The osteoinductive properties of Nell-1 in a rat spinal fusion model

Spine Journal

Volumn 7, Issue 1, 2007, Pages 50-60

  Lu, Steven S ^a   Zhang, Xinli ^a   Soo, Chia ^a   Hsu, Tiffany ^a   Napoli, Antonia ^b   Aghaloo, Tara ^a   Wu, Benjamin M ^c   Tsou, Paul ^b   Ting, Kang ^a   Wang, Jeffrey C ^b  

^a UCLA SCHOOL OF DENTISTRY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Department of Civil and Environmental Engineering   (United States)

Author keywords

Demineralized bone matrix; Gene therapy; Nell 1; Rat model; Spinal fusion

Indexed keywords

BETA GALACTOSIDASE; BONE MORPHOGENETIC PROTEIN 2; EOSIN; EPIDERMAL GROWTH FACTOR; HEMATOXYLIN; NEL LIKE MOLECULE 1 PROTEIN; OSTEOGENIC PROTEIN 1; PROTEIN NELL 1; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ACCURACY; ADENOVIRUS VECTOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEMINERALIZATION; BONE GRAFT; BONE MATRIX; BONE MATURATION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SPECIFICITY; FEASIBILITY STUDY; HISTOPATHOLOGY; LUMBAR SPINE; MALE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PALPATION; PRIORITY JOURNAL; RAT; SPINE FUSION; SPINE RADIOGRAPHY; STATISTICAL SIGNIFICANCE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ADENOVIRIDAE; ANIMALS; BONE MATRIX; DISEASE MODELS, ANIMAL; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; LUMBAR VERTEBRAE; MALE; NERVE TISSUE PROTEINS; OSSEOINTEGRATION; OSTEOGENESIS; RATS; RATS, NUDE; RATS, SPRAGUE-DAWLEY; SPINAL FUSION; TOMOGRAPHY, X-RAY COMPUTED; TRANSDUCTION, GENETIC;

EID: 33845786651     PISSN: 15299430     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.spinee.2006.04.020     Document Type: Article

References (47)

1. Sandhu H.S., Grewal H.S., and Parvataneni H. Bone grafting for spinal fusion. Orthop Clin North Am 30 (1999) 685-698
2. Vail T.P., and Urbaniak J.R. Donor-site morbidity with use of vascularized autogenous fibular grafts. J Bone Joint Surg Am 78 (1996) 204-211
3. Sawin P.D., Traynelis V.C., and Menezes A.H. A comparative analysis of fusion rates and donor-site morbidity for autogeneic rib and iliac crest bone grafts in posterior cervical fusions. J Neurosurg 88 (1998) 255-265
4. Herkowitz H.N., and Kurz L.T. Degenerative lumbar spondylolisthesis with spinal stenosis: a prospective study comparing decompression with decompression and intertransverse process arthrodesis. J Bone Joint Surg Am 73 (1991) 802-808
5. Boden S.D. Biology of lumbar spine fusion and use of bone graft substitutes: present, future, and next generation. Tissue Eng 6 (2000) 383-399
6. Fischgrund J.S., Mackay M., Herkowitz H.N., Brower R., Montgomery D.M., and Kurz L.T. 1997 Volvo Award winner in clinical studies. Degenerative lumbar spondylolisthesis with spinal stenosis: a prospective, randomized study comparing decompressive laminectomy and arthrodesis with and without spinal instrumentation. Spine 22 (1997) 2807-2812
7. Boden S.D., Titus L., Hair G., et al. Lumbar spine fusion by local gene therapy with a cDNA encoding a novel osteoinductive protein (LMP-1). Spine 23 (1998) 2486-2492
8. Boden S.D., and Schimandle J.H. Biologic enhancement of spinal fusion. Spine 20 (1995) 113S-123S
9. Boden S.D. Overview of the biology of lumbar spine fusion and principles for selecting a bone graft substitute. Spine 27 (2002) S26-S31
10. Peterson B., Whang P.G., Iglesias R., Wang J.C., and Lieberman J.R. Osteoinductivity of commercially available demineralized bone matrix: preparations in a spine fusion model. J Bone Joint Surg Am 86-A (2004) 2243-2250
11. Takikawa S., Bauer T.W., Kambic H., and Togawa D. Comparative evaluation of the osteoinductivity of two formulations of human demineralized bone matrix. J Biomed Mater Res A 65 (2003) 37-42
12. Laurencin C, Khan Y. Bone graft substitute materials: emedicine: http://www.emedicine.com/orthoped/topic611.htm. Accessed January 5, 2006.
13. Saito H., Mimatsu K., Sato K., and Hashizume Y. Histopathologic and morphometric study of spinal cord lesion in a chronic cord compression model using bone morphogenetic protein in rabbits. Spine 17 (1992) 1368-1374
14. Miyamoto S., Takaoka K., Yonenobu K., and Ono K. Ossification of the ligamentum flavum induced by bone morphogenetic protein: an experimental study in mice. J Bone Joint Surg Br 74 (1992) 279-283
15. Mimatsu K., Kishi S., and Hashizume Y. Experimental chronic compression on the spinal cord of the rabbit by ectopic bone formation in the ligamentum flavum with bone morphogenetic protein. Spinal Cord 35 (1997) 740-746
16. Riew DK, Tungsiripat R, Wathanaapisith T, Taylor B. Bmp2 for anterior cervical surgery does it increase early postoperative swallowing difficulties? Cervial Spine Research Society Annual Meeting, San Diego, 2005.
17. Van den Bergh J.P., ten Bruggenkate C.M., Groeneveld H.H., Burger E.H., and Tuinzing D.B. Recombinant human bone morphogenetic protein-7 in maxillary sinus floor elevation surgery in 3 patients compared to autogenous bone grafts: a clinical pilot study. J Clin Periodontol 27 (2000) 627-636
18. Smucker JD, Rhee JM, Singh K et al. Increased postoperative airway or swallowing complications associated with use of rhBMP-2 in anterior cervical fusion. Cervial Spine Research Society Annual Meeting, San Diego, 2005.
19. Vaccaro A.R., Patel T., Fischgrund J., et al. A 2-year follow-up pilot study evaluating the safety and efficacy of OP-1 putty (rhBMP-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions. Eur Spine J 14 (2005) 623-629
20. Ting K., Vastardis H., Mulliken J.B., et al. Human NELL-1 expressed in unilateral coronal synostosis. J Bone Miner Res 14 (1999) 80-89
21. Aubin J.E. Regulation of osteoblast formation and function. Rev Endocr Metab Disord 2 (2001) 81-94
22. Aghaloo T., Cowan C.M., Chou Y.F., Zhang X., Lee H., Miao S., et al. Nell-1-induced bone regeneration in calvarial defects. Am J Pathol 169 (2006) 903-915
23. Jiang X, Wu B, Zhang Z, Ting K, Zhang X. Nell-1, Cbfa-1 downstream mediator, in inducing bone formation. J Dent Res 2005.
24. Truong T, Zhang X, Pathmanathan D, Soo C, Ting K. Craniosynostosis-associated gene Nell-1 is regulated by Runx2. JBMR. In press.
25. Miao Y.P., Ting K., Wong J., Truong T., and Zhang X. Partial compensation of Cbfa1 deficiency by Nell-1 overexpression. J Dent Res 83 (2004) 1306
26. Zhang X., Kuroda S., Carpenter D., et al. Craniosynostosis in transgenic mice overexpressing Nell-1. J Clin Invest 110 (2002) 861-870
27. Zhu W., Rawlins B.A., Boachie-Adjei O., et al. Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic differentiation and spine fusion in a rodent model. J Bone Miner Res 19 (2004) 2021-2032
28. Alden T.D., Pittman D.D., Beres E.J., et al. Percutaneous spinal fusion using bone morphogenetic protein-2 gene therapy. J Neurosurg 90 (1999) 109-114
29. Wang J.C., Kanim L.E., Yoo S., Campbell P.A., Berk A.J., and Lieberman J.R. Effect of regional gene therapy with bone morphogenetic protein-2-producing bone marrow cells on spinal fusion in rats. J Bone Joint Surg Am 85-A (2003) 905-911
30. Evans C.H., and Robbins P.D. Possible orthopaedic applications of gene therapy. J Bone Joint Surg Am 77a (1995) 1103-1114
31. Zhou Y.X., Xu X., Chen L., Li C., Brodie S.G., and Deng C.X. A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures. Hum Mol Genet 9 (2000) 2001-2008
32. Watanabe T.K., Katagiri T., Suzuki M., et al. Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats. Genomics 38 (1996) 273-276
33. Kuroda S., Oyasu M., Kawakami M., et al. Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2. Biochem Biophys Res Commun 265 (1999) 79-86
34. Zhao G.Q. Consequences of knocking out BMP signaling in the mouse. Genesis 35 (2003) 43-56
35. Chen D., Zhao M., and Mundy G.R. Bone morphogenetic proteins. Growth Factors 22 (2004) 233-241
36. Ducy P., and Karsenty G. The family of bone morphogenetic proteins. Kidney Int 57 (2000) 2207-2214
37. Lieberman J.R., Le L.Q., Wu L., et al. Regional gene therapy with a BMP-2-producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents. J Orthop Res 16 (1998) 330-339
38. Lieberman J.R., Daluiski A., Stevenson S., et al. The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats. J Bone Joint Surg Am 81 (1999) 905-917
39. Grauer J.N., Patel T.C., Erulkar J.S., Troiano N.W., Panjabi M.M., and Friedlaender G.E. Evaluation of OP-1 as a graft substitute for intertransverse process lumbar fusion. Spine 15 (2001) 127-133
40. Bomback D.A., Grauer J.N., Lugo R., Troiano N., Patel T., and Friedlaender G.E. Comparison of posterolateral lumbar fusion rates of Grafton Putty and OP-1 Putty in an athymic rat model. Spine 29 (2004) 1612-1617
41. Williams A.L., Gornet M.F., and Burkus J.K. CT evaluation of lumbar interbody fusion: current concepts. Am J Neuroradiol 26 (2005) 2057-2066
42. Schwartz Z., Somers A., Mellonig J.T., et al. Addition of human recombinant bone morphogenetic protein-2 to inactive commercial human demineralized freeze-dried bone allograft makes an effective composite bone inductive implant material. J Periodontol 69 (1998) 1337-1345
43. An H.S., Simpson J.M., Glover J.M., and Stephany J. Comparison between allograft plus demineralized bone matrix versus autograft in anterior cervical fusion: a prospective multicenter study. Spine 15 (1995) 2211-2216
44. Zhao M., Zhao Z., Koh J.T., Jin T., and Franceschi R.T. Combinatorial gene therapy for bone regeneration: cooperative interactions between adenovirus vectors expressing bone morphogenetic proteins 2, 4 and 7. J Cell Biochem 95 (2005) 1-16
45. Israel D.I., Nove J., Kerns K.M., et al. Heterodimeric bone morphogenetic proteins show enhanced activity in vitro and in vivo. Growth Factors 13 (1996) 291-300
46. Yang S., Wei D., Wang D., Phimphilai M., Krebsbach P.H., and Franceschi R.T. In vitro and in vivo synergistic interactions between the Runx2/Cbfa1 transcription factor and bone morphogenetic protein-2 in stimulating osteoblast differentiation. J Bone Miner Res 18 (2003) 705-715
47. Franceschi R.T., Yang S., Rutherford R.B., Krebsbach P.H., Zhao M., and Wang D. Gene therapy approaches for bone regeneration. Cells Tissues Organs 176 (2004) 95-108