Detection of αII-spectrin and breakdown products in humans after severe traumatic brain injury

Journal of Neurosurgical Sciences

Volumn 50, Issue 2, 2006, Pages 25-31

  Cardali, S ^a,b   Maugeri, R ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

Brain injury; Spectrin; Trauma

Indexed keywords

BIOLOGICAL MARKER; CALPAIN; CASPASE 3; PROTEIN ALPHA2 SPECTRIN; SPECTRIN; UNCLASSIFIED DRUG; PEPTIDE FRAGMENT;

ADULT; AGED; ARTICLE; BLOOD PRESSURE MONITORING; CEREBROSPINAL FLUID DRAINAGE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GLASGOW COMA SCALE; HEART VENTRICLE PRESSURE; HUMAN; MALE; OUTCOME ASSESSMENT; PROTEIN ANALYSIS; PROTEIN DEGRADATION; TRAUMATIC BRAIN INJURY; ADOLESCENT; APOPTOSIS; BRAIN INJURY; CASE CONTROL STUDY; CEREBROSPINAL FLUID; METABOLISM; MIDDLE AGED; NECROSIS; PATHOLOGY; PROSPECTIVE STUDY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; BIOLOGICAL MARKERS; BRAIN INJURIES; CALPAIN; CASE-CONTROL STUDIES; CASPASE 3; FEMALE; GLASGOW COMA SCALE; HUMANS; MALE; MIDDLE AGED; NECROSIS; PEPTIDE FRAGMENTS; PROSPECTIVE STUDIES; SPECTRIN;

EID: 33749397324     PISSN: 00264881     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Hanlon RE, Demery JA, Martinovich Z, Kelly JP. Effects of acute injury characteristics on neurophysical status and vocational outcome following mild traumatic brain injury. Brain Inj 1999;13:873-87.
2. Kurth SM, Bigler ED, Blatter DD. Neuropsychological outcome and quantitative image analysis of acute haemorrhage in traumatic brain injury: preliminary findings. Brain Inj 1994;8:489-500.
3. Wilson JT, Hadley DM, Wiedmann KD, Teasdale GM. Neuropsychological consequences of two patterns of brain damage shown by MRI in survivors of severe head injury. J Neurol Neurosurg Psych 1995;59:328-31.
4. Choi DW. Exploratory clinical testing of neuroscience drugs. Nat Neurosci 2002;5 Suppl:1023-5.
5. Ingebrigtsen T, Romner B. Biochemical Serum Markers of TBI. J Trauma 2002;52:798-808.
6. Pineda JA, Wang KK, Hayes RL. Biomarkers of proteolytic damage following traumatic brain injury. Brain Pathol 2004;14:202-9.
7. Berger RP, Pierce MC, Wisniewski SR, Adelson PD, Clark RS, Ruppel RA et al. Neuron-specific enolase and S100B in cerebrospinal fluid after severe traumatic brain injury in infants and children. Pediatrics 2002;109:E31.
8. Guan W, Yang YL, Xia WM, Li L, Gong DS, Chin J. Significance of serum neuron-specific enolase in patients with acute traumatic brain injury. Traumatology 2003;6:218-21.
9. Raabe A, Kopetsch O, Woszczyk A, Lang J, Gerlach R, Zimmermann M et al. Serum S-100B protein as a molecular marker in severe traumatic brain injury. Restor Neurol Neurosci 2003;21:159-69.
10. Johnsson P. Markers of cerebral ischemia after cardiac surgery. J Cardiothorac Vasc Anesth 1996;10:120-6.
11. Varma S, Janesko KL, Wisniewski SR, Bayir H, Adelson PD, Thomas NJ et al. F2-isoprostane and neuron-specific enolase in cerebrospinal fluid after severe traumatic brain injury in infants and children. J Neurotrauma 2003;20:781-6.
12. Skogseid IM, Nordby HK, Urdal P, Paus E, Lilleaas F. Increased serum creatine kinase BB and neuron specific enolase following head injury indicates brain damage. Acta Neurochir (Wien) 1992;115:106-11.
13. Yamazaki Y, Yada K, Morii S, Kitahara T, Ohwada T. Diagnostic significance of serum neuron-specific enolase and myelin basic protein assay in patients with acute head injury. Surg Neurol 1995;43:267-70.
14. Herrmann M, Curio N, Jost S, Wunderlich MT, Synowitz H, Wallesch CW. Protein S-100B and neuron specific enolase as early neurobiochemical markers of the severity of traumatic brain injury. Restor Neurol Neurosci 1999;14:109-14.
15. Ross SA, Cunningham RT, Johnston CF, Rowlands BJ. Neuron-specific enolase as an aid to outcome prediction in head injury. Br J Neurosurg 1996;10:471-6.
16. Fridriksson T, Kini N, Walsh-Kelly C, Hennes H. Serum neuron-specific enolase as a predictor of intracranial lesions in children with head trauma: a pilot study. Acad Emerg Med 2000;7:816-20.
17. Raabe A, Grolms, C, Keller M, Dohnert J, Sorge O, Seifert V. Correlation of computed tomography findings and serum brain damage markers following severe head injury. Acta Neurochir (Wien) 1998;140:787-91.
18. Raabe A, Grolms C, Seifert, V. Serum markers of brain damage and outcome prediction in patients after severe head injury. Br J Neurosurg 1999;13:56-9.
19. Cooper E. Neuron-specific enolase. Int J Biol Markers 1994;9:205-10.
20. Woertgen C, Rothoerl RD, Holzschuh M, Metz C, Brawanski A. Comparison of serial S-100 and NSE serum measurements after severe head injury. Acta Neurochir (Wien) 1997;139:1161-4.
21. Michetti F, Gazzolo D. S100B protein in biological fluids: a tool for perinatal medicine. Clin Chem 2002;48:2097-104.
22. Anderson RE, Hansson LO, Nilsson O, Dijlai-Merzoug R, Settergen G. High serum S100B levels for trauma patients without head injuries. Neurosurgery 2001;44:1255-8.
23. Pelinka LE, Toegel E, Mauritz W, Redl H. Serum S 100 B: a marker of brain damage in traumatic brain injury with and without multiple trauma. Shock 2003;19:195-200.
24. Shaw GJ, Jauch EC, Zemlan FP. Serum cleaved tau protein levels and clinical outcome in adult patients with closed head injury. Ann Emerg Med 2002;39:254-7.
25. Zemlan FP, Jauch EC, Mulchahey JJ. C-tau biomarker of neuronal damage in severe brain injured patients: association with elevated intracranial pressure and clinical outcome. Brain Res 2002;947:131-9.
26. Zemlan FP, Rosenberg WS, Luebbe PA. Quantification of axonal damage in traumatic brain injury: affinity purification and characterization of cerebrospinal fluid tau proteins. J Neurochem 1999;72:741-50.
27. Chatfield DA, Zemlan FP, Day DJ, Menon DK. Discordant temporal patterns of S100beta and cleaved tau protein elevation after head injury: a pilot study. Br J Neurosurg 2002;16:471-6.
28. Pike BR, Flint J, Dutta S, Johnson E, Wang KK, Hayes RL. Accumulation of non-erythroid alpha II-spectrin and calpain-cleaved alpha II-spectrin breakdown products in cerebrospinal fluid after traumatic brain injury in rats. J Neurochem 2001;78:1297-306.
29. Pike BR, Flint J, Dave JR, Lu XC, Wang KK, Tortella FC et al. Accumulation of calpain and caspase-3 proteolytic fragments of brain-derived αll-spectrin in cerebral spinal fluid after middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab 2004;24:98-106.
30. Ringger NC, O'Steen BE, Brabham JG, Silver X, Pineda J, Wang KK et al. A novel marker for traumatic brain injury: CSF-II-spectrin breakdown product levels. J Neurotrauma 2004;21:1443-56.
31. Goodman SR, Zimmer WE, Clark MB, Zagon IS, Barker JE, Bloom ML. Brain spectrin: of mice and men. Brain Res Bull 1995;36:593-606.
32. Riederer BM, Zagon IS, Goodman SR. Brain spectrin (240/235) and brain spectrin (240/235E): differential expression during mouse brain development. J Neurosci 1987;7:864-74.
33. Wang KK, Posmantur R, Nath R, McGinnis K, Whitton M, Talanian RV et al. Simultaneous degradation of alphaII- and betaII-spectrin by caspase 3 (CPP32) in apoptotic cells. J Biol Chem 1998;273:22490-7.
34. Beer R, Franz G, Srinivasan A, Hayes RL, Pike BR, Newcomb JK et al. Temporal profile and cell subtype distribution of activated caspase-3 following experimental traumatic brain injury. J Neurochem 2000;75:1264-73.
35. Buki A, Siman R, Trojanowski JQ, Povlishock JT. The role of calpain-mediated spectrin proteolysis in traumatically induced axonal injury. J Neuropathol Exp Neurol 1999;58:365-75.
36. Knoblach SM, Nikolaeva M, Huang X, Fan L, Krajewski S, Reed JC et al. Multiple caspases are activated after traumatic brain injury: evidence for involvement in functional outcome. J Neurotrauma 2002;19:1155-70.
37. Newcomb JK, Kampfl A, Posmantur RM, Zhao X, Pike BR, Liu SJ et al. Immunohistochemical study of calpain-mediated breakdown products to alpha-spectrin following controlled cortical impact injury in the rat. J Neurotrauma 1997;14:369-83.
38. Pike BR, Zhao X, Newcomb JK, Posmantur RM, Wang KKW, Hayes RL. Regional calpain and caspase-3 proteolysis of alpha-spectrin after traumatic brain injury. NeuroReport 1998;9:2437-42.
39. Saatman KE, Bozyczko-Coyne D, Marcy V, Siman R, Mcintosh TK. Prolonged calpain-mediated spectrin breakdown occurs regionally following experimental brain injury in the rat. J Neuropathol Exp Neurol 1996;55:850-60.
40. Yakovlev AG, Knoblach SM, Fan L, Fox GB, Goodnight R, Faden AI. Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. J Neurosci 1997;17:7415-24.
41. Jennett B, Bond M. Assessment of outcome after severe brain damage. A practical scale. Lancet 1975;1:480-4.
42. Ingebrigtsen T, Romner B, Marup-Jensen S, Dons M, Lundqvist C, Bellner J et al. The clinical value of serum S-100 protein measurements in minor head injury: a Scandinavian multicentre study. Brain Inj 2000;114:1047-55.