메뉴 건너뛰기




Volumn 7, Issue 1, 2009, Pages 43-55

Pharmacogenetics of depression in elderly patients;Pharmacogénétique de la dépression du sujet âgé

Author keywords

CYP2D6; Depression; Elderly; Pharmacogenetics; Serotonin transporter

Indexed keywords

AMITRIPTYLINE; CIMETIDINE; CITALOPRAM; CYTOCHROME P450 2D6; DILTIAZEM; DIPHENHYDRAMINE; FLUVOXAMINE; MIRTAZAPINE; NORTRIPTYLINE; ORPHENADRINE; PAROXETINE; QUINIDINE; SEROTONIN TRANSPORTER; SERTRALINE; VENLAFAXINE;

EID: 65349169456     PISSN: 17601703     EISSN: 19506988     Source Type: Journal    
DOI: 10.3684/pnv.2009.0157     Document Type: Review
Times cited : (2)

References (89)
  • 1
    • 27244444795 scopus 로고    scopus 로고
    • The evolution of the Global Burden of Disease framework for disease, injury and risk factor quantification : Developing the evidence base for national, regional and global public health action
    • Lopez AD. The evolution of the Global Burden of Disease framework for disease, injury and risk factor quantification : developing the evidence base for national, regional and global public health action. Global Health 2005 ; 1 : 5.
    • (2005) Global Health , vol.1 , pp. 5
    • Lopez, A.D.1
  • 2
    • 0031789272 scopus 로고    scopus 로고
    • The global burden of disease, 1990-2020
    • Lopez AD, Murray CC. The global burden of disease, 1990-2020. Nat Med 1998; 4: 1241-3.
    • (1998) Nat Med , vol.4 , pp. 1241-1243
    • Lopez, A.D.1    Murray, C.C.2
  • 3
    • 0029907597 scopus 로고    scopus 로고
    • Evidence-based health policy--lessons from the Global Burden of Disease Study
    • Murray CJ, Lopez AD. Evidence-based health policy--lessons from the Global Burden of Disease Study. Science 1996; 274: 740-3.
    • (1996) Science , vol.274 , pp. 740-743
    • Murray, C.J.1    Lopez, A.D.2
  • 4
    • 33845338724 scopus 로고    scopus 로고
    • Projections of global mortality and burden of disease from 2002 to 2030
    • Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 2006 ; 3 : e442.
    • (2006) PLoS Med , vol.3
    • Mathers, C.D.1    Loncar, D.2
  • 5
    • 35748945434 scopus 로고    scopus 로고
    • Lifetime prevalence and age-of-onset distributions of mental disorders in the World Health Organization's World Mental Health Survey Initiative
    • Kessler RC, Angermeyer M, Anthony JC, De Graaf R, Demytte- naere K, Gasquet I, et al. Lifetime prevalence and age-of-onset distributions of mental disorders in the World Health Organization's World Mental Health Survey Initiative. World Psychiatry 2007 ; 6 : 168-76.
    • (2007) World Psychiatry , vol.6 , pp. 168-176
    • Kessler, R.C.1    Angermeyer, M.2    Anthony, J.C.3    De Graaf, R.4    Demytte- naere, K.5    Gasquet, I.6
  • 6
    • 0028156958 scopus 로고
    • Lifetime and 12-month prevalence of DSM- III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey
    • Kessler RC, McGonagle KA, Zhao S, Nelson CB, Hughes M, Eshleman S, et al. Lifetime and 12-month prevalence of DSM- III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry 1994; 51 :8-19.
    • (1994) Arch Gen Psychiatry , vol.51 , pp. 8-19
    • Kessler, R.C.1    McGonagle, K.A.2    Zhao, S.3    Nelson, C.B.4    Hughes, M.5    Eshleman, S.6
  • 7
    • 52449123092 scopus 로고    scopus 로고
    • Pharmacogenetics of major depression : Insights from level 1 of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial
    • Lekman M, Paddock S, McMahon FJ. Pharmacogenetics of major depression : insights from level 1 of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial. Mol Diagn Ther 2008 ; 12 : 321-30.
    • (2008) Mol Diagn Ther , vol.12 , pp. 321-330
    • Lekman, M.1    Paddock, S.2    McMahon, F.J.3
  • 8
    • 33645501005 scopus 로고    scopus 로고
    • Pharmacogenomics and antidepressant drugs
    • Binder EB, Holsboer F. Pharmacogenomics and antidepressant drugs. Ann Med 2006 ; 38 : 82-94.
    • (2006) Ann Med , vol.38 , pp. 82-94
    • Binder, E.B.1    Holsboer, F.2
  • 9
    • 0346639205 scopus 로고    scopus 로고
    • Individualized medicine - implementation of pharmacogenetic diagnostics in antidepressant drug treatment of major depressive disorders
    • Kirchheiner J, Bertilsson L, Bruus H, Wolff A, Roots I, Bauer M. Individualized medicine - implementation of pharmacogenetic diagnostics in antidepressant drug treatment of major depressive disorders. Pharmacopsychiatry 2003 ; 36(Suppl. 3) : S235-43.
    • (2003) Pharmacopsychiatry , vol.36 , Issue.SUPPL. 3
    • Kirchheiner, J.1    Bertilsson, L.2    Bruus, H.3    Wolff, A.4    Roots, I.5    Bauer, M.6
  • 10
    • 25444532003 scopus 로고    scopus 로고
    • Aging and clinical pharmacology: Implications for antidepressants
    • Lotrich FE, Pollock BG. Aging and clinical pharmacology: implications for antidepressants. J Clin Pharmacol 2005 ; 45 :1106-22.
    • (2005) J Clin Pharmacol , vol.45 , pp. 1106-1122
    • Lotrich, F.E.1    Pollock, B.G.2
  • 11
    • 0347185032 scopus 로고    scopus 로고
    • Pharmacogenomics and "individualized drug therapy": High expectations and disappointing achievements
    • Nebert DW, Jorge-Nebert L, Vesell ES. Pharmacogenomics and "individualized drug therapy": high expectations and disappointing achievements. Am J Pharmacogenomics 2003; 3: 361-70.
    • (2003) Am J Pharmacogenomics , vol.3 , pp. 361-370
    • Nebert, D.W.1    Jorge-Nebert, L.2    Vesell, E.S.3
  • 12
    • 34249016361 scopus 로고    scopus 로고
    • The convergence of conventional therapeutic drug monitoring and pharmacogenetic testing in personalized medicine : Focus on antidepressants
    • Sjöqvist F, Eliasson E. The convergence of conventional therapeutic drug monitoring and pharmacogenetic testing in personalized medicine : focus on antidepressants. Clin Pharmacol Ther 2007 ; 81 : 899-902.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 899-902
    • Sjöqvist, F.1    Eliasson, E.2
  • 13
    • 0001994324 scopus 로고
    • On mice, microsomes and man
    • Brodie BB. On mice, microsomes and man. Pharmacologist 1964 ; 6 : 12-26.
    • (1964) Pharmacologist , vol.6 , pp. 12-26
    • Brodie, B.B.1
  • 14
    • 0033973925 scopus 로고    scopus 로고
    • Pharmacogenetic method as a complement to therapeutic monitoring of antidepressants and neuroleptics
    • Dahl ML, Sjöqvist F. Pharmacogenetic method as a complement to therapeutic monitoring of antidepressants and neuroleptics. Drug Monitoring 2000 ; 22 : 114-7.
    • (2000) Drug Monitoring , vol.22 , pp. 114-117
    • Dahl, M.L.1    Sjöqvist, F.2
  • 16
    • 0000616920 scopus 로고
    • Enzymatic deficiency in primaquine sensitive erythrocytes
    • Carson PE, Flanagan CL, Ickes CE, Alvong AS. Enzymatic deficiency in primaquine sensitive erythrocytes. Science 1956; 124: 484-5.
    • (1956) Science , vol.124 , pp. 484-485
    • Carson, P.E.1    Flanagan, C.L.2    Ickes, C.E.3    Alvong, A.S.4
  • 17
    • 49749154208 scopus 로고
    • Familial incidence of low pseudocholinesterase level
    • Kalow W. Familial incidence of low pseudocholinesterase level. Lancet 1956; II : 576-7.
    • (1956) Lancet , vol.2 , pp. 576-577
    • Kalow, W.1
  • 21
    • 0024236331 scopus 로고
    • The molecular biology of cytochrome P450s
    • Gonzalez FJ. The molecular biology of cytochrome P450s. Pharmacol Rev 1988 ; 40 : 243-88.
    • (1988) Pharmacol Rev , vol.40 , pp. 243-288
    • Gonzalez, F.J.1
  • 22
    • 0023854270 scopus 로고
    • Characterization of the common genetic defect in humans deficient in debrisoquine metabolism
    • Gonzalez FJ, Skoda RC, Kimura S, Umeno M, Zanger UM, Nebert DW, et al. Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature 1988;331 : 442-6.
    • (1988) Nature , vol.331 , pp. 442-446
    • Gonzalez, F.J.1    Skoda, R.C.2    Kimura, S.3    Umeno, M.4    Zanger, U.M.5    Nebert, D.W.6
  • 24
    • 0032964679 scopus 로고    scopus 로고
    • Polymorphic cytochromes P450 and drugs used in psychiatry
    • Coutts RT, Urichuk LJ. Polymorphic cytochromes P450 and drugs used in psychiatry. CellMolNeurobiol1999; 19: 325-54.
    • (1999) CellMolNeurobiol , vol.19 , pp. 325-354
    • Coutts, R.T.1    Urichuk, L.J.2
  • 25
    • 0042787570 scopus 로고    scopus 로고
    • Antidepressant drugs in the elderly-role of the cytochrome P450 2D6
    • Vandel P. Antidepressant drugs in the elderly-role of the cytochrome P450 2D6. World J Biol Psychiatry 2003 ; 4 : 74-80.
    • (2003) World J Biol Psychiatry , vol.4 , pp. 74-80
    • Vandel, P.1
  • 26
    • 20244366089 scopus 로고    scopus 로고
    • Cytochrome p450 polymorphisms in geriatric patients : Impact on adverse drug reactions-- a pilot study
    • Egger T, Dormann H, Ahne G, Pahl A, Runge U, Azaz-Livshits T, et al. Cytochrome p450 polymorphisms in geriatric patients : impact on adverse drug reactions-- a pilot study. Drugs Aging 2005 ; 22 : 265-72.
    • (2005) Drugs Aging , vol.22 , pp. 265-272
    • Egger, T.1    Dormann, H.2    Ahne, G.3    Pahl, A.4    Runge, U.5    Azaz-Livshits, T.6
  • 27
    • 9144246190 scopus 로고    scopus 로고
    • Drug development and use in the elderly : Search for the right dose and dosing regimen (Parts I and II)
    • Shah RR. Drug development and use in the elderly : search for the right dose and dosing regimen (Parts I and II). Br J Clin Pharmacol 2004 ; 58 : 452-69.
    • (2004) Br J Clin Pharmacol , vol.58 , pp. 452-469
    • Shah, R.R.1
  • 28
    • 0034112529 scopus 로고    scopus 로고
    • Antidepressants in the elderly: Challenges for study design and their interpretation
    • Parikh C. Antidepressants in the elderly: challenges for study design and their interpretation. Br J Clin Pharmacol 2000; 49:539-47.
    • (2000) Br J Clin Pharmacol , vol.49 , pp. 539-547
    • Parikh, C.1
  • 29
    • 54449099519 scopus 로고    scopus 로고
    • Assessment of the prescription of antidepressant drugs in elderly nursing home patients : A clinical and laboratory follow-up investigation
    • Cherma MD, Lofgren UB, Almkvist G, Hallert C, Bengtsson F. Assessment of the prescription of antidepressant drugs in elderly nursing home patients : a clinical and laboratory follow-up investigation. J Clin Psychopharmacol 2008 ; 28 : 424-31.
    • (2008) J Clin Psychopharmacol , vol.28 , pp. 424-431
    • Cherma, M.D.1    Lofgren, U.B.2    Almkvist, G.3    Hallert, C.4    Bengtsson, F.5
  • 30
    • 0032833203 scopus 로고    scopus 로고
    • Adverse reactions of antidepressants in elderly patients
    • Pollock BG. Adverse reactions of antidepressants in elderly patients. J Clin Psychiatry 1999 ; 60(Suppl. 20): 4-8.
    • (1999) J Clin Psychiatry , vol.60 , Issue.SUPPL. 20 , pp. 4-8
    • Pollock, B.G.1
  • 32
    • 0034783988 scopus 로고    scopus 로고
    • Murphy Jr. GM, Pollock BG, Kirshner MA, Pascoe N, CheukW, Mulsant BH, et al. CYP2D6 genotyping with oligonucleotide microarrays and nortriptyline concentrations in geriatric depression. Neuropsychopharmacology 2001 ; 25 : 737-43.
    • Murphy Jr. GM, Pollock BG, Kirshner MA, Pascoe N, CheukW, Mulsant BH, et al. CYP2D6 genotyping with oligonucleotide microarrays and nortriptyline concentrations in geriatric depression. Neuropsychopharmacology 2001 ; 25 : 737-43.
  • 34
    • 20944450478 scopus 로고    scopus 로고
    • Treating depression in the elderly : An update on antidepressants
    • Buffum MD, Buffum JC. Treating depression in the elderly : an update on antidepressants. Geriatr Nurs 2005; 26: 138-42.
    • (2005) Geriatr Nurs , vol.26 , pp. 138-142
    • Buffum, M.D.1    Buffum, J.C.2
  • 35
    • 0032066120 scopus 로고    scopus 로고
    • Treatment of depression in elderly patients : Recent advances
    • Dasgupta K. Treatment of depression in elderly patients : recent advances. Arch Fam Med 1998 ; 7 : 274-80.
    • (1998) Arch Fam Med , vol.7 , pp. 274-280
    • Dasgupta, K.1
  • 36
    • 23044438927 scopus 로고    scopus 로고
    • The efficacy of antidepressants in the treatment of late-life depression
    • Roose SP, Schatzberg AF. The efficacy of antidepressants in the treatment of late-life depression. J Clin Psychopharmacol 2005 ; 25 : S1-7.
    • (2005) J Clin Psychopharmacol , vol.25
    • Roose, S.P.1    Schatzberg, A.F.2
  • 37
    • 0014693146 scopus 로고
    • Steady-state plasma levels of nortriptyline in twins : Influence of genetic factors and drug therapy
    • Alexanderson B, Evans DA, Sjoqvist F. Steady-state plasma levels of nortriptyline in twins : influence of genetic factors and drug therapy. Br Med J 1969 ; 4 : 764-8.
    • (1969) Br Med J , vol.4 , pp. 764-768
    • Alexanderson, B.1    Evans, D.A.2    Sjoqvist, F.3
  • 38
    • 0014128388 scopus 로고
    • Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds
    • Hammer W, Sjcöqvist F. Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds. Life Sci 1967 ; 6 : 1895-903.
    • (1967) Life Sci , vol.6 , pp. 1895-1903
    • Hammer, W.1    Sjcöqvist, F.2
  • 39
    • 33846134330 scopus 로고    scopus 로고
    • Pharmacogenetics and drug therapy in psychiatry--the role of the CYP2D6 polymorphism
    • Vandel P, Talon JM, Haffen E, Sechter D. Pharmacogenetics and drug therapy in psychiatry--the role of the CYP2D6 polymorphism. Curr Pharm Des 2007 ; 13 : 241-50.
    • (2007) Curr Pharm Des , vol.13 , pp. 241-250
    • Vandel, P.1    Talon, J.M.2    Haffen, E.3    Sechter, D.4
  • 40
    • 0034894010 scopus 로고    scopus 로고
    • CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants : A first step towards subpopulation- specific dosages
    • Kirchheiner J, Brosen K, Dahl ML, Gram LF, Kasper S, Roots I, et al. CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants : a first step towards subpopulation- specific dosages. Acta Psychiatr Scand 2001 ; 104 : 173-92.
    • (2001) Acta Psychiatr Scand , vol.104 , pp. 173-192
    • Kirchheiner, J.1    Brosen, K.2    Dahl, M.L.3    Gram, L.F.4    Kasper, S.5    Roots, I.6
  • 41
    • 13544249943 scopus 로고    scopus 로고
    • Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6) : Clinical consequences, evolutionary aspects and functional diversity
    • Ingelman-Sundberg M. Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6) : clinical consequences, evolutionary aspects and functional diversity. Pharmacogenomics J 2005; 5:6-13.
    • (2005) Pharmacogenomics J , vol.5 , pp. 6-13
    • Ingelman-Sundberg, M.1
  • 43
    • 0030860004 scopus 로고    scopus 로고
    • Polymorphism of the cytochrome P450 CYP2D6 gene in a European population : Characterization of 48 mutations and 53 alleles, their frequencies and evolution
    • Marez D, Legrand M, Sabbagh N, Guidice JM, Spire C, Lafitte JJ, et al. Polymorphism of the cytochrome P450 CYP2D6 gene in a European population : characterization of 48 mutations and 53 alleles, their frequencies and evolution. Pharmacogenetics 1997 ;7 : 193-202.
    • (1997) Pharmacogenetics , vol.7 , pp. 193-202
    • Marez, D.1    Legrand, M.2    Sabbagh, N.3    Guidice, J.M.4    Spire, C.5    Lafitte, J.J.6
  • 44
    • 0031038038 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 variants in a Caucasian population : Allele frequencies and phenotypic consequences
    • Sachse C, Brockmoller J, Bauer S, Roots I. Cytochrome P450 2D6 variants in a Caucasian population : allele frequencies and phenotypic consequences. Am J Hum Genet 1997 ; 60 : 284-95.
    • (1997) Am J Hum Genet , vol.60 , pp. 284-295
    • Sachse, C.1    Brockmoller, J.2    Bauer, S.3    Roots, I.4
  • 45
    • 0346363770 scopus 로고    scopus 로고
    • CYP2D6 genotyping strategy based on gene copy number determination by TaqMan real-time PCR
    • Schaeffeler E, Schwab M, Eichelbaum M, Zanger UM. CYP2D6 genotyping strategy based on gene copy number determination by TaqMan real-time PCR. Hum Mutat 2003 ; 22 : 476-85.
    • (2003) Hum Mutat , vol.22 , pp. 476-485
    • Schaeffeler, E.1    Schwab, M.2    Eichelbaum, M.3    Zanger, U.M.4
  • 46
    • 0025805934 scopus 로고
    • Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debriso- quine/sparteine polymorphism
    • Gaedigk A, Blum M, Gaedigk R, Eichelbaum M, Meyer UA. Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debriso- quine/sparteine polymorphism. Am J Hum Genet 1991; 48:943-50.
    • (1991) Am J Hum Genet , vol.48 , pp. 943-950
    • Gaedigk, A.1    Blum, M.2    Gaedigk, R.3    Eichelbaum, M.4    Meyer, U.A.5
  • 47
    • 0033790979 scopus 로고    scopus 로고
    • Elucidation of the genetic basis of the common 'intermediate metabolizer' phenotype for drug oxidation by CYP2D6
    • Raimundo S, Fischer J, Eichelbaum M, Griese EU, Schwab M, Zanger UM. Elucidation of the genetic basis of the common 'intermediate metabolizer' phenotype for drug oxidation by CYP2D6. Pharmacogenetics 2000 ; 10 : 577-81.
    • (2000) Pharmacogenetics , vol.10 , pp. 577-581
    • Raimundo, S.1    Fischer, J.2    Eichelbaum, M.3    Griese, E.U.4    Schwab, M.5    Zanger, U.M.6
  • 49
    • 36148976077 scopus 로고    scopus 로고
    • Influence of cytochrome P450 polymorphisms on drug therapies : Pharmacogenetic, pharmacoepigenetic and clinical aspects
    • Ingelman-Sundberg M, Sim SC, Gomez A, Rodriguez-Antona C. Influence of cytochrome P450 polymorphisms on drug therapies : pharmacogenetic, pharmacoepigenetic and clinical aspects. Pharmacol Ther 2007 ; 116 : 496-526.
    • (2007) Pharmacol Ther , vol.116 , pp. 496-526
    • Ingelman-Sundberg, M.1    Sim, S.C.2    Gomez, A.3    Rodriguez-Antona, C.4
  • 50
    • 0031949132 scopus 로고    scopus 로고
    • Dalen P, Dahl ML, Ruiz ML, Nordin C, Bertilsson L. 10- hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes. Clin Pharamcol Ther 1998 ; 63 :444-52.
    • Dalen P, Dahl ML, Ruiz ML, Nordin C, Bertilsson L. 10- hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes. Clin Pharamcol Ther 1998 ; 63 :444-52.
  • 51
    • 0036204756 scopus 로고    scopus 로고
    • Molecular genetics of CYP2D6 : Clinical relevance with focus on psychotropic drugs
    • Bertilsson L, Dahl ML, Dalen P, Al-Shurbaji A. Molecular genetics of CYP2D6 : clinical relevance with focus on psychotropic drugs. Br J Clin Pharmacol 2002 ; 53 : 111-22.
    • (2002) Br J Clin Pharmacol , vol.53 , pp. 111-122
    • Bertilsson, L.1    Dahl, M.L.2    Dalen, P.3    Al-Shurbaji, A.4
  • 53
    • 12944281041 scopus 로고    scopus 로고
    • Amitriptyline or not, that is the question : Pharmaco- genetic testing of CYP2D6 and CYP2C19 identifies patients with low or high risk for side effects in amitriptyline therapy
    • Steimer W, Zopf K, von Amelunxen S, Pfeiffer H, Bachofer J, Popp J, et al. Amitriptyline or not, that is the question : pharmaco- genetic testing of CYP2D6 and CYP2C19 identifies patients with low or high risk for side effects in amitriptyline therapy. Clin Chem 2005 ; 51 : 376-85.
    • (2005) Clin Chem , vol.51 , pp. 376-385
    • Steimer, W.1    Zopf, K.2    von Amelunxen, S.3    Pfeiffer, H.4    Bachofer, J.5    Popp, J.6
  • 54
    • 29544449443 scopus 로고    scopus 로고
    • Clinical guidelines for psychiatrists for the use of pharmacogenetic testing for CYP450 2D6 and CYP450 2C19
    • de Leon J, Armstrong SC, Cozza KL. Clinical guidelines for psychiatrists for the use of pharmacogenetic testing for CYP450 2D6 and CYP450 2C19. Psychosomatics 2006 ; 47 : 75-85.
    • (2006) Psychosomatics , vol.47 , pp. 75-85
    • de Leon, J.1    Armstrong, S.C.2    Cozza, K.L.3
  • 55
    • 33846380861 scopus 로고    scopus 로고
    • Clinical implications of pharmaco- genetics of cytochrome P450 drug metabolizing enzymes
    • Kirchheiner J, Seeringer A. Clinical implications of pharmaco- genetics of cytochrome P450 drug metabolizing enzymes. Bio- chim Biophys Acta 2007 ; 1770 : 489-94.
    • (2007) Bio- chim Biophys Acta , vol.1770 , pp. 489-494
    • Kirchheiner, J.1    Seeringer, A.2
  • 60
    • 0024573529 scopus 로고
    • The influence of cimetidine on debrisoquine 4-hydroxylation in extensive metabolizers
    • Philip PA, James CA, Rogers HJ. The influence of cimetidine on debrisoquine 4-hydroxylation in extensive metabolizers. Eur J Clin Pharmacol 1989 ; 36 : 319-21.
    • (1989) Eur J Clin Pharmacol , vol.36 , pp. 319-321
    • Philip, P.A.1    James, C.A.2    Rogers, H.J.3
  • 61
    • 0023279624 scopus 로고
    • Debrisoquine metabolism in parkinsonian patients treated with antihista- mine drugs
    • Poirier J, Roy M, Campanella G, Cloutier T, Paris S. Debrisoquine metabolism in parkinsonian patients treated with antihista- mine drugs. Lancet 1987 ; 2 : 386.
    • (1987) Lancet , vol.2 , pp. 386
    • Poirier, J.1    Roy, M.2    Campanella, G.3    Cloutier, T.4    Paris, S.5
  • 62
    • 0023002985 scopus 로고
    • Quinidine and the identification of drugs whose elimination is impaired in subjects classified as poor metabolizers of debrisoquine
    • Speirs CJ, Murray S, Boobis AR, Seddon CE, Davies DS. Quinidine and the identification of drugs whose elimination is impaired in subjects classified as poor metabolizers of debrisoquine. Br J Clin Pharmacol 1986 ; 22 : 739-43.
    • (1986) Br J Clin Pharmacol , vol.22 , pp. 739-743
    • Speirs, C.J.1    Murray, S.2    Boobis, A.R.3    Seddon, C.E.4    Davies, D.S.5
  • 64
    • 33749335980 scopus 로고    scopus 로고
    • Monoamine transporter gene polymorphisms and antidepressant response in Koreans with late-life depression
    • Kim H, Lim SW, Kim S, Kim JW, Chang YH, Carroll BJ, et al. Monoamine transporter gene polymorphisms and antidepressant response in Koreans with late-life depression. JAMA 2006 ; 296 :1609-18.
    • (2006) JAMA , vol.296 , pp. 1609-1618
    • Kim, H.1    Lim, S.W.2    Kim, S.3    Kim, J.W.4    Chang, Y.H.5    Carroll, B.J.6
  • 65
    • 7744233997 scopus 로고    scopus 로고
    • Effects of the serotonin transporter gene promoter polymorphism on mirtazapine and paroxetine efficacy and adverse events in geriatric major depression
    • Murphy Jr. GM, Hollander SB, Rodrigues HE, Kremer C, Schatzberg AF. Effects of the serotonin transporter gene promoter polymorphism on mirtazapine and paroxetine efficacy and adverse events in geriatric major depression. Arch Gen Psychiatry 2004 ; 61 : 1163-9.
    • (2004) Arch Gen Psychiatry , vol.61 , pp. 1163-1169
    • Murphy Jr., G.M.1    Hollander, S.B.2    Rodrigues, H.E.3    Kremer, C.4    Schatzberg, A.F.5
  • 67
    • 0029926315 scopus 로고    scopus 로고
    • Steady-state plasma levels of nortriptyline and its 10-hydroxy metabolite : Relationship to the CYP2D6 genotype
    • Dahl ML, Bertilsson L, Nordin C. Steady-state plasma levels of nortriptyline and its 10-hydroxy metabolite : relationship to the CYP2D6 genotype. Psychopharmacology 1996 ; 123 : 315-9.
    • (1996) Psychopharmacology , vol.123 , pp. 315-319
    • Dahl, M.L.1    Bertilsson, L.2    Nordin, C.3
  • 68
    • 0034115770 scopus 로고    scopus 로고
    • Steady-state plasma levels of nortriptyline and its hydro-xylated metabolites in Japanese patients : Impact of CYP2D6 genotype on the hydroxylation of nortriptyline
    • Morita S, Shimoda K, Someya T, Yoshimura Y, Kamijima K, Kato N. Steady-state plasma levels of nortriptyline and its hydro-xylated metabolites in Japanese patients : impact of CYP2D6 genotype on the hydroxylation of nortriptyline. J Clin Psychophar- macol 2000; 20: 141-9.
    • (2000) J Clin Psychophar- macol , vol.20 , pp. 141-149
    • Morita, S.1    Shimoda, K.2    Someya, T.3    Yoshimura, Y.4    Kamijima, K.5    Kato, N.6
  • 69
    • 0031668683 scopus 로고    scopus 로고
    • Pharmacokinetics of nortriptyline and its 10-hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes
    • Yue QY, Zhong ZH, Tybring G, Dalen P, Dahl ML, Bertilsson L, et al. Pharmacokinetics of nortriptyline and its 10-hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes. Clin Pharmacol Ther 1998 ; 64 : 385-90.
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 385-390
    • Yue, Q.Y.1    Zhong, Z.H.2    Tybring, G.3    Dalen, P.4    Dahl, M.L.5    Bertilsson, L.6
  • 70
    • 0006463359 scopus 로고    scopus 로고
    • Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
    • Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996;274 : 1527-31.
    • (1996) Science , vol.274 , pp. 1527-1531
    • Lesch, K.P.1    Bengel, D.2    Heils, A.3    Sabol, S.Z.4    Greenberg, B.D.5    Petri, S.6
  • 71
    • 0033525170 scopus 로고    scopus 로고
    • Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets
    • Greenberg BD, Tolliver TJ, Huang SJ, Li Q, Bengel D, Murphy DL. Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am J Med Genet 1999 ; 88 : 83-7.
    • (1999) Am J Med Genet , vol.88 , pp. 83-87
    • Greenberg, B.D.1    Tolliver, T.J.2    Huang, S.J.3    Li, Q.4    Bengel, D.5    Murphy, D.L.6
  • 73
    • 0034176712 scopus 로고    scopus 로고
    • A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity
    • Heinz A, Jones DW, Mazzanti C, Goldman D, Ragan P, Hommer D, et al. A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity. Biol Psychiatry 2000 ; 47 : 643-9.
    • (2000) Biol Psychiatry , vol.47 , pp. 643-649
    • Heinz, A.1    Jones, D.W.2    Mazzanti, C.3    Goldman, D.4    Ragan, P.5    Hommer, D.6
  • 74
    • 0033984363 scopus 로고    scopus 로고
    • Efficacy of paroxetine in depression is influenced by a functional polymorphism within the promoter of the serotonin transporter gene
    • Zanardi R, Benedetti F, Di Bella D, Catalano M, Smeraldi E. Efficacy of paroxetine in depression is influenced by a functional polymorphism within the promoter of the serotonin transporter gene. J Clin Psychopharmacol 2000 ; 20 : 105-7.
    • (2000) J Clin Psychopharmacol , vol.20 , pp. 105-107
    • Zanardi, R.1    Benedetti, F.2    Di Bella, D.3    Catalano, M.4    Smeraldi, E.5
  • 75
    • 0031736757 scopus 로고    scopus 로고
    • Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine
    • Smeraldi E, Zanardi R, Benedetti F, Di Bella D, Perez J, Cata- lano M. Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine. Mol Psychiatry 1998 ; 3 : 508-11.
    • (1998) Mol Psychiatry , vol.3 , pp. 508-511
    • Smeraldi, E.1    Zanardi, R.2    Benedetti, F.3    Di Bella, D.4    Perez, J.5    Cata- lano, M.6
  • 76
    • 33750684329 scopus 로고    scopus 로고
    • Pooling pharmacogenetic studies on the serotonin transporter : A mega-analysis
    • Serretti A, Cusin C, Rausch JL, Bondy B, Smeraldi E. Pooling pharmacogenetic studies on the serotonin transporter : a mega-analysis. Psychiatry Res 2006 ; 145 : 61-5.
    • (2006) Psychiatry Res , vol.145 , pp. 61-65
    • Serretti, A.1    Cusin, C.2    Rausch, J.L.3    Bondy, B.4    Smeraldi, E.5
  • 78
    • 45549090747 scopus 로고    scopus 로고
    • Serotonin transporter gene polymorphisms and sertra- line response in major depression patients
    • Dogan O, Yuksel N, Ergun MA, Yilmaz A, Ilhan MN, Karslioglu HE, et al. Serotonin transporter gene polymorphisms and sertra- line response in major depression patients. Genet Test 2008 ; 12 :225-31.
    • (2008) Genet Test , vol.12 , pp. 225-231
    • Dogan, O.1    Yuksel, N.2    Ergun, M.A.3    Yilmaz, A.4    Ilhan, M.N.5    Karslioglu, H.E.6
  • 79
    • 33847282339 scopus 로고    scopus 로고
    • Analysis of association between the serotonin transporter and antidepressant response in a large clinical sample
    • Kraft JB, Peters EJ, Slager SL, Jenkins GD, Reinalda MS, McGrath PJ, et al. Analysis of association between the serotonin transporter and antidepressant response in a large clinical sample. Biol Psychiatry 2007 ; 61 : 734-42.
    • (2007) Biol Psychiatry , vol.61 , pp. 734-742
    • Kraft, J.B.1    Peters, E.J.2    Slager, S.L.3    Jenkins, G.D.4    Reinalda, M.S.5    McGrath, P.J.6
  • 80
    • 0035805390 scopus 로고    scopus 로고
    • Serotonin-2A-receptor and -transporter polymorphisms : Lack of association in patients with major depression
    • Minov C, Baghai TC, Schule C, Zwanzger P, Schwarz MJ, Zill P, et al. Serotonin-2A-receptor and -transporter polymorphisms : lack of association in patients with major depression. Neurosci Lett 2001 ; 303 : 119-22.
    • (2001) Neurosci Lett , vol.303 , pp. 119-122
    • Minov, C.1    Baghai, T.C.2    Schule, C.3    Zwanzger, P.4    Schwarz, M.J.5    Zill, P.6
  • 81
    • 0036140426 scopus 로고    scopus 로고
    • Influence of the serotonin transporter gene-linked polymorphic region on the antidepressant response to fluvoxamine in Japanese depressed patients
    • Yoshida K, Ito K, Sato K, Takahashi H, Kamata M, Higuchi H, et al. Influence of the serotonin transporter gene-linked polymorphic region on the antidepressant response to fluvoxamine in Japanese depressed patients. Prog Neuropsychopharmacol Biol Psychiatry 2002 ; 26 : 383-6.
    • (2002) Prog Neuropsychopharmacol Biol Psychiatry , vol.26 , pp. 383-386
    • Yoshida, K.1    Ito, K.2    Sato, K.3    Takahashi, H.4    Kamata, M.5    Higuchi, H.6
  • 82
    • 0036931893 scopus 로고    scopus 로고
    • Association study of the serotonin transporter promoter polymorphism and symptomatology and antidepressant response in major depressive disorders
    • Yu YW, Tsai SJ, Chen TJ, Lin CH, Hong CJ. Association study of the serotonin transporter promoter polymorphism and symptomatology and antidepressant response in major depressive disorders. Mol Psychiatry 2002 ; 7 : 1115-9.
    • (2002) Mol Psychiatry , vol.7 , pp. 1115-1119
    • Yu, Y.W.1    Tsai, S.J.2    Chen, T.J.3    Lin, C.H.4    Hong, C.J.5
  • 83
    • 0033807374 scopus 로고    scopus 로고
    • Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression
    • Pollock BG, Ferrell RE, Mulsant BH, Mazumdar S, Miller M, Sweet RA, et al. Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression. Neuropsychopharmacology 2000 ; 23 : 587-90.
    • (2000) Neuropsychopharmacology , vol.23 , pp. 587-590
    • Pollock, B.G.1    Ferrell, R.E.2    Mulsant, B.H.3    Mazumdar, S.4    Miller, M.5    Sweet, R.A.6
  • 84
    • 33750061011 scopus 로고    scopus 로고
    • Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response
    • Wong ML, Whelan F, Deloukas P, Whittaker P, Delgado M, Cantor RM, et al. Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response. Proc Natl Acad Sci USA 2006 ; 103 : 15124-9.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 15124-15129
    • Wong, M.L.1    Whelan, F.2    Deloukas, P.3    Whittaker, P.4    Delgado, M.5    Cantor, R.M.6
  • 85
    • 34249943795 scopus 로고    scopus 로고
    • Association between treatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the STAR*D study
    • Perlis RH, Purcell S, Fava M, Fagerness J, Rush AJ, Trivedi MH, et al. Association between treatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the STAR*D study. Arch Gen Psychiatry 2007 ; 64 : 689-97.
    • (2007) Arch Gen Psychiatry , vol.64 , pp. 689-697
    • Perlis, R.H.1    Purcell, S.2    Fava, M.3    Fagerness, J.4    Rush, A.J.5    Trivedi, M.H.6
  • 86
    • 41549162842 scopus 로고    scopus 로고
    • Association analysis between variants of the interleukin-1beta and the interleukin-1 receptor antagonist gene and antidepressant treatment response in major depression
    • Tadic A, Rujescu D, Muller MJ, Kohnen R, Stassen HH, Szegedi A, et al. Association analysis between variants of the interleukin-1beta and the interleukin-1 receptor antagonist gene and antidepressant treatment response in major depression. Neu- ropsychiatr Dis Treat 2008; 4: 269-76.
    • (2008) Neu- ropsychiatr Dis Treat , vol.4 , pp. 269-276
    • Tadic, A.1    Rujescu, D.2    Muller, M.J.3    Kohnen, R.4    Stassen, H.H.5    Szegedi, A.6
  • 87
    • 13544263559 scopus 로고    scopus 로고
    • The catechol-O-methyltransferase Val108/158Met polymorphism affects short-term treatment response to mirtazapine, but not to paroxetine in major depression
    • Szegedi A, Rujescu D, Tadic A, Muller MJ, Kohnen R, Stassen HH, et al. The catechol-O-methyltransferase Val108/158Met polymorphism affects short-term treatment response to mirtazapine, but not to paroxetine in major depression. Pharmacogenomics J 2005 ; 5 : 49-53.
    • (2005) Pharmacogenomics J , vol.5 , pp. 49-53
    • Szegedi, A.1    Rujescu, D.2    Tadic, A.3    Muller, M.J.4    Kohnen, R.5    Stassen, H.H.6
  • 88
    • 58149097604 scopus 로고    scopus 로고
    • Sexually dimorphic effect of catechol-O-methyltransferase val158met polymorphism on clinical response to fluoxetine in major depressive patients
    • Tsai SJ, Gau YT, Hong CJ, Liou YJ, Yu YW, Chen TJ. Sexually dimorphic effect of catechol-O-methyltransferase val158met polymorphism on clinical response to fluoxetine in major depressive patients. J Affect Disord 2009 ; 113 : 183-7.
    • (2009) J Affect Disord , vol.113 , pp. 183-187
    • Tsai, S.J.1    Gau, Y.T.2    Hong, C.J.3    Liou, Y.J.4    Yu, Y.W.5    Chen, T.J.6
  • 89
    • 47749098274 scopus 로고    scopus 로고
    • How can we realize the promise of personalized antidepressant medicines ?
    • Holsboer F. How can we realize the promise of personalized antidepressant medicines ? Nat Rev Neurosci 2008 ; 9 : 638-46.
    • (2008) Nat Rev Neurosci , vol.9 , pp. 638-646
    • Holsboer, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.