Microtubule-targeted drugs inhibit VEGF receptor-2 expression by both transcriptional and post-transcriptional mechanisms

Journal of Investigative Dermatology

Volumn 128, Issue 8, 2008, Pages 2084-2091

  Meissner, Markus ^a   Pinter, Andreas ^a   Michailidou, Despina ^a   Hrgovic, Igor ^a   Kaprolat, Natalia ^a   Stein, Monika ^a   Holtmeier, Wolfgang ^a   Kaufmann, Roland ^a   Gille, Jens ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COLCHICINE; DNA; MESSENGER RNA; NOCODAZOLE; TRANSCRIPTION FACTOR SP1; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VINBLASTINE;

ACTIN FILAMENT; ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA BINDING; DRUG INHIBITION; DRUG MECHANISM; ENDOTHELIUM CELL; GEL MOBILITY SHIFT ASSAY; GENE CONSTRUCT; GENETIC TRANSCRIPTION; HALF LIFE TIME; HUMAN; HUMAN CELL; MICROTUBULE; MICROTUBULE ASSEMBLY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY MECHANISM;

EID: 47349115296     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2008.37     Document Type: Article

References (35)

1. Baguley BC, Holdaway KM, Thomsen LL, Zhuang L, Zwi LJ (1991) Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine: evidence for a vascular mechanism. Eur J Cancer 27:482-7
2. Bandyopadhyay S, Sengupta TK, Fernandes DJ, Spicer EK (2003) Taxol- and okadaic acid-induced destabilization of bcl-2 mRNA is associated with decreased binding of proteins to a bcl-2 instability element. Biochem Pharmacol 66:1151-62
3. Bayless KJ, Davis GE (2004) Microtubule depolymerization rapidly collapses capillary tube networks in vitro and angiogenic vessels in vivo through the small GTPase Rho. J Biol Chem 279:11686-95
4. Bourgarel-Rey V, Vallee S, Rimet O, Champion S, Braguer D, Desobry A et al. (2001) Involvement of nuclear factor kappaB in c-Myc induction by tubulin polymerization inhibitors. Mol Pharmacol 59:1165-70
5. Carmeliet P, Jain RK (2000) Angiogenesis in cancer and other diseases. Nature 407:249-57
6. D'Addario M, Arora PD, Ellen RP, McCulloch CA (2003) Regulation of tension-induced mechanotranscriptional signals by the microtubule network in fibroblasts. J Biol Chem 278:53090-7
7. Davis HW, VandenBerg E, Reid MD, Roy-Chaudhury P, Edwards JD (2005) Paclitaxel impairs endothelial cell adhesion but not cytokine-induced cellular adhesion molecule expression. Ann Vasc Surg 19:398-406
8. Detmar M (1996) Molecular regulation of angiogenesis in the skin. J Invest Dermatol 106:207-8
9. Detmar M, Brown LF, Claffey KP, Yeo KT, Kocher O, Jackman RW et al. (1994) Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis. J Exp Med 180:1141-6
10. Fava RA, Olsen NJ, Spencer-Green G, Yeo KT, Yeo TK, Berse B et al. (1994) Vascular permeability factor/endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue. J Exp Med 180:341-6
11. Ferrara N (1999) Vascular endothelial growth factor: molecular and biological aspects. Curr Top Microbiol Immunol 237:1-30
12. Flusberg DA, Numaguchi Y, Ingber DE (2001) Cooperative control of Akt phosphorylation, bcl-2 expression, and apoptosis by cytoskeletal microfilaments and microtubules in capillary endothelial cells. Mol Biol Cell 12:3087-94
13. Franchimont N, Lambert C, Huynen P, Ribbens C, Relic B, Chariot A et al. (2005) Interleukin-6 receptor shedding is enhanced by interleukin-1beta and tumor necrosis factor alpha and is partially mediated by tumor necrosis factor alpha-converting enzyme in osteoblast-like cells. Arthritis Rheum 52:84-93
14. Giannakakou P, Nakano M, Nicolaou KC, O'Brate A, Yu J, Blagosklonny MV et al. (2002) Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics. Proc Natl Acad Sci USA 99:10855-60
15. Jordan MA, Wilson L (2004) Microtubules as a target for anticancer drugs. Nat Rev Cancer 4:253-65
16. Lacroix I, Lipcey C, Imbert J, Kahn-Perles B (2002) Sp1 transcriptional activity is upregulated by phosphatase 2A in dividing T lymphocytes. J Biol Chem 277:9598-605
17. Manie S, Schmid-Alliana A, Kubar J, Ferrua B, Rossi B (1993) Disruption of microtubule network in human monocytes induces expression of interleukin-1 but not that of interleukin-6 nor tumor necrosis factor-alpha. Involvement of protein kinase A stimulation. J Biol Chem 268:13675-81
18. Meissner M, Stein M, Urbich C, Reisinger K, Suske G, Staels B et al. (2004) PPARalpha activators inhibit vascular endothelial growth factor receptor-2 expression by repressing Sp1-dependent DNA binding and transactivation. Circ Res 94:324-32
19. Millauer B, Wizigmann-Voos S, Schnurch H, Martinez R, Moller NP, Risau W et al. (1993) High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72:835-46
20. Ozawa F, Kasuya Y, Hama H, Asada S, Inada T, Goto K (1997) Microtubule dynamics regulates the level of endothelin-B receptor in rat cultured astrocytes. J Neurochem 69:562-9
21. Pasquier E, Carre M, Pourroy B, Camoin L, Rebai O, Briand C et al. (2004) Antiangiogenic activity of paclitaxel is associated with its cytostatic effect, mediated by the initiation but not completion of a mitochondrial apoptotic signaling pathway. Mol Cancer Ther 3:1301-10
22. Peiretti F, Canault M, Bernot D, Bonardo B, Deprez-Beauclair P, Juhan-Vague I et al. (2005) Proteasome inhibition activates the transport and the ectodomain shedding of TNF-alpha receptors in human endothelial cells. J Cell Sci 118(Part 5):1061-70
23. Petrova TV, Makinen T, Alitalo K (1999) Signaling via vascular endothelial growth factor receptors. Exp Cell Res 253:117-30
24. Pourroy B, Honore S, Pasquier E, Bourgarel-Rey V, Kruczynski A, Briand C et al. (2006) Antiangiogenic concentrations of vinflunine increase the interphase microtubule dynamics and decrease the motility of endothelial cells. Cancer Res 66:3256-63
25. Rahimi N, Dayanir V, Lashkari K (2000) Receptor chimeras indicate that the VEGFR-1 modulates mitogenic activity of VEGFR-2 in endothelial cells. J Biol Chem 275:16986-92
26. Rao P, Falk LA, Dougherty SF, Sawada T, Pluznik DH (1997) Colchicine downregulates lipopolysaccharide-induced granulocyte-macrophage colony-stimulating factor production in murine macrophages. J Immunol 159:3531-9
27. Samarakoon R, Higgins PJ (2002) MEK/ERK pathway mediates cell-shape-dependent plasminogen activator inhibitor type 1 gene expression upon drug-induced disruption of the microfilament and microtubule networks. J Cell Sci 115(Part 15):3093-103
28. Schlaeppi JM, Wood JM (1999) Targeting vascular endothelial growth factor (VEGF) for anti-tumor therapy, by anti-VEGF neutralizing monoclonal antibodies or by VEGF receptor tyrosine-kinase inhibitors. Cancer Metastasis Rev 18:473-81
29. Shannon JM, Pan T, Edeen KE, Nielsen LD (1998) Influence of the cytoskeleton on surfactant protein gene expression in cultured rat alveolar type II cells. Am J Physiol 274(1 Part 1):L87-96
30. Shibuya M, Ito N, Claesson-Welsh L (1999) Structure and function of vascular endothelial growth factor receptor-1 and -2. Curr Top Microbiol Immunol 237:59-83
31. Subbaramaiah K, Hart JC, Norton L, Dannenberg AJ (2000) Microtubule-interfering agents stimulate the transcription of cyclooxygenase-2. Evidence for involvement of ERK1/2 AND p38 mitogen-activated protein kinase pathways. J Biol Chem 275:14838-45
32. Urbich C, Stein M, Reisinger K, Kaufmann R, Dimmeler S, Gille J (2003) Fluid shear stress-induced transcriptional activation of the vascular endothelial growth factor receptor-2 gene requires Sp1-dependent DNA binding. FEBS Lett 535:87-93
33. Waltenberger J, Claesson-Welsh L, Siegbahn A, Shibuya M, Heldin CH (1994) Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J Biol Chem 269:26988-95
34. Wang J, Lou P, Lesniewski R, Henkin J (2003) Paclitaxel at ultra low concentrations inhibits angiogenesis without affecting cellular microtubule assembly. Anticancer Drugs 14:13-9
35. Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J (2000) Vascular-specific growth factors and blood vessel formation. Nature 407:242-8