Genetically modified human derived bone marrow cells for posterolateral lumbar spine fusion in athymic rats: Beyond conventional autologous bone grafting

Spine

Volumn 30, Issue 3, 2005, Pages 283-289

  Peterson, Brett ^a   Iglesias, Roberto ^a   Zhang, Jeffrey ^a   Wang, Jeffrey C ^a   Lieberman, Jay R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adenovirus; Bone graft substitute; Bone morphogenetic protein; Gene therapy; Spine fusion

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; COLLAGEN; COMPLEMENTARY DNA; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2;

ANIMAL EUTHANASIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL BASED GENE THERAPY; CELL CULTURE; CONTROLLED STUDY; EXPLANT; HISTOLOGY; HUMAN; HUMAN CELL; LUMBAR SPINE; NONHUMAN; OSSIFICATION; PALPATION; PRIORITY JOURNAL; RADIOGRAPHY; RAT; RAT STRAIN; SPINE FUSION; TIME SERIES ANALYSIS; VERTEBRA;

ADENOVIRIDAE; ANIMALS; BONE MARROW TRANSPLANTATION; BONE MORPHOGENETIC PROTEINS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; GENE THERAPY; HUMANS; LUMBAR VERTEBRAE; OSTEOGENESIS; RATS; RATS, NUDE; SPINAL FUSION; TRANSDUCTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 13444268948     PISSN: 03622436     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.brs.0000152380.71248.fe     Document Type: Article

References (45)

1. Boden SD. Percutaneous spinal fusion using bone morphogenetic protein-2 gene therapy. Tissue Eng 2000;6:383-99.
2. Buckwalter JA. Biology of lumbar spine fusion and use of bone graft substitutes: present, future, and next generation. Instr Course Lect 1997;46:459-69.
3. Haynesworth SE, Goshima J, Goldberg VM, et al. LMP-1, a LIM-domain protein, mediates BMP-6 effects on bone formation. Bone 1992;13:81-8.
4. Quarto R, Thomas D, Liang CT. Posterolateral lumbar intertransverse process spine arthrodesis with recombinant human bone morphogenetic protein 2/hydroxyapatite-tricalcium phosphate after laminectomy in the nonhuman primate. Calcif Tissue Int 1995;56:123-9.
5. Sawin PD, Dickman CA, Crawford NR, et al. Lumbar spine fusion by local gene therapy with a cDNA encoding a novel osteoinductive protein (LMP-1). J Neurosurg 2001;94:76-81.
6. Porter SE, Hanley EN Jr. The use of rhBMP-2 in interbody fusion cages. Definitive evidence of osteoinduction in humans: a preliminary report. J Am Acad Orthop Surg 2001;9:9-17.
7. Einhorn TA. A roentgenographic evaluation of frozen allografts versus autografts in anterior cervical spine fusions. J Bone Miner Res 2002;17:977-8.
8. Brown MD, Malinin TI, Davis PB. Maintaining and restoring mobility in middle and old age: the importance of the soft tissues. Clin Orthop 1976; 119:231-6.
9. Young WF, Rosenwasser RH. Recombinant human bone morphogenetic protein-7 induces healing in a canine long-bone segmental defect model. Spine 1993;18:1123-4.
10. Kozak JA, Heilman AE, O'Brien JP. The effect of recombinant human osteogenic protein-1 on healing of large segmental bone defects. Clin Orthop 1994;300:45-51.
11. Silcox DH 3rd. In vivo evaluation of recombinant human osteogenic protein (rhOP-1) implants as a bone graft substitute for spinal fusions. Orthop Clin North Am 1998;29:655-63.
12. Zdeblick TA, Ducker TB. Effect of recombinant human osteogenic protein-1 on healing of segmental defects in non-human primates. Spine 1991;16:726-9.
13. Jorgenson SS, Lowe TG, France J, et al. The family of bone morphogenetic proteins. Spine 1994;19:2048-53.
14. Morone MA, Boden SD. Do inhibitors of cyclooxygenase-2 impair bone healing? Spine 1998;23:159-67.
15. Price CT, Connolly JF, Carantzas AC, et al. Augmentation of autograft using rhBMP-2 and different carrier media in the canine spinal fusion model. Spine 2003;28:793-8.
16. Ducy P, Karsemy G. Gene therapy for bone formation: in vitro and in vivo osteogenic activity of an adenovirus expressing BMP7. Kidney Int 2000;57:2207-14.
17. Yasko AW, Lane JM, Fellinger EJ, et al. Interbody, posterior, and combined lumbar fusions. J Bone Joint Surg Am 1992;74:659-70.
18. Cook SD, Baffes GC, Wolfe MW, et al. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. Clin Orthop 1994; 301:302-12.
19. Cook SD, Baffes GC, Wolfe MW, et al. Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy. J Bone Joint Surg Am 1994;76:827-38.
20. Gerhart TN, Kirker-Head CA, Kriz MJ, et al. Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein. Clin Orthop 1993;293:317-26.
21. Cook SD, Wolfe MW, Salkeld SL, et al. Characterization of cells with osteogenic potential from human marrow. J Bone Joint Surg Am 1995;77:734-50.
22. Cook SD, Dalton JE, Tan EH, et al. Use of bone morphogenetic protein-9 gene therapy to induce spinal arthrodesis in the rodent. Spine 1994;19:1655-63.
23. Schimandle JH, Boden SD, Hutton WC. Morphology of the lumbar intertransverse process fusion mass in the rabbit model: a comparison between two bone graft materials-rhBMP-2 and autograft. Spine 1995;20:1326-37.
24. Boden SD, Martin GJ Jr, Morone MA, et al. Human bone morphogenetic protein allografting for reconstruction of femoral nonunion. Spine 1999;24:1179-85.
25. Holliger EH, Trawick RH, Boden SD, et al. A prospective analysis of autograft versus allograft in posterolateral lumbar fusion in the same patient. J Spinal Disord 1996;9:125-8.
26. Johnson EE, Urist MR. Anterior lumbar fusion options. Technique and graft materials. Clin Orthop 2000;37161-74.
27. Boden SD, Zdeblick TA, Sandhu HS, et al. The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats. Spine 2000;25:376-81.
28. Friedlaender GE, Perry CR, Cole JD, et al. Cartilage and bone regeneration using gene-enhanced tissue engineering. J Bone Joint Surg Am 2001;83(suppl 1):151-8.
29. Franceschi RT, Wang D, Krebsbach PH, et al. Experimental posterolateral lumbar spinal fusion with a demineralized bone matrix gel. J Cell Biochem 2000;78:476-86.
30. Peng H, Wright V, Usas A, et al. Potential role for gene therapy in the enhancement of fracture healing. J Clin Invest 2002;110:751-9.
31. Niyibizi C, Baltzer A, Lattermann C, et al. Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4. Clin Orthop 1998;355(suppl):148-53.
32. Wright V, Peng H, Usas A, et al. The musculoskeletal effects of smoking. Mol Ther 2002;6:169-78.
33. Mason JM, Breitbart AS, Barcia M, et al. Comparison of bone grafts for posterior spinal fusion in adolescent idiopathic scoliosis. Clin Orthop 2000; 379(suppl):171-8.
34. Lieberman JR, Daluiski A, Stevenson S, et al. Bone progenitor cell deficits and the age-associated decline in bone repair capacity. J Bone Joint Surg Am 1999;81:905-17.
35. Boden SD, Titus L, Hair G, et al. Induction of bone formation using a recombinant adenoviral vector carrying the human BMP-2 gene in a rabbit spinal fusion model. Spine 1998;23:2486-92.
36. Fischgrund JS, James SB, Chabot MC, et al. The effects of dexamethasone on bone fusion in an experimental model of posterolateral lumbar spinal arthrodesis. J Spinal Disord 1997;10:467-72.
37. Fraser RD. Experimental spinal fusion with recombinant human bone morphogenetic protein-2. Spine 1995;20(suppl):167-77.
38. Uludag H, D'Augusta D, Palmer R, et al. Laparoscopic bone dowel fusions of the lumbar spine. J Biomed Mater Res 1999;46:193-202.
39. Alden TD, Pittman DD, Beres EJ, et al. Characterization of rhBMP-2 pharmacokinetics implanted with biomaterial carriers in the rat ectopic model. J Neurosurg 1999;90:109-114.
40. Helm GA, Alden TD, Beres EJ, et al. Adenoviral delivery of LIM mineralization protein-1 induces new-bone formation in vitro and in vivo. J Neurosurg 2000;92:191-96.
41. Riew KD, Wright NM, Cheng S, et al. Effect of regional gene therapy with bone morphogenetic protein-2-producing bone marrow cells on spinal fusion in rats. Calcif Tissue Int 1998;63:357-60.
42. Viggeswarapu M, Boden SD, Liu Y, et al. BMP4-expressing muscle-derived stem cells differentiate into osteogenic lineage and improve bone healing in immunocompetent mice. J Bone Joint Surg Am 2001;83:364-76.
43. Boden SD, Liu Y, Hair GA, et al. The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2). A radiographic, histological, and biomechanical study in rats. Endocrinology 1998;139:5125-34.
44. Gazit D, Turgeman G, Kelley P, et al. An early comparative analysis of the use of fibular allograft versus autologous iliac crest graft for interbody fusion after anterior cervical discectomy. J Gene Med 1999;1:121-33.
45. Wang JC, Kanim LE, Yoo S, et al. The use of freeze-dried allograft bone for anterior cervical fusions. J Bone Joint Surg Am 2003;85:905-11.