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Volumn 12, Issue 5-6, 2007, Pages 241-248

Expanding the therapeutic use of androgens via selective androgen receptor modulators (SARMs)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANDROSTANOLONE; ANTIANDROGEN; AROMATASE INHIBITOR; FINASTERIDE; FLUOXYMESTERONE; FLUTAMIDE; HYDANTOIN DERIVATIVE; METHYLTESTOSTERONE; NANDROLONE; OXANDROLONE; QUINOLINE DERIVATIVE; SELECTIVE ANDROGEN RECEPTOR MODULATOR; STEROID; STEROID 5ALPHA REDUCTASE; TESTOSTERONE; TESTOSTERONE ESTER; UNCLASSIFIED DRUG;

EID: 33847184616     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2007.01.003     Document Type: Review
Times cited : (175)

References (65)
  • 1
    • 25444496757 scopus 로고    scopus 로고
    • Chemistry and structural biology of androgen receptor
    • Gao W., et al. Chemistry and structural biology of androgen receptor. Chem. Rev. 105 (2005) 3352-3370
    • (2005) Chem. Rev. , vol.105 , pp. 3352-3370
    • Gao, W.1
  • 2
    • 10744231103 scopus 로고    scopus 로고
    • Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor
    • Fang H., et al. Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor. Chem. Res. Toxicol. 16 (2003) 1338-1358
    • (2003) Chem. Res. Toxicol. , vol.16 , pp. 1338-1358
    • Fang, H.1
  • 4
    • 17844376217 scopus 로고    scopus 로고
    • Structural basis for antagonism and resistance of bicalutamide in prostate cancer
    • Bohl C.E., et al. Structural basis for antagonism and resistance of bicalutamide in prostate cancer. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 6201-6206
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 6201-6206
    • Bohl, C.E.1
  • 5
    • 0034714276 scopus 로고    scopus 로고
    • Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations
    • Matias P.M., et al. Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations. J. Biol. Chem. 275 (2000) 26164-26171
    • (2000) J. Biol. Chem. , vol.275 , pp. 26164-26171
    • Matias, P.M.1
  • 6
    • 30944451963 scopus 로고    scopus 로고
    • A comparative molecular modeling study of dydrogesterone with other progestational agents through theoretical calculations and nuclear magnetic resonance spectroscopy
    • Colombo D., et al. A comparative molecular modeling study of dydrogesterone with other progestational agents through theoretical calculations and nuclear magnetic resonance spectroscopy. J. Steroid Biochem. Mol. Biol. 98 (2006) 56-62
    • (2006) J. Steroid Biochem. Mol. Biol. , vol.98 , pp. 56-62
    • Colombo, D.1
  • 7
    • 0033304913 scopus 로고    scopus 로고
    • Selective androgen receptor modulators (SARMs): a novel approach to androgen therapy for the new millennium
    • Negro-Vilar A. Selective androgen receptor modulators (SARMs): a novel approach to androgen therapy for the new millennium. J. Clin. Endocrinol. Metab. 84 (1999) 3459-3462
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 3459-3462
    • Negro-Vilar, A.1
  • 8
    • 33645703903 scopus 로고    scopus 로고
    • Therapeutic potential of the SARMs: revisiting the androgen receptor for drug discovery
    • Segal S., et al. Therapeutic potential of the SARMs: revisiting the androgen receptor for drug discovery. Expert Opin. Investig. Drugs 15 (2006) 377-387
    • (2006) Expert Opin. Investig. Drugs , vol.15 , pp. 377-387
    • Segal, S.1
  • 9
    • 0041923632 scopus 로고    scopus 로고
    • Suppressive function of androgen receptor in bone resorption
    • Kawano H., et al. Suppressive function of androgen receptor in bone resorption. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 9416-9421
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 9416-9421
    • Kawano, H.1
  • 10
    • 22544467523 scopus 로고    scopus 로고
    • Discovery and therapeutic promise of selective androgen receptor modulators
    • Chen J., et al. Discovery and therapeutic promise of selective androgen receptor modulators. Mol. Interv. 5 (2005) 173-188
    • (2005) Mol. Interv. , vol.5 , pp. 173-188
    • Chen, J.1
  • 12
    • 0037396460 scopus 로고    scopus 로고
    • Androgens and coronary artery disease
    • Wu F.C., and von Eckardstein A. Androgens and coronary artery disease. Endocr. Rev. 24 (2003) 183-217
    • (2003) Endocr. Rev. , vol.24 , pp. 183-217
    • Wu, F.C.1    von Eckardstein, A.2
  • 13
    • 85003093901 scopus 로고
    • Biological actions of androgens
    • Mooradian A.D., et al. Biological actions of androgens. Endocr. Rev. 8 (1987) 1-28
    • (1987) Endocr. Rev. , vol.8 , pp. 1-28
    • Mooradian, A.D.1
  • 14
    • 0141631436 scopus 로고    scopus 로고
    • Testosterone and atherosclerosis
    • Eckardstein A., and Wu F.C. Testosterone and atherosclerosis. Growth Horm IGF Res 13 Suppl A (2003) S72-S84
    • (2003) Growth Horm IGF Res , vol.13 , Issue.SUPPL. A
    • Eckardstein, A.1    Wu, F.C.2
  • 15
    • 0032803807 scopus 로고    scopus 로고
    • Medical management of benign prostatic hyperplasia
    • Chacon A., and Monga M. Medical management of benign prostatic hyperplasia. Geriatr. Nephrol. Urol. 9 (1999) 39-48
    • (1999) Geriatr. Nephrol. Urol. , vol.9 , pp. 39-48
    • Chacon, A.1    Monga, M.2
  • 16
    • 0029963510 scopus 로고    scopus 로고
    • Estrogen reduction by aromatase inhibition for benign prostatic hyperplasia: results of a double-blind, placebo-controlled, randomized clinical trial using two doses of the aromatase-inhibitor atamestane. Atamestane Study Group
    • Radlmaier A., et al. Estrogen reduction by aromatase inhibition for benign prostatic hyperplasia: results of a double-blind, placebo-controlled, randomized clinical trial using two doses of the aromatase-inhibitor atamestane. Atamestane Study Group. Prostate 29 (1996) 199-208
    • (1996) Prostate , vol.29 , pp. 199-208
    • Radlmaier, A.1
  • 17
    • 0029046770 scopus 로고
    • Placebo controlled double-blind study to test the efficacy of the aromatase inhibitor atamestane in patients with benign prostatic hyperplasia not requiring operation. The Schering 90.062 Study Group
    • Gingell J.C., et al. Placebo controlled double-blind study to test the efficacy of the aromatase inhibitor atamestane in patients with benign prostatic hyperplasia not requiring operation. The Schering 90.062 Study Group. J. Urol. 154 (1995) 399-401
    • (1995) J. Urol. , vol.154 , pp. 399-401
    • Gingell, J.C.1
  • 18
    • 0027322594 scopus 로고
    • Management of benign prostatic hyperplasia with particular emphasis on aromatase inhibitors
    • Habenicht U.F., et al. Management of benign prostatic hyperplasia with particular emphasis on aromatase inhibitors. J. Steroid Biochem. Mol. Biol. 44 (1993) 557-563
    • (1993) J. Steroid Biochem. Mol. Biol. , vol.44 , pp. 557-563
    • Habenicht, U.F.1
  • 19
    • 0001877218 scopus 로고    scopus 로고
    • The androgen receptor: a mediator of diverse responses
    • Keller E.T., et al. The androgen receptor: a mediator of diverse responses. Front. Biosci. 1 (1996) d59-d71
    • (1996) Front. Biosci. , vol.1
    • Keller, E.T.1
  • 20
    • 0030593681 scopus 로고    scopus 로고
    • ER beta: identification and characterization of a novel human estrogen receptor
    • Mosselman S., et al. ER beta: identification and characterization of a novel human estrogen receptor. FEBS Lett. 392 (1996) 49-53
    • (1996) FEBS Lett. , vol.392 , pp. 49-53
    • Mosselman, S.1
  • 21
    • 0026730788 scopus 로고
    • Molecular genetics of steroid 5 alpha-reductase 2 deficiency
    • Thigpen A.E., et al. Molecular genetics of steroid 5 alpha-reductase 2 deficiency. J. Clin. Invest. 90 (1992) 799-809
    • (1992) J. Clin. Invest. , vol.90 , pp. 799-809
    • Thigpen, A.E.1
  • 22
    • 0033305674 scopus 로고    scopus 로고
    • Androgen-induced regrowth in the castrated rat ventral prostate: role of 5alpha-reductase
    • Wright A.S., et al. Androgen-induced regrowth in the castrated rat ventral prostate: role of 5alpha-reductase. Endocrinology 140 (1999) 4509-4515
    • (1999) Endocrinology , vol.140 , pp. 4509-4515
    • Wright, A.S.1
  • 23
    • 0346501854 scopus 로고    scopus 로고
    • Testosterone metabolism, dose-response relationships and receptor polymorphisms: selected pharmacological/toxicological considerations on benefits versus risks of testosterone therapy in men
    • Oettel M. Testosterone metabolism, dose-response relationships and receptor polymorphisms: selected pharmacological/toxicological considerations on benefits versus risks of testosterone therapy in men. Aging Male 6 (2003) 230-256
    • (2003) Aging Male , vol.6 , pp. 230-256
    • Oettel, M.1
  • 24
    • 12044259684 scopus 로고
    • The molecular genetics of steroid 5 alpha-reductases
    • Russell D.W., et al. The molecular genetics of steroid 5 alpha-reductases. Recent Prog. Horm. Res. 49 (1994) 275-284
    • (1994) Recent Prog. Horm. Res. , vol.49 , pp. 275-284
    • Russell, D.W.1
  • 25
    • 0036924950 scopus 로고    scopus 로고
    • Is there a role for estrogens in the maintenance of men's health?
    • Oettel M. Is there a role for estrogens in the maintenance of men's health?. Aging Male 5 (2002) 248-257
    • (2002) Aging Male , vol.5 , pp. 248-257
    • Oettel, M.1
  • 26
    • 0038332174 scopus 로고    scopus 로고
    • The importance of oestrogens in males
    • de Ronde W., et al. The importance of oestrogens in males. Clin. Endocrinol. (Oxf.) 58 (2003) 529-542
    • (2003) Clin. Endocrinol. (Oxf.) , vol.58 , pp. 529-542
    • de Ronde, W.1
  • 27
    • 0033304659 scopus 로고    scopus 로고
    • Endogenous sex hormones and cognitive function in older men
    • Barrett-Connor E., et al. Endogenous sex hormones and cognitive function in older men. J. Clin. Endocrinol. Metab. 84 (1999) 3681-3685
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 3681-3685
    • Barrett-Connor, E.1
  • 28
    • 1842834450 scopus 로고    scopus 로고
    • Differential contribution of testosterone and estradiol in the determination of cholesterol and lipoprotein profile in healthy middle-aged men
    • Van Pottelbergh I., et al. Differential contribution of testosterone and estradiol in the determination of cholesterol and lipoprotein profile in healthy middle-aged men. Atherosclerosis 166 (2003) 95-102
    • (2003) Atherosclerosis , vol.166 , pp. 95-102
    • Van Pottelbergh, I.1
  • 29
    • 0037133622 scopus 로고    scopus 로고
    • Testosterone attenuates expression of vascular cell adhesion molecule-1 by conversion to estradiol by aromatase in endothelial cells: implications in atherosclerosis
    • Mukherjee T.K., et al. Testosterone attenuates expression of vascular cell adhesion molecule-1 by conversion to estradiol by aromatase in endothelial cells: implications in atherosclerosis. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 4055-4060
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 4055-4060
    • Mukherjee, T.K.1
  • 30
    • 0035078693 scopus 로고    scopus 로고
    • Oestrogen at the neonatal stage is critical for the reproductive ability of male mice as revealed by supplementation with 17beta-oestradiol to aromatase gene (Cyp19) knockout mice
    • Toda K., et al. Oestrogen at the neonatal stage is critical for the reproductive ability of male mice as revealed by supplementation with 17beta-oestradiol to aromatase gene (Cyp19) knockout mice. J. Endocrinol. 168 (2001) 455-463
    • (2001) J. Endocrinol. , vol.168 , pp. 455-463
    • Toda, K.1
  • 31
    • 0034521393 scopus 로고    scopus 로고
    • Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men
    • Falahati-Nini A., et al. Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men. J. Clin. Invest. 106 (2000) 1553-1560
    • (2000) J. Clin. Invest. , vol.106 , pp. 1553-1560
    • Falahati-Nini, A.1
  • 32
    • 0347630358 scopus 로고    scopus 로고
    • Men, bone and estrogen: unresolved issues
    • Orwoll E.S. Men, bone and estrogen: unresolved issues. Osteoporos. Int. 14 (2003) 93-98
    • (2003) Osteoporos. Int. , vol.14 , pp. 93-98
    • Orwoll, E.S.1
  • 33
    • 0030925683 scopus 로고    scopus 로고
    • Steroid receptor interactions with heat shock protein and immunophilin chaperones
    • Pratt W.B., and Toft D.O. Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr. Rev. 18 (1997) 306-360
    • (1997) Endocr. Rev. , vol.18 , pp. 306-360
    • Pratt, W.B.1    Toft, D.O.2
  • 34
    • 0036219918 scopus 로고    scopus 로고
    • Androgen receptor (AR) coregulators: an overview
    • Heinlein C.A., and Chang C. Androgen receptor (AR) coregulators: an overview. Endocr. Rev. 23 (2002) 175-200
    • (2002) Endocr. Rev. , vol.23 , pp. 175-200
    • Heinlein, C.A.1    Chang, C.2
  • 35
    • 0036208492 scopus 로고    scopus 로고
    • Formation of the androgen receptor transcription complex
    • Shang Y., et al. Formation of the androgen receptor transcription complex. Mol. Cell 9 (2002) 601-610
    • (2002) Mol. Cell , vol.9 , pp. 601-610
    • Shang, Y.1
  • 36
    • 0038517838 scopus 로고    scopus 로고
    • Selective modulation of genomic and nongenomic androgen responses by androgen receptor ligands
    • Lutz L.B., et al. Selective modulation of genomic and nongenomic androgen responses by androgen receptor ligands. Mol. Endocrinol. 17 (2003) 1106-1116
    • (2003) Mol. Endocrinol. , vol.17 , pp. 1106-1116
    • Lutz, L.B.1
  • 37
    • 0042315340 scopus 로고    scopus 로고
    • Testosterone stimulates intracellular calcium release and mitogen-activated protein kinases via a G protein-coupled receptor in skeletal muscle cells
    • Estrada M., et al. Testosterone stimulates intracellular calcium release and mitogen-activated protein kinases via a G protein-coupled receptor in skeletal muscle cells. Endocrinology 144 (2003) 3586-3597
    • (2003) Endocrinology , vol.144 , pp. 3586-3597
    • Estrada, M.1
  • 38
    • 0035831020 scopus 로고    scopus 로고
    • Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity
    • Kousteni S., et al. Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity. Cell 104 (2001) 719-730
    • (2001) Cell , vol.104 , pp. 719-730
    • Kousteni, S.1
  • 39
    • 1642453682 scopus 로고    scopus 로고
    • Signaling cross-talk from Gbeta4 subunit to Elk-1 in the rapid action of androgens
    • Zagar Y., et al. Signaling cross-talk from Gbeta4 subunit to Elk-1 in the rapid action of androgens. J. Biol. Chem. 279 (2004) 2403-2413
    • (2004) J. Biol. Chem. , vol.279 , pp. 2403-2413
    • Zagar, Y.1
  • 40
    • 0036717596 scopus 로고    scopus 로고
    • The human prostate cancer cell line LNCaP bears functional membrane testosterone receptors that increase PSA secretion and modify actin cytoskeleton
    • Kampa M., et al. The human prostate cancer cell line LNCaP bears functional membrane testosterone receptors that increase PSA secretion and modify actin cytoskeleton. FASEB J. 16 (2002) 1429-1431
    • (2002) FASEB J. , vol.16 , pp. 1429-1431
    • Kampa, M.1
  • 41
    • 4944237502 scopus 로고    scopus 로고
    • Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence
    • Unni E., et al. Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence. Cancer Res. 64 (2004) 7156-7168
    • (2004) Cancer Res. , vol.64 , pp. 7156-7168
    • Unni, E.1
  • 42
    • 0345874610 scopus 로고    scopus 로고
    • Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model
    • Norman A.W., et al. Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model. Nat. Rev. Drug Discov. 3 (2004) 27-41
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 27-41
    • Norman, A.W.1
  • 43
    • 0034675994 scopus 로고    scopus 로고
    • Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation
    • Migliaccio A., et al. Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation. EMBO J. 19 (2000) 5406-5417
    • (2000) EMBO J. , vol.19 , pp. 5406-5417
    • Migliaccio, A.1
  • 44
    • 0344844462 scopus 로고    scopus 로고
    • Pharmacological uncoupling of androgen receptor-mediated prostate cancer cell proliferation and prostate-specific antigen secretion
    • Sathya G., et al. Pharmacological uncoupling of androgen receptor-mediated prostate cancer cell proliferation and prostate-specific antigen secretion. Cancer Res. 63 (2003) 8029-8036
    • (2003) Cancer Res. , vol.63 , pp. 8029-8036
    • Sathya, G.1
  • 45
    • 31544451068 scopus 로고    scopus 로고
    • Interplay between two hormone-independent activation domains in the androgen receptor
    • Callewaert L., et al. Interplay between two hormone-independent activation domains in the androgen receptor. Cancer Res. 66 (2006) 543-553
    • (2006) Cancer Res. , vol.66 , pp. 543-553
    • Callewaert, L.1
  • 46
    • 14844288915 scopus 로고    scopus 로고
    • The androgen receptor recruits nuclear receptor corepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists
    • Hodgson M.C., et al. The androgen receptor recruits nuclear receptor corepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists. J. Biol. Chem. 280 (2005) 6511-6519
    • (2005) J. Biol. Chem. , vol.280 , pp. 6511-6519
    • Hodgson, M.C.1
  • 47
    • 0025091523 scopus 로고
    • A comparative study of the selectivity and efficiency of target tissue uptake of five tritium-labeled androgens in the rat
    • Carlson K.E., and Katzenellenbogen J.A. A comparative study of the selectivity and efficiency of target tissue uptake of five tritium-labeled androgens in the rat. J. Steroid Biochem. 36 (1990) 549-561
    • (1990) J. Steroid Biochem. , vol.36 , pp. 549-561
    • Carlson, K.E.1    Katzenellenbogen, J.A.2
  • 48
    • 33747333101 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of a nonsteroidal bromine-76-labeled androgen receptor ligand 3-[76Br]bromo-hydroxyflutamide
    • Parent E.E., et al. Synthesis and biological evaluation of a nonsteroidal bromine-76-labeled androgen receptor ligand 3-[76Br]bromo-hydroxyflutamide. Nucl. Med. Biol. 33 (2006) 705-713
    • (2006) Nucl. Med. Biol. , vol.33 , pp. 705-713
    • Parent, E.E.1
  • 49
    • 9444244523 scopus 로고    scopus 로고
    • Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5alpha-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia
    • Gao W., et al. Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5alpha-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia. Endocrinology 145 (2004) 5420-5428
    • (2004) Endocrinology , vol.145 , pp. 5420-5428
    • Gao, W.1
  • 50
    • 4344679375 scopus 로고    scopus 로고
    • Estrogen receptor-dependent activation of AP-1 via non-genomic signalling
    • Bjornstrom L., and Sjoberg M. Estrogen receptor-dependent activation of AP-1 via non-genomic signalling. Nucl. Recept. 2 (2004) 3
    • (2004) Nucl. Recept. , vol.2 , pp. 3
    • Bjornstrom, L.1    Sjoberg, M.2
  • 51
    • 0037174675 scopus 로고    scopus 로고
    • Reversal of bone loss in mice by nongenotropic signaling of sex steroids
    • Kousteni S., et al. Reversal of bone loss in mice by nongenotropic signaling of sex steroids. Science 298 (2002) 843-846
    • (2002) Science , vol.298 , pp. 843-846
    • Kousteni, S.1
  • 52
    • 0032489326 scopus 로고    scopus 로고
    • Discovery of nonsteroidal androgens
    • Dalton J.T., et al. Discovery of nonsteroidal androgens. Biochem. Biophys. Res. Commun. 244 (1998) 1-4
    • (1998) Biochem. Biophys. Res. Commun. , vol.244 , pp. 1-4
    • Dalton, J.T.1
  • 53
    • 0032492668 scopus 로고    scopus 로고
    • New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g] quinolinone
    • Edwards J.P., et al. New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g] quinolinone. Bioorg. Med. Chem. Lett. 8 (1998) 745-750
    • (1998) Bioorg. Med. Chem. Lett. , vol.8 , pp. 745-750
    • Edwards, J.P.1
  • 54
    • 0037371461 scopus 로고    scopus 로고
    • Pharmacodynamics of selective androgen receptor modulators
    • Yin D., et al. Pharmacodynamics of selective androgen receptor modulators. J. Pharmacol. Exp. Ther. 304 (2003) 1334-1340
    • (2003) J. Pharmacol. Exp. Ther. , vol.304 , pp. 1334-1340
    • Yin, D.1
  • 55
    • 4444371195 scopus 로고    scopus 로고
    • Bone anabolic effects of S-40503, a novel nonsteroidal selective androgen receptor modulator (SARM), in rat models of osteoporosis
    • Hanada K., et al. Bone anabolic effects of S-40503, a novel nonsteroidal selective androgen receptor modulator (SARM), in rat models of osteoporosis. Biol. Pharm. Bull. 26 (2003) 1563-1569
    • (2003) Biol. Pharm. Bull. , vol.26 , pp. 1563-1569
    • Hanada, K.1
  • 56
    • 33845888293 scopus 로고    scopus 로고
    • An orally-active selective androgen receptor modulator is efficacious on bone, muscle and sex function with reduced impact on prostate
    • 10.1210/en.2006-0793
    • Miner J.N., et al. An orally-active selective androgen receptor modulator is efficacious on bone, muscle and sex function with reduced impact on prostate. Endocrinology (2006). http://endo.endojournals.org 10.1210/en.2006-0793
    • (2006) Endocrinology
    • Miner, J.N.1
  • 57
    • 33646156657 scopus 로고    scopus 로고
    • Selective androgen receptor modulators in drug discovery: medicinal chemistry and therapeutic potential
    • Cadilla R., and Turnbull P. Selective androgen receptor modulators in drug discovery: medicinal chemistry and therapeutic potential. Curr. Top. Med. Chem. 6 (2006) 245-270
    • (2006) Curr. Top. Med. Chem. , vol.6 , pp. 245-270
    • Cadilla, R.1    Turnbull, P.2
  • 58
    • 33746894825 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligands
    • Gao W., et al. Pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligands. Pharm. Res. 23 (2006) 1641-1658
    • (2006) Pharm. Res. , vol.23 , pp. 1641-1658
    • Gao, W.1
  • 59
    • 18744368209 scopus 로고    scopus 로고
    • Non-steroidal steroid receptor modulators
    • Buijsman R.C., et al. Non-steroidal steroid receptor modulators. Curr. Med. Chem. 12 (2005) 1017-1075
    • (2005) Curr. Med. Chem. , vol.12 , pp. 1017-1075
    • Buijsman, R.C.1
  • 60
    • 26844496083 scopus 로고    scopus 로고
    • Selective androgen receptor modulator (SARM) treatment improves muscle strength and body composition, and prevents bone loss in orchidectomized rats
    • Gao W., et al. Selective androgen receptor modulator (SARM) treatment improves muscle strength and body composition, and prevents bone loss in orchidectomized rats. Endocrinology 146 (2005) 4887-4897
    • (2005) Endocrinology , vol.146 , pp. 4887-4897
    • Gao, W.1
  • 61
    • 13244284678 scopus 로고    scopus 로고
    • A selective androgen receptor modulator for hormonal male contraception
    • Chen J., et al. A selective androgen receptor modulator for hormonal male contraception. J. Pharmacol. Exp. Ther. 312 (2005) 546-553
    • (2005) J. Pharmacol. Exp. Ther. , vol.312 , pp. 546-553
    • Chen, J.1
  • 62
    • 0029561444 scopus 로고    scopus 로고
    • The preclinical development of bicalutamide: pharmacodynamics and mechanism of action
    • discussion 29-32
    • Furr B.J., and Tucker H. The preclinical development of bicalutamide: pharmacodynamics and mechanism of action. Urology 47 Suppl. 1A (1996) 13-25 discussion 29-32
    • (1996) Urology , vol.47 , Issue.SUPPL. 1A , pp. 13-25
    • Furr, B.J.1    Tucker, H.2
  • 63
    • 7444242095 scopus 로고    scopus 로고
    • Bicalutamide: clinical pharmacokinetics and metabolism
    • Cockshott I.D. Bicalutamide: clinical pharmacokinetics and metabolism. Clin. Pharmacokinet. 43 (2004) 855-878
    • (2004) Clin. Pharmacokinet. , vol.43 , pp. 855-878
    • Cockshott, I.D.1
  • 64
    • 25444478057 scopus 로고    scopus 로고
    • Development of peptide antagonists for the androgen receptor using combinatorial peptide phage display
    • Chang C.Y., et al. Development of peptide antagonists for the androgen receptor using combinatorial peptide phage display. Mol. Endocrinol. 19 (2005) 2478-2490
    • (2005) Mol. Endocrinol. , vol.19 , pp. 2478-2490
    • Chang, C.Y.1
  • 65
    • 30044433051 scopus 로고    scopus 로고
    • Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators
    • Arnold L.A., et al. Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators. J. Biol. Chem. 280 (2005) 43048-43055
    • (2005) J. Biol. Chem. , vol.280 , pp. 43048-43055
    • Arnold, L.A.1


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