Serotonin transporter gene polymorphisms and sertraline response in major depression patients

Genetic Testing

Volumn 12, Issue 2, 2008, Pages 225-231

  Dogan, Ozlem ^a   Yuksel, Nevzat ^a   Ergun, Mehmet Ali ^a   Yilmaz, Akin ^a   Ilhan, Mustafa N ^a   Karslioglu, Hatice Ersin ^a   Koc, Aysegul ^a   Menevse, Adnan ^a  

^a GAZI UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN TRANSPORTER; SERTRALINE;

ADULT; ARTICLE; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DNA POLYMORPHISM; DRUG DOSE INCREASE; DRUG RESPONSE; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; NUCLEOTIDE SEQUENCE; SCORING SYSTEM; SEROTONIN TRANSPORTER GENE;

ADOLESCENT; ADULT; ANTIDEPRESSIVE AGENTS; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MINISATELLITE REPEATS; POLYMORPHISM, GENETIC; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; SERTRALINE; TREATMENT OUTCOME; TURKEY;

EID: 45549090747     PISSN: 10906576     EISSN: None     Source Type: Journal    
DOI: 10.1089/gte.2007.0089     Document Type: Article

References (31)

1. Blakely RD (2001) Physiological genomics of antidepressant targets: keeping the periphery in mind. J Neurosci 21:8319-8323.
2. Blakely RD, Louis JF, Hartzell HC (1994) Molecular physiology of norepinephrine and serotonin transporters. J Exp Biol 196:263-281.
3. Celada P, Puig MV, Amargos-Bosch M, Adell A, Artigas F (2004) The therapeutic role of 5-HT1A and 5-HT2A receptors in depression. J Psychiatry Neurosci 29:252-265.
4. Chen F, Lawrence AJ (2003) The effects of antidepressant treatment on serotonergic and dopaminergic systems in Fawn-Hooded rats: a quantitative autoradiography study. Brain Res 976:22-29.
5. David LR, Walline CC, Rodriguez GJ, Barker EL (2003) Interactions of antidepressants with the serotonin transporter: a contemporary molecular analysis. Euro J Pharmcol 479:53-63.
6. Evans J, Battersby S, Ogilvie AD, Smith CAD, Harmar AJ, Nutt DJ, Goodwin GM (1997) Association of short alleles of a VNTR of the serotonin transporter gene with anxiety symptoms in patients presenting after deliberate self harm. Neuropharmacology 36:439-443.
7. Gursoy S, Erdal E, Herken H, Madenci E, Alaşehirli B (2002) Absence of association of the serotonin transporter gene polymorphism with the mentally healthy subset of fibromyalgia patients. Clin Rheumatol 21:194-197.
8. Gutierrez B, Pintor L, Gastro C, Rosa A, Bertranpetit J, Vieta E, Fananas L (1998) Variability in the serotonin transporter gene and increased risk for major depression with melancholia. Hum Genet 103:319-322.
9. Hammoumi S, Payen A, Favre JD, Balmes JL, Benard JY, Husson M, Ferrand JB, Martin JP, Daoust M (1999) Does the short variant of the serotonin transporter linked polymorphic region constitute a marker of alcohol dependence. Alcohol 17:107-112.
10. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, Lesch P (1996) Allelic variation of human serotonin transporter gene expression. J Neurochem 66:2621-2624.
11. Hranilovic D, Stefujl J, Schwab S, Borrmann-Hessenbach M, Albus M, Jernel B, Wildenauer D (2004) Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants end gene expression. Biol Psychiatry 29:1-5.
12. Ito K, Yoshida K, Sato K, Takahashi H, Kamata M, Higuchi H, Shimizu T, Itoh K, Inoue K, Tezuka T, Suzuki T, Ohkuba T, Sugawara K, Otani K (2002) A variable number of tandem repeats in the serotonin transporter gene does not affect the antidepressant response to fluvoxamin. Psychiatry Res 111:235-239.
13. Kim D, Lim SW, Lee S (2000) Serotonin transporter gene polymorphism and antidepressant response. Neuroreport 11:215-219.
14. Lesch KP (2004) Gene-environment interaction and the genetics of depression. J Psychiatry Neurosci 29:174-184.
15. Lesch KP, Balling U, Gross J, Strauss K, Wolozin BL, Murphy DL, Riederer P (1994) Organization of the human serotonin transporter gene. J Neural Transm Gen Sect 95:157-162.
16. Lydiard RB, Perera P, Batzar E, Clary CM (1999) From the bench to the trench: a comparison of sertraline treatment of major depression in clinical and research patients samples. J Clin Psychiatry 1:154-162.
17. Mackenzie A, Quinn J (1999) A serotonin transporter gene intron2 polymorphic region, correlated with affective disordered has allele-dependent differential enhancer-like properties in the mouse embryo. Proc Natl Acad Sci USA 96:15251-15255.
18. Narita M, Nishigami N, Narita N, Yamaguti K, Okado N, Watanabe Y, Kuratsune H (2003) Association between serotonin transporter gene polymorphism and chronic fatigue syndrome. Biochem Biophys Res Commun 311:264-266.
19. Ng CH, Easteal S, Tan S, Schweither HO, Aziz B (2006) Serotonin transporter polymorphisms and clinical response to sertraline across ethnicities. Prog Neuropsychopharmacol Biol Psychiatry 30:953-957.
20. Pata C, Erdal ME, Derici E, Yazar A, Kanik A, Ulu O (2002) Serotonin transporter gene polymorphism in irritable bowel syndrome. Am J Gastroenterology 97:1780-1784.
21. Pivac N, Muck-Seler D, Sagud M, Jakovljevic M, Mustapic M, Peles AM (2003) Long-term sertraline treatment and peripheral biochemical markers in female depressed patients. Prog Neuropsychopharmacol Biol Psychiatry 27:759-765.
22. Rothman RB, Baumann MH (2002) Therapeutic and adverse actions of serotonin transporter substrates. Pharmacol Ther 95:73-88.
23. Russ MJ, Lachman HM, Kashdan T, Saito T, Bajmakovic-Kacila S (2000) Analysis of catechol-O-methyltransferase and 5-hydroxytryptamine transporter polymorphisms in patients et risk for suicide. Psychiatry Res 93:73-78.
24. Savrun MB (1999) Definition of depression and epidemiology. I.U. Depression, Somatitation and Psychiatric Urgents Symposium. Istanbul University, Cerrahpasa Medicine Faculty, Commission of Lasting Medicine Education, pp 11-17.
25. Takahashi H, Yoshida K, Ito K, Sato K, Kamata M, Higuchi H, Shimizu T, Itoh K, Inonue K, Tezuka T, Suzuki T, Ohkuba T, Sugawara K (2002) No association between the serotonergic polymorphism and incidence of neusa induced by fluvoxamine treatment. Eur Neuropsychopharmacol 12:477-481.
26. Thompson MD, Gonzalez N, Nguyen T, Comings DE, George SR, O'Dowd B (2000) Serotonin transporter gene polymorphisms in alcohol dependence. Alcohol 22:61-67.
27. Tsai SJ, Hong CJ (2003) Pharmacogenetics of selective serotonin reuptake inhibitor response in major depression. Curr Pharm 1:121-127.
28. Unal S, Kuey L, Gulec C, Bekaroglu M, Evlice YE, Kirli S (2002) Risk agent in depressive anomaly. Clin Psychiatry 5:8-15.
29. Valuck R (2004) Selective serotonin reuptake inhibitors: a class review. Pharmacol Ther 29:234-243.
30. Yuksel N (2000) Cyclic, Cruising and End. First Step Depression: Diagnostic and Therapy. Cizgi Tip Publisher, pp 57-62.
31. Zoroglu SS, Erdal ME, Alasehirli B, Erdal N, Sivasli E, Tutkun H, Savas HA (2002) Significance of serotonin transporter gene 5-HTTLPR and variable number of tandem repeat polymorphism in attention deficit hyperactivity disorder. Neuropsychobiology 45:176-181.