Regulation of phospholipase D isoenzymes by transforming Ras and atypical protein kinase C-ι

Biochemical Journal

Volumn 359, Issue 1, 2001, Pages 211-217

  Mwanjewe, J ^a   Spitaler, M ^a   Ebner, M ^a   Windegger, M ^a   Geiger, M ^a   Kampfer, S ^a   Hofmann, J ^a   Uberall F ^a   Grunicke, H H ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

COS 7; HC11; PKC ; PLD1b; PLD2; Ras

Indexed keywords

CELLS; CLONING;

ENZYME ACTIVATION;

ENZYMES;

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; ISOENZYME; PHOSPHOLIPASE D; PROTEIN KINASE C; RAS PROTEIN; BISINDOLYLMALEIMIDE I; CYCLIN D1; ENZYME INHIBITOR; INDOLE DERIVATIVE; LUCIFERASE; MALEIMIDE DERIVATIVE; PHOSPHOLIPASE D1; PHOSPHOLIPASE D2; PROTEIN KINASE C IOTA; RO 31-8220;

ANIMAL CELL; ARTICLE; BREAST EPITHELIUM; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; IN VIVO STUDY; MAMMAL CELL; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; CELL STRAIN COS1; CELL TRANSFORMATION; CERCOPITHECUS; ENZYMOLOGY; EPITHELIUM CELL; EXPERIMENTAL NEOPLASM; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; ONCOGENE RAS; PATHOLOGY; PHYSIOLOGY; PROTEIN BINDING;

ANIMAL; CELL TRANSFORMATION, NEOPLASTIC; CERCOPITHECUS AETHIOPS; COS CELLS; CYCLIN D1; ENZYME INHIBITORS; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, RAS; HUMAN; INDOLES; ISOENZYMES; LUCIFERASE; MALEIMIDES; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; PHOSPHOLIPASE D; PROTEIN BINDING; PROTEIN KINASE C; SUPPORT, NON-U.S. GOV'T; TRANSFECTION;

EID: 0035476981     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3590211     Document Type: Article

References (38)

1. Phospholipase D: Molecular and cell biology of a novel gene family
2. Regulation of phospholipase D
3. Mammalian phospholipase D structure and regulation
4. Activation of type D phospholipase by serum stimulation and ras-induced transformation in NIH3T3 cells
5. Activation of phospholipase D by growth factors and oncogenes in murine fibroblasts follow alternative but cross-talking pathways
6. Phospholipase D: Regulation and functional significance
7. Messenger functions of phosphatidic acid
8. Expression of phospholipase D isoforms in mammalian cells
9. Phospholipase D
10. Ras protein is involved in the physiological regulation of phospholipase D by platelet derived growth factor
11. Phospholipase D stimulation by receptor tyrosine kinases mediated by protein kinase C and a Ras/Ral signaling cascade
12. Phospholipase D and RalA cooperate with the epidermal growth factor receptor to transform 3Y1 rat fibroblasts
13. RalA requirement for v-Src- and v-Ras-induced tumorigenicity and overproduction of urokinase-type plasminogen activator: Involvement of metalloproteases
14. Activation of phospholipase D1 by direct interaction with ADP- ribosylation factor 1 and RalA
15. RalA interacts directly with the Arf-responsive, PIP2-dependent phospholipase D1
16. Evidence that atypical protein kinase C-lambda and atypical protein kinase C-zeta participate in Ras-mediated reorganization of the F-actin cytoskeleton
17. Transcriptional activation of c-fos by oncogenic Ha-Ras in mouse mammary epithelial cells requires the combined activities of PKC-lambda, epsilon and zeta
18. Implication of atypical protein kinase C isoenzymes lambda and zeta in Ras mediated reorganization of the actin cytoskeleton and cyclin D1-induction
19. Reversion of Ras- and phosphatidylcholine-hydrolyzing phospholipase C-mediated transformation of NIH 3T3 cells by a dominant interfering mutant of protein kinase C lambda is accompanied by the loss of constitutive nuclear mitogen-activated protein kinase/extracellular signal-regulated kinase activity
20. Purification and characterization of the zeta isoform of protein kinase C from bovine kidney
21. Phosphatidic acid activation of protein kinase C-zeta overexpressed in COS cells: Comparison with other protein kinase C isotypes and other acidic lipids
22. Interleukin 1-beta-induced protein kinase C-zeta activation is mimicked by exogenous phospholipase D
23. A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells
24. Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells
25. Carboxyl-terminal phosphorylation regulates the function and subcellular localization of protein kinase C betall
26. Diacylglycerol generated by exogenous phospholipase C activates the mitogen-activated protein kinase pathway independent of Ras- and phorbol ester-sensitive protein kinase C: Dependence on protein kinase C-zeta
27. Platelet-derived growth factor activation of mitogen-activated protein kinase depends on the sequential activation of phosphatidylcholine-specific phospholipase C, protein kinase C-zeta and Raf-1
28. Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976
29. Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions
30. Transcriptional regulation of the cyclin D1 promoter by STAT5: Its involvement in cytokine-dependent growth of hematopoietic cells
31. Activation of phospholipase D by ras proteins is independent of protein kinase C
32. Phospholipase D activation in fibroblast membranes by the alpha and beta isoforms of protein kinase C
33. The extended protein kinase C superfamily
34. New insights into the regulation of protein kinase C and novel phorbol ester receptors
35. Structural analysis of human phospholipase D1
36. Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo
37. The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C
38. Regulation of protein kinase C zeta by Pl 3-kinase and PDK-1