Different structural requirements for the constitutive and the agonist-induced activities of the β2-adrenergic receptor

Journal of Biological Chemistry

Volumn 280, Issue 25, 2005, Pages 23464-23474

  Ambrosio, Caterina ^a   Molinari, Paola ^a   Fanelli, Francesca ^b   Chuman, Yoshiro ^c,e   Sbraccia, Maria ^a   Ugur, Ozlem ^d   Costa, Tommaso ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c KYUSHU UNIVERSITY   (Japan)

^d ANKARA UNIVERSITY   (Turkey)

^e HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; ALCOHOLS; AMINO ACIDS; BINDING ENERGY; CORRELATION THEORY; HYDROGEN BONDS; HYDROPHOBICITY; LINEARIZATION; REDUCTION;

ADRENERGIC RECEPTORS; HALOSTACHIN; LIGANDS; MUTANTS;

BIOCHEMISTRY;

ADRENALIN; ASPARTIC ACID; BETA 2 ADRENERGIC RECEPTOR; GUANOSINE TRIPHOSPHATE; HALOSTACHIN; HISTIDINE; ISOLEUCINE; ISOPRENALINE; LYSINE; MUTANT PROTEIN; PARTIAL AGONIST; PINDOLOL; SERINE; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; LIGAND BINDING; MOLECULAR MODEL; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; WILD TYPE;

ADRENERGIC BETA-AGONISTS; ANIMALS; CELL LINE; HUMANS; MODELS, MOLECULAR; MUTAGENESIS; PROTEIN CONFORMATION; RECEPTORS, ADRENERGIC, BETA-2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 21244467605     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M502901200     Document Type: Article

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