Doping control analysis of tricyclic tetrahydroquinoline-derived selective androgen receptor modulators using liquid chromatography/electrospray ionization tandem mass spectrometry

Rapid Communications in Mass Spectrometry

Volumn 22, Issue 16, 2008, Pages 2471-2478

  Thevis, Mario ^a   Kohler, Maxie ^a   Thomas, Andreas ^a   Schlörer, Nils ^b   Schänzer, Wilhelm ^a  

^a GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DIAGNOSIS; DISSOCIATION; DRUG PRODUCTS; IONIZATION OF GASES; IONS; LABORATORIES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY;

ANDROGEN RECEPTORS; DISSOCIATION PATHWAYS; DOPING CONTROL ANALYSIS; DRUG CANDIDATES; ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY ELECTROSPRAY; MUSCLE WASTING; PRODUCT IONS; SYNTHESISED; TETRAHYDROQUINOLINES;

ELECTROSPRAY IONIZATION;

EID: 50249168698     PISSN: 09514198     EISSN: 10970231     Source Type: Journal    
DOI: 10.1002/rcm.3637     Document Type: Article

References (38)

1. Cadilla R, Turnbull P. Curr. Topics Med. Chem. 2006; 6: 245.
2. Gao W, Dalton JT. Drug Discov. Today 2007; 12: 241.
3. Kilbourne EJ, Moore WJ, Freedman LP, Nagpal S. Curr. Opin. Investig. Drugs 2007; 8: 821.
4. Negro-Vilar A. J. Clin. Endocrinol. Metab. 1999; 84: 3459.
5. Omwancha J, Brown TR. Curr. Opin. Investig. Drugs 2006; 7: 873.
6. Mohler ML, Nair VA, Hwang DJ, Rakov IM, Patil R, Miller DD. Exp. Opin. Ther. Patents 2005; 15: 1565.
7. Dalton JT, Mukherjee A, Zhu Z, Kirkovsky L, Miller DD. Biochem. Biophi/s. Res. Commun. 1998; 244: 1.
8. Hamann LG, Manfredi MC, Sun C, Krystek SR Jr, Huang Y, Bi Y, Augeri DJ, Wang T, Zou Y, Betebenner DA, Fura A, Seethala R, Golla R, Kuhns JE, Lupisella JA, Darienzo CJ, Custer LL, Price JL, Johnson JM, Biller SA, Zahler R, Ostrowski J. Bioorg. Med. Chem. Lett. 2007; 17: 1860.
9. Hamann LG, Mani NS, Davis RL, Wang XN, Marschke KB, Jones TK. J. Med. Chem. 1999; 42: 210.
10. van Oeveren A, Motamedi M, Mani NS, Marschke KB, Lopez FJ, Schrader WT, Negro-Vilar A, Zhi L. J. Med. Chem. 2006; 49: 6143.
11. van Oeveren A, Pio BA, Tegley CM, Higuchi RI, Wu M, Jones TK, Marschke KB, Negro-Vilar A, Zhi L. Bioorg. Med. Chem. Lett. 2007; 17: 1523.
12. European Patent Kaken Pharmaceuticals, Germany, 2007.
13. Hanada K, Furuya K, Yamamoto N, Nejishima H, Ichikawa K, Nakamura T, Miyakawa M, Amano S, Sumita Y, Oguro N. Biol. Pharm. Bull. 2003; 26: 1563.
14. Gao W, Wu Z, Bohl CE, Yang J, Miller DD, Dalton JT. Drug Metab. Dispos. 2006; 34: 243.
15. Wu D, Wu Z, Yang J, Nair VA, Miller DD, Dalton JT. Drug Metab. Dispos. 2006; 34: 483.
16. Thevis M, Kamber M, Schänzer W. Rapid Commun. Mass Spectrom. 2006; 20: 870.
17. Thevis M, Kohler M, Maurer J, Schlörer N, Kamber M, Schänzer W. Rapid Commun. Mass Spectrom. 2007; 21: 3477.
18. Thevis M, Kohler M, Schlörer N, Kamber M, Kuhn A, Linscheid MW, Schänzer W. J. Mass Spectrom. 2008; 43: 639.
19. Thevis M, Schänzer W. Mini. Rev. Med. Chem. 2007; 7: 533.
20. Kuuranne T, Leinonen A, Schänzer W, Kamber M, Kostiainen R, Thevis M. Drug Metab. Dispos. 2008; 36: 571.
21. World Anti-Doping Agency. 2008; Available: http://www. wada-ama.org/rtecontent/document/2008_List_En.pdf (28-11-2007).
22. Riemschneider R, Grabitz EB. Monatsh. Chem. 1958; 89: 748.
23. Frank HP, Krzemicki K. Monatsh. Chem. 1964; 95: 410.
24. Stiller ET, Harris SA, Finkelstein J, Keresztesy JC, Folkers K. J. Am. Chem. Soc. 1940; 62: 1785.
25. Thevis M, Schänzer W. J. Chromatogr. Sci. 2005; 43: 22.
26. Thevis M, Geyer H, Mareck U, Schänzer W. J. Mass Spectrom. 2005; 40: 955.
27. International Conference on Harmonization (ICH). 2004; Available: http://www.ich.org/LOB/media/MEDIA417. pdf (28-01-2007).
28. Kromidas A. Validierung in der Analytik. Wiley-VCH: Weinheim, 1999.
29. Dams R, Huestis MA, Lambert WE, Murphy CM. J. Am. Soc. Mass Spectrom. 2003; 14: 1290.
30. Matuszewski BK, Constanzer ML, Chavez-Eng CM. Anal. Chem. 2003; 75: 3019.
31. Levsen K, Schiebel HM, Terlouw JK, Jobst KJ, Elend M, Preiss A, Thiele H, Ingendoh A. J. Mass Spectrom. 2007; 42: 1024.
32. Murena F, Gioia F. J. Haz. Mat. 1998; 60: 271.
33. Eckert-Maksic M, Hodoscek M, Kovacek D, Maksic ZB, Primorac M. J. Mol. Struct. (Theochem). 1997; 417: 131.
34. Wysocki VH, Tsaprailis G, Smith LL, Breci LA. J. Mass Spectrom. 2000; 35: 1399.
35. Jemal M, Ouyang Z, Zhao W, Zhu M, Wu WW. Rapid Commun. Mass Spectrom. 2003; 17: 2732.
36. Hakala KS, Kostiainen R, Ketola RA. Rapid Commun. Mass Spectrom. 2006; 20: 2081.
37. Li AC, Gohdes MA, Shou WZ. Rapid Commun. Mass Spectrom. 2007; 21: 1421.
38. Xia YQ, Miller JD, Bakhtiar R, Franklin RB, Liu DQ. Rapid Commun. Mass Spectrom. 2003; 17: 1137.