메뉴 건너뛰기




Volumn 41, Issue 8, 2008, Pages 585-591

Regulatory T cells in autologous stem cell transplantation for autoimmune disease

Author keywords

Autologous stem cell transplantation; Regulatory T cells; Tolerance

Indexed keywords

INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA;

EID: 65449126209     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.1080/08916930802200182     Document Type: Review
Times cited : (22)

References (53)
  • 2
    • 16844365788 scopus 로고    scopus 로고
    • Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
    • Sakaguchi, S. (2005) Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol, 6:4, pp. 345-352.
    • (2005) Nat Immunol , vol.6 , Issue.4 , pp. 345-352
    • Sakaguchi, S.1
  • 3
    • 0016313249 scopus 로고
    • Suppressor cells in normal immunisation as a basic homeostatic phenomenon
    • Katz, SI, Parker, D., Sommer, G. and Turk, JL (1974) Suppressor cells in normal immunisation as a basic homeostatic phenomenon. Nature, 248:449, pp. 612-614.
    • (1974) Nature , vol.248 , Issue.449 , pp. 612-614
    • Katz, S.I.1    Parker, D.2    Sommer, G.3    Turk, J.L.4
  • 4
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25)
    • Sakaguchi, S., Sakaguchi, N. Asano, M. et al. (1995) Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol, 155:3, pp. 1151-1164.
    • (1995) J Immunol , vol.155 , Issue.3 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3
  • 5
    • 34247277666 scopus 로고    scopus 로고
    • Foxp3 in control of the regulatory T cell lineage
    • Zheng, Y. and Rudensky, AY (2007) Foxp3 in control of the regulatory T cell lineage. Nat Immunol, 8:5, pp. 457-462.
    • (2007) Nat Immunol , vol.8 , Issue.5 , pp. 457-462
    • Zheng, Y.1    Rudensky, A.Y.2
  • 6
    • 0033136302 scopus 로고    scopus 로고
    • Thymus and autoimmunity: Production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
    • Itoh, M., Takahashi, T. Sakaguchi, N. et al. (1999) Thymus and autoimmunity: Production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol, 162:9, pp. 5317-5326.
    • (1999) J Immunol , vol.162 , Issue.9 , pp. 5317-5326
    • Itoh, M.1    Takahashi, T.2    Sakaguchi, N.3
  • 7
    • 33846485153 scopus 로고    scopus 로고
    • Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    • Kim, JM, Rasmussen, JP and Rudensky, AY (2007) Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol, 8:2, pp. 191-197.
    • (2007) Nat Immunol , vol.8 , Issue.2 , pp. 191-197
    • Kim, J.M.1    Rasmussen, J.P.2    Rudensky, A.Y.3
  • 8
    • 16844362608 scopus 로고    scopus 로고
    • Mechanisms of suppression by suppressor T cells
    • von Boehmer, H. (2005) Mechanisms of suppression by suppressor T cells. Nat Immunol, 6:4, pp. 338-344.
    • (2005) Nat Immunol , vol.6 , Issue.4 , pp. 338-344
    • von Boehmer, H.1
  • 9
    • 2542420993 scopus 로고    scopus 로고
    • In vivo instruction of suppressor commitment in naive T cells
    • Apostolou, I. and von Boehmer, H. (2004) In vivo instruction of suppressor commitment in naive T cells. J Exp Med, 199:10, pp. 1401-1408.
    • (2004) J Exp Med , vol.199 , Issue.10 , pp. 1401-1408
    • Apostolou, I.1    von Boehmer, H.2
  • 10
    • 0030704726 scopus 로고    scopus 로고
    • A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • Groux, H., O'Garra, A. Bigler, M. et al. (1997) A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature, 389:6652, pp. 737-742.
    • (1997) Nature , vol.389 , Issue.6652 , pp. 737-742
    • Groux, H.1    O'Garra, A.2    Bigler, M.3
  • 11
    • 0035186416 scopus 로고    scopus 로고
    • Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells
    • Weiner, HL (2001) Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol Rev, 182, pp. 207-214.
    • (2001) Immunol Rev , vol.182 , pp. 207-214
    • Weiner, H.L.1
  • 12
    • 20144386375 scopus 로고    scopus 로고
    • Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients
    • Muraro, PA, Douek, DC Packer, A. et al. (2005) Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients. J Exp Med, 201:5, pp. 805-816.
    • (2005) J Exp Med , vol.201 , Issue.5 , pp. 805-816
    • Muraro, P.A.1    Douek, D.C.2    Packer, A.3
  • 13
    • 0030462050 scopus 로고    scopus 로고
    • Effective treatment of relapsing experimental autoimmune encephalomyelitis with pseudoautologous bone marrow transplantation
    • van Gelder M and van Bekkum, DW (1996) Effective treatment of relapsing experimental autoimmune encephalomyelitis with pseudoautologous bone marrow transplantation. Bone Marrow Transplant, 18:6, pp. 1029-1034.
    • (1996) Bone Marrow Transplant , vol.18 , Issue.6 , pp. 1029-1034
    • van Gelder, M.1    van Bekkum, D.W.2
  • 14
    • 0033997327 scopus 로고    scopus 로고
    • Conditioning regimens for the treatment of experimental arthritis with autologous bone marrow transplantation
    • van Bekkum, DW (2000) Conditioning regimens for the treatment of experimental arthritis with autologous bone marrow transplantation. Bone Marrow Transplant, 25:4, pp. 357-364.
    • (2000) Bone Marrow Transplant , vol.25 , Issue.4 , pp. 357-364
    • van Bekkum, D.W.1
  • 15
    • 4344705888 scopus 로고    scopus 로고
    • Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: Analysis of clinical effects, mortality, and transplant related morbidity
    • De Kleer, IM, Brinkman, DM Ferster, A. et al. (2004) Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: analysis of clinical effects, mortality, and transplant related morbidity. Ann Rheum Dis, 63:10, pp. 1318-1326.
    • (2004) Ann Rheum Dis , vol.63 , Issue.10 , pp. 1318-1326
    • De Kleer, I.M.1    Brinkman, D.M.2    Ferster, A.3
  • 16
    • 20844437575 scopus 로고    scopus 로고
    • Autologous hematopoietic stem cell transplantation for autoimmune diseases
    • Gratwohl, A., Passweg, J. Bocelli-Tyndall, C. et al. (2005) Autologous hematopoietic stem cell transplantation for autoimmune diseases. Bone Marrow Transplant, 35:9, pp. 869-879.
    • (2005) Bone Marrow Transplant , vol.35 , Issue.9 , pp. 869-879
    • Gratwohl, A.1    Passweg, J.2    Bocelli-Tyndall, C.3
  • 17
    • 0029943897 scopus 로고    scopus 로고
    • Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing
    • Mackall, CL, Bare, CV Granger, LA et al. (1996) Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing. J Immunol, 156:12, pp. 4609-4616.
    • (1996) J Immunol , vol.156 , Issue.12 , pp. 4609-4616
    • Mackall, C.L.1    Bare, C.V.2    Granger, L.A.3
  • 18
    • 33846456970 scopus 로고    scopus 로고
    • T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis
    • Hirota, K., Hashimoto, M. Yoshitomi, H. et al. (2007) T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. J Exp Med, 204:1, pp. 41-47.
    • (2007) J Exp Med , vol.204 , Issue.1 , pp. 41-47
    • Hirota, K.1    Hashimoto, M.2    Yoshitomi, H.3
  • 19
    • 11144221749 scopus 로고    scopus 로고
    • The new paradigm of T-cell homeostatic proliferation-induced autoimmunity
    • Baccala, R. and Theofilopoulos, AN (2005) The new paradigm of T-cell homeostatic proliferation-induced autoimmunity. Trends Immunol, 26:1, pp. 5-8.
    • (2005) Trends Immunol , vol.26 , Issue.1 , pp. 5-8
    • Baccala, R.1    Theofilopoulos, A.N.2
  • 20
    • 0034909449 scopus 로고    scopus 로고
    • T cell homeostasis and systemic autoimmunity
    • Theofilopoulos, AN, Dummer, W. and Kono, DH (2001) T cell homeostasis and systemic autoimmunity. J Clin Invest, 108:3, pp. 335-340.
    • (2001) J Clin Invest , vol.108 , Issue.3 , pp. 335-340
    • Theofilopoulos, A.N.1    Dummer, W.2    Kono, D.H.3
  • 21
    • 33746189876 scopus 로고    scopus 로고
    • Autoimmunity during lymphopenia: A two-hit model
    • Krupica Jr, T., Fry, T. J. and Mackall, CL (2006) Autoimmunity during lymphopenia: A two-hit model. Clin Immunol, 120:2, pp. 121-128.
    • (2006) Clin Immunol , vol.120 , Issue.2 , pp. 121-128
    • Krupica Jr., T.1    Fry, T.J.2    Mackall, C.L.3
  • 22
    • 0035284804 scopus 로고    scopus 로고
    • CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10
    • Annacker, O., Pimenta-Araujo, R. Burlen-Defranoux, O. et al. (2001) CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J Immunol, 166:5, pp. 3008-3018.
    • (2001) J Immunol , vol.166 , Issue.5 , pp. 3008-3018
    • Annacker, O.1    Pimenta-Araujo, R.2    Burlen-Defranoux, O.3
  • 23
    • 4644317228 scopus 로고    scopus 로고
    • A role for CD28 in lymphopenia-induced proliferation of CD4 T cells
    • Hagen, KA, Moses, CT Drasler, EF et al. (2004) A role for CD28 in lymphopenia-induced proliferation of CD4 T cells. J Immunol, 173:6, pp. 3909-3915.
    • (2004) J Immunol , vol.173 , Issue.6 , pp. 3909-3915
    • Hagen, K.A.1    Moses, C.T.2    Drasler, E.F.3
  • 24
    • 31044431958 scopus 로고    scopus 로고
    • Control of homeostatic proliferation by regulatory T cells
    • Shen, S., Ding, Y. Tadokoro, CE et al. (2005) Control of homeostatic proliferation by regulatory T cells. J Clin Invest, 115:12, pp. 3517-3526.
    • (2005) J Clin Invest , vol.115 , Issue.12 , pp. 3517-3526
    • Shen, S.1    Ding, Y.2    Tadokoro, C.E.3
  • 25
    • 0036839102 scopus 로고    scopus 로고
    • Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers
    • Almeida, AR, Legrand, N., Papiernik, M. and Freitas, AA (2002) Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J Immunol, 169:9, pp. 4850-4860.
    • (2002) J Immunol , vol.169 , Issue.9 , pp. 4850-4860
    • Almeida, A.R.1    Legrand, N.2    Papiernik, M.3    Freitas, A.A.4
  • 26
    • 0037097503 scopus 로고    scopus 로고
    • Cutting edge: Depletion of CD4+CD25+ regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease
    • McHugh, RS and Shevach, EM (2002) Cutting edge: Depletion of CD4+CD25+ regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease. J Immunol, 168:12, pp. 5979-5983.
    • (2002) J Immunol , vol.168 , Issue.12 , pp. 5979-5983
    • McHugh, R.S.1    Shevach, E.M.2
  • 27
    • 23944511180 scopus 로고    scopus 로고
    • Tolerance induction by bone marrow transplantation in a multiple sclerosis model
    • Herrmann, MM, Gaertner, S. Stadelmann, C. et al. (2005) Tolerance induction by bone marrow transplantation in a multiple sclerosis model. Blood, 106:5, pp. 1875-1883.
    • (2005) Blood , vol.106 , Issue.5 , pp. 1875-1883
    • Herrmann, M.M.1    Gaertner, S.2    Stadelmann, C.3
  • 28
    • 22244448391 scopus 로고    scopus 로고
    • Effective treatment of collagen-induced arthritis by adoptive transfer of CD25+ regulatory T cells
    • Morgan, ME, Flierman, R. van Duivenvoorde, LM et al. (2005) Effective treatment of collagen-induced arthritis by adoptive transfer of CD25+ regulatory T cells. Arthritis Rheum, 52:7, pp. 2212-2221.
    • (2005) Arthritis Rheum , vol.52 , Issue.7 , pp. 2212-2221
    • Morgan, M.E.1    Flierman, R.2    van Duivenvoorde, L.M.3
  • 29
    • 32644442191 scopus 로고    scopus 로고
    • Autologous stem cell transplantation for autoimmunity induces immunologic self-tolerance by reprogramming autoreactive T cells and restoring the CD4+CD25+ immune regulatory network
    • De Kleer, I., Vastert, B. Klein, M. et al. (2006) Autologous stem cell transplantation for autoimmunity induces immunologic self-tolerance by reprogramming autoreactive T cells and restoring the CD4+CD25+ immune regulatory network. Blood, 107:4, pp. 1696-1702.
    • (2006) Blood , vol.107 , Issue.4 , pp. 1696-1702
    • De Kleer, I.1    Vastert, B.2    Klein, M.3
  • 30
    • 0036144888 scopus 로고    scopus 로고
    • Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo
    • Gavin, MA, Clarke, SR Negrou, E. et al. (2002) Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo. Nat Immunol, 3:1, pp. 33-41.
    • (2002) Nat Immunol , vol.3 , Issue.1 , pp. 33-41
    • Gavin, M.A.1    Clarke, S.R.2    Negrou, E.3
  • 31
    • 34547423966 scopus 로고    scopus 로고
    • Full restoration of peripheral Foxp3+ regulatory T cell pool by radioresistant host cells in scurfy bone marrow chimeras
    • Komatsu N and Hori S (2007) Full restoration of peripheral Foxp3+ regulatory T cell pool by radioresistant host cells in scurfy bone marrow chimeras. Proc Natl Acad Sci USA, 104:21, pp. 8959-8964.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.21 , pp. 8959-8964
    • Komatsu, N.1    Hori, S.2
  • 32
    • 33646869754 scopus 로고    scopus 로고
    • Functional regulatory T cells are collected in stem cell autografts by mobilization with high-dose cyclophosphamide and granulocyte colony-stimulating factor
    • Condomines, M., Quittet, P. Lu, ZY et al. (2006) Functional regulatory T cells are collected in stem cell autografts by mobilization with high-dose cyclophosphamide and granulocyte colony-stimulating factor. J Immunol, 176:11, pp. 6631-6639.
    • (2006) J Immunol , vol.176 , Issue.11 , pp. 6631-6639
    • Condomines, M.1    Quittet, P.2    Lu, Z.Y.3
  • 33
    • 10344220512 scopus 로고    scopus 로고
    • CD25- T cells generate CD25+Foxp3+ regulatory T cells by peripheral expansion
    • Curotto de Lafaille, MA, Lino, AC, Kutchukhidze, N. and Lafaille, JJ (2004) CD25- T cells generate CD25+Foxp3+ regulatory T cells by peripheral expansion. J Immunol, 173:12, pp. 7259-7268.
    • (2004) J Immunol , vol.173 , Issue.12 , pp. 7259-7268
    • Curotto de Lafaille, M.A.1    Lino, A.C.2    Kutchukhidze, N.3    Lafaille, J.J.4
  • 34
    • 12344307563 scopus 로고    scopus 로고
    • Conversion of CD4+ CD25- cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus
    • Liang, S., Alard, P. Zhao, Y. et al. (2005) Conversion of CD4+ CD25- cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus. J Exp Med, 201:1, pp. 127-137.
    • (2005) J Exp Med , vol.201 , Issue.1 , pp. 127-137
    • Liang, S.1    Alard, P.2    Zhao, Y.3
  • 35
    • 17044430217 scopus 로고    scopus 로고
    • Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter
    • Wan, YY and Flavell, RA (2005) Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc Natl Acad Sci USA, 102:14, pp. 5126-5131.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.14 , pp. 5126-5131
    • Wan, Y.Y.1    Flavell, R.A.2
  • 36
    • 34047174849 scopus 로고    scopus 로고
    • Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production
    • Allan, SE, Crome, SQ Crellin, NK et al. (2007) Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. Int Immunol, 19:4, pp. 345-354.
    • (2007) Int Immunol , vol.19 , Issue.4 , pp. 345-354
    • Allan, S.E.1    Crome, S.Q.2    Crellin, N.K.3
  • 37
    • 33846375082 scopus 로고    scopus 로고
    • Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells
    • Wang, J., Ioan-Facsinay, A. van der Voort, EI et al. (2007) Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells. Eur J Immunol, 37:1, pp. 129-138.
    • (2007) Eur J Immunol , vol.37 , Issue.1 , pp. 129-138
    • Wang, J.1    Ioan-Facsinay, A.2    van der Voort, E.I.3
  • 38
    • 34548721641 scopus 로고    scopus 로고
    • Prevalence of newly generated naive regulatory T cells (Treg) is critical for Treg suppressive function and determines Treg dysfunction in multiple sclerosis
    • Haas, J., Fritzsching, B. Trubswetter, P. et al. (2007) Prevalence of newly generated naive regulatory T cells (Treg) is critical for Treg suppressive function and determines Treg dysfunction in multiple sclerosis. J Immunol, 179:2, pp. 1322-1330.
    • (2007) J Immunol , vol.179 , Issue.2 , pp. 1322-1330
    • Haas, J.1    Fritzsching, B.2    Trubswetter, P.3
  • 39
    • 0033555440 scopus 로고    scopus 로고
    • Comparison of immune reconstitution after unrelated and related T-cell-depleted bone marrow transplantation: Effect of patient age and donor leukocyte infusions
    • Small, TN, Papadopoulos, EB Boulad, F. et al. (1999) Comparison of immune reconstitution after unrelated and related T-cell-depleted bone marrow transplantation: Effect of patient age and donor leukocyte infusions. Blood, 93:2, pp. 467-480.
    • (1999) Blood , vol.93 , Issue.2 , pp. 467-480
    • Small, T.N.1    Papadopoulos, E.B.2    Boulad, F.3
  • 40
    • 4444300314 scopus 로고    scopus 로고
    • CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: Differences in the presence, phenotype, and function between peripheral blood and synovial fluid
    • van Amelsfort, JM, Jacobs, KM Bijlsma, JW et al. (2004) CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: Differences in the presence, phenotype, and function between peripheral blood and synovial fluid. Arthritis Rheum, 50:9, pp. 2775-2785.
    • (2004) Arthritis Rheum , vol.50 , Issue.9 , pp. 2775-2785
    • van Amelsfort, J.M.1    Jacobs, K.M.2    Bijlsma, J.W.3
  • 41
    • 22344432319 scopus 로고    scopus 로고
    • Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia
    • Ruprecht, CR, Gattorno, M. Ferlito, F. et al. (2005) Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia. J Exp Med, 201:11, pp. 1793-1803.
    • (2005) J Exp Med , vol.201 , Issue.11 , pp. 1793-1803
    • Ruprecht, C.R.1    Gattorno, M.2    Ferlito, F.3
  • 42
    • 33846817153 scopus 로고    scopus 로고
    • Increased frequency of CD4+ CD25+ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients
    • Feger, U., Luther, C. Poeschel, S. et al. (2007) Increased frequency of CD4+ CD25+ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients. Clin Exp Immunol, 147:3, pp. 412-418.
    • (2007) Clin Exp Immunol , vol.147 , Issue.3 , pp. 412-418
    • Feger, U.1    Luther, C.2    Poeschel, S.3
  • 43
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli, E., Carrier, Y. Gao, W. et al. (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature, 441:7090, pp. 235-238.
    • (2006) Nature , vol.441 , Issue.7090 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3
  • 44
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    • Pasare C, C and Medzhitov R, R (2003) Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science, 299:5609, pp. 1033-1036.
    • (2003) Science , vol.299 , Issue.5609 , pp. 1033-1036
    • Pasare, C.C.1    Medzhitov, R.R.2
  • 45
    • 33646370647 scopus 로고    scopus 로고
    • TNF downmodulates the function of human CD4+CD25hi T-regulatory cells
    • Valencia, X., Stephens, G. Goldbach-Mansky, R. et al. (2006) TNF downmodulates the function of human CD4+CD25hi T-regulatory cells. Blood, 108:1, pp. 253-261.
    • (2006) Blood , vol.108 , Issue.1 , pp. 253-261
    • Valencia, X.1    Stephens, G.2    Goldbach-Mansky, R.3
  • 46
    • 34147128572 scopus 로고    scopus 로고
    • Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation
    • Korn, T., Reddy, J. Gao, W. et al. (2007) Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med, 13:4, pp. 423-431.
    • (2007) Nat Med , vol.13 , Issue.4 , pp. 423-431
    • Korn, T.1    Reddy, J.2    Gao, W.3
  • 48
    • 3242801352 scopus 로고    scopus 로고
    • Large-scale in vitro expansion of polyclonal human CD4(+)CD25 high regulatory T cells
    • Hoffmann, P., Eder, R. Kunz-Schughart, LA et al. (2004) Large-scale in vitro expansion of polyclonal human CD4(+)CD25 high regulatory T cells. Blood, 104:3, pp. 895-903.
    • (2004) Blood , vol.104 , Issue.3 , pp. 895-903
    • Hoffmann, P.1    Eder, R.2    Kunz-Schughart, L.A.3
  • 49
    • 33747079987 scopus 로고    scopus 로고
    • Ex vivo expansion of human CD4+ CD25 high regulatory T cells from transplant recipients permits functional analysis of small blood samples
    • Kreijveld, E., Koenen, HJ, Hilbrands, LB and Joosten, I. (2006) Ex vivo expansion of human CD4+ CD25 high regulatory T cells from transplant recipients permits functional analysis of small blood samples. J Immunol Methods, 314:12, pp. 103-113.
    • (2006) J Immunol Methods , vol.314 , Issue.12 , pp. 103-113
    • Kreijveld, E.1    Koenen, H.J.2    Hilbrands, L.B.3    Joosten, I.4
  • 50
    • 17144374934 scopus 로고    scopus 로고
    • Regulatory T-cell therapy: Is it ready for the clinic?
    • Bluestone, JA (2005) Regulatory T-cell therapy: Is it ready for the clinic?. Nat Rev Immunol, 5:4, pp. 343-349.
    • (2005) Nat Rev Immunol , vol.5 , Issue.4 , pp. 343-349
    • Bluestone, J.A.1
  • 51
    • 6944244007 scopus 로고    scopus 로고
    • Regulation of antigen-specific regulatory T-cell induction via nasal and oral mucosa
    • Samsom, JN (2004) Regulation of antigen-specific regulatory T-cell induction via nasal and oral mucosa. Crit Rev Immunol, 24:3, pp. 157-177.
    • (2004) Crit Rev Immunol , vol.24 , Issue.3 , pp. 157-177
    • Samsom, J.N.1
  • 52
    • 31044440026 scopus 로고    scopus 로고
    • T cell epitope-specific immune therapy for rheumatic diseases
    • Albani, S. and Prakken, B. (2006) T cell epitope-specific immune therapy for rheumatic diseases. Arthritis Rheum, 54:1, pp. 19-25.
    • (2006) Arthritis Rheum , vol.54 , Issue.1 , pp. 19-25
    • Albani, S.1    Prakken, B.2
  • 53
    • 21844457408 scopus 로고    scopus 로고
    • Tolerogenic immune responses to novel T-cell epitopes from heat-shock protein 60 in juvenile idiopathic arthritis
    • Kamphuis, S., Kuis, W. de Jager, W. et al. (2005) Tolerogenic immune responses to novel T-cell epitopes from heat-shock protein 60 in juvenile idiopathic arthritis. Lancet, 366:9479, pp. 50-56.
    • (2005) Lancet , vol.366 , Issue.9479 , pp. 50-56
    • Kamphuis, S.1    Kuis, W.2    de Jager, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.