Development of novel thiazolopyrimidines as CDC25B phosphatase inhibitors

ChemMedChem

Volumn 4, Issue 4, 2009, Pages 633-648

  Kolb, Stéphanie ^a,b   Mondésert, Odile ^c,d   Goddard, Mary Lorène ^a,b   Jullien, Denis ^c,d   Villoutreix, Bruno O ^b   Ducommun, Bernard ^c,d,e   Garbay, Christiane ^a,b   Braud, Emmanuelle ^a,b  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b INSERM   (France)

^c UNIVERSITÉ DE TOULOUSE   (France)

^d CNRS   (France)

^e CHU PURPAN   (France)

Author keywords

Cancer; Cdc25 Phosphatase; Cell Cycle; Structure Activity Relationships; Thiazolopyrimidines

Indexed keywords

2 CYANOMETHYL 4 (1,3 BENZODIOXOL 5 YL) 6 METHYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; 4 (1,3 BENZODIOXOL 5 YL) 6 METHYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLIC ACID; 5 (1,3 BENZODIOXOL 5 YL) 7 METHYL 3 OXO 2,3 DIHYDRO 5H(1,3)THIAZOLO(3,2 A)PYRIMIDINE 6 CARBOXYLIC ACID; ANTINEOPLASTIC AGENT; BENZYL 4 (1,3 BENZODIOXOL 5 YL) 6 METHYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; BENZYL 5 (1,3 BENZODIOXOL 5 YL) 7 METHYL 3 OXO 2,3 DIHYDRO 5H(1,3)THIAZOLO(3,2 A)PYRIMIDINE 6 CARBOXYLATE; ETHYL 4 (1,3 BENZODIOXOL 5 YL) 6 METHYL 2 SELENOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (1,3 BENZODIOXOL 5 YL) 6 METHYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (1,3 BENZODIOXOL 5 YL) 6 PHENYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (2,3 DIHYDRO 1,4 BENZODIOXIN 6 YL) 6 METHYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (3 HYDROXYPHENYL) 6 METHYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (3,4 DICHLOROPHENYL) 6 METHYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (3,4 DIMETHOXYPHENYL) 6 METHYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (3.4 DIHYDROXYPHENYL) 6 METHL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (4 HYDROXYPHENYL) 6 METHYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 5 (1,3 BENZODIOXOL 5 YL) 3 OXO 7 PHENYL 2,3 DIHYDRO 5H(1,3)THIAZOLO(3,2 A)PYRIMIDINE 6 CARBOXYLATE; ETHYL 5 (1,3 BENZODIOXOL 5 YL) 7 METHYL 3 OXO 2,3 DIHYDRO 5H(1,3)SELENAZOLO(3,2 A)PYRIMIDINE 6 CARBOXYLATE; ETHYL 5 (1,3 BENZODIOXOL 5 YL) 7 METHYL 3 OXO 2,3 DIHYDRO 5H(1,3)THIAZOLO(3,2 A)PYRIMIDINE 6 CARBOXYLATE; ETHYL 5 (3,4 DICHLOROPHENYL) 7 METHYL 3 OXO 2,3 DIHYDRO 5H(1,3)THIAZOLO(3,2 A)PYRIMIDINE 6 CARBOXYLATE; ETHYL 5 (3,4 DIMETHOXYPHENYL) 7 METHYL 3 OXO 2,3 DIHYDRO 5H(1,3)THIAZOLO(3,2 A)PYRIMIDINE 6 CARBOXYLATE; ETHYL 6 METHYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 6 METHYL 4 (2 NAPHTHYL) 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 6 METHYL 4 (3,4,5 TRIMETHOXYPHENYL) 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 6 METHYL 4 (4 METHYL 1 NAPHTHYL) 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 6 METHYL 4 PHENYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 7 METHYL 3 OXO 2,3 DIHYDRO 5H(1,3)THIAZOLO(3,2 A)PYRIMIDINE 6 CARBOXYLATE; ETHYL 7 METHYL 3 OXO 5 PHENYL 2,3 DIHYDRO 5H(1,3)THIAZOLO(3,2 A)PYRIMIDINE 6 CARBOXYLATE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; PANCREAS ADENOCARCINOMA; PHARMACOPHORE; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA;

CDC25 PHOSPHATASES; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DISCOVERY; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 65549135298     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200800415     Document Type: Article

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