Relationships among body mass, brain size, gut length, and blood tryptophan and serotonin in young wild-type mice

BMC Physiology

Volumn 9, Issue 1, 2009, Pages

  Albay, Ricardo ^a   Chen, Angela ^a   Anderson, George M ^b   Tatevosyan, Maggie ^a   Janušonis, Skirmantas ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN; TRYPTOPHAN;

AMINO ACID BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; BODY HEIGHT; BODY MASS; BRAIN GROWTH; BRAIN SIZE; CONTROLLED STUDY; FEMALE; GENOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; INTESTINE; MALE; MOUSE; NISSL STAINING; NONHUMAN; SEROTONIN BLOOD LEVEL; SEROTONINERGIC SYSTEM; SEXUAL MATURITY; THROMBOCYTE; WILD TYPE; AGE; ANIMAL; BLOOD; BODY WEIGHT; BRAIN; HISTOLOGY; MUSCLE RELAXATION; ORGAN SIZE; SEXUAL DEVELOPMENT; THREE DIMENSIONAL IMAGING;

AGE FACTORS; ANIMALS; BODY WEIGHT; BRAIN; GENOTYPE; HIPPOCAMPUS; IMAGING, THREE-DIMENSIONAL; INTESTINES; MICE; MUSCLE RELAXATION; ORGAN SIZE; SEROTONIN; SEX CHARACTERISTICS; TRYPTOPHAN;

EID: 65149101825     PISSN: None     EISSN: 14726793     Source Type: Journal    
DOI: 10.1186/1472-6793-9-4     Document Type: Article

References (79)

1. Ontogeny of brain and blood serotonin levels in 5-HT 1A receptor knockout mice: potential relevance to the neurobiology of autism. S Janǔonis GM Anderson I Shifrovich P Rakic, J Neurochem 2006 99 1019 1031 16981893
2. Origin of the blood hyperserotonemia of autism. S Janǔonis, Theor Biol Med Model 2008 5 10 18498654
3. Autism as a theoretical problem and the significance of blood hyperserotonemia. S Janǔonis, Causes and Risks for Autism Hauppauge, NY: Nova Science Publishers, Giordano AC, Lombardi VA, 2009
4. The hyperserotonemia of autism. GM Anderson WC Horne D Chatterjee DJ Cohen, Ann N Y Acad Sci 1990 600 331 340 2252319
5. Genetics of childhood disorders: XLV. Autism, part 4: serotonin in autism. GM Anderson, J Am Acad Child Adolesc Psychiatry 2002 41 1513 1516 12447040
6. The serotonin system in autism. EH Cook BL Leventhal, Curr Opin Pediatr 1996 8 348 354 9053096 (Pubitemid 26393877)
7. Hyperserotonemia and amine metabolites in autistic and retarded children. HG Hanley SM Stahl DX Freedman, Arch Gen Psychiatry 1977 34 521 531 860890
8. Whole blood serotonin in autistic and normal subjects. GM Anderson DX Freedman DJ Cohen FR Volkmar EL Hoder P McPhedran RB Minderaa CR Hansen JG Young, J Child Psychol Psychiatry 1987 28 885 900 3436995
9. Effects of diagnosis, race, and puberty on platelet serotonin levels in autism and mental retardation. PA McBride GM Anderson ME Hertzig ME Snow SM Thompson VD Khait T Shapiro DJ Cohen, J Am Acad Child Adolesc Psychiatry 1998 37 767 776 9666633 (Pubitemid 28304541)
10. Variants of the serotonin transporter gene (SLC6A4) significantly contribute to hyperserotonemia in autism. AM Coutinho G Oliveira T Morgadinho C Fesel TR Macedo C Bento C Marques A Ataide T Miguel L Borges, Mol Psychiatry 2004 9 264 271 15094787 (Pubitemid 38496717)
11. Platelet serotonin levels in pervasive developmental disorders and mental retardation: Diagnostic group differences, within-group distribution, and behavioral correlates. EJ Mulder GM Anderson IP Kema BA De ND Van Lang JA Den Boer RB Minderaa, J Am Acad Child Adolesc Psychiatry 2004 43 491 499 15187810 (Pubitemid 38812390)
12. Hyperserotonemia in adults with autistic disorder. D Hranilovic Z Bujas-Petkovic R Vragovic T Vuk K Hock B Jernej, J Autism Dev Disord 2007 37 1934 1940 17165147 (Pubitemid 47609349)
13. Abnormal melatonin synthesis in autism spectrum disorders. J Melke BH Goubran P Chaste C Betancur G Nygren H Anckarsater M Rastam O Stahlberg IC Gillberg R Delorme, Mol Psychiatry 2008 13 90 98 17505466 (Pubitemid 350275181)
14. Hyperserotonemia in autism: the potential role of 5HT-related gene variants. D Hranilovic R Novak M Babic M Novokmet Z Bujas-Petkovic B Jernej, Coll Antropol 2008 32 Suppl 1 75 80 18405062
15. Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children. RJ Schain DX Freedman, J Pediatr 1961 58 315 320 13747230
16. A unified genetic theory for sporadic and inherited autism. X Zhao A Leotta V Kustanovich C Lajonchere DH Geschwind K Law P Law S Qiu C Lord J Sebat, Proc Natl Acad Sci USA 2007 104 12831 12836 17652511 (Pubitemid 47255240)
17. Mapping autism risk loci using genetic linkage and chromosomal rearrangements. P Szatmari AD Paterson L Zwaigenbaum W Roberts J Brian XQ Liu JB Vincent JL Skaug AP Thompson L Senman, Nat Genet 2007 39 319 328 17322880 (Pubitemid 46328498)
18. Advances in autism genetics: on the threshold of a new neurobiology. BS Abrahams DH Geschwind, Nat Rev Genet 2008 9 341 355 18414403
19. Novel submicroscopic chromosomal abnormalities detected in autism spectrum disorder. SL Christian CW Brune J Sudi RA Kumar S Liu S Karamohamed JA Badner S Matsui J Conroy D McQuaid, Biol Psychiatry 2008 63 1111 1117 18374305
20. Strong association of de novo copy number mutations with autism. J Sebat B Lakshmi D Malhotra J Troge C Lese-Martin T Walsh B Yamrom S Yoon A Krasnitz J Kendall, Science 2007 316 445 449 17363630 (Pubitemid 46651493)
21. Autistic phenotypes and genetic testing: state-of-the-art for the clinical geneticist. C Lintas AM Persico, J Med Genet 2009 46 1 8 18728070
22. Autism: many genes, common pathways? DH Geschwind, Cell 2008 135 391 395 18984147
23. Review article: serotonin receptors and transporters roles in normal and abnormal gastrointestinal motility. MD Gershon, Aliment Pharmacol Ther 2004 20 Suppl 7 3 14 15521849 (Pubitemid 39657670)
24. Synthesis of serotonin by a second tryptophan hydroxylase isoform. DJ Walther JU Peter S Bashammakh H Hortnagl M Voits H Fink M Bader, Science 2003 299 76 12511643 (Pubitemid 36042402)
25. Steady-state model for plasma free and platelet serotonin in man. GM Anderson JM Stevenson DJ Cohen, Life Sci 1987 41 1777 1785 3657383 (Pubitemid 18006405)
26. 5-hydroxytryptamine in the circulation of the dog. DP Thomas JR Vane, Nature 1967 216 335 338 6053807
27. Evidence of linkage between the serotonin transporter and autistic disorder. EH Cook Jr R Courchesne C Lord NJ Cox S Yan A Lincoln R Haas E Courchesne BL Leventhal, Mol Psychiatry 1997 2 247 250 9152989 (Pubitemid 27217689)
28. Serotonin transporter promoter variants in autism: functional effects and relationship to platelet hyperserotonemia. GM Anderson L Gutknecht DJ Cohen S Brailly-Tabard JH Cohen P Ferrari PL Roubertoux S Tordjman, Mol Psychiatry 2002 7 831 836 12232775
29. Serotonin transporter gene promoter variants do not explain the hyperserotoninemia in autistic children. AM Persico T Pascucci S Puglisi-Allegra R Militerni C Bravaccio C Schneider R Melmed S Trillo F Montecchi M Palermo, Mol Psychiatry 2002 7 795 800 12192626
30. Lack of association between serotonin transporter gene promoter variants and autistic disorder in two ethnically distinct samples. AM Persico R Militerni C Bravaccio C Schneider R Melmed M Conciatori V Damiani A Baldi F Keller, Am J Med Genet 2000 96 123 127 10686565 (Pubitemid 30077663)
31. Lack of evidence for association between the serotonin transporter gene (SLC6A4) polymorphisms and autism in the Chinese trios. S Wu Y Guo M Jia Y Ruan M Shuang J Liu X Gong Y Zhang J Yang X Yang, Neurosci Lett 2005 381 1 5 15882779 (Pubitemid 40693132)
32. Lack of evidence for association of the serotonin transporter gene SLC6A4 with autism. N Ramoz JG Reichert TE Corwin CJ Smith JM Silverman E Hollander JD Buxbaum, Biol Psychiatry 2006 60 186 191 16616719
33. SERT Ileu425Val in autism, Asperger syndrome and obsessive-compulsive disorder. JR Wendland TB DeGuzman F McMahon G Rudnick SD tera-Wadleigh DL Murphy, Psychiatr Genet 2008 18 31 39 18197083
34. Urinary 5-hydroxyindoleacetic acid and whole blood serotonin and tryptophan in autistic and normal subjects. RB Minderaa GM Anderson FR Volkmar GW Akkerhuis DJ Cohen, Biol Psychiatry 1987 22 933 940 2440483 (Pubitemid 17095316)
35. Serotonergic disturbances in autistic disorder: L-5-hydroxytryptophan administration to autistic youngsters increases the blood concentrations of serotonin in patients but not in controls. J Croonenberghs R Verkerk S Scharpe D Deboutte M Maes, Life Sci 2005 76 2171 2183 15733932 (Pubitemid 40283642)
36. Statistical distribution of blood serotonin as a predictor of early autistic brain abnormalities. S Janǔonis, Theor Biol Med Model 2005 2 27 16029508 (Pubitemid 41259093)
37. Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels. AM Coutinho I Sousa M Martins C Correia T Morgadinho C Bento C Marques A Ataide TS Miguel JH Moore, Hum Genet 2007 121 243 256 17203304 (Pubitemid 46404458)
38. Brief report: normal intestinal permeability at elevated platelet serotonin levels in a subgroup of children with pervasive developmental disorders in Curacao (The Netherlands antilles). RF Kemperman FD Muskiet AI Boutier IP Kema FA Muskiet, J Autism Dev Disord 2008 38 401 406 17661166
39. Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. AM Carneiro EH Cook DL Murphy RD Blakely, J Clin Invest 2008 118 1544 1552 18317590
40. Augmented brain 5-HT crosses the blood-brain barrier through the 5-HT transporter in rat. Y Nakatani I Sato-Suzuki N Tsujino A Nakasato Y Seki M Fumoto H Arita, Eur J Neurosci 2008 27 2466 2472 18445233
41. Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter. KP Lesch BL Wolozin DL Murphy P Reiderer, J Neurochem 1993 60 2319 2322 7684072 (Pubitemid 23148809)
42. Functional expression of the serotonin transporter in immortalized rat brain microvessel endothelial cells. P Brust A Friedrich IA Krizbai R Bergmann F Roux V Ganapathy B Johannsen, J Neurochem 2000 74 1241 1248 10693957 (Pubitemid 30104322)
43. Localization of norepinephrine and serotonin transporter in mouse brain capillary endothelial cells. K Wakayama S Ohtsuki H Takanaga K Hosoya T Terasaki, Neurosci Res 2002 44 173 180 12354632 (Pubitemid 38365959)
44. The serotonin signaling system: From basic understanding to drug development for functional GI disorders. MD Gershon J Tack, Gastroenterology 2007 132 397 414 17241888 (Pubitemid 46127672)
45. MRI volumes of amygdala and hippocampus in non-mentally retarded autistic adolescents and adults. EH Aylward NJ Minshew G Goldstein NA Honeycutt AM Augustine KO Yates PE Barta GD Pearlson, Neurology 1999 53 2145 2150 10599796
46. Detection and mapping of hippocampal abnormalities in autism. R Nicolson TJ DeVito CN Vidal Y Sui KM Hayashi DJ Drost PC Williamson N Rajakumar AW Toga PM Thompson, Psychiatry Res 2006 148 11 21 17056234 (Pubitemid 44667442)
47. Brain structural abnormalities in young children with autism spectrum disorder. BF Sparks SD Friedman DW Shaw EH Aylward D Echelard AA Artru KR Maravilla JN Giedd J Munson G Dawson, Neurology 2002 59 184 192 12136055
48. RB Kline, Principles and practice of structural equation modeling New York: The Guilford Press Second 2005
49. The earth is round (p <.05). J Cohen, Am Psychologist 1994 49 997 1003 (Pubitemid 24976676)
50. Postnatal development and localization of 5-HT 1A receptor mRNA in rat forebrain and cerebellum. MC Miquel HK Kia C Boni E Doucet G Daval L Matthiessen M Hamon D Verge, Brain Res Dev Brain Res 1994 80 149 157 7955340
51. Ontogeny of 5-HT 1A receptor expression in the developing hippocampus. TD Patel FC Zhou, Brain Res Dev Brain Res 2005 157 42 57 15939084
52. Regional distribution and ontogeny of 5-HT 4 binding sites in rodent brain. C Waeber M Sebben A Nieoullon J Bockaert A Dumuis, Neuropharmacology 1994 33 527 541 7984292
53. Transient localization of 5-HT 1A receptors in human cerebellum during development. E del Olmo A Diaz M Guirao-Pineyro C del Arco J Pascual A Pazos, Neurosci Lett 1994 166 149 152 8177491
54. SM Blinkov II Glezer, The Human Brain in Figures and Tables: A Quantitative Handbook New York, NY: Plenum Press 1968
55. JR Baker, Principles of Biological Microtechnique London: Methuen & Co, Ltd 1958
56. G Paxinos KBJ Franklin, The Mouse Brain in Steterotaxic Coordinates: Deluxe Edition of the Atlas San Diego, CA: Academic Press Second 2001
57. Rapid DNA extraction and PCR-sexing of mouse embryos. PJ McClive AH Sinclair, Mol Reprod Dev 2001 60 225 226 11553922 (Pubitemid 32847133)
58. J Cohen P Cohen SG West LS Aiken, Applied Multiple Regression/Correlation Analysis for the Behavioral Sciences Mahwah, NJ: Lawrence Erlbaum Associates Third 2003
59. Density of the ratio of two normal random variables and applications. T Pham-Gia N Turkkan E Marchand, Comm Stat Theory Meth 2006 35 1569 1591 (Pubitemid 44451556)
60. Maternal serotonin is crucial for murine embryonic development. F Cote C Fligny E Bayard JM Launay MD Gershon J Mallet G Vodjdani, Proc Natl Acad Sci USA 2007 104 329 334 17182745 (Pubitemid 46068031)
61. Maternal serotonin influences cardiac function in adult offspring. C Fligny Y Fromes P Bonnin M Darmon E Bayard JM Launay F Cote J Mallet G Vodjdani, FASEB J 2008 22 2340 2349 18267982
62. Pregnant rats treated with a serotonin precursor have reduced fetal weight and lower plasma volume and kallikrein levels. SP Salas A Giacaman W Romero P Downey E Aranda D Mezzano CP Vio, Hypertension 2007 50 773 779 17646571 (Pubitemid 47447911)
63. Birth weight and gestational age characteristics of children with autism, including a comparison with other developmental disabilities. D Schendel TK Bhasin, Pediatrics 2008 121 1155 1164 18519485
64. Clinical, morphological, and biochemical correlates of head circumference in autism. R Sacco R Militerni A Frolli C Bravaccio A Gritti M Elia P Curatolo B Manzi S Trillo C Lenti, Biol Psychiatry 2007 62 1038 1047 17644070 (Pubitemid 47562373)
65. Thalamocortical maturation in mice is influenced by body weight. A Hoerder-Suabedissen O Paulsen Z Molnar, J Comp Neurol 2008 511 415 420 18803242
66. Serotonin and brain development: role in human developmental diseases. PM Whitaker-Azmitia, Brain Res Bull 2001 56 479 485 11750793 (Pubitemid 34031783)
67. Great apes prefer cooked food. V Wobber B Hare R Wrangham, J Hum Evol 2008 55 340 348 18486186
68. Paleoanthropology. Food for thought. A Gibbons, Science 2007 316 1558 1560 17569838
69. Acute tryptophan depletion dose dependently impairs object memory in serotonin transporter knockout rats. JD Olivier LA Jans GA Korte-Bouws SM Korte PM Deen AR Cools BA Ellenbroek A Blokland, Psychopharmacology (Berl) 2008 200 243 254 18542930
70. Chronic reduction in dietary tryptophan leads to a selective impairment of contextual fear memory in mice. S Uchida H Umeeda A Kitamoto S Masushige S Kida, Brain Res 2007 1149 149 156 17382305 (Pubitemid 46659897)
71. Modification of dendritic development. A Feria-Velasco AR del Angel I Gonzalez-Burgos, Prog Brain Res 2002 136 135 143 12143377 (Pubitemid 35460974)
72. Serotonin 1A receptor acts during development to establish normal anxiety-like behaviour in the adult. C Gross X Zhuang K Stark S Ramboz R Oosting L Kirby L Santarelli S Beck R Hen, Nature 2002 416 396 400 11919622
73. Origin and functional role of the extracellular serotonin in the midbrain raphe nuclei. A Adell P Celada MT Abellan F Artigas, Brain Res Brain Res Rev 2002 39 154 180 12423765 (Pubitemid 35341097)
74. Fetal human brain exhibits a prenatal peak in the density of serotonin 5-HT 1A receptors. O Bar-Peled R Gross-Isseroff H Ben Hur I Hoskins Y Groner A Biegon, Neurosci Lett 1991 127 173 176 1831889
75. Identification of cells that express 5-hydroxytryptamine1A receptors in the nervous systems of the bowel and pancreas. AL Kirchgessner MT Liu JR Raymond MD Gershon, J Comp Neurol 1996 364 439 455 8820876 (Pubitemid 26039430)
76. Developmental changes of serotonin 4(a) receptor expression in the rat pre-Botzinger complex. T Manzke S Preusse S Hulsmann DW Richter, J Comp Neurol 2008 506 775 790 18076058
77. Regional distribution and ontogeny of 5-HT 4 binding sites in rat brain. C Waeber M Sebben J Bockaert A Dumuis, Behav Brain Res 1996 73 259 262 8788514
78. Expression and function of 5-HT4 receptors in the mouse enteric nervous system. M Liu MS Geddis Y Wen W Setlik MD Gershon, Am J Physiol Gastrointest Liver Physiol 2005 289 G1148 G1163 16037544 (Pubitemid 41740621)
79. Gene expression profiling for the identification of G-protein coupled receptors in human platelets. S Amisten OO Braun A Bengtsson D Erlinge, Thromb Res 2008 122 47 57 17920662