Inactivation of FIP200 leads to inflammatory skin disorder, but not tumorigenesis, in conditional knock-out mouse models

Journal of Biological Chemistry

Volumn 284, Issue 9, 2009, Pages 6004-6013

  Wei, Huijun ^a   Gan, Boyi ^a,b   Wu, Xiaoyang ^a,c   Guan, Jun Lin ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER; CHEMOKINES; DISEASE PROCESS; EPIDERMAL CELLS; FOCAL ADHESION KINASE; IMMUNE CELLS; IN-VITRO; IN-VIVO; INFLAMMATORY DISORDERS; INTRACELLULAR SIGNALING PATHWAYS; KERATINOCYTES; KNOCK OUTS; LYMPHOMAGENESIS; MAMMARY EPITHELIAL CELLS; MAMMARY TUMORS; MOUSE MODELS; NORMAL SKIN; NOVEL FUNCTIONS; PARACRINE; PROINFLAMMATORY CYTOKINES; SKIN DEFECTS; SKIN DISORDERS; SPONTANEOUS DEVELOPMENT; T CELLS; TUMOR NECROSIS FACTORS; TUMORIGENESIS;

CELL MEMBRANES; MACROPHAGES; ONCOGENIC VIRUSES; TUMORS;

SKIN;

CALGRANULIN A; FOCAL ADHESION KINASE; FOCAL ADHESION KINASE INTERACTING PROTEIN OF 200; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN P53; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CHEMOKINE; CRE RECOMBINASE; CYTOKINE; INTEGRASE; MESSENGER RNA; RB1CC1 PROTEIN, MOUSE; SIGNAL PEPTIDE;

ACANTHOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST CANCER; CARCINOGENESIS; CELL ISOLATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DERMIS; ENZYME ACTIVATION; EPIDERMIS; EPIDERMIS HYPERPLASIA; GENE ACTIVATION; GRANULOCYTE; HOMEOSTASIS; HYPERKERATOSIS; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY CELL; KERATINOCYTE; KNOCKOUT MOUSE; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MOUSE; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SKIN BLOOD VESSEL; SKIN INFLAMMATION; T LYMPHOCYTE; ANIMAL; DISEASE MODEL; ENZYME IMMUNOASSAY; EXPERIMENTAL NEOPLASM; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HYPERPLASIA; INFLAMMATION; METABOLISM; MOUSE MAMMARY TUMOR ONCOVIRUS; MOUSE MUTANT; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN DISEASE; WESTERN BLOTTING;

MOUSE MAMMARY TUMOR VIRUS; MUS;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; CHEMOKINES; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HYPERPLASIA; IMMUNOENZYME TECHNIQUES; INFLAMMATION; INTEGRASES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KERATINOCYTES; MAMMARY NEOPLASMS, EXPERIMENTAL; MAMMARY TUMOR VIRUS, MOUSE; MICE; MICE, KNOCKOUT; NF-KAPPA B; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SKIN DISEASES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 65549159637     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M806375200     Document Type: Article

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