Synthesis and evaluation of some 1,2,3,4-tetrahydropyrimidine-2-thione and condensed pyrimidine derivatives as potential antihypertensive agents

Arzneimittel-Forschung/Drug Research

Volumn 56, Issue 5, 2006, Pages 322-327

  Ismail, Magda M F ^a,e   El Sayed, Nehad A M ^b   Rateb, Heba S ^a   Ellithey, Mohey ^c   Ammar, Yousry A ^d  

^a Cairo University   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

^c NATIONAL RESEARCH CENTRE   (Egypt)

^d Al Azhar University   (Egypt)

^e AL AZHAR UNIVERSITY   (Egypt)

Author keywords

1,2,3,4 Tetrahydropyrimidine 2 thione derivatives, antihypertenslve activity, synthesis; Antihypertensives; Octahydroquinazoline 2 thione derivatives, antihypertensive activity, synthesis; Thiazolo 3,2 a pyrimidines, antihypertensive activity, synthesis

Indexed keywords

1,2,3,4 TETRAHYDROPYRIMIDINE 2 THIONE; 4 (3,4,5 TRIMETHOXYPHENYL)-1,2,3,4,5,6,7,8 OCTAHYDROQUINAZOLINE 2 THIONE; ANTIHYPERTENSIVE AGENT; CARBOXYLIC ACID DERIVATIVE; ETHYL 2 (4 BENZYLIDENE) 7 METHYL 3 OXO 5 (3,4,5 TRIMETHOXYPHENYL) 2,3 DIHYDRO 5H THIAZOLO[3,2 A] PYRIMIDINE 6 CARBOXYLIC ACID; ETHYL 2 (4 BENZYLIDENE) 7 PHENYL 3 OXO 5 (3,4,5 TRIMETHOXYPHENYL) 2,3 DIHYDRO 5H THIAZOLO[3,2 A] PYRIMIDINE 6 CARBOXYLIC ACID; ETHYL 2 (ALKYLTHIO) 6 PHENYL 4 (3,4,5 TRIMETHOXYPHENYL) 1,4 DIHYDROPYRAMIDINE 5 CARBOXYLIC ACID; ETHYL 3 ACETYL 6 PHENYL 2 THIOXO 4 (3,4,5 TRIMETHOXYPHENYL) 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLIC ACID; ETHYL 3 BENZOYL 6 PHENYL 2 THIOXO 4 (3,4,5 TRIMETHOXYPHENYL) 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLIC ACID; ETHYL 3 FORMYL 6 PHENYL 2 THIOXO 4 (3,4,5 TRIMETHOXYPHENYL) 1,2,3,4 TETRAHYDROPYRAMIDINE 5 CARBOXYLIC ACID; ETHYL 5 (3,4,5 TRIMETHOXYPHENYL 3 METHYL 7 PHENYL 5H THIAZOLO[3,2 A]PYRAMIDINE 6 CARBOXYLIC ACID; ETHYL 6 METHYL (PHENYL) 2 THIOXO 4 (3,4,5 TRIMETHOXYPHENYL) 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLIC ACID; ETHYL 6 METHYL 2 THIOXO 3 (AMINO) 4 (3,4,5 TRIMETHOXYPHENYL) 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLIC ACID; ETHYL 7 METHYL 3 OXO 5 (3,4,5 TRIMETHOXYPHENYL) 2,3 DIHYDRO 5H THIAZOLO[3,2 A]PYRIMIDINE 6 CARBOXYLIC ACID; NIFEDIPINE; OCTAHYDROQUINAZOLINE 2 THIONE; PYRIMIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE; THIAZOLO[3,2 A]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HYPERTENSION; MALE; NONHUMAN; RAT;

EID: 33745056512     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296729     Document Type: Article

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