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Volumn 9, Issue 4, 2009, Pages 360-368

Effect of c-MYC and E2F1 gene silencing and of 5-azacytidine treatment on telomerase activity in pancreatic cancer-derived cell lines

Author keywords

5 Azacytidine; C MYC; E2F1; HTERT; Methylation; Pancreatic cancer; SiRNA; Telomerase

Indexed keywords

AZACITIDINE; MESSENGER RNA; MYC PROTEIN; SMALL INTERFERING RNA; TELOMERASE REVERSE TRANSCRIPTASE; TRANSCRIPTION FACTOR E2F1;

EID: 65649090276     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1159/000212094     Document Type: Article
Times cited : (20)

References (32)
  • 1
    • 0033558281 scopus 로고    scopus 로고
    • Cloning and characterization of the promoter region of human telomerase reverse tran-scriptase gene
    • Horikawa I, Cable PL, Afshari C, Barrett JC: Cloning and characterization of the promoter region of human telomerase reverse tran-scriptase gene. Cancer Res 1999; 59:826- 830.
    • (1999) Cancer Res , vol.59 , pp. 826-830
    • Horikawa, I.1    Cable, P.L.2    Afshari, C.3    Barrett, J.C.4
  • 2
    • 0033001621 scopus 로고    scopus 로고
    • Reversible activation of c-MYC in skin: Induction of a complex neoplastic phe-notype by a single oncogenic lesion
    • Pelengaris S, Littlewood T, Khan M, Elia G, Evan G: Reversible activation of c-MYC in skin: induction of a complex neoplastic phe-notype by a single oncogenic lesion. Mol Cell 1999; 3:565-577.
    • (1999) Mol Cell , vol.3 , pp. 565-577
    • Pelengaris, S.1    Littlewood, T.2    Khan, M.3    Elia, G.4    Evan, G.5
  • 4
    • 0042169025 scopus 로고    scopus 로고
    • Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms
    • Horikawa I, Barrett JC: Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms. Carcinogenesis 2003; 24: 1167-1176.
    • (2003) Carcinogenesis , vol.24 , pp. 1167-1176
    • Horikawa, I.1    Barrett, J.C.2
  • 5
    • 0034107095 scopus 로고    scopus 로고
    • Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells
    • Misiti S, Nanni S, Fontemaggi G, et al: Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells. Mol Cell Biol 2000; 20:3764- 3771.
    • (2000) Mol Cell Biol , vol.20 , pp. 3764-3771
    • Misiti, S.1    Nanni, S.2    Fontemaggi, G.3
  • 6
    • 0034624675 scopus 로고    scopus 로고
    • Identification of Mad as a repressor of the human telomerase (hTERT) gene
    • Oh S, Song YH, Yim J, Kim TK: Identification of Mad as a repressor of the human telomerase (hTERT) gene. Oncogene 2000; 19: 1485-1490.
    • (2000) Oncogene , vol.19 , pp. 1485-1490
    • Oh, S.1    Song, Y.H.2    Yim, J.3    Kim, T.K.4
  • 7
    • 0035394055 scopus 로고    scopus 로고
    • E2F-1 represses transcription of the human telomerase reverse transcriptase gene
    • Crowe DL, Nguyen DC, Tsang KJ, Kyo S: E2F-1 represses transcription of the human telomerase reverse transcriptase gene. Nucleic Acids Res 2001; 29: 2789-2794.
    • (2001) Nucleic Acids Res , vol.29 , pp. 2789-2794
    • Crowe, D.L.1    Nguyen, D.C.2    Tsang, K.J.3    Kyo, S.4
  • 9
    • 42649083023 scopus 로고    scopus 로고
    • Trans-duction of E2F-1 TAT fusion proteins represses expression of hTERT in primary duc-tal breast carcinoma cell lines
    • Elliott KA, Rickords LF, Labrum JM: Trans-duction of E2F-1 TAT fusion proteins represses expression of hTERT in primary duc-tal breast carcinoma cell lines. Mol Cancer 2008; 7:28.
    • (2008) Mol Cancer , vol.7 , pp. 28
    • Elliott, K.A.1    Rickords, L.F.2    Labrum, J.M.3
  • 10
    • 0033180211 scopus 로고    scopus 로고
    • Reversible tumori-genesis by MYC in hematopoietic lineages
    • Felsher DW, Bishop JM: Reversible tumori-genesis by MYC in hematopoietic lineages. Mol Cell 1999; 4:199-207.
    • (1999) Mol Cell , vol.4 , pp. 199-207
    • Felsher, D.W.1    Bishop, J.M.2
  • 11
    • 4043169898 scopus 로고    scopus 로고
    • Overexpression of E2F-1 in esophageal squamous cell carcinoma correlates with tumor progression
    • Ebihara Y, et al: Overexpression of E2F-1 in esophageal squamous cell carcinoma correlates with tumor progression. Dis Esophagus 2004; 17: 150 -154.
    • (2004) Dis Esophagus , vol.17 , pp. 150-154
    • Ebihara, Y.1
  • 12
    • 0036186574 scopus 로고    scopus 로고
    • Meth-ylation status and expression of human telomerase reverse transcriptase mRNA in relation to hypermethylation of the p16 gene in colorectal cancer as analyzed by bisulfite PCR-SSCP
    • Nomoto K, Maekawa M, Sugano K, Ushiama M, Fukayama N, Fujita S, Kakizoe T: Meth-ylation status and expression of human telomerase reverse transcriptase mRNA in relation to hypermethylation of the p16 gene in colorectal cancer as analyzed by bisulfite PCR-SSCP. Jpn J Clin Oncol 2002; 32:3-8.
    • (2002) Jpn J Clin Oncol , vol.32 , pp. 3-8
    • Nomoto, K.1    Maekawa, M.2    Sugano, K.3    Ushiama, M.4    Fukayama, N.5    Fujita, S.6    Kakizoe, T.7
  • 13
    • 0033572577 scopus 로고    scopus 로고
    • DNA methyla-tion analysis of the promoter region of the human telomerase reverse transcriptase (hTERT) gene
    • Devereux TR, Horikawa I, Anna CH, Annab LA, Afshari CA, Barrett JC: DNA methyla-tion analysis of the promoter region of the human telomerase reverse transcriptase (hTERT) gene. Cancer Res 1999; 59:6087-6090.
    • (1999) Cancer Res , vol.59 , pp. 6087-6090
    • Devereux, T.R.1    Horikawa, I.2    Anna, C.H.3    Annab, L.A.4    Afshari, C.A.5    Barrett, J.C.6
  • 15
    • 0018860957 scopus 로고
    • Cellular differentiation, cytidine analogs and DNA methylation
    • Jones PA, Taylor SM: Cellular differentiation, cytidine analogs and DNA methylation. Cell 1980; 20:85-93.
    • (1980) Cell , vol.20 , pp. 85-93
    • Jones, P.A.1    Taylor, S.M.2
  • 18
    • 0014949207 scopus 로고
    • Cleavage of the structural proteins during the assembly of head of bacteriophage T4
    • Laemmli UK: Cleavage of the structural proteins during the assembly of head of bacteriophage T4. Nature 1970; 227:680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 19
    • 0009482260 scopus 로고
    • Electro-phoretic transfer of proteins from polyacryl-amide gels to nitrocellulose sheets: Procedure and some applications
    • Towbin H, Skachelin T, Gordon J: Electro-phoretic transfer of proteins from polyacryl-amide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979; 76: 4350-4354.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 4350-4354
    • Towbin, H.1    Skachelin, T.2    Gordon, J.3
  • 20
    • 0030886553 scopus 로고    scopus 로고
    • Lack of cell cycle regulation of telomerase activity in human cells
    • Holt SE, Aisner DL, Shay JW, Wright WE: Lack of cell cycle regulation of telomerase activity in human cells. Proc Natl Acad Sci USA 1997; 94:10687-10692.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 10687-10692
    • Holt, S.E.1    Aisner, D.L.2    Shay, J.W.3    Wright, W.E.4
  • 21
    • 0031945210 scopus 로고    scopus 로고
    • A phase II study of 5-aza-2′-deoxycytidine (decitabine) in hormone independent metastatic (D2) prostate cancer
    • Thibault A, Figg WD, Bergan RC, Lush RM, Myers CE, Tompkins A, et al: A phase II study of 5-aza-2′-deoxycytidine (decitabine) in hormone independent metastatic (D2) prostate cancer. Tumori 1998; 84: 87-89.
    • (1998) Tumori , vol.84 , pp. 87-89
    • Thibault, A.1    Figg, W.D.2    Bergan, R.C.3    Lush, R.M.4    Myers, C.E.5    Tompkins, A.6
  • 22
    • 0033912372 scopus 로고    scopus 로고
    • Demethylating reagent 5-azacytidine inhibits telomerase activity in human prostate cancer cells through transcriptional repression of hTERT
    • Kitagawa Y, Kyo S, Takakura M, Kanaya T, Kashida K, Namiki M, et al: Demethylating reagent 5-azacytidine inhibits telomerase activity in human prostate cancer cells through transcriptional repression of hTERT. Clin Cancer Res 2000; 6:2868-2875.
    • (2000) Clin Cancer Res , vol.6 , pp. 2868-2875
    • Kitagawa, Y.1    Kyo, S.2    Takakura, M.3    Kanaya, T.4    Kashida, K.5    Namiki, M.6
  • 23
    • 0343673898 scopus 로고    scopus 로고
    • Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1
    • Gunes C, Lichtsteiner S, Vasserot AP, Eng-lert C: Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1. Cancer Res 2000; 60: 2116-2121.
    • (2000) Cancer Res , vol.60 , pp. 2116-2121
    • Gunes, C.1    Lichtsteiner, S.2    Vasserot, A.P.3    Eng-lert, C.4
  • 24
    • 0035957406 scopus 로고    scopus 로고
    • Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells
    • Xu D, Popov N, Hou M, Wang Q, Bjorkholm M, Gruber A, Menkel AR, Henriksson M: Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells. Proc Natl Acad Sci USA 2001; 98: 3826-3831.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 3826-3831
    • Xu, D.1    Popov, N.2    Hou, M.3    Wang, Q.4    Bjorkholm, M.5    Gruber, A.6    Menkel, A.R.7    Henriksson, M.8
  • 28
    • 0031590735 scopus 로고    scopus 로고
    • Telomerase activity in human leukemic cell lines is inhibited by antisense pentadeoxynucleotides targeted against c-myc mRNA
    • Fujimoto K, Takahashi M: Telomerase activity in human leukemic cell lines is inhibited by antisense pentadeoxynucleotides targeted against c-myc mRNA. Biochem Biophys Res Commun 1997; 241: 775 -781.
    • (1997) Biochem Biophys Res Commun , vol.241 , pp. 775-781
    • Fujimoto, K.1    Takahashi, M.2
  • 29
    • 0034069354 scopus 로고    scopus 로고
    • The paradox of E2F1: Oncogene and tumor suppressor gene
    • Johnson DG: The paradox of E2F1: oncogene and tumor suppressor gene. Mol Carcinog 2000; 27: 151-157.
    • (2000) Mol Carcinog , vol.27 , pp. 151-157
    • Johnson, D.G.1
  • 32
    • 0028356521 scopus 로고
    • E2F-dependent regulation of human MYC: Trans-activation by cyclins D1 and A overrides tumour suppressor protein functions
    • Oswald F, Lovec H, Moroy T, Lipp M: E2F-dependent regulation of human MYC: trans-activation by cyclins D1 and A overrides tumour suppressor protein functions. Onco-gene 1994; 9:2029-2036.
    • (1994) Onco-gene , vol.9 , pp. 2029-2036
    • Oswald, F.1    Lovec, H.2    Moroy, T.3    Lipp, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.