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Volumn 345, Issue 4, 2006, Pages 1565-1572

Gene expression of cyclin-dependent kinase inhibitors and effect of heparin on their expression in mice with hypoxia-induced pulmonary hypertension

Author keywords

CDK inhibitor; Gene array; Heparin; Hypoxia; Mice; Pulmonary hypertension

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN DEPENDENT KINASE INHIBITOR 1C; CYCLIN DEPENDENT KINASE INHIBITOR 2B; CYCLIN DEPENDENT KINASE INHIBITOR 2C; CYCLIN DEPENDENT KINASE INHIBITOR 2D; HEPARIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PROTEIN P16INK4A; SB 203508; UNCLASSIFIED DRUG;

EID: 33744510570     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.05.060     Document Type: Article
Times cited : (31)

References (36)
  • 1
    • 0035676884 scopus 로고    scopus 로고
    • Pulmonary vascular remodeling: a target for therapeutic intervention in pulmonary hypertension
    • Jeffery T.K., and Wanstall J.C. Pulmonary vascular remodeling: a target for therapeutic intervention in pulmonary hypertension. Pharmacol. Ther. 92 (2001) 1-20
    • (2001) Pharmacol. Ther. , vol.92 , pp. 1-20
    • Jeffery, T.K.1    Wanstall, J.C.2
  • 2
    • 12344285420 scopus 로고    scopus 로고
    • Pulmonary vascular remodeling in hypoxic pulmonary hypertension
    • Yuan J.X.-J. (Ed), Kluwer Academic Publishers, Dordrecht
    • Rabinovitch M. Pulmonary vascular remodeling in hypoxic pulmonary hypertension. In: Yuan J.X.-J. (Ed). Hypoxic Pulmonary Vasoconstriction: Cellular and Molecular Mechanisms (2004), Kluwer Academic Publishers, Dordrecht 403-418
    • (2004) Hypoxic Pulmonary Vasoconstriction: Cellular and Molecular Mechanisms , pp. 403-418
    • Rabinovitch, M.1
  • 3
    • 0036180120 scopus 로고    scopus 로고
    • Molecular aspects of the mammalian cell cycle and cancer
    • Sandal T. Molecular aspects of the mammalian cell cycle and cancer. Oncologist 7 (2002) 73-81
    • (2002) Oncologist , vol.7 , pp. 73-81
    • Sandal, T.1
  • 4
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: positive and negative regulators of G1-phase progression
    • Sherr C.J., and Roberts J.M. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13 (1999) 1501-1512
    • (1999) Genes Dev. , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 5
    • 0037042177 scopus 로고    scopus 로고
    • Oncogenic functions of tumor suppressor p21 (Waf1/Cip1/Sdi1): association with cell senescence and tumor-promoting activities of stromal fibroblasts
    • Roninson I.B. Oncogenic functions of tumor suppressor p21 (Waf1/Cip1/Sdi1): association with cell senescence and tumor-promoting activities of stromal fibroblasts. Cancer Lett. 179 (2002) 1-14
    • (2002) Cancer Lett. , vol.179 , pp. 1-14
    • Roninson, I.B.1
  • 6
    • 0034595296 scopus 로고    scopus 로고
    • F.C. Tanner, M. Boehm, L.M. Akyurek, H. San, Z.Y.Yang, J. Tashiro, G.J. Nabel, E.G. Nabel, Differential effects of the cyclin-dependent kinase inhibitors p27(Kip1), p21(Cip1), and p16(Ink4) on vascular smooth muscle cell proliferation, Circulation 101 (Circulation) 2022-2025.
  • 7
    • 0029794891 scopus 로고    scopus 로고
    • Role of the p21 cyclin-dependent kinase inhibitor in limiting intimal cell proliferation in response to arterial injury
    • Yang Z.Y., Simari R.D., Perkins N.D., San H., Gordon D., Nabel G.J., and Nabel E.G. Role of the p21 cyclin-dependent kinase inhibitor in limiting intimal cell proliferation in response to arterial injury. Proc. Natl. Acad. Sci. USA 93 (1996) 7905-7910
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 7905-7910
    • Yang, Z.Y.1    Simari, R.D.2    Perkins, N.D.3    San, H.4    Gordon, D.5    Nabel, G.J.6    Nabel, E.G.7
  • 8
    • 0033844456 scopus 로고    scopus 로고
    • Heparin-like molecules inhibit pulmonary vascular periocyte proliferation in vitro
    • Khoury J., and Langleben D. Heparin-like molecules inhibit pulmonary vascular periocyte proliferation in vitro. Am. J. Physiol. Lung Cell Mol. Physiol. 279 (2000) L252-L261
    • (2000) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.279
    • Khoury, J.1    Langleben, D.2
  • 10
    • 0012335543 scopus 로고    scopus 로고
    • Distinct regulation of mitogen-activated protein kinases and p27Kip1 in smooth muscle cells from different vascular beds. A potential role in establishing regional phenotypic variance
    • Castro C., Diez-Juan A., Cortes M.J., and Andres V. Distinct regulation of mitogen-activated protein kinases and p27Kip1 in smooth muscle cells from different vascular beds. A potential role in establishing regional phenotypic variance. J. Biol. Chem. 278 (2003) 4482-4490
    • (2003) J. Biol. Chem. , vol.278 , pp. 4482-4490
    • Castro, C.1    Diez-Juan, A.2    Cortes, M.J.3    Andres, V.4
  • 11
    • 27644564685 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitor p27Kip1, but not p21WAF1/Cip1, is required for inhibition of hypoxia-induced pulmonary hypertension and remodeling by heparin in mice
    • Yu L., Quinn D.A., Garg H.G., and Hales C.A. Cyclin-dependent kinase inhibitor p27Kip1, but not p21WAF1/Cip1, is required for inhibition of hypoxia-induced pulmonary hypertension and remodeling by heparin in mice. Circ. Res. 97 (2005) 937-945
    • (2005) Circ. Res. , vol.97 , pp. 937-945
    • Yu, L.1    Quinn, D.A.2    Garg, H.G.3    Hales, C.A.4
  • 12
    • 0035066383 scopus 로고    scopus 로고
    • Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
    • Kyriakis J.M., and Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 81 (2001) 807-869
    • (2001) Physiol. Rev. , vol.81 , pp. 807-869
    • Kyriakis, J.M.1    Avruch, J.2
  • 13
    • 0037213568 scopus 로고    scopus 로고
    • Overexpression of p73 causes apoptosis in vascular smooth muscle cells
    • Davis B.B., Dong Y., and Weiss R.H. Overexpression of p73 causes apoptosis in vascular smooth muscle cells. Am. J. Physiol. Cell Physiol. 284 (2003) C16-C23
    • (2003) Am. J. Physiol. Cell Physiol. , vol.284
    • Davis, B.B.1    Dong, Y.2    Weiss, R.H.3
  • 14
    • 0038485631 scopus 로고    scopus 로고
    • MAP kinase-dependent degradation of p27Kip1 by calpains in choroidal melanoma cells. Requirement of p27Kip1 nuclear export
    • Delmas C., Aragou N., Poussard S., Cottin P., Darbon J.M., and Manenti S. MAP kinase-dependent degradation of p27Kip1 by calpains in choroidal melanoma cells. Requirement of p27Kip1 nuclear export. J. Biol. Chem. 278 (2003) 12443-12451
    • (2003) J. Biol. Chem. , vol.278 , pp. 12443-12451
    • Delmas, C.1    Aragou, N.2    Poussard, S.3    Cottin, P.4    Darbon, J.M.5    Manenti, S.6
  • 17
    • 0037352731 scopus 로고    scopus 로고
    • Hypoxia, angiotensin-II, and norepinephrine mediated apoptosis is stimulus specific in canine failed cardiomyocytes: a role for p38 MAPK, Fas-L and cyclin D1
    • Sharov V.G.V.G., Todor A., Suzuki G., Morita H., Tanhehco E.J., and Sabbah H.N. Hypoxia, angiotensin-II, and norepinephrine mediated apoptosis is stimulus specific in canine failed cardiomyocytes: a role for p38 MAPK, Fas-L and cyclin D1. Eur. J. Heart Fail. 5 (2003) 121-129
    • (2003) Eur. J. Heart Fail. , vol.5 , pp. 121-129
    • Sharov, V.G.V.G.1    Todor, A.2    Suzuki, G.3    Morita, H.4    Tanhehco, E.J.5    Sabbah, H.N.6
  • 18
    • 1942533531 scopus 로고    scopus 로고
    • Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene
    • Wykoff C.C., Sotiriou C., Cockman M.E., Ratcliffe P.J., Maxwell P., Liu E., and Harris A.L. Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene. Br. J. Cancer. 90 (2004) 1235-1243
    • (2004) Br. J. Cancer. , vol.90 , pp. 1235-1243
    • Wykoff, C.C.1    Sotiriou, C.2    Cockman, M.E.3    Ratcliffe, P.J.4    Maxwell, P.5    Liu, E.6    Harris, A.L.7
  • 19
    • 0033551609 scopus 로고    scopus 로고
    • Selective activation of p38α and p38γ by hypoxia. Role in regulation of cyclin D1 by hypoxia in PC12 cells
    • Conrad P.W., Rust R.T., Han J., Millhorn D.E., and Beitner-Johnson D. Selective activation of p38α and p38γ by hypoxia. Role in regulation of cyclin D1 by hypoxia in PC12 cells. J. Biol. Chem. 274 (1999) 23570-23576
    • (1999) J. Biol. Chem. , vol.274 , pp. 23570-23576
    • Conrad, P.W.1    Rust, R.T.2    Han, J.3    Millhorn, D.E.4    Beitner-Johnson, D.5
  • 21
    • 0032746886 scopus 로고    scopus 로고
    • Hypoxia modulates cyclin and cytokine expression and inhibits peripheral mononuclear cell proliferation
    • Naldini A., and Carraro F. Hypoxia modulates cyclin and cytokine expression and inhibits peripheral mononuclear cell proliferation. J. Cell Physiol. 181 (1999) 448-454
    • (1999) J. Cell Physiol. , vol.181 , pp. 448-454
    • Naldini, A.1    Carraro, F.2
  • 22
    • 0032771749 scopus 로고    scopus 로고
    • Molecular analysis of selected cell cycle regulatory proteins during aerobic and hypoxic maintenance of human ovarian carcinoma cells
    • Krtolica A.A., Krucher N.A., and Ludlow J.W. Molecular analysis of selected cell cycle regulatory proteins during aerobic and hypoxic maintenance of human ovarian carcinoma cells. Br. J. Cancer 80 (1999) 1875-1883
    • (1999) Br. J. Cancer , vol.80 , pp. 1875-1883
    • Krtolica, A.A.1    Krucher, N.A.2    Ludlow, J.W.3
  • 23
    • 0036070507 scopus 로고    scopus 로고
    • Hypoxia stimulates p16 expression and association with cdk4
    • Zygmunt A., Tedesco V.C., Udho E., and Krucher N.A. Hypoxia stimulates p16 expression and association with cdk4. Exp. Cell Res. 278 (2002) 53-60
    • (2002) Exp. Cell Res. , vol.278 , pp. 53-60
    • Zygmunt, A.1    Tedesco, V.C.2    Udho, E.3    Krucher, N.A.4
  • 24
  • 25
    • 0027518447 scopus 로고
    • Hypoxic stress induces reversible hypophosphorylation of pRB and reduction in cyclin A abundance independent of cell cycle progression
    • Ludlow J.W., Howell R.L., and Smith H.C. Hypoxic stress induces reversible hypophosphorylation of pRB and reduction in cyclin A abundance independent of cell cycle progression. Oncogene 8 2 (1993) 331-339
    • (1993) Oncogene , vol.8 , Issue.2 , pp. 331-339
    • Ludlow, J.W.1    Howell, R.L.2    Smith, H.C.3
  • 26
    • 21344459451 scopus 로고    scopus 로고
    • The role of p27 in controlling the oxygen-dependent checkpoint of mammalian cells in late G1
    • Graff P., Amellem O., Seim J., Stokke T., and Pettersen E.O. The role of p27 in controlling the oxygen-dependent checkpoint of mammalian cells in late G1. Anticancer Res. 25 3B (2005) 2259-2267
    • (2005) Anticancer Res. , vol.25 , Issue.3 B , pp. 2259-2267
    • Graff, P.1    Amellem, O.2    Seim, J.3    Stokke, T.4    Pettersen, E.O.5
  • 27
    • 0036765807 scopus 로고    scopus 로고
    • Hypoxia-induced changes in the expression of VEGF, HIF-1α and cell cycle-related molecules in ovarian cancer cells
    • Horiuchi A., Imai T., Shimizu M., Oka K., Wang C., Nikaido T., and Konishi I. Hypoxia-induced changes in the expression of VEGF, HIF-1α and cell cycle-related molecules in ovarian cancer cells. Anticancer Res. 22 5 (2002) 2697-2702
    • (2002) Anticancer Res. , vol.22 , Issue.5 , pp. 2697-2702
    • Horiuchi, A.1    Imai, T.2    Shimizu, M.3    Oka, K.4    Wang, C.5    Nikaido, T.6    Konishi, I.7
  • 29
  • 30
    • 0035145591 scopus 로고    scopus 로고
    • p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest
    • Green S.L., Freoberg R.A., and Giaccia A.J. p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest. Mol. Cell. Biol. 21 (2001) 1196-1206
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 1196-1206
    • Green, S.L.1    Freoberg, R.A.2    Giaccia, A.J.3
  • 31
    • 10344240885 scopus 로고    scopus 로고
    • Cell cycle kinase inhibitor expression and hypoxia-induced cell cycle arrest in human cancer cell lines
    • Box A.H., and Demetrick D.J. Cell cycle kinase inhibitor expression and hypoxia-induced cell cycle arrest in human cancer cell lines. Carcinogenesis 25 (2004) 2325-2335
    • (2004) Carcinogenesis , vol.25 , pp. 2325-2335
    • Box, A.H.1    Demetrick, D.J.2
  • 32
    • 0036844533 scopus 로고    scopus 로고
    • Inhibition of hypoxia-induced apoptosis by modulation of retinoblastoma protein-dependent signaling in cardiomyocytes
    • Hauck L., Hansmann G., Dietz R., and von Harsdorf R. Inhibition of hypoxia-induced apoptosis by modulation of retinoblastoma protein-dependent signaling in cardiomyocytes. Circ. Res. 91 (2002) 782-789
    • (2002) Circ. Res. , vol.91 , pp. 782-789
    • Hauck, L.1    Hansmann, G.2    Dietz, R.3    von Harsdorf, R.4
  • 33
    • 0034667433 scopus 로고    scopus 로고
    • Hyperinducibility of hypoxia-responsive genes without p53/p21-dependent checkpoint in aggressive prostate cancer
    • Salnikow K., Costa M., Figg W.D., and Blagosklonny M.V. Hyperinducibility of hypoxia-responsive genes without p53/p21-dependent checkpoint in aggressive prostate cancer. Cancer Res. 60 (2000) 5630-5634
    • (2000) Cancer Res. , vol.60 , pp. 5630-5634
    • Salnikow, K.1    Costa, M.2    Figg, W.D.3    Blagosklonny, M.V.4
  • 34
    • 0141592531 scopus 로고    scopus 로고
    • Hyperoxia induces macrophage cell cycle arrest by adhesion-dependent induction of p21Cip1 and activation of the retinoblastoma protein
    • Nyunoya T.T., Powers L.S., Yarovinsky T.O., Butler N.S., Monick M.M., and Hunninghake G.W. Hyperoxia induces macrophage cell cycle arrest by adhesion-dependent induction of p21Cip1 and activation of the retinoblastoma protein. J. Biol. Chem. 278 (2003) 36099-36106
    • (2003) J. Biol. Chem. , vol.278 , pp. 36099-36106
    • Nyunoya, T.T.1    Powers, L.S.2    Yarovinsky, T.O.3    Butler, N.S.4    Monick, M.M.5    Hunninghake, G.W.6
  • 35
    • 0035041604 scopus 로고    scopus 로고
    • Cell cycle progression and cell division are sensitive to hypoxia in Drosophila melanogaster embryos
    • Douglas R.M., Xu T., and Haddad G.G. Cell cycle progression and cell division are sensitive to hypoxia in Drosophila melanogaster embryos. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280 (2001) R1555-R1563
    • (2001) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.280
    • Douglas, R.M.1    Xu, T.2    Haddad, G.G.3
  • 36
    • 0027261345 scopus 로고
    • Heparin inhibits mitogen-activated protein kinase activation in intact rat vascular smooth muscle cells
    • Ottlinger M.E., Pukac L.A., and Karnovsky M.J. Heparin inhibits mitogen-activated protein kinase activation in intact rat vascular smooth muscle cells. J. Biol. Chem. 268 (1993) 19173-19176
    • (1993) J. Biol. Chem. , vol.268 , pp. 19173-19176
    • Ottlinger, M.E.1    Pukac, L.A.2    Karnovsky, M.J.3


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