TGF- Bβ 1-induced expression of the poor prognosis SERPINE1/PAI-1 gene requires EGFR signaling: A new target for anti-EGFR therapy

Journal of Oncology

Volumn , Issue , 2009, Pages

  Higgins, Paul J ^a   Samarakoon, Rohan ^a   Higgins, Craig E ^a   Higgins, Stephen P ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; NEUROSERPIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEINASE; PROTEINASE INHIBITOR; TRANSFORMING GROWTH FACTOR BETA1;

ANGIOGENESIS; ARTICLE; CANCER GROWTH; CANCER INVASION; CANCER MODEL; CARCINOMA; CELL ASSAY; CELL MIGRATION; CELL STIMULATION; EPITHELIUM; GENE AMPLIFICATION; GENE CONTROL; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE INTERACTION; GENETIC ANALYSIS; GENETIC MODEL; HUMAN; INFLAMMATION; MICROENVIRONMENT; NONHUMAN; PHENOTYPE; PLASTICITY; PROGNOSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SKIN CANCER; SKIN CARCINOMA; SQUAMOUS CELL CARCINOMA; STROMA; TRANSCRIPTION INITIATION; UPREGULATION; WOUND HEALING;

EID: 65349172621     PISSN: 16878450     EISSN: 16878469     Source Type: Journal    
DOI: 10.1155/2009/342391     Document Type: Article

References (56)

1. Breitkreutz D., Boukamp P., Ryle C. M., Stark H.-J., Roop D. R., Fusenig N. E., Epidermal morphogenesis and keratin expression in c-Ha- ras -transfected tumorigenic clones of the human HaCaT cell line Cancer Research 1991 51 16 4402 4409
2. Dlugosz A., Merlino G., Yuspa S. H., Progress in cutaneous cancer research Journal of Investigative Dermatology Symposium Proceedings 2002 7 1 17 26 (Pubitemid 36151090)
3. Boukamp P., UV-induced skin cancer: similarities variations Journal der Deutschen Dermatologischen Gesellschaft 2005 3 7 493 503
4. Boukamp P., Peter W., Pascheberg U., Step-wise progression in human skin carcinogenesis in vitro involves mutational inactivation of p53, rasH oncogene activation and additional chromosome loss Oncogene 1995 11 5 961 969
5. Smoller B. R., Squamous cell carcinoma: from precursor lesions to high-risk variants Modern Pathology 2006 19 supplement 2 S88 S92 (Pubitemid 43172311)
6. Tsai K. Y., Tsao H., The genetics of skin cancer American Journal of Medical Genetics Part C 2004 131 1 82 92 (Pubitemid 39441637)
7. Akhurst R. J., Balmain A., Genetic events and the role of TGF in epithelial tumour progression The Journal of Pathology 1999 187 1 82 90 (Pubitemid 29009837)
8. Cui W., Fowlis D. J., Bryson S., TGF 1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice Cell 1996 86 4 531 542 (Pubitemid 26299485)
9. Portella G., Cumming S. A., Liddell J., Transforming growth factor is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion Cell Growth Differentiation 1998 9 5 393 404 (Pubitemid 28345878)
10. Derynck R., Akhurst R. J., Balmain A., TGF- signaling in tumor suppression and cancer progression Nature Genetics 2001 29 2 117 129 (Pubitemid 32952643)
11. Oft M., Akhurst R. J., Balmain A., Metastasis is driven by sequental elevation of H-ras and Smad2 levels Nature Cell Biology 2002 4 7 487 494 (Pubitemid 34752433)
12. Han G., Lu S.-L., Li A. G., Distinct mechanisms of TGF- 1-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis The Journal of Clinical Investigation 2005 115 7 1714 1723 (Pubitemid 40979710)
13. Kretzschmar M., Doody J., Timokhina I., Massagu J., A mechanism of repression of TGFf /Smad signaling by oncogenic Ras Genes Development 1999 13 7 804 816 (Pubitemid 29169840)
14. Rho O., Beltrn L. M., Gimenez-Conti I. B., DiGiovanni J., Altered expression of the epidermal growth factor receptor and transforming growth factor- during multistage skin carcinogenesis in SENCAR mice Molecular Carcinogenesis 1994 11 1 19 28 (Pubitemid 24337381)
15. Yuspa S. H., The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis Journal of Dermatological Science 1998 17 1 1 7 (Pubitemid 28253040)
16. O-Charoenrat P., Rhys-Evans P., Modjtahedi H., Court W., Box G., Eccles S., Overexpression of epidermal growth factor receptor in human head and neck squamous carcinoma cell lines correlates with matrix metalloproteinase-9 expression and in vitro invasion International Journal of Cancer 2000 86 3 307 317 (Pubitemid 30187489)
17. O-Charoenrat P., Rhys-Evans P. H., Archer D. J., Eccles S. A., C- erb B receptors in squamous cell carcinomas of the head and neck: clinical significance and correlation with matrix metalloproteinases and vascular endothelial growth factors Oral Oncology 2002 38 1 73 80 (Pubitemid 34076575)
18. Moghal N., Sternberg P. W., Multiple positive and negative regulators of signaling by the EGF-receptor Current Opinion in Cell Biology 1999 11 2 190 196 (Pubitemid 29164033)
19. Shimizu T., Izumi H., Oga A., Epidermal growth factor receptor overexpression and genetic aberrations in metastatic squamous-cell carcinoma of the skin Dermatology 2001 202 3 203 206 (Pubitemid 32506966)
20. Zavadil J., Bttinger E. P., TGF- and epithelial-to-mesenchymal transitions Oncogene 2005 24 37 5764 5774 (Pubitemid 43086136)
21. Zavadil J., Bitzer M., Liang D., Genetic programs of epithelial cell plasticity directed by transforming growth factor- Proceedings of the National Academy of Sciences of the United States of America 2001 98 12 6686 6691 (Pubitemid 32538277)
22. Thiery J. P., Sleeman J. P., Complex networks orchestrate epithelial-mesenchymal transitions Nature Reviews Molecular Cell Biology 2006 7 2 131 142 (Pubitemid 43278296)
23. Peinado H., Quintanilla M., Cano A., Transforming growth factor -1 induces snail transcription factor in epithelial cell lines. Mechanisms for epithelial mesenchymal transitions The Journal of Biological Chemistry 2003 278 23 21113 21123 (Pubitemid 36806424)
24. Wilkins-Port C. E., Higgins C. E., Freytag J., Higgins S. P., Carlson J. A., Higgins P. J., PAI-1 is a critical upstream regulator of the TGF- 1/EGF-induced invasive phenotype in mutant p53 human cutaneous squamous cell carcinoma Journal of Biomedicine and Biotechnology 2007 2007 8 (Pubitemid 46609224)
25. Wilkins-Port C. E., Higgins P. J., Regulation of extracellular matrix remodeling following transforming growth factor- 1/epidermal growth factor-stimulated epithelial-mesenchymal transition in human premalignant keratinocytes Cells Tissues Organs 2007 185 13 116 122 (Pubitemid 46956852)
26. Qi L., Higgins S. P., Lu Q., SERPINE1 (PAI-1) is a prominent member of the early G 0 → G 1 transition wound repair transcriptome in p53 mutant human keratinocytes Journal of Investigative Dermatology 2008 128 3 749 753
27. Akiyoshi S., Ishii M., Nemoto N., Kawabata M., Aburatani H., Miyazono K., Targets of transcriptional regulation by transforming growth factor- expression profile analysis using oligonucleotide arrays Japanese Journal of Cancer Research 2001 92 3 257 268 (Pubitemid 32288287)
28. Moreno-Bueno G., Cubillo E., Sarri D., Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for snail, slug, and E47 Factors in epithelial- mesenchymal transition Cancer Research 2006 66 19 9543 9556 (Pubitemid 44623653)
29. Andreasen P. A., Kj F8;ller L., Christensen L., Duffy M. J., The urokinase-type plasminogen activator system in cancer metastasis: a review International Journal of Cancer 1997 72 1 1 22 (Pubitemid 27314632)
30. Bajou K., Masson V., Gerard R. D., The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin: implications for antiangiogenic strategies Journal of Cell Biology 2001 152 4 777 784 (Pubitemid 34280162)
31. Bajou K., No EB;l A., Gerard R. D., Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization Nature Medicine 1998 4 8 923 928 (Pubitemid 28364031)
32. Chen Y.-J., Lin S.-C., Kao T., Genome-wide profiling of oral squamous cell carcinoma The Journal of Pathology 2004 204 3 326 332 (Pubitemid 39430093)
33. Lindberg P., Larsson , Nielsen B. S., Expression of plasminogen activator inhibitor-1, urokinase receptor and laminin -2 chain is an early coordinated event in incipient oral squamous cell carcinoma International Journal of Cancer 2006 118 12 2948 2956
34. Illemann M., Hansen U., Nielsen H. J., Leading-edge myofibroblasts in human colon cancer express plasminogen activator inhibitor-1 American Journal of Clinical Pathology 2004 122 2 256 265 (Pubitemid 38971359)
35. Offersen B. V., Nielsen B. S., HF8;yer-Hansen G., The myofibroblast is the predominant plasminogen activator inhibitor-1-expressing cell type in human breast carcinomas American Journal of Pathology 2003 163 5 1887 1899 (Pubitemid 37310019)
36. Robert C., Bolon I., Gazzeri S., Veyrenc S., Brambilla C., Brambilla E., Expression of plasminogen activator inhibitors 1 and 2 in lung cancer and their role in tumor progression Clinical Cancer Research 1999 5 8 2094 2102 (Pubitemid 29399264)
37. Vairaktaris E., Yapijakis C., Serefoglou Z., Plasminogen activator inhibitor-1 polymorphism is associated with increased risk for oral cancer Oral Oncology 2006 42 9 888 892 (Pubitemid 44467859)
38. Hundsdorfer B., Zeilhofer H.-F., Bock K. P., Tumour-associated urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in normal and neoplastic tissues of patients with squamous cell cancer of the oral cavity-clinical relevance and prognostic value Journal of Cranio-Maxillofacial Surgery 2005 33 3 191 196 (Pubitemid 40614180)
39. Maquerlot F., Galiacy S., Malo M., Dual role for plasminogen activator inhibitor type 1 as soluble and as matricellular regulator of epithelial alveolar cell wound healing American Journal of Pathology 2006 169 5 1624 1632
40. Higgins P. J., TGF- 1-stimulated p21 r a s -ERK signaling regulates expression of the angiogenic SERPIN PAI-1 Recent Research Developments in Biochemistry 2006 7 31 45
41. Maillard C., Jost M., Rmer M. U., Host plasminogen activator inhibitor-1 promotes human skin carcinoma progression in a stage-dependent manner Neoplasia 2005 7 1 57 66 (Pubitemid 40209471)
42. Galibert M.-D., Carreira S., Goding C. R., The Usf-1 transcription factor is a novel target for the stress-responsive p38 kinase and mediates UV-induced Tyrosinase expression The EMBO Journal 2001 20 17 5022 5031 (Pubitemid 32851035)
43. Kutz S. M., Higgins C. E., Samarakoon R., TGF-1-induced PAI-1 expression is e box/USF-dependent and requires EGFR signaling Experimental Cell Research 2006 312 7 1093 1105
44. Qi L., Allen R. R., Lu Q., Higgins C. E., Garone R., Staiano-Coico L., Higgins P. J., PAI-1 transcriptional regulation during the G 0 → G 1 transition in human epidermal keratinocytes Journal of Cellular Biochemistry 2006 99 2 495 507 (Pubitemid 44435566)
45. Derynck R., Zhang Y. E., Smad-dependent and Smad-independent pathways in TGF- family signalling Nature 2003 425 6958 577 584 (Pubitemid 37280136)
46. Samarakoon R., Higgins C. E., Higgins S. P., Kutz S. M., Higgins P. J., Plasminogen activator inhibitor type-1 gene expression and induced migration in TGF-1-stimulated smooth muscle cells is pp60 c-s r c /MEK-dependent Journal of Cellular Physiology 2005 204 1 236 246 (Pubitemid 40776827)
47. Samarakoon R., Higgins S. P., Higgins C. E., Higgins P. J., TGF- 1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60 c-s r c / EGFR Y 845 and Rho/ROCK signaling Journal of Molecular and Cellular Cardiology 2008 44 3 527 538
48. Ishizawar R., Parsons S. J., C-Src and cooperating partners in human cancer Cancer Cell 2004 6 3 209 214 (Pubitemid 39222033)
49. Chen S., Crawford M., Day R. M., RhoA modulates Smad signaling during transforming growth factor- -induced smooth muscle differentiation The Journal of Biological Chemistry 2006 281 3 1765 1770 (Pubitemid 43752494)
50. Kita T., Hata Y., Kano K., Transforming growth factor- 2 and connective tissue growth factor in proliferative vitreoretinal diseases: possible involvement of hyalocytes and therapeutic potential of Rho kinase inhibitor Diabetes 2007 56 1 231 238 (Pubitemid 46263122)
51. Itoh S., ten Dijke P., Negative regulation of TGF- receptor/Smad signal transduction Current Opinion in Cell Biology 2007 19 2 176 184 (Pubitemid 46386411)
52. Lin X., Duan X., Liang Y.-Y., PPM1A functions as a Smad phosphatase to terminate TGF signaling Cell 2006 125 5 915 928 (Pubitemid 43795197)
53. Allen R. R., Qi L., Higgins P. J., Upstream stimulatory factor regulates E box-dependent PAI-1 transcription in human epidermal keratinocytes Journal of Cellular Physiology 2005 203 1 156 165 (Pubitemid 40328182)
54. Hua X., Miller Z. A., Wu G., Shi Y., Lodish H. F., Specificity in transforming growth factor-induced transcription of the plasminogen activator inhibitor-1 gene: interactions of promoter DNA, transcription factor E3, and Smad proteins Proceedings of the National Academy of Sciences of the United States of America 1999 96 23 13130 13135
55. Zhang Y. E., Non-Smad pathways in TGF- signaling Cell Research 2009 19 1 128 139
56. Lee M. K., Pardoux C., Hall M. C., TGF- activates Erk MAP kinase signalling through direct phsophorylation of ShcA The EMBO Journal 2007 26 3957 3967 (Pubitemid 47367487)