Induction of genomic instability in cultured human colon epithelial cells following exposure to isocyanates

Cell Biology International

Volumn 33, Issue 6, 2009, Pages 675-683

  Mishra, Pradyumna Kumar ^a   Bhargava, Arpit ^a   Raghuram, Gorantla Venkata ^a   Jatawa, Suresh Kumar ^a   Akhtar, Nabila ^a   Khan, Saba ^a   Tiwari, Archana ^b   Maudar, Kewal Krishan ^a  

^a BHOPAL MEMORIAL HOSPITAL AND RESEARCH CENTRE   (India)

^b UNIVERSITY INSTITUTE OF TECHNOLOGY   (India)

Author keywords

Apoptosis; DNA damage; Genomic instability; Inflammation; Isocyanates

Indexed keywords

ATM PROTEIN; CYTOKINE; HISTONE H2AX; METHYL ISOCYANATE; PERICENTRIN; PROTEIN P53;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; COLON MUCOSA; CONTROLLED STUDY; DNA DAMAGE; EPITHELIUM CELL; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; INTER SIMPLE SEQUENCE REPEAT; MICROSATELLITE INSTABILITY; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ANTIGENS; APOPTOSIS; CELL LINE; COLON; CYTOKINES; DNA DAMAGE; EPITHELIAL CELLS; G2 PHASE; GENOMIC INSTABILITY; HUMANS; ISOCYANATES; KARYOTYPING; METAPHASE; SIGNAL TRANSDUCTION;

EID: 65649142544     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellbi.2009.03.008     Document Type: Article

References (51)

1. Abraham R.T. PI 3-kinase related kinases: 'big' players in stress-induced signaling pathways. DNA Repair (Amst) 3 (2004) 883-887
2. Al-Saleh I., Arif J., El-Doush I., Al-Sanea N., Jabbar A.A., Billedo G., et al. Carcinogen DNA adducts and the risk of colon cancer: case-control study. Biomarkers 13 (2008) 201-216
3. Anderson D., Goyle S., Phillips B.J., Tee A., Beech L., and Butler W.H. Effects of methyl isocyanate on rat muscle cells in culture. Br J Ind Med 45 (1988) 269-274
4. Bakkenist C.J., and Kastan M.B. Initiating cellular stress responses. Cell 118 (2004) 9-17
5. Bartek J., and Lukas J. DNA damage checkpoints: from initiation to recovery or adaptation. Curr Opin Cell Biol 19 (2007) 238-245
6. Brew R., Southern S.A., Flanagan B.F., McDicken I.W., and Christmas S.E. Detection of interleukin-8 mRNA and protein in human colorectal carcinoma cells. Eur J Cancer 32A (1996) 2142-2147
7. Burum-Auensen E., DeAngelis P.M., Schjølberg A.R., Røislien J., Mjåland O., and Clausen O.P. Reduced level of the spindle checkpoint protein BUB1B is associated with aneuploidy in colorectal cancers. Cell Prolif 41 (2008) 645-659
8. Chen N., Stoler D.L., Dutt S.S., Jahreis G.P., Rodriguez-Bigas M.A., Petrelli N.J., et al. Analysis of inter-(simple sequence repeat) PCR products from human colorectal cancers. Oncol Res 15 (2005) 233-238
9. Doxsey S., Zimmerman W., and Mikule K. Centrosome control of the cell cycle. Trends Cell Biol 15 (2005) 303-311
10. Eckmann L., Jung H.C., Schuerer-Maly C.C., Panja A., Morzycka-Wroblewska E., and Kagnoff M.F. Differential cytokine expression by human intestinal epithelial cell lines: regulated expression of interleukin-8. Gastroenterology 105 (1993) 1689-1697
11. Ghosh B.B., Sengupta S., Roy A., Maity S., Ghosh S., Talukder G., et al. Cytogenetic studies in human populations exposed to gas leak at Bhopal, India. Environ Health Perspect 86 (1990) 323-326
12. Gorgoulis V.G., Vassiliou L.V., Karakaidos P., Zacharatos P., Kotsinas A., Liloglou T., et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434 (2005) 907-913
13. Goswami H.K., Chandorkar M., Bhattacharya K., Vaidyanath G., Parmar D., Sengupta S., et al. Search for chromosomal variations among gas-exposed persons in Bhopal. Hum Genet 84 (1990) 172-176
14. Grady W.M. Genomic instability and colon cancer. Cancer Metastasis Rev 23 (2004) 11-27
15. Greenblatt M.S., Bennett W.P., Hollstein M., and Harris C.C. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 54 (1994) 4855-4878
16. Gupta M., and Prabha V. Changes in brain and plasma amino acids of mice intoxicated with methyl isocyanate. J Appl Toxicol 16 (1996) 469-473
17. Hagmar L., Strömberg U., Welinder H., and Mikoczy Z. Incidence of cancer and exposure to toluene diisocyanate and methylene diphenyldiisocyanate: a cohort based case-referent study in the polyurethane foam manufacturing industry. Br J Ind Med 50 (1993) 1003-1007
18. Hofseth L.J., Khan M.A., Ambrose M., Nikolayeva O., Xu-Welliver M., Kartalou M., et al. The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation. J Clin Invest 112 (2003) 1887-1894
19. Hsu C.P., and Chung Y.C. Influence of interleukin-6 on the invasiveness of human colorectal carcinoma. Anticancer Res 26 (2006) 4607-4614
20. Isshiki H., Akira S., Tanabe O., Nakajima T., Shimamoto T., Hirano T., et al. Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-1-responsive element in the IL-6 gene. Mol Cell Biol 10 (1990) 2757-2764
21. Kang J., Ferguson D., Song H., Bassing C., Eckersdorff M., Alt F.W., et al. Functional interaction of H2AX, NBS1, and p53 in ATM dependent DNA damage responses and tumor suppression. Mol Cell Biol 25 (2005) 661-670
22. Kar R.N., Khan K.A., and Sethi N. Genotoxicity studies on mice after short term inhalation exposure to methyl isocyanate. Cytobios 59 (1989) 167-176
23. Kargozaran H., Kahlenberg M., and Khatri V.P. The implications of colorectal cancer molecular biology in clinical practice. Surg Oncol Clin N Am 17 (2008) 341-355
24. Kundu J.K., and Surh Y.J. Inflammation: gearing the journey to cancer. Mutat Res 659 (2008) 15-30
25. Kuo H.H., Shyu S.S., and Wang T.C. Genotoxicity of low dose N-nitroso propoxur to human gastric cells. Food Chem Toxicol 46 (2008) 1619-1626
26. Kurz E.U., and Lees-Miller S.P. DNA damage-induced activation of ATM and ATM-dependent signaling pathways. DNA Repair (Amst) 3 (2004) 889-900
27. Lichtenstein P., Holm N.V., Verkasalo P.K., Iliadou A., Kaprio J., Koskenvuo M., et al. Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 13 (2000) 78-85
28. Mantovani A., Allavena P., Sica A., and Balkwill F. Cancer-related inflammation. Nature 454 (2008) 436-444
29. Martinez J., Oiry J., Imbach J.L., and Winternitz F. Activated N-nitrosocarbamates for regioselective synthesis of N-nitrosoureas. J Med Chem 25 (1982) 178-182
30. Mason J.M., Zeiger E., Haworth S., Ivett J., and Valencia R. Genotoxicity studies of methyl isocyanate in Salmonella, Drosophila, and cultured Chinese hamster ovary cells. Environ Mutagen 9 (1987) 19-28
31. Mikoczy Z., Welinder H., Tinnerberg H., and Hagmar L. Cancer incidence and mortality of isocyanate exposed workers from the Swedish polyurethane foam industry: updated findings 1959-98. Occup Environ Med 61 (2004) 432-437
32. Mills K.D., Ferguson D.O., and Alt F.W. The role of DNA breaks in genomic instability and tumorigenesis. Immunol Rev 194 (2003) 77-95
33. Mishra P.K., Panwar H., Bhargava A., Gorantla V.R., Jain S.K., Banerjee S., et al. Isocyanates induce DNA damage, apoptosis, oxidative stress and inflammation in cultured human lymphocytes. J Biochem Mol Toxicol 22 (2008) 429-440
34. Pearson P.G., Slatter J.G., Rashed M.S., Han D.H., Grillo M.P., and Baillie T.A. S-(N methylcarbamoyl) glutathione: a reactive S-linked metabolite of methyl isocyanate. Biochem Biophys Res Commun 166 (1990) 245-250
35. Pihan G.A., Wallace J., Zhou Y., and Doxsey S.J. Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomas. Cancer Res 63 (2003) 1398-1404
36. Rajagopalan H., Nowak M.A., Vogelstein B., and Lengauer C. The significance of unstable chromosomes in colorectal cancer. Nat Rev Cancer 3 (2003) 695-701
37. Rios-Doria J., Fay A., Velkova A., and Monteiro A.N. DNA damage response determining the fate of phosphorylated histone H2AX. Cancer Biol Ther 5 (2006) 142-144
38. Samowitz W.S., Slattery M.L., Sweeney C., Herrick J., Wolff R.K., and Albertsen H. APC mutations and other genetic and epigenetic changes in colon cancer. Mol Cancer Res 5 (2007) 165-170
39. Satsu H., Matsuda T., Toshimitsu T., Mori A., Mae T., Tsukagawa M., et al. Regulation of interleukin-8 secretion in human intestinal epithelial Caco-2 cells by alpha-humulene. Biofactors 21 (2004) 137-139
40. Segal A., Solomon J.J., and Life J. Isolation of methylcarbamyl - adducts of adenine and cytosine following in-vitro reactions of methyl isocyanate with calf thymus DNA. Chem Biol Interact 69 (1989) 359-372
41. Shelby M.D., Allen J.W., Caspary W.J., Haworth S., Ivett J., Kligerman A., et al. Results of in vitro and in vivo genetic toxicity tests on methyl isocyanate. Environ Health Perspect 72 (1987) 183-187
42. Shiloh Y., and Lehmann A.R. Maintaining integrity. Nat Cell Biol 6 (2004) 923-928
43. Shirota K., LeDuy L., Yuan S., and Jothy S. Interleukin-6 and its receptor are expressed in human intestinal epithelial cells. Virchows Arch B Cell Pathol 58 (1990) 303-308
44. Slatter J.G., Rashed M.S., Pearson P.G., Han D.H., and Baillie T.A. Biotransformation of methyl isocyanate in the rat. Evidence of glutathione conjugation as a major pathway of metabolism and implications for isocyanate-mediated toxicities. Chem Res Toxicol 4 (1991) 157-161
45. Sugai T., Habano W., Uesugi N., Jiao Y.F., Nakamura S.I., Yoshida T., et al. Frequent allelic imbalance at the ATM locus in DNA multiploid colorectal carcinomas. Oncogene 20 (2001) 6095-6101
46. Tamura N., Aoki K., and Lee M.S. Selective reactivities of isocyanates towards DNA bases and genotoxicity of methylcarbamylation of the DNA. Mutat Res 283 (1992) 97-106
47. Veloso M., Wrba F., Kaserer K., Heinze G., Magalhães A., Herbst F., et al. p53 gene status and expression of p53, mdm2, and p21Waf1/Cip1 proteins in colorectal cancer. Virchows Arch 437 (2000) 241-247
48. Worthy W. Methyl isocyanate: the chemistry of a hazard. Chicago. Chem Eng News 62 (1985) 27-33
49. Xie K. Interleukin-8 and human cancer biology. Cytokine Growth Factor Rev 12 (2001) 375-391
50. Yoon J.Y., Oh S.H., Yoo S.M., Sohn S., Lee B.H., Moon C.K., et al. N nitrosocarbofuran, but not carbofuran, induces apoptosis and cell cycle arrest in CHL cells. Toxicology 169 (2001) 153-161
51. Zeng L., Wu G.Z., Goh K.J., Lee Y.M., Ng C.C., You A.B., et al. Saturated fatty acids modulate cell response to DNA damage: implication for their role in tumorigenesis. PLoS ONE 3 (2008) e2329