메뉴 건너뛰기




Volumn 4, Issue 4, 2008, Pages 264-271

Illicit organogenesis: Methods and substances of doping and manipulation

Author keywords

Anabolics; Doping; HIF; Insulin; Mass spectrometry; S107; Sport

Indexed keywords

CALCIUM CHANNEL; ERYTHROPOIETIN; HYPOXIA INDUCIBLE FACTOR 1; INSULIN; RYANODINE RECEPTOR; SELECTIVE ANDROGEN RECEPTOR MODULATOR; SYNTHETIC INSULIN;

EID: 57349182202     PISSN: 15476278     EISSN: 15558592     Source Type: Journal    
DOI: 10.4161/org.4.4.7286     Document Type: Review
Times cited : (6)

References (57)
  • 2
    • 47749110133 scopus 로고    scopus 로고
    • World Anti-Doping Agency
    • World Anti-Doping Agency. The 2008 Prohibited List 2008; www.wada-ama.org/rtecontent/document/2008_List_En.pdf.
    • (2008) The 2008 Prohibited List
  • 3
    • 0037114935 scopus 로고    scopus 로고
    • Detection of isoelectric profiles of erythropoietin in urine: Differentiation of natural and administered recombinant hormones
    • Lasne F, Martin L, Crepin N, de Ceaurriz J. Detection of isoelectric profiles of erythropoietin in urine: differentiation of natural and administered recombinant hormones. Anal Biochem 2002; 311:119-26.
    • (2002) Anal Biochem , vol.311 , pp. 119-126
    • Lasne, F.1    Martin, L.2    Crepin, N.3    de Ceaurriz, J.4
  • 4
    • 0342646961 scopus 로고    scopus 로고
    • Recombinant erythropoietin in urine
    • Lasne F, de Ceaurriz J. Recombinant erythropoietin in urine. Nature 2000; 405:635.
    • (2000) Nature , vol.405 , pp. 635
    • Lasne, F.1    de Ceaurriz, J.2
  • 5
    • 28844488390 scopus 로고    scopus 로고
    • Identification and Characterization of Peptides and Proteins in Doping Control Analysis
    • Thevis M, Schänzer W. Identification and Characterization of Peptides and Proteins in Doping Control Analysis. Curr Proteomics 2005; 2:191-208.
    • (2005) Curr Proteomics , vol.2 , pp. 191-208
    • Thevis, M.1    Schänzer, W.2
  • 8
    • 44349094812 scopus 로고    scopus 로고
    • Growth hormone, IGF-I and insulin and their abuse in sport
    • Holt RI, Sonksen PH. Growth hormone, IGF-I and insulin and their abuse in sport. Br J Pharmacol 2008; 154:542-56.
    • (2008) Br J Pharmacol , vol.154 , pp. 542-556
    • Holt, R.I.1    Sonksen, P.H.2
  • 9
    • 23244446577 scopus 로고    scopus 로고
    • Screening for unknown synthetic steroids in human urine by liquid chromatography-tandem mass spectrometry
    • Thevis M, Geyer H, Mareck U, Schänzer W. Screening for unknown synthetic steroids in human urine by liquid chromatography-tandem mass spectrometry. J Mass Spectrom 2005; 40:955-62.
    • (2005) J Mass Spectrom , vol.40 , pp. 955-962
    • Thevis, M.1    Geyer, H.2    Mareck, U.3    Schänzer, W.4
  • 10
    • 34249802320 scopus 로고    scopus 로고
    • Emerging Drugs-Potential for misuse in sport and doping control detection strategies
    • Thevis M, Schänzer W. Emerging Drugs-Potential for misuse in sport and doping control detection strategies. Mini-Rev Med Chem 2007;7:533-9.
    • (2007) Mini-Rev Med Chem , vol.7 , pp. 533-539
    • Thevis, M.1    Schänzer, W.2
  • 14
    • 47749101721 scopus 로고    scopus 로고
    • Mass spectrometry of selective androgen receptor modulators
    • Thevis M, Schänzer W. Mass spectrometry of selective androgen receptor modulators. J Mass Spectrom 2008; 43:865-76.
    • (2008) J Mass Spectrom , vol.43 , pp. 865-876
    • Thevis, M.1    Schänzer, W.2
  • 15
    • 33644643993 scopus 로고    scopus 로고
    • Screening for metabolically stable aryl-propionamide-derived selective androgen receptor modulators for doping control purposes
    • Thevis M, Kamber M, Schänzer W. Screening for metabolically stable aryl-propionamide-derived selective androgen receptor modulators for doping control purposes. Rapid Commun Mass Spectrom 2006; 20:870-6.
    • (2006) Rapid Commun Mass Spectrom , vol.20 , pp. 870-876
    • Thevis, M.1    Kamber, M.2    Schänzer, W.3
  • 17
    • 42449084465 scopus 로고    scopus 로고
    • Determination of benzimidazole- and bicyclic hydantoin-derived selective androgen receptor antagonists and agonists in human urine using LC-MS/MS
    • Thevis M, Kohler M, Thomas A, Maurer J, Schlörer N, Kamber M, Schänzer W. Determination of benzimidazole- and bicyclic hydantoin-derived selective androgen receptor antagonists and agonists in human urine using LC-MS/MS. Anal Bioanal Chem 2008; 391:251-61.
    • (2008) Anal Bioanal Chem , vol.391 , pp. 251-261
    • Thevis, M.1    Kohler, M.2    Thomas, A.3    Maurer, J.4    Schlörer, N.5    Kamber, M.6    Schänzer, W.7
  • 19
    • 85036857916 scopus 로고    scopus 로고
    • Thevis M, Kohler M, Schlörer N, Fusshöller G, Schänzer W. Detection of 2-quinolinone-derived SARMs using GC-MS and LC-MS/MS, in Recent Advances in Doping Analysis (Schänzer W, Geyer H, Gotzmann A and Mareck U, Eds.), Sport&Buch Strauss, Cologne 2008.
    • Thevis M, Kohler M, Schlörer N, Fusshöller G, Schänzer W. Detection of 2-quinolinone-derived SARMs using GC-MS and LC-MS/MS, in Recent Advances in Doping Analysis (Schänzer W, Geyer H, Gotzmann A and Mareck U, Eds.), Sport&Buch Strauss, Cologne 2008.
  • 20
    • 50249168698 scopus 로고    scopus 로고
    • Doping control analysis of tricyclic tetrahydroquinoline-derived selective androgen receptor modulators using liquid chromatography/electrospray ionization tandem mass spectrometry
    • Thevis M, Kohler M, Thomas A, Schlörer N, Schänzer W. Doping control analysis of tricyclic tetrahydroquinoline-derived selective androgen receptor modulators using liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom 2008; 22:2471-8.
    • (2008) Rapid Commun Mass Spectrom , vol.22 , pp. 2471-2478
    • Thevis, M.1    Kohler, M.2    Thomas, A.3    Schlörer, N.4    Schänzer, W.5
  • 21
    • 84862519844 scopus 로고    scopus 로고
    • International Diabetes Federation. Diabetes epidemic out of control 2006; www.idf.org/home/index.cfm?unode=7F22F450-B1ED-43BB-A57C-B975D16A812D.
    • (2006) Diabetes epidemic out of control
  • 22
    • 0031033686 scopus 로고    scopus 로고
    • Insulin analogues
    • Barnett AH, Owens DR. Insulin analogues. Lancet 1997; 349:47-51.
    • (1997) Lancet , vol.349 , pp. 47-51
    • Barnett, A.H.1    Owens, D.R.2
  • 23
    • 37249011308 scopus 로고    scopus 로고
    • Mass spectrometric determination of insulins and their degradation products in sports drug testing
    • Thevis M, Thomas A, Schänzer W. Mass spectrometric determination of insulins and their degradation products in sports drug testing. Mass Spectrom Rev 2008; 27:35-50.
    • (2008) Mass Spectrom Rev , vol.27 , pp. 35-50
    • Thevis, M.1    Thomas, A.2    Schänzer, W.3
  • 24
    • 85036879058 scopus 로고    scopus 로고
    • Conte V. Victor Conte's letter to Dwain Chambers. In: Times Online (London) 2008.
    • Conte V. Victor Conte's letter to Dwain Chambers. In: Times Online (London) 2008.
  • 25
    • 85036861290 scopus 로고    scopus 로고
    • Steiner A, Wagner RA. Insulin. ISP-Verlag, Arnsberg 2002; 3:4-73.
    • Steiner A, Wagner RA. Insulin. ISP-Verlag, Arnsberg 2002; 3:4-73.
  • 26
    • 20444381979 scopus 로고    scopus 로고
    • Qualitative Determination of Synthetic Analogues of Insulin in Human Plasma by Immunoaffinity Purification and Liquid Chromatography-Tandem Mass Spectrometry for Doping Control Purposes
    • Thevis M, Thomas A, Delahaut P, Bosseloir A, Schänzer W. Qualitative Determination of Synthetic Analogues of Insulin in Human Plasma by Immunoaffinity Purification and Liquid Chromatography-Tandem Mass Spectrometry for Doping Control Purposes. Anal Chem 2005; 77:3579-85.
    • (2005) Anal Chem , vol.77 , pp. 3579-3585
    • Thevis, M.1    Thomas, A.2    Delahaut, P.3    Bosseloir, A.4    Schänzer, W.5
  • 27
    • 33645239462 scopus 로고    scopus 로고
    • Doping control analysis of intact rapid-acting insulin analogues in human urine by liquid chromatography-tandem mass spectrometry
    • Thevis M, Thomas A, Delahaut P, Bosseloir A, Schanzer W. Doping control analysis of intact rapid-acting insulin analogues in human urine by liquid chromatography-tandem mass spectrometry. Anal Chem 2006; 78:1897-903.
    • (2006) Anal Chem , vol.78 , pp. 1897-1903
    • Thevis, M.1    Thomas, A.2    Delahaut, P.3    Bosseloir, A.4    Schanzer, W.5
  • 28
    • 33947390452 scopus 로고    scopus 로고
    • Mass spectrometric identification of degradation products of insulin and its long-acting analogues in human urine for doping control purposes
    • Thomas A, Thevis M, Delahaut P, Bosseloir A, Schanzer W. Mass spectrometric identification of degradation products of insulin and its long-acting analogues in human urine for doping control purposes. Anal Chem 2007; 79:2518-24.
    • (2007) Anal Chem , vol.79 , pp. 2518-2524
    • Thomas, A.1    Thevis, M.2    Delahaut, P.3    Bosseloir, A.4    Schanzer, W.5
  • 29
    • 0036469146 scopus 로고    scopus 로고
    • Transcription. Oxygen sensing gets a second wind
    • Bruick RK, McKnight SL. Transcription. Oxygen sensing gets a second wind. Science 2002; 295:807-8.
    • (2002) Science , vol.295 , pp. 807-808
    • Bruick, R.K.1    McKnight, S.L.2
  • 30
    • 0242330181 scopus 로고    scopus 로고
    • Oxygen sensing in the hypoxic response pathway: Regulation of the hypoxiainducible transcription factor
    • Bruick R. Oxygen sensing in the hypoxic response pathway: regulation of the hypoxiainducible transcription factor. Genes Dev 2003; 17:2614-23.
    • (2003) Genes Dev , vol.17 , pp. 2614-2623
    • Bruick, R.1
  • 31
    • 0037362890 scopus 로고    scopus 로고
    • HIF hydroxylation and the mammalian oxygen-sensing pathway
    • Safran M, Kaelin WG Jr. HIF hydroxylation and the mammalian oxygen-sensing pathway. J Clin Invest 2003; 111:779-83.
    • (2003) J Clin Invest , vol.111 , pp. 779-783
    • Safran, M.1    Kaelin Jr., W.G.2
  • 32
    • 0043234538 scopus 로고    scopus 로고
    • Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
    • Hirsilä M, Koivunen P, Günzler V, Kivirikko K, Myllyharju J. Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J Biol Chem 2003; 278:30772-80.
    • (2003) J Biol Chem , vol.278 , pp. 30772-30780
    • Hirsilä, M.1    Koivunen, P.2    Günzler, V.3    Kivirikko, K.4    Myllyharju, J.5
  • 33
    • 17944375360 scopus 로고    scopus 로고
    • Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001; 107:43-54.
    • Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001; 107:43-54.
  • 34
    • 0035834409 scopus 로고    scopus 로고
    • A conserved family of prolyl-4-hydroxylases that modify HIF
    • Bruick RK, McKnight SL. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 2001; 294:1337-40.
    • (2001) Science , vol.294 , pp. 1337-1340
    • Bruick, R.K.1    McKnight, S.L.2
  • 37
    • 0035859692 scopus 로고    scopus 로고
    • HIF-1alpha binding to VHL is regulated by stimulussensitive proline hydroxylation
    • Yu F, White SB, Zhao Q, Lee FS. HIF-1alpha binding to VHL is regulated by stimulussensitive proline hydroxylation. Proc Natl Acad Sci USA 2001; 98:9630-5.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 9630-9635
    • Yu, F.1    White, S.B.2    Zhao, Q.3    Lee, F.S.4
  • 38
    • 2542450917 scopus 로고    scopus 로고
    • HIF hydroxylation and cellular oxygen sensing
    • Metzen E, Ratcliffe P. HIF hydroxylation and cellular oxygen sensing. Biol Chem 2004; 385:223-30.
    • (2004) Biol Chem , vol.385 , pp. 223-230
    • Metzen, E.1    Ratcliffe, P.2
  • 40
    • 0035476508 scopus 로고    scopus 로고
    • Building better vasculature
    • Bruick RK, McKnight SL. Building better vasculature. Genes Dev 2001; 15:2497-502.
    • (2001) Genes Dev , vol.15 , pp. 2497-2502
    • Bruick, R.K.1    McKnight, S.L.2
  • 41
    • 4644283464 scopus 로고    scopus 로고
    • Molecular biology of erythropoietin
    • Jelkmann W. Molecular biology of erythropoietin. Intern Med 2004; 43:649-59.
    • (2004) Intern Med , vol.43 , pp. 649-659
    • Jelkmann, W.1
  • 42
    • 0036037635 scopus 로고    scopus 로고
    • From erythropoietin to oxygen: Hypoxia-inducible factor hydroxylases and the hypoxia signal pathway
    • Ratcliffe P. From erythropoietin to oxygen: hypoxia-inducible factor hydroxylases and the hypoxia signal pathway. Blood Purif 2002; 20:445-50.
    • (2002) Blood Purif , vol.20 , pp. 445-450
    • Ratcliffe, P.1
  • 43
    • 1542300383 scopus 로고    scopus 로고
    • The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen
    • del Peso L, Castellanos M, Temes E, Martin-Puig S, Cuevas Y, Olmos G, Landazuri M. The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen. J Biol Chem 2003; 278:48690-5.
    • (2003) J Biol Chem , vol.278 , pp. 48690-48695
    • del Peso, L.1    Castellanos, M.2    Temes, E.3    Martin-Puig, S.4    Cuevas, Y.5    Olmos, G.6    Landazuri, M.7
  • 44
    • 57349128628 scopus 로고    scopus 로고
    • Fibrogen Inc
    • Fibrogen Inc. Development Pipeline 2007; http://www.fibrogen.com/ pipeline/chart/anemia.html#mid.
    • (2007) Development Pipeline
  • 45
    • 33744779997 scopus 로고    scopus 로고
    • Stimulation of erythropoiesis and treatment of anemia in rodents by oral administration of FG-2216, a novel HIF-prolyl hydroxylase inhibitor
    • Wang Q, Gou G, Guenzler V, Neff T, Klaus S, Turtle E, Molineaux C, Yeowell D, Lin A. Stimulation of erythropoiesis and treatment of anemia in rodents by oral administration of FG-2216, a novel HIF-prolyl hydroxylase inhibitor. J Am Soc Nephrol 2004; 15:773.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 773
    • Wang, Q.1    Gou, G.2    Guenzler, V.3    Neff, T.4    Klaus, S.5    Turtle, E.6    Molineaux, C.7    Yeowell, D.8    Lin, A.9
  • 47
    • 85036860045 scopus 로고    scopus 로고
    • Stern. Inside the Blood Doping Investigation 2006; www.spiegel.de/ international/spiegel/0,1518,425939,00.html.
    • Stern. Inside the Blood Doping Investigation 2006; www.spiegel.de/ international/spiegel/0,1518,425939,00.html.
  • 48
    • 38349077239 scopus 로고    scopus 로고
    • Gas Phase Reaction of Substituted Isoquinolines to Carboxylic Acids in Ion Trap and Triple Quadrupole Mass Spectrometers after Electrospray Ionization and Collision-Induced Dissociation
    • Thevis M, Kohler M, Schlörer N, Schänzer W. Gas Phase Reaction of Substituted Isoquinolines to Carboxylic Acids in Ion Trap and Triple Quadrupole Mass Spectrometers after Electrospray Ionization and Collision-Induced Dissociation. J Am Soc Mass Spectrom 2008; 19:151-8.
    • (2008) J Am Soc Mass Spectrom , vol.19 , pp. 151-158
    • Thevis, M.1    Kohler, M.2    Schlörer, N.3    Schänzer, W.4
  • 50
    • 0345490780 scopus 로고    scopus 로고
    • Altered function and regulation of cardiac ryanodine receptors in cardiac disease
    • Wehrens XH, Marks AR. Altered function and regulation of cardiac ryanodine receptors in cardiac disease. Trends Biochem Sci 2003; 28:671-8.
    • (2003) Trends Biochem Sci , vol.28 , pp. 671-678
    • Wehrens, X.H.1    Marks, A.R.2
  • 52
    • 4444367635 scopus 로고    scopus 로고
    • Calstabin deficiency, ryanodine receptors and sudden cardiac death
    • Lehnart SE, Wehrens XH, Marks AR. Calstabin deficiency, ryanodine receptors and sudden cardiac death. Biochem Biophys Res Commun 2004; 322:1267-79.
    • (2004) Biochem Biophys Res Commun , vol.322 , pp. 1267-1279
    • Lehnart, S.E.1    Wehrens, X.H.2    Marks, A.R.3
  • 54
    • 23744513192 scopus 로고    scopus 로고
    • Ryanodine receptor-targeted anti-arrhythmic therapy
    • Wehrens XH, Lehnart SE, Marks AR. Ryanodine receptor-targeted anti-arrhythmic therapy. Ann NY Acad Sci 2005; 1047:366-75.
    • (2005) Ann NY Acad Sci , vol.1047 , pp. 366-375
    • Wehrens, X.H.1    Lehnart, S.E.2    Marks, A.R.3
  • 56
    • 38849094092 scopus 로고    scopus 로고
    • Stressed out: The skeletal muscle ryanodine receptor as a target of stress
    • Bellinger AM, Mongillo M, Marks AR. Stressed out: the skeletal muscle ryanodine receptor as a target of stress. J Clin Invest 2008; 118:445-53.
    • (2008) J Clin Invest , vol.118 , pp. 445-453
    • Bellinger, A.M.1    Mongillo, M.2    Marks, A.R.3
  • 57
    • 35948957478 scopus 로고    scopus 로고
    • Long-term engraftment following transplantation of pig pancreatic primordia into nonimmunosuppressed diabetic rhesus macaques
    • Rogers SA, Chen F, Talcott MR, Faulkner C, Thomas JM, Thevis M, Hammerman MR. Long-term engraftment following transplantation of pig pancreatic primordia into nonimmunosuppressed diabetic rhesus macaques. Xenotransplantation 2007; 14:591-602.
    • (2007) Xenotransplantation , vol.14 , pp. 591-602
    • Rogers, S.A.1    Chen, F.2    Talcott, M.R.3    Faulkner, C.4    Thomas, J.M.5    Thevis, M.6    Hammerman, M.R.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.