Lack of association between serotonin transporter gene promoter variants and autistic disorder in two ethnically distinct samples

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 96, Issue 1, 2000, Pages 123-127

  Persico, Antonio M ^a   Militerni, Roberto ^b   Bravaccio, Carmela ^b   Schneider, Cindy ^c   Melmed, Raun ^c   Conciatori, Monica ^a   Damiani, Valerio ^a   Baldi, Alfonso ^a   Keller, Flavio ^a,d  

^a UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c Southwest Autism Research and Resource Center   (United States)

^d Lab of Neuroscience   (Italy)

Author keywords

Haplotype relative risk; Pervasive developmental disorders; Transmission disequilibrium test

Indexed keywords

SEROTONIN TRANSPORTER;

ADULT; ARTICLE; AUTISM; CHILD; DEVELOPMENTAL DISORDER; ETHNOLOGY; FAMILY STUDY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC LINKAGE; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; ITALY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; UNITED STATES;

ADOLESCENT; AUTISTIC DISORDER; BASE SEQUENCE; CARRIER PROTEINS; CHILD; CHILD, PRESCHOOL; DNA PRIMERS; FEMALE; HAPLOTYPES; HUMANS; ITALY; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; PROMOTER REGIONS (GENETICS); SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; UNITED STATES;

GENETTA;

EID: 0034615162     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(20000207)96:1<123::AID-AJMG24>3.0.CO;2-N     Document Type: Article

References (30)

1. American Psychiatric Association. 1994. Diagnostic and Statistical Manual of Mental Disorders (4th ed.). Washington, DC: American Psychiatric Association.
2. Anderson GM, Horne WC, Chatterjee D, Cohen DJ. 1990. The hyperserotoninemia of autism. Ann New York Acad Sci 600:331-340.
3. Bailey A, Le Couteur A, Gottesman I, Bolton P, Simonoff E, Yuzda E, Rutter M. 1995. Autism as a strongly genetic disorder: evidence from a British twin study. Psychol Med 25:63-78.
4. Bailey CH, Chen MC, Keller F, Kandel ER. 1992. Serotonin-mediated endocytosis of apCAM: an early step of learning-related synaptic growth in Aplysia. Science 256:645-649.
5. Cases O, Vitalis T, Seif I, De Maeyer E, Sotelo C, Gaspar P. 1996. Lack of barrels in the somatosensory cortex of monoamine oxidase A-deficient mice: role of a serotonin excess during the critical period. Neuron 16: 297-307.
6. Cook EH Jr, Courchesne R, Lord C, Cox NJ, Yan S, Lincoln A, Haas R, Courchesne E, Leventhal BL. 1997. Evidence of linkage between the serotonin transporter and autistic disorder. Mol Psychiatry 2:247-250.
7. Cook EH Jr, Leventhal BL, Freedman DX. 1988. Free serotonin in plasma: autistic children and their first-degree relatives. Biol Psychiatry 24: 488-491.
8. Gelernter J, Kranzler H, Cubells JF. 1997. Serotonin transporter protein (SCL6A4) allele and haplotype frequencies and linkage disequilibria in African and European American and Japanese populations and in alcohol-dependent subjects. Hum Genet 101:243-246.
9. Griffiths R. 1992. Griffiths mental developmental dcales. Oxon RG9 4AE: the test agency.
10. International Molecular Genetic Study of Autism Consortium. 1998. A full genome screen for autism with evidence for linkage to a region on chromosome 7q. Hum Mol Genet 7:571-578.
11. 3H-serotonin uptake by platelets in infantile autism and developmental language disorder (including five pairs of twins). J Autism Dev Disord 16:69-76.
12. Klauck SM, Poustka F, Benner A, Lesch KP, Poutska A. 1997. Serotonin transporter (5-HTT) gene variants associated with autism? Hum Mol Genet 6:2233-2238.
13. Krug DA, Arick, JR, Almond PJ. 1980. Behavior checklist for identifying severely handicapped individuals with high levels of autistic behavior. J Child Psychol Psychiatry 21:221-229.
14. Leiter RG. 1948. Leiter International Performance Scale. Chicago: Stoelting.
15. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Mueller CR, Hamer DH, Murphy DL. 1996. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531.
16. Lesch KP, Wolozin BL, Murphy DL, Riederer P. 1993. Primary structure of the human platelet serotonin (5-HT) uptake site: identity with the brain 5-HT transporter. J Neurochem 60:2319-2322.
17. Levitt P, Harvey JA, Friedman E, Simansky K, Murphy EH. 1997. New evidence for neurotransmitter influences on brain development. Trends Neurosci 20:269-274.
18. McDougle CJ, Epperson CN, Price LH, Gelernter J. 1998. Evidence of linkage disequilibrium between serotonin transporter protein gene (SCL6A4) and obsessive compulsive disorder. Mol Psychiatry 3:270-273.
19. Michaelovsky E, Frisch A, Rockah R, Peleg L, Magal N, Shohat M, Weizman R. 1999. A novel allele in the promoter region of the human serotonin transporter gene. Mol Psychiatry 4:97-99.
20. Persico AM, Baldi A, Calia E, Moessner R, Lesch KP, Murphy DL, Keller F. 1998. Alterations in neonatal barrel cortex and in the aging brain of serotonin transporter knockout mice. Soc Neurosci Abs 24:1111.
21. Persico AM, Macciardi F, 1997. Genotypic association between dopamine transporter gene polymorphisms and schizophrenia. Am J Med Genet 74:53-57.
22. Pickles A, Bolton P, MacDonald H, Bailey A, Le Couteur A, Sim CH, Rutter M. 1995. Latent-class analysis of recurrence risks for complex phenotypes with selection and measurement error: a twin and family history study of autism. Am J Hum Genet 57:717-726.
23. Piven J, Tsai G, Nehme E, Coyle JT, Chase GA, Folstein SE. 1991. Platelet serotonin, a possible marker for familial autism. J Autism Dev Disord 21:51-59.
24. Rousseau F, Heitz D Biancalana V, Blumenfeld S, Kretz C, Boué J, Tommerup N, Van Der Hagen C, DeLozier-Blanchet C, Croquette MF, Gilgenkrantz S, Jalbert P, Voelckel MA, Oberli I, Mandel JL. 1991. Direct diagnosis by DNA analysis of the fragile X mental retardation syndrome. N Engl J Med 325:1673-1681.
25. Schopler E, Reichler RJ, Rochen Renner BR. 1986. The Childhood Autism Rating Scale for Diagnostic Screening and Classification of Autism. New York: Irvington.
26. Smalley SL. 1997. Genetic influences in childhood-onset psychiatric disorders: autism and attention-deficit/hyperactivity disorder. Am J Hum Genet 60:1276-1282.
27. Sparrow SS, Balla DA, Cicchetti DV. 1984. Vineland Adaptive Behavior Scales - Survey Form. Circle Pines, MN: American Guidance Service.
28. Spielman RS, Ewens WJ. 1996. The TDT and other family-based tests for linkage disequilibrium and association. Am J Hum Genet 59:983-989.
29. Spielman RS, McGinnis RE, Ewens WJ. 1993. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-516.
30. Terwilliger JD, Ott J. 1992. A haplotype-based "haplotype relative risk" approach to detecting allelic associations. Hum Hered 42:337-346.