaedic applications of gene therapy. J Bone Joint Surg Am 77a (1995) 1103-1114
    • (1995) J Bone Joint Surg Am , vol.77 a , pp. 1103-1114
    • Evans, C.H.1    Robbins, P.D.2
  • 31
    • 0034641606 scopus 로고    scopus 로고
    • A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures
    • Zhou Y.X., Xu X., Chen L., Li C., Brodie S.G., and Deng C.X. A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures. Hum Mol Genet 9 (2000) 2001-2008
    • (2000) Hum Mol Genet , vol.9 , pp. 2001-2008
    • Zhou, Y.X.1    Xu, X.2    Chen, L.3    Li, C.4    Brodie, S.G.5    Deng, C.X.6
  • 32
    • 0030589616 scopus 로고    scopus 로고
    • Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats
    • Watanabe T.K., Katagiri T., Suzuki M., et al. Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats. Genomics 38 (1996) 273-276
    • (1996) Genomics , vol.38 , pp. 273-276
    • Watanabe, T.K.1    Katagiri, T.2    Suzuki, M.3
  • 33
    • 0033547346 scopus 로고    scopus 로고
    • Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2
    • Kuroda S., Oyasu M., Kawakami M., et al. Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2. Biochem Biophys Res Commun 265 (1999) 79-86
    • (1999) Biochem Biophys Res Commun , vol.265 , pp. 79-86
    • Kuroda, S.1    Oyasu, M.2    Kawakami, M.3
  • 34
    • 0037250476 scopus 로고    scopus 로고
    • Consequences of knocking out BMP signaling in the mouse
    • Zhao G.Q. Consequences of knocking out BMP signaling in the mouse. Genesis 35 (2003) 43-56
    • (2003) Genesis , vol.35 , pp. 43-56
    • Zhao, G.Q.1
  • 35
    • 12344291865 scopus 로고    scopus 로고
    • Bone morphogenetic proteins
    • Chen D., Zhao M., and Mundy G.R. Bone morphogenetic proteins. Growth Factors 22 (2004) 233-241
    • (2004) Growth Factors , vol.22 , pp. 233-241
    • Chen, D.1    Zhao, M.2    Mundy, G.R.3
  • 36
    • 0034128748 scopus 로고    scopus 로고
    • The family of bone morphogenetic proteins
    • Ducy P., and Karsenty G. The family of bone morphogenetic proteins. Kidney Int 57 (2000) 2207-2214
    • (2000) Kidney Int , vol.57 , pp. 2207-2214
    • Ducy, P.1    Karsenty, G.2
  • 37
    • 0032077625 scopus 로고    scopus 로고
    • Regional gene therapy with a BMP-2-producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents
    • Lieberman J.R., Le L.Q., Wu L., et al. Regional gene therapy with a BMP-2-producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents. J Orthop Res 16 (1998) 330-339
    • (1998) J Orthop Res , vol.16 , pp. 330-339
    • Lieberman, J.R.1    Le, L.Q.2    Wu, L.3
  • 38
    • 0032866489 scopus 로고    scopus 로고
    • The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats
    • Lieberman J.R., Daluiski A., Stevenson S., et al. The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats. J Bone Joint Surg Am 81 (1999) 905-917
    • (1999) J Bone Joint Surg Am , vol.81 , pp. 905-917
    • Lieberman, J.R.1    Daluiski, A.2    Stevenson, S.3
  • 40
    • 3543004680 scopus 로고    scopus 로고
    • Comparison of posterolateral lumbar fusion rates of Grafton Putty and OP-1 Putty in an athymic rat model
    • Bomback D.A., Grauer J.N., Lugo R., Troiano N., Patel T., and Friedlaender G.E. Comparison of posterolateral lumbar fusion rates of Grafton Putty and OP-1 Putty in an athymic rat model. Spine 29 (2004) 1612-1617
    • (2004) Spine , vol.29 , pp. 1612-1617
    • Bomback, D.A.1    Grauer, J.N.2    Lugo, R.3    Troiano, N.4    Patel, T.5    Friedlaender, G.E.6
  • 41
    • 32944469789 scopus 로고    scopus 로고
    • CT evaluation of lumbar interbody fusion: current concepts
    • Williams A.L., Gornet M.F., and Burkus J.K. CT evaluation of lumbar interbody fusion: current concepts. Am J Neuroradiol 26 (2005) 2057-2066
    • (2005) Am J Neuroradiol , vol.26 , pp. 2057-2066
    • Williams, A.L.1    Gornet, M.F.2    Burkus, J.K.3
  • 42
    • 0032248688 scopus 로고    scopus 로고
    • Addition of human recombinant bone morphogenetic protein-2 to inactive commercial human demineralized freeze-dried bone allograft makes an effective composite bone inductive implant material
    • Schwartz Z., Somers A., Mellonig J.T., et al. Addition of human recombinant bone morphogenetic protein-2 to inactive commercial human demineralized freeze-dried bone allograft makes an effective composite bone inductive implant material. J Periodontol 69 (1998) 1337-1345
    • (1998) J Periodontol , vol.69 , pp. 1337-1345
    • Schwartz, Z.1    Somers, A.2    Mellonig, J.T.3
  • 43
    • 0028850122 scopus 로고
    • Comparison between allograft plus demineralized bone matrix versus autograft in anterior cervical fusion: a prospective multicenter study
    • An H.S., Simpson J.M., Glover J.M., and Stephany J. Comparison between allograft plus demineralized bone matrix versus autograft in anterior cervical fusion: a prospective multicenter study. Spine 15 (1995) 2211-2216
    • (1995) Spine , vol.15 , pp. 2211-2216
    • An, H.S.1    Simpson, J.M.2    Glover, J.M.3    Stephany, J.4
  • 44
    • 23844546987 scopus 로고    scopus 로고
    • Combinatorial gene therapy for bone regeneration: cooperative interactions between adenovirus vectors expressing bone morphogenetic proteins 2, 4 and 7
    • Zhao M., Zhao Z., Koh J.T., Jin T., and Franceschi R.T. Combinatorial gene therapy for bone regeneration: cooperative interactions between adenovirus vectors expressing bone morphogenetic proteins 2, 4 and 7. J Cell Biochem 95 (2005) 1-16
    • (2005) J Cell Biochem , vol.95 , pp. 1-16
    • Zhao, M.1    Zhao, Z.2    Koh, J.T.3    Jin, T.4    Franceschi, R.T.5
  • 45
    • 0029862206 scopus 로고    scopus 로고
    • Heterodimeric bone morphogenetic proteins show enhanced activity in vitro and in vivo
    • Israel D.I., Nove J., Kerns K.M., et al. Heterodimeric bone morphogenetic proteins show enhanced activity in vitro and in vivo. Growth Factors 13 (1996) 291-300
    • (1996) Growth Factors , vol.13 , pp. 291-300
    • Israel, D.I.1    Nove, J.2    Kerns, K.M.3
  • 46
    • 0042807407 scopus 로고    scopus 로고
    • In vitro and in vivo synergistic interactions between the Runx2/Cbfa1 transcription factor and bone morphogenetic protein-2 in stimulating osteoblast differentiation
    • Yang S., Wei D., Wang D., Phimphilai M., Krebsbach P.H., and Franceschi R.T. In vitro and in vivo synergistic interactions between the Runx2/Cbfa1 transcription factor and bone morphogenetic protein-2 in stimulating osteoblast differentiation. J Bone Miner Res 18 (2003) 705-715
    • (2003) J Bone Miner Res , vol.18 , pp. 705-715
    • Yang, S.1    Wei, D.2    Wang, D.3    Phimphilai, M.4    Krebsbach, P.H.5    Franceschi, R.T.6


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