Lipid droplet biogenesis induced by stress involves triacylglycerol synthesis that depends on Group VIA phospholipase A2

Journal of Biological Chemistry

Volumn 284, Issue 9, 2009, Pages 5697-5708

  Gubern, Albert ^a   Barceló Torns, Miguel ^a   Casas, Javier ^b   Barneda, David ^a   Masgrau, Roser ^a   Picatoste, Fernando ^a   Balsinde, Jesús ^b   Balboa, María A ^b   Claro, Enrique ^a  

^a INSTITUT DE NEUROCIÈNCIES   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; DROPS; GLYCEROL; PHOSPHOLIPIDS;

DOWN-REGULATION; EXTERNAL SOURCES; FATTY ACID SYNTHASE; LIPID DROPLETS; OVER-EXPRESSION; PHOSPHOLIPASE A2; TRIACYLGLYCEROLS; TUNICAMYCIN;

FATTY ACIDS;

CERAMIDE; CERULENIN; FAT DROPLET; FATTY ACID SYNTHASE; PHOSPHOLIPASE A2 GROUP VI; PHOSPHOLIPASE A2 GROUP VIA; SMALL INTERFERING RNA; TRIACYLGLYCEROL; TUNICAMYCIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; CALCIUM; DRUG DERIVATIVE; ENZYME INHIBITOR; FATTY ACID; GLUCOSE; N ACETYLSPHINGOSINE; N-ACETYLSPHINGOSINE; PHOSPHOLIPASE C; SPHINGOSINE;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; GENE ACTIVATION; GENE OVEREXPRESSION; GENE SILENCING; LIPOGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; STRESS; ANIMAL; BIOSYNTHESIS; CHO CELL; CRICETULUS; DRUG ANTAGONISM; FLOW CYTOMETRY; FLUORESCENCE; GENETICS; HAMSTER; LIPID METABOLISM; METABOLISM; OXIDATIVE STRESS; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALS; ANTI-BACTERIAL AGENTS; CALCIUM; CHO CELLS; CRICETINAE; CRICETULUS; ENZYME INHIBITORS; FATTY ACID SYNTHETASE COMPLEX; FATTY ACIDS; FLOW CYTOMETRY; FLUORESCENCE; GLUCOSE; GROUP VI PHOSPHOLIPASES A2; LIPID METABOLISM; OXIDATIVE STRESS; PHOSPHORYLATION; RNA, SMALL INTERFERING; SPHINGOSINE; TRIGLYCERIDES; TUNICAMYCIN; TYPE C PHOSPHOLIPASES;

EID: 65549164326     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M806173200     Document Type: Article

References (55)

1. Brasaemle, D. L. (2007) J. Lipid Res. 48, 2547-2559
2. Martin, S., and Parton, R. G. (2006) Nat. Rev. Mol. Cell. Biol. 7, 373-377
3. Wolins, N. E., Brasaemle, D. L., and Bickel, P. E. (2006) FEBS Lett. 580, 5484-5491
4. Murphy, D. J. (2001) Prog. Lipid Res. 40, 325-438
5. Boström, P., Andersson, L., Rutberg, M., Perman, J., Lidberg, U., Johansson, B. R., Fernandez-Rodriguez, J., Ericson, J., Nilsson, T., Borén, J., and Olofsson, S. O. (2007) Nat. Cell Biol. 9, 1286-1293
6. Guo, G., Walther, T. C., Rao, M., Stuurman, N., Goshima, G., Terayama, K., Wong, J. S., Vale, R. D., Walter, P., and Farese, R. V. (2008) Nature 453, 657-661
7. Gubern, A., Casas, J., Barceló-Torns, M., Barneda, D., de la Rosa, X., Masgrau, R., Picatoste, F., Balsinde, J., Balboa, M. A., and Claro, E. (2008) J. Biol. Chem. 283, 27369-27382
8. Iorio, E., Di Vito, M., Spadaro, F., Ramoni, C., Lococo, E., Carnevale, R., Lenti, L., Strom, R., and Podo, F. (2003) Biochim. Biophys. Acta 1634, 1-14
9. Ramos, B., El-Mouedden, M., Claro, E., and Jackowski, S. (2002) Mol. Pharmacol. 62, 1068-1075
10. Ramos, B., Lahti, J. M., Claro, E., and Jackowski, S. (2003) Mol. Pharmacol. 64, 502-511
11. Cui, Z., and Houweling, M. (2002) Biochim. Biophys. Acta 1585, 87-96
12. Fuentes, L., Pérez, R., Nieto, M. L., Balsinde, J., and Balboa, M. A. (2003) J. Biol. Chem. 278, 44683-44690
13. Balsinde, J., Pérez, R., and Balboa, M. A. (2006) Biochim. Biophys. Acta 1761, 1344-1350
14. Balsinde, J., and Balboa, M. A. (2005) Cell. Signal. 17, 1052-1062
15. Kim, S. J., Gershov, D., Ma, X., Brot, N., and Elkon, K. B. (2002) J. Exp. Med. 196, 655-665
16. Lauber, K., Bohn, E., Kröber, S. M., Xiao, Y. J., Blumenthal, S. G., Lindemann, R. K., Marini, P., Wiedig, C., Zobywalski, A., Baksh, S., Xu, Y., Autenrieth, I. B., Schulze-Osthoff, K., Belka, C., Stuhler, G., and Wesselborg, S. (2003) Cell 113, 717-730
17. Pérez, R., Balboa, M. A., and Balsinde, J. (2006) J. Immunol. 176, 2555-2561
18. Winstead, M. V., Balsinde, J., and Dennis, E. A. (2000) Biochim. Biophys. Acta 1488, 28-39.
19. Casas, J., Gijón, M. A., Vigo, A. G., Sánchez-Crespo, M., Balsinde, J., and Balboa, M. A. (2006) J. Biol. Chem. 281, 6106-6116
20. Bligh, E. G., and Dyer, W. J. (1959) Can. J. Biochem. Physiol. 37, 911-917
21. Menendez, J. A., and Lupu, R. (2007) Nat. Rev. Cancer 7, 763-777
22. Barba, I., Cabañas, M. E., and Arús, C. (1999) Cancer Res. 59, 1861-1868
23. Barba, I., Mann, P., Cabañas, M. E., Arús, C., and Gasparovic, C. (2001) NMR Biomed. 14, 33-40
24. Dricu, A., Carlberg, M., Wang, M., and Larsson, O. (1997) Cancer Res. 57, 543-548
25. Marciniak, S. J., and Ron, D. (2006) Physiol. Rev. 86, 1133-1149
26. Høyer-Hansen, M., and Jäättelä, M. (2007) Cell Death Differ. 14, 1576-1582
27. Aki, T., Yamaguchi, K., Fujimiya, T., and Mizukami, Y. (2003) Oncogene 22, 8529-8535
28. Feng, Z., Zhang, H., Levine, A. J., and Jin, S. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 8204-8209
29. Okoshi, R., Ozaki, T., Yamamoto, H., Ando, K., Koida, N., Ono, S., Koda, T., Kamijo, T., Nakagawara, A., and Kizaki, H. (2008) J. Biol. Chem. 283, 3979-3987
30. Bleasdale, J. E., Thakur, N. R., Gremban, R. S., Bundy, G. L., Fitzpatrick, F. A., Smith, R. J., and Bunting, S. (1990) J. Pharmacol. Exp. Ther. 255, 756-768
31. Servitja, J. M., Masgrau, R., Sarri, E., and Picatoste, F. (2001) J. Neurochem. 72, 1441-1447
32. Jenkins, C. M., Han, X., Mancuso, D. J., and Gross, R. W. (2002) J. Biol. Chem. 277, 32807-32814
33. Balsinde, J., and Dennis, E. A. (1996) J. Biol. Chem. 271, 31937-31941
34. Balboa, M. A., Balsinde, J., and Dennis, E. A. (1998) J. Biol. Chem. 273, 7684-7690
35. Tang, J., Kriz, R. W., Wolfman, N., Shaffer, M., Seehra, J., and Jones, S. S. (1997) J. Biol. Chem. 272, 8567-8575
36. Al-Saffar, N. M., Titley, J. C., Robertson, D., Clarke, P. A., Jackson, L. E., Leach, M. O., and Ronen, S. M. (2002) Br. J. Cancer 86, 963-970
37. Coleman, R. A., and Lee, D. P. (2004) Prog. Lipid Res. 43, 134-176
38. Jackowski, S., Wang, J., and Baburina, I. (2000) Biochim. Biophys. Acta 1483, 301-315
39. Baburina, I., and Jackowski, S. (1998) J. Biol. Chem. 273, 2169-2173
40. Boggs, K. P., Rock, C. O., and Jackowski, S. (1998) Biochim. Biophys. Acta 1389, 1-12
41. Manguikian, A. D., and Barbour, S. E. (2004) J. Biol. Chem. 279, 55881-55892
42. Atsumi, G., Murakami, M., Kojima, K., Hadano, A., Tajima, M., and Kudo, I. (2000) J. Biol. Chem. 275, 18248-18258
43. Balsinde, J., Balboa, M. A., and Dennis, E. A. (1997) J. Biol. Chem. 272, 29317-29321
44. Baburina, I., and Jackowski, S. (1999)) J. Biol. Chem. 274, 9400-9408
45. Barbour, S. E., Kapur, A., and Deal, C. L. (1999) Biochim. Biophys. Acta 1439, 77-88
46. Zhang, X. H., Zhao, C., Seleznev, K., Song, K., Manfredi, J. J., and Ma, Z. A. (2006) J. Cell Sci. 119, 1005-1015
47. Seleznev, K., Zhao, C., Zhang, X. H., Song, K., and Ma, Z. A. (2006) J. Biol. Chem. 281, 22275-22288
48. Atsumi, G., Tajima, M., Hadano, A., Nakatani, Y., Murakami, M., and Kudo, I. (1998) J. Biol. Chem. 273, 13870-13877
49. Pérez, R., Melero, R., Balboa, M. A., and Balsinde, J. (2004) J. Biol. Chem. 279, 40385-40391
50. Mancuso, D. J., Han, X., Jenkins, C. M., Lehman, J. J., Sambandam, N., Sims, H. F., Yang, J., Yan, W., Yang, K., Green, K., Abendschein, D. R., Saffitz, J. E., and Gross, R. W. (2007) J. Biol. Chem. 282, 9216-9227
51. Listenberger, L. L., Han, X., Lewis, S. E., Cases, S., Farese, Jr., R. V., Ory, D. S., and Schaffer, J. E. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 3077-3082
52. Unger, R. H., and Orci, L. (2002) Biochim. Biophys. Acta 1585, 202-212
53. Finn, P. F., and Dice, J. F. (2006) Nutrition 22, 830-844
54. Ducharne, N. A., and Bickel, P. E. (2007) Endocrinology 149, 942-949
55. Du, L., Hickey, R. W., Bayir, H., Watkins, S. C., Tyurin, V. A., Guo, F., Kochanek, P. M., Jenkins, L. W., Ren, J., Gibson, G., Chu, C. T., Kagan, V. E., and Clark, R. S. B. (2009) J. Biol. Chem. 284, 2383-2396