Discovery, biosynthesis, and structure elucidation of metabolites of a doping agent and a direct analogue, tetrahydrogestrinone and gestrinone, using human hepatocytes

Analytical Chemistry

Volumn 77, Issue 10, 2005, Pages 3164-3172

  Lévesque, Jean François ^a   Templeton, Erin ^a   Trimble, Laird ^a   Berthelette, Carl ^a   Chauret, Nathalie ^a,b  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b Virochem Pharma   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANALOGUES; HEPATOCYTES; HYDROXYL GROUP; URINARY MARKERS;

BIOMARKERS; BIOSYNTHESIS; CHEMICAL COMPOUNDS; DOPING (ADDITIVES); EXTRACTION; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION;

METABOLISM;

ANDROGEN; GESTRINONE; GLUCURONIDE; HYDROXYL GROUP; TETRAHYDROGESTRINONE;

ARTICLE; ATHLETE; BIOSYNTHESIS; CONTROLLED STUDY; DOPING; DRUG CONJUGATION; DRUG EXCRETION; DRUG GLUCURONIDATION; DRUG MARKETING; DRUG METABOLISM; DRUG OXIDATION; DRUG STRUCTURE; GLUCUROCONJUGATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS; URINALYSIS;

ANABOLIC AGENTS; BIOLOGICAL MARKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOPING IN SPORTS; GESTRINONE; GLUCURONIC ACID; GLYCOCONJUGATES; HEPATOCYTES; HUMANS; HYDROXYLATION; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; OXIDATION-REDUCTION; RECEPTORS, ANTIGEN, T-CELL;

EID: 18844422694     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac050150y     Document Type: Article

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