메뉴 건너뛰기




Volumn 9, Issue 3, 2009, Pages 318-323

The role of WNT in rheumatoid arthritis and its therapeutic implication

Author keywords

FRP; Matrix metalloproteinase; Rheumatoid arthritis; Synovium; WNT; catenin

Indexed keywords

6 HYDROXY 2 (4 HYDROXYPHENYL) 3 [4 [2 (1 PYRROLIDINYL)ETHOXY]BENZOYL]BENZO[B]THIOPHENE; ABATACEPT; ACETYLSALICYLIC ACID; ADALIMUMAB; ANTIINFLAMMATORY AGENT; CPG 049090; DISEASE MODIFYING ANTIRHEUMATIC DRUG; ESTROGEN; ETANERCEPT; FH 535; FJ 9; GROWTH FACTOR; ICG 001; INFLIXIMAB; NONSTEROID ANTIINFLAMMATORY AGENT; PKF 115 584; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RITUXIMAB; UNCLASSIFIED DRUG; WNT PROTEIN; WNT1 INDUCIBLE SIGNALING PATHWAY PROTEIN;

EID: 65349134126     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389557510909030318     Document Type: Review
Times cited : (7)

References (53)
  • 1
    • 0036307319 scopus 로고    scopus 로고
    • Androgens and estrogens modulate the immune and inflammatory responses in rheumatoid arthritis
    • Cutolo, M.; Seriolo, B.; Villaggio, B.; Pizzorni, C.; Craviotto, C.; Sulli, A. Androgens and estrogens modulate the immune and inflammatory responses in rheumatoid arthritis. Ann. N. Y. Acad. Sci., 2002, 966, 131-42.
    • (2002) Ann. N. Y. Acad. Sci , vol.966 , pp. 131-142
    • Cutolo, M.1    Seriolo, B.2    Villaggio, B.3    Pizzorni, C.4    Craviotto, C.5    Sulli, A.6
  • 2
    • 0242524396 scopus 로고    scopus 로고
    • Abnormal levels of serum dehydroepiandrosterone, estrogen, and estradiol in men with rheumatoid arthritis: High correlation between serum estradiol and current degree of inflammation
    • Tengstrand, B.; Carlstrom, K.; Fellander-Tsai, L.; Hafstrom, I. Abnormal levels of serum dehydroepiandrosterone, estrogen, and estradiol in men with rheumatoid arthritis: high correlation between serum estradiol and current degree of inflammation. J. Rheumatol., 2003, 30, 2338-43.
    • (2003) J. Rheumatol , vol.30 , pp. 2338-2343
    • Tengstrand, B.1    Carlstrom, K.2    Fellander-Tsai, L.3    Hafstrom, I.4
  • 3
    • 0345472069 scopus 로고    scopus 로고
    • Increased estrogen formation and estrogen to androgen ratio in the synovial fluid of patients with rheumatoid arthritis
    • Castagnetta, L.A.; Carruba, G.; Granata, O.M.; Stefano, R.; Miele, M.; Schmidt, M.; Cutolo, M.; Straub, R.H. Increased estrogen formation and estrogen to androgen ratio in the synovial fluid of patients with rheumatoid arthritis. J. Rheumatol., 2003, 30, 2597-605.
    • (2003) J. Rheumatol , vol.30 , pp. 2597-2605
    • Castagnetta, L.A.1    Carruba, G.2    Granata, O.M.3    Stefano, R.4    Miele, M.5    Schmidt, M.6    Cutolo, M.7    Straub, R.H.8
  • 4
    • 33847407408 scopus 로고    scopus 로고
    • 17beta-estradiol induces IL-1alpha gene expression in rheumatoid fibroblast-like synovial cells through estrogen receptor alpha (ERalpha) and augmentation of transcriptional activity of Sp1 by dissociating histone deacetylase 2 from ERalpha
    • Itoh, Y.; Hayashi, H.; Miyazawa, K.; Kojima, S.; Akahoshi, T.; Onozaki, K. 17beta-estradiol induces IL-1alpha gene expression in rheumatoid fibroblast-like synovial cells through estrogen receptor alpha (ERalpha) and augmentation of transcriptional activity of Sp1 by dissociating histone deacetylase 2 from ERalpha. J. Immunol., 2007, 178, 3059-66.
    • (2007) J. Immunol , vol.178 , pp. 3059-3066
    • Itoh, Y.1    Hayashi, H.2    Miyazawa, K.3    Kojima, S.4    Akahoshi, T.5    Onozaki, K.6
  • 7
    • 0038011833 scopus 로고    scopus 로고
    • Evolving concepts of rheumatoid arthritis
    • Firestein, G.S. Evolving concepts of rheumatoid arthritis. Nature, 2003, 423, 356-61.
    • (2003) Nature , vol.423 , pp. 356-361
    • Firestein, G.S.1
  • 8
    • 0025255530 scopus 로고
    • Quantitative analysis of cytokine gene expression in rheumatoid arthritis
    • Firestein, G.S.; Alvaro-Gracia, J.M.; Maki, R. Quantitative analysis of cytokine gene expression in rheumatoid arthritis. J. Immunol., 1990, 144, 3347-53.
    • (1990) J. Immunol , vol.144 , pp. 3347-3353
    • Firestein, G.S.1    Alvaro-Gracia, J.M.2    Maki, R.3
  • 10
    • 50249142459 scopus 로고    scopus 로고
    • Purification of matrix metalloproteinases by column chromatography
    • Imai, K.; Okada, Y. Purification of matrix metalloproteinases by column chromatography. Nat. Prot., 2008, 3, 1111-24.
    • (2008) Nat. Prot , vol.3 , pp. 1111-1124
    • Imai, K.1    Okada, Y.2
  • 12
    • 33750288586 scopus 로고    scopus 로고
    • The role of the synovial fibroblast in rheumatoid arthritis: Cartilage destruction and the regulation of matrix metalloproteinases
    • Abeles, A.M.; Pillinger, M.H. The role of the synovial fibroblast in rheumatoid arthritis: cartilage destruction and the regulation of matrix metalloproteinases. Bull. NYU Hosp. Jt. Dis., 2006, 64, 20-4.
    • (2006) Bull. NYU Hosp. Jt. Dis , vol.64 , pp. 20-24
    • Abeles, A.M.1    Pillinger, M.H.2
  • 13
    • 0034469496 scopus 로고    scopus 로고
    • Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis
    • Pap, T.; Muller-Ladner, U.; Gay, R.E.; Gay, S. Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis. Arthritis Res., 2000, 2, 361-7.
    • (2000) Arthritis Res , vol.2 , pp. 361-367
    • Pap, T.1    Muller-Ladner, U.2    Gay, R.E.3    Gay, S.4
  • 14
    • 0035883897 scopus 로고    scopus 로고
    • Rheumatoid arthritis
    • Lee, D.M.; Weinblatt, M.E. Rheumatoid arthritis. Lancet, 2001, 358, 903-11.
    • (2001) Lancet , vol.358 , pp. 903-911
    • Lee, D.M.1    Weinblatt, M.E.2
  • 15
  • 16
    • 0034053069 scopus 로고    scopus 로고
    • Wnt signaling in oncogenesis and embryo-genesis - a look outside the nucleus
    • Peifer, M.; Polakis, P. Wnt signaling in oncogenesis and embryo-genesis - a look outside the nucleus. Science, 2000, 287, 1606-9.
    • (2000) Science , vol.287 , pp. 1606-1609
    • Peifer, M.1    Polakis, P.2
  • 17
    • 2342579511 scopus 로고    scopus 로고
    • Activation of WNT family expression and signaling in squamous cell carcinomas of the oral cavity
    • Uraguchi, M.; Morikawa, M.; Shirakawa, M.; Sanada, K.; Imai, K. Activation of WNT family expression and signaling in squamous cell carcinomas of the oral cavity. J. Dent. Res., 2004, 83, 327-32.
    • (2004) J. Dent. Res , vol.83 , pp. 327-332
    • Uraguchi, M.1    Morikawa, M.2    Shirakawa, M.3    Sanada, K.4    Imai, K.5
  • 18
    • 4844230621 scopus 로고    scopus 로고
    • The Frizzled family: Receptors for multiple signal transduction pathways
    • Huang, H.C.; Klein, P.S. The Frizzled family: receptors for multiple signal transduction pathways. Genome Biol., 2004, 5, 234.
    • (2004) Genome Biol , vol.5 , pp. 234
    • Huang, H.C.1    Klein, P.S.2
  • 19
    • 0342425883 scopus 로고
    • Local proliferation of fibroblast-like synoviocytes contributes to synovial hyperplasia. Results of proliferating cell nuclear antigen/cyclin, c-myc, and nucleolar organizer region staining
    • Qu, Z.; Garcia, C.H.; O'Rourke, L.M.; Planck, S.R.; Kohli, M.; Rosenbaum, J.T. Local proliferation of fibroblast-like synoviocytes contributes to synovial hyperplasia. Results of proliferating cell nuclear antigen/cyclin, c-myc, and nucleolar organizer region staining. Arthritis Rheum., 1994, 37, 212-20.
    • (1994) Arthritis Rheum , vol.37 , pp. 212-220
    • Qu, Z.1    Garcia, C.H.2    O'Rourke, L.M.3    Planck, S.R.4    Kohli, M.5    Rosenbaum, J.T.6
  • 20
    • 34147142891 scopus 로고    scopus 로고
    • Serum levels of matrix metallo-proteinase 3 (stromelysin 1) for monitoring synovitis in rheumatoid arthritis
    • Kobayashi, A.; Naito, S.; Enomoto, H., Shiomi, T.; Kimura, T.; Obata, K.; Inoue, K.; Okada, Y. Serum levels of matrix metallo-proteinase 3 (stromelysin 1) for monitoring synovitis in rheumatoid arthritis. Arch. Pathol. Lab. Med., 2007, 131, 563-70.
    • (2007) Arch. Pathol. Lab. Med , vol.131 , pp. 563-570
    • Kobayashi, A.1    Naito, S.2    Enomoto, H.3    Shiomi, T.4    Kimura, T.5    Obata, K.6    Inoue, K.7    Okada, Y.8
  • 22
    • 0035421799 scopus 로고    scopus 로고
    • CD44 is the physiological trigger of Fas up-regulation on rheumatoid synovial cells
    • Fujii, K.; Fujii, Y.; Hubscher, S.; Tanaka, Y. CD44 is the physiological trigger of Fas up-regulation on rheumatoid synovial cells. J. Immunol., 2001, 167, 1198-203.
    • (2001) J. Immunol , vol.167 , pp. 1198-1203
    • Fujii, K.1    Fujii, Y.2    Hubscher, S.3    Tanaka, Y.4
  • 23
    • 0141788312 scopus 로고    scopus 로고
    • Vegfb gene knockout mice display reduced pathology and synovial angiogenesis in both antigen-induced and collagen-induced models of arthritis
    • Mould, A.W.; Tonks, I.D.; Cahill, M.M.; Pettit, A.R.; Thomas, R.; Hayward, N.K.; Kay, G.F. Vegfb gene knockout mice display reduced pathology and synovial angiogenesis in both antigen-induced and collagen-induced models of arthritis. Arthritis Rheum., 2003, 48, 2660-9.
    • (2003) Arthritis Rheum , vol.48 , pp. 2660-2669
    • Mould, A.W.1    Tonks, I.D.2    Cahill, M.M.3    Pettit, A.R.4    Thomas, R.5    Hayward, N.K.6    Kay, G.F.7
  • 24
    • 0036845163 scopus 로고    scopus 로고
    • Regulation of fibronectin and metalloproteinase expression by Wnt signaling in rheumatoid arthritis synoviocytes
    • Sen, M.; Reifert, J.; Lauterbach, K.; Wolf, V.; Rubin, J.S.; Corr, M.; Carson, D.A. Regulation of fibronectin and metalloproteinase expression by Wnt signaling in rheumatoid arthritis synoviocytes. Arthritis Rheum., 2002, 46, 2867-77.
    • (2002) Arthritis Rheum , vol.46 , pp. 2867-2877
    • Sen, M.1    Reifert, J.2    Lauterbach, K.3    Wolf, V.4    Rubin, J.S.5    Corr, M.6    Carson, D.A.7
  • 26
    • 21244440341 scopus 로고    scopus 로고
    • Expression profiles and functional analyses of Wnt-related genes in human joint disorders
    • Nakamura, Y.; Nawata, M.; Wakitani, S. Expression profiles and functional analyses of Wnt-related genes in human joint disorders. Am. J. Pathol., 2005, 167, 97-105.
    • (2005) Am. J. Pathol , vol.167 , pp. 97-105
    • Nakamura, Y.1    Nawata, M.2    Wakitani, S.3
  • 27
    • 33744533911 scopus 로고    scopus 로고
    • Differential expression of WNTs and FRPs in the synovium of rheumatoid arthritis and osteoarthritis
    • Imai, K.; Morikawa, M.; D'Armiento, J.; Matsumoto, H.; Komiya, K.; Okada, Y. Differential expression of WNTs and FRPs in the synovium of rheumatoid arthritis and osteoarthritis. Biochem. Biophys. Res. Commun., 2006, 345, 1615-20.
    • (2006) Biochem. Biophys. Res. Commun , vol.345 , pp. 1615-1620
    • Imai, K.1    Morikawa, M.2    D'Armiento, J.3    Matsumoto, H.4    Komiya, K.5    Okada, Y.6
  • 29
    • 33748768971 scopus 로고    scopus 로고
    • Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors
    • Rodda, S.J.; McMahon, A.P. Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development, 2006, 133, 3231-44.
    • (2006) Development , vol.133 , pp. 3231-3244
    • Rodda, S.J.1    McMahon, A.P.2
  • 34
    • 67649173248 scopus 로고    scopus 로고
    • Activation of beta-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult beta-Catenin Conditional Activation Mice
    • early publication online
    • Zhu, M.; Tang, D.; Wu, Q.; Hao, S.; Chen, M.; Xie, C.; Rosier, R.; O'Keefe, R.; Zuscik, M.; Chen, D. Activation of beta-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult beta-Catenin Conditional Activation Mice. J. Bone Miner. Res., 2008, early publication online.
    • (2008) J. Bone Miner. Res
    • Zhu, M.1    Tang, D.2    Wu, Q.3    Hao, S.4    Chen, M.5    Xie, C.6    Rosier, R.7    O'Keefe, R.8    Zuscik, M.9    Chen, D.10
  • 35
    • 47249108982 scopus 로고    scopus 로고
    • Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction
    • Zhu, M.; Chen, M.; Zuscik, M.; Wu, Q.; Wang, Y.J.; Rosier, R.N.; O'Keefe, R.J.; Chen, D. Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction. Arthritis Rheum., 2008, 58, 2053-64.
    • (2008) Arthritis Rheum , vol.58 , pp. 2053-2064
    • Zhu, M.1    Chen, M.2    Zuscik, M.3    Wu, Q.4    Wang, Y.J.5    Rosier, R.N.6    O'Keefe, R.J.7    Chen, D.8
  • 36
    • 0347915577 scopus 로고    scopus 로고
    • CCN proteins: Multifunctional signalling regulators
    • Perbal, B. CCN proteins: multifunctional signalling regulators. Lancet, 2004, 363, 62-4.
    • (2004) Lancet , vol.363 , pp. 62-64
    • Perbal, B.1
  • 37
    • 0035834695 scopus 로고    scopus 로고
    • Differential modulation of transcriptional activity of estrogen receptors by direct protein-protein interactions with the T cell factor family of transcription factors
    • El-Tanani, M.; Fernig, D.G.; Barraclough, R.; Green, C.; Rudland, P. Differential modulation of transcriptional activity of estrogen receptors by direct protein-protein interactions with the T cell factor family of transcription factors. J. Biol. Chem., 2001, 276, 41675-82.
    • (2001) J. Biol. Chem , vol.276 , pp. 41675-41682
    • El-Tanani, M.1    Fernig, D.G.2    Barraclough, R.3    Green, C.4    Rudland, P.5
  • 40
    • 27744436066 scopus 로고    scopus 로고
    • the British Society of Paediatric and Adolescent Rheumatolgy; Donn, R. Wnt-1-inducible signaling pathway protein 3 and susceptibility to juvenile idiopathic arthritis
    • Lamb, R.; Thomson, W.; Ogilvie, E.; the British Society of Paediatric and Adolescent Rheumatolgy; Donn, R. Wnt-1-inducible signaling pathway protein 3 and susceptibility to juvenile idiopathic arthritis. Arthritis Rheum., 2005, 52, 3548-53.
    • (2005) Arthritis Rheum , vol.52 , pp. 3548-3553
    • Lamb, R.1    Thomson, W.2    Ogilvie, E.3
  • 41
    • 0035056003 scopus 로고    scopus 로고
    • Anti-TNF alpha therapy of rheumatoid arthritis: What have we learned?
    • Feldmann, M.; Maini, R.N. Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? Annu. Rev. Immunol., 2001, 19, 163-96.
    • (2001) Annu. Rev. Immunol , vol.19 , pp. 163-196
    • Feldmann, M.1    Maini, R.N.2
  • 43
    • 35348922481 scopus 로고    scopus 로고
    • Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis
    • Jochems, C.; Islander, U.; Kallkopf, A.; Lagerquist, M.; Ohlsson, C.; Carlsten, H. Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis. Arthritis Rheum., 2007, 56, 3261-70.
    • (2007) Arthritis Rheum , vol.56 , pp. 3261-3270
    • Jochems, C.1    Islander, U.2    Kallkopf, A.3    Lagerquist, M.4    Ohlsson, C.5    Carlsten, H.6
  • 44
    • 26844475420 scopus 로고    scopus 로고
    • Superior efficacy of combination therapy for rheumatoid arthritis: Fact or fiction?
    • Smolen, J.S.; Aletaha, D.; Keystone, E. Superior efficacy of combination therapy for rheumatoid arthritis: fact or fiction? Arthritis Rheum., 2005, 52, 2975-83.
    • (2005) Arthritis Rheum , vol.52 , pp. 2975-2983
    • Smolen, J.S.1    Aletaha, D.2    Keystone, E.3
  • 45
    • 41649098360 scopus 로고    scopus 로고
    • A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities
    • Handeli, S.; Simon, J.A. A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities. Mol. Cancer Ther., 2008, 7, 521-9.
    • (2008) Mol. Cancer Ther , vol.7 , pp. 521-529
    • Handeli, S.1    Simon, J.A.2
  • 46
    • 26944439459 scopus 로고    scopus 로고
    • Investigating Wnt signaling: A chemogenomic safari
    • McMillan, M.; Kahn, M. Investigating Wnt signaling: a chemogenomic safari. Drug Discov. Today, 2005, 10, 1467-74.
    • (2005) Drug Discov. Today , vol.10 , pp. 1467-1474
    • McMillan, M.1    Kahn, M.2
  • 48
    • 0242300130 scopus 로고    scopus 로고
    • Nitric oxide-donating aspirin inhibits beta-catenin/T cell factor (TCF) signaling in SW480 colon cancer cells by disrupting the nuclear beta-catenin-TCF association
    • Nath, N; Kashfi, K.; Chen, J.; Rigas, B. Nitric oxide-donating aspirin inhibits beta-catenin/T cell factor (TCF) signaling in SW480 colon cancer cells by disrupting the nuclear beta-catenin-TCF association. Proc. Natl. Acad. Sci. USA, 2003, 100, 12584-89.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 12584-12589
    • Nath, N.1    Kashfi, K.2    Chen, J.3    Rigas, B.4
  • 50
    • 33751530490 scopus 로고    scopus 로고
    • Mining the Wnt pathway for cancer therapeutics
    • Barker, N.; Clevers, H. Mining the Wnt pathway for cancer therapeutics. Nat. Rev. Drug. Discov., 2006, 5, 997-1014.
    • (2006) Nat. Rev. Drug. Discov , vol.5 , pp. 997-1014
    • Barker, N.1    Clevers, H.2
  • 51
    • 0024410743 scopus 로고
    • Immunohistological features in the synovium obtained from clinically uninvolved knee joints of patients with rheumatoid arthritis
    • Soden, M.; Rooney, M.; Cullen, A.; Whelan, A.; Feighery, C.; Bresnihan, B. Immunohistological features in the synovium obtained from clinically uninvolved knee joints of patients with rheumatoid arthritis. Br. J. Rheumatol., 1989, 28, 287-92.
    • (1989) Br. J. Rheumatol , vol.28 , pp. 287-292
    • Soden, M.1    Rooney, M.2    Cullen, A.3    Whelan, A.4    Feighery, C.5    Bresnihan, B.6
  • 52
    • 34848849889 scopus 로고    scopus 로고
    • The performance of anti-cyclic citrullinated peptide antibodies in predicting the severity of radiologic damage in inflammatory polyarthritis: Results from the Norfolk Arthritis Register
    • Bukhari, M.; Thomson, W.; Naseem, H.; Bunn, D.; Silman, A.; Symmons, D.; Barton, A. The performance of anti-cyclic citrullinated peptide antibodies in predicting the severity of radiologic damage in inflammatory polyarthritis: results from the Norfolk Arthritis Register. Arthritis Rheum., 2007, 57, 2929-35.
    • (2007) Arthritis Rheum , vol.57 , pp. 2929-2935
    • Bukhari, M.1    Thomson, W.2    Naseem, H.3    Bunn, D.4    Silman, A.5    Symmons, D.6    Barton, A.7
  • 53
    • 38149092561 scopus 로고    scopus 로고
    • Differences in synovial tissue infiltrates between anti-cyclic citrullinated peptide-positive rheumatoid arthritis and anti-cyclic citrullinated peptide-negative rheumatoid arthritis
    • van Oosterhout, M.; Bajema, I.; Levarht, E.W.; Toes, R.E.; Huizinga, T.W.; van Laar, J.M. Differences in synovial tissue infiltrates between anti-cyclic citrullinated peptide-positive rheumatoid arthritis and anti-cyclic citrullinated peptide-negative rheumatoid arthritis. Arthritis Rheum., 2008, 58, 53-60.
    • (2008) Arthritis Rheum , vol.58 , pp. 53-60
    • van Oosterhout, M.1    Bajema, I.2    Levarht, E.W.3    Toes, R.E.4    Huizinga, T.W.5    van Laar, J.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.