Synthesis, pharmacological and in silico evaluation of 1-(4-di-hydroxy-3,5-dioxa-4-borabicyclo[4.4.0]deca-7,9,11-trien-9-yl)-2- (tert-butylamino)ethanol, a compound designed to act as a β 2 adrenoceptor agonist

European Journal of Medicinal Chemistry

Volumn 44, Issue 7, 2009, Pages 2840-2846

  Soriano Ursúa, Marvin A ^a,b   Valencia Hernández, Ignacio ^b,c   Arellano Mendoza, Mónica G ^b,c   Correa Basurto, José ^a,b,c   Trujillo Ferrara, José G ^a,c  

^a Departamento de Bioquímica   (Mexico)

^b Departamento de Fisiología y Farmacología   (Brazil)

^c INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

2 Adrenoceptor agonist; Boron; BR AEA; Docking

Indexed keywords

1 (4 DI HYDROXY 3, 5 DIOXA 4 BORABICYCLO[4.4.0]DECA 7,9,11 TRIEN 9 YL) 2 TERT BUTYLAMINO)ETHANOL; 3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; ADRENERGIC RECEPTOR STIMULATING AGENT; ALCOHOL; BETA 2 ADRENERGIC RECEPTOR; BORON; HISTAMINE; PROPRANOLOL; SALBUTAMOL; UNCLASSIFIED DRUG;

ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; GUINEA PIG; HYDROGEN BOND; IN VITRO STUDY; MOLECULAR MODEL; NONHUMAN; TRACHEA; VASODILATATION;

ANIMALS; BICYCLO COMPOUNDS; BINDING SITES; BUTYLAMINES; COMPUTATIONAL BIOLOGY; DRUG DESIGN; ETHANOL; GUINEA PIGS; HUMANS; LIGANDS; MALE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; RECEPTORS, ADRENERGIC, BETA-2; TRACHEA;

EID: 65449156870     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.12.016     Document Type: Article

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