6-Amino-4-oxo-1,3-diphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl derivatives as a new class of potent inhibitors of Interleukin-8-induced neutrophil chemotaxis

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 10, 2009, Pages 3580-3587

  Cesarini, Sara ^a   Spallarossa, Andrea ^a   Ranise, Angelo ^a   Bruno, Olga ^a   Arduino, Nicoletta ^a   Bertolotto, Maria ^a   Dallegri, Franco ^a   Tognolini, Massimiliano ^b   Gobbetti, Thomas ^b   Barocelli, Elisabetta ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

Author keywords

Chemotaxis; Inhibitors; Interleukin 8; Neutrophil; Peritonitis

Indexed keywords

6 AMINO 4 OXO 1,3 DIPHENYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBONYL DERIVATIVE; CARBONYL DERIVATIVE; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; COMPLEMENT COMPONENT C5A; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; DEXAMETHASONE; ETHYL 6 [[2 (DIETHYLAMINO)ETHYL]AMINO] 4 OXO 1,3 DIPHENYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; INTERLEUKIN 8; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; ZYMOSAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MIGRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; HUMAN; HUMAN CELL; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PERITONITIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; CARBOXYLIC ACIDS; CHEMOTAXIS, LEUKOCYTE; DISEASE MODELS, ANIMAL; INTERLEUKIN-8; MICE; NEUTROPHILS; PERITONITIS; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 65349133069     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.04.006     Document Type: Article

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