Investigation of the marine compound spongistatin 1 links the inhibition of PKCα translocation to nonmitotic effects of tubulin antagonism in angiogenesis

FASEB Journal

Volumn 23, Issue 4, 2009, Pages 1127-1137

  Rothmeier, Andrea S ^a   Ischenko, Ivan ^b   Joore, Jos ^c   Garczarczyk, Dorota ^d   Fürst, Robert ^a   Bruns, Christiane J ^b   Vollmar, Angelika M ^a   Zahler, Stefan ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c Pepscan Systems   (Netherlands)

^d INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Angiogenesis; Chemotaxis; Microtubules; Protein kinase c

Indexed keywords

COMBRETASTATIN A4 PHOSPHATE; PACLITAXEL; PROTEIN KINASE C ALPHA; SPONGISTATIN 1; TUBULIN; VINBLASTINE; ANGIOGENESIS INHIBITOR; MACROLIDE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL ASSAY; CELL MEMBRANE; CELL MIGRATION; CELL PROLIFERATION; CHEMOTAXIS; CONTROLLED STUDY; CORNEA; CYTOTOXICITY; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IC 50; IMAGING; IN VITRO STUDY; IN VIVO CULTURE; MALE; MITOSIS; MITOSIS INHIBITION; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; VASCULAR RING; ABDOMINAL AORTA; ANIMAL; CELL CULTURE; CELL MOTION; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENDOTHELIUM; GENETIC TRANSFECTION; IMMUNOHISTOCHEMISTRY; METABOLISM; MICROTUBULE; MOUSE STRAIN; PHOSPHORYLATION; SPONGE (PORIFERA); UMBILICAL VEIN;

ANGIOGENESIS INHIBITORS; ANIMALS; AORTA, ABDOMINAL; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CHEMOTAXIS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ENDOTHELIUM; HUMANS; IMMUNOHISTOCHEMISTRY; INHIBITORY CONCENTRATION 50; MACROLIDES; MICE; MICE, INBRED STRAINS; MICROTUBULES; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHORYLATION; PORIFERA; PROTEIN KINASE C-ALPHA; TRANSFECTION; TUBULIN; UMBILICAL VEINS;

EID: 65349154519     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.08-117127     Document Type: Article

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