Origin of the blood hyperserotonemia of autism

Theoretical Biology and Medical Modelling

Volumn 5, Issue , 2008, Pages

  Janušonis, Skirmantas ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ARTICLE; AUTISM; BIOLOGICAL MODEL; HUMAN; LINEAR SYSTEM; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; NONLINEAR SYSTEM; PARAMETER; PLATELET HYPERSEROTONEMIA; SENSITIVITY ANALYSIS; SEROTONIN BLOOD LEVEL; SEROTONIN METABOLISM; SEROTONIN RELEASE; SEROTONIN UPTAKE; STEADY STATE; THROMBOCYTE; AORTA; BLOOD; BLOOD BRAIN BARRIER; CHILD; INTESTINE; LIVER; LUNG; METABOLISM; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL; THEORETICAL MODEL;

AORTA; AUTISTIC DISORDER; BLOOD PLATELETS; BLOOD-BRAIN BARRIER; CHILD; HUMANS; INTESTINES; LIVER; LUNG; MODELS, BIOLOGICAL; MODELS, STATISTICAL; MODELS, THEORETICAL; SENSITIVITY AND SPECIFICITY; SEROTONIN;

EID: 48349083166     PISSN: None     EISSN: 17424682     Source Type: Journal    
DOI: 10.1186/1742-4682-5-10     Document Type: Article

References (53)

1. Genetics of childhood disorders: XLV. Autism, part 4: Serotonin in autism. GM Anderson, J Am Acad Child Adolesc Psychiatry 2002 41 1513 1516 10.1097/00004583-200212000-00025 12447040
2. Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children. RJ Schain DX Freedman, J Pediatr 1961 58 315 320 10.1016/S0022-3476(61)80261-8 13747230
3. Hyperserotonemia and amine metabolites in autistic and retarded children. HG Hanley SM Stahl DX Freedman, Arch Gen Psychiatry 1977 34 521 531 860890
4. The hyperserotonemia of autism. GM Anderson WC Horne D Chatterjee DJ Cohen, Ann N Y Acad Sci 1990 600 331 340 10.1111/j.1749-6632.1990.tb16893.x 2252319
5. Brief report: Pathophysiology of autism: Neurochemistry. EH Cook, J Autism Dev Disord 1996 26 221 225 10.1007/BF02172016 8744489
6. Effects of diagnosis, race, and puberty on platelet serotonin levels in autism and mental retardation. PA McBride GM Anderson ME Hertzig ME Snow SM Thompson VD Khait T Shapiro DJ Cohen, J Am Acad Child Adolesc Psychiatry 1998 37 767 776 10.1097/00004583-199807000-00017 9666633
7. Platelet serotonin levels in pervasive developmental disorders and mental retardation: Diagnostic group differences, within-group distribution, and behavioral correlates. EJ Mulder GM Anderson IP Kema A deBildt ND van Lang JA den Boer RB Minderaa, J Am Acad Child Adolesc Psychiatry 2004 43 491 499 10.1097/00004583-200404000-00016 15187810
8. Hyperserotonemia in adults with autistic disorder. D Hranilovic Z Bujas-Petkovic R Vragovic T Vuk K Hock B Jernej, J Autism Dev Disord 2007 37 1934 1940 10.1007/s10803-006-0324-6 17165147
9. Abnormal melatonin synthesis in autism spectrum disorders. J Melke H Goubran Botros P Chaste C Betancur G Nygren H Anckarsater M Rastam O Stahlberg IC Gillberg R Delorme N Chabane MC Mouren-Simeoni F Fauchereau CM Durand F Chevalier X Drouot C Collet JM Launay M Leboyer C Gillberg T Bourgeron, Mol Psychiatry 2008 13 90 98 17505466 10.1038/sj.mp.4002016
10. Review article: Serotonin receptors and transporters - roles in normal and abnormal gastrointestinal motility. MD Gershon, Aliment Pharmacol Ther 2004 20 Suppl 7 3 14 10.1111/j.1365-2036.2004.02180.x 15521849
11. The serotonin signaling system: From basic understanding to drug development for functional GI disorders. MD Gershon J Tack, Gastroenterology 2007 132 397 414 10.1053/j.gastro.2006.11.002 17241888
12. Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters. JJ Chen Z Li H Pan DL Murphy H Tamir H Koepsell MD Gershon, J Neurosci 2001 21 6348 6361 11487658
13. 5-hydroxytryptamine in the circulation of the dog. DP Thomas JR Vane, Nature 1967 216 335 338 10.1038/216335a0 6053807
14. Steady-state model for plasma free and platelet serotonin in man. GM Anderson JM Stevenson DJ Cohen, Life Sci 1987 41 1777 1785 10.1016/0024-3205(87) 90696-5 3657383
15. Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Autism-Genome-Project-Consortium, Nat Genet 2007 39 319 328 10.1038/ng1985 17322880
16. Strong association of de novo copy number mutations with autism. J Sebat B Lakshmi D Malhotra J Troge C Lese-Martin T Walsh B Yamrom S Yoon A Krasnitz J Kendall A Leotta D Pai R Zhang YH Lee J Hicks SJ Spence AT Lee K Puura T Lehtimaki D Ledbetter PK Gregersen J Bregman JS Sutcliffe V Jobanputra W Chung D Warburton MC King D Skuse DH Geschwind TC Gilliam K Ye M Wigler, Science 2007 316 445 449 10.1126/science.1138659 17363630
17. Primary structure of the human platelet serotonin uptake site: Identity with the brain serotonin transporter. KP Lesch BL Wolozin DL Murphy P Reiderer, J Neurochem 1993 60 2319 2322 10.1111/j.1471-4159.1993.tb03522.x 7684072
18. Serotonin transporter promoter variants in autism: Functional effects and relationship to platelet hyperserotonemia. GM Anderson L Gutknecht DJ Cohen S Brailly-Tabard JH Cohen P Ferrari PL Roubertoux S Tordjman, Mol Psychiatry 2002 7 831 836 10.1038/sj.mp.4001099 12232775
19. Variants of the serotonin transporter gene (SLC6A4) significantly contribute to hyperserotonemia of autism. AM Coutinho G Oliveira T Morgadinho C Fesel TR Macedo C Bento C Marques A Ataide T Miguel L Borges AM Vicente, Mol Psychiatry 2004 9 264 271 10.1038/sj.mp.4001409 15094787
20. Serotonin promoter gene variants do not explain the hyperserotonemia in autistic children. AM Persico T Pascucci S Puglisi-Allegra R Militerni C Bravaccio C Schneider R Melmed S Trillo F Montecchi M Palermo D Rabinowitz KL Reichelt M Conciatori R Marino F Keller, Mol Psychiatry 2002 7 795 800 10.1038/sj.mp.4001069 12192626
21. Serotonergic disturbances in autistic disorder: L-5-hydroxytryptophan administration to autistic youngsters increases the blood concentrations of serotonin in patients but not controls. J Croonenberghs R Verkerk S Scharpe D Deboutte M Maes, Life Sci 2005 76 2171 2183 10.1016/j.lfs.2004.06.032 15733932
22. Statistical distribution of blood serotonin as a predictor of early autistic brain abnormalities. S Janušonis, Theor Biol Med Model 2005 2 27 16029508 10.1186/1742-4682-2-27
23. Ontogeny of brain and blood serotonin levels in 5-HT1A receptor knockout mice: Potential relevance to the neurobiology of autism. S Janušonis GM Anderson I Shifrovich P Rakic, J Neurochem 2006 99 1019 1031 10.1111/j.1471-4159.2006.04150.x 16981893
24. Serotonin-, protein kinase C-, and His-5-associated distribution of the platelet serotonin transporter. AMD Carneiro RD Blakely, J Biol Chem 2006 281 24769 24780 10.1074/jbc.M603877200 16803896
25. Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels. AM Coutinho I Sousa M Martins C Correia T Morgadinho C Bento C Marques A Ataide TS Miguel JH Moore G Oliveira AM Vicente, Hum Genet 2007 121 243 256 10.1007/s00439-006-0301-3 17203304
26. Hyperserotonemia in autism: The potential role of 5-HT-related gene variants. D Hranilovic R Novak M Babic M Novokmet Z Bujas-Petkovic B Jernej, Coll Antropol 2008 32 Suppl 1 75 80 18405062
27. Increase in density and accumulation of serotonin by human aging platelets. D Mezzano E Aranda S Rodriguez A Foradori P Lira, Am J Hematol 1984 17 11 21 10.1002/ajh.2830170103 6741929
28. Determination of human platelet survival utilizing C-14-labeled serotonin. RM Heyssel, J Clin Invest 1961 40 2134 2142 13907152 10.1172/JCI104439
29. A simple nonradioisotope technic for the determination of platelet life-span. MJ Stuart S Murphy FA Oski, N Engl J Med 1975 292 25 1310 1313 1168851
30. On the accurate determination of serotonin in human plasma. O Beck NH Wallen A Broijersen PT Larsson P Hjemdahl, Biochem Biophys Res Commun 1993 196 260 266 10.1006/bbrc.1993.2243 8216301
31. Measurement of plasma serotonin in autism. GM Anderson, Pediatr Neurol 2007 36 138 10.1016/j.pediatrneurol.2006.11.007 17275674
32. Origin and functional role of the extracellular serotonin in the midbrain raphe nuclei. A Adell P Celada MT Abellan F Artigas, Brain Res Brain Res Rev 2002 39 154 180 10.1016/S0165-0173(02)00182-0 12423765
33. Autoreceptors can modulate 5-hydroxytryptamine release from porcine and human small intestine in vitro. H Schworer G Ramadori, Naunyn Schmiedebergs Arch Pharmacol 1998 357 548 552 10.1007/PL00005206 9650808
34. Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. DK Kim TJ Tolliver SJ Huang BJ Martin AM Andrews C Wichems A Holmes KP Lesch DL Murphy, Neuropharmacology 2005 49 6 798 810 10.1016/j.neuropharm.2005.08.010 16183083
35. Characterization of the serotonin transporter knockout rat: A selective change in the functioning of the serotonergic system. JR Homberg JD Olivier BM Smits JD Mul J Mudde M Verheul OF Nieuwenhuizen AR Cools E Ronken T Cremers AN Schoffelmeer BA Ellenbroek E Cuppen, Neuroscience. 2007 146 4 1662 1676 10.1016/j.neuroscience.2007.03.030 17467186
36. Cloning and expression of the mouse serotonin transporter. AS Chang SM Chang DM Starnes S Schroeter AL Bauman RD Blakely, Brain Res Mol Brain Res 1996 43 185 192 10.1016/S0169-328X(96)00172-6 9037532
37. Kinetics of 3H-serotonin uptake by platelets in infantile autism and developmental language disorder (including five pairs of twins). T Katsui M Okuda S Usuda T Koizumi, J Autism Dev Disord 1986 16 69 76 10.1007/BF01531579 3957859
38. Increased density of the platelet serotonin transporter in autism. D Marazziti F Muratori A Cesari I Masala S Baroni G Giannaccini L Dell'Osso A Cosenza P Pfanner GB Cassano, Pharmacopsychiatry 2000 33 165 168 10.1055/s-2000-7588 11071017
39. Identification of cells that express 5-hydroxytryptamine1A receptors in the nervous system of the bowel and pancreas. AL Kirchgessner MT Liu JR Raymond MD Gershon, J Comp Neurol 1996 364 439 455 10.1002/(SICI)1096-9861(19960115)364: 3<439::AID-CNE5>3.0.CO;2-5 8820876
40. Investigation of serotonin type 4 receptor expression in human and non-human primate gastrointestinal samples. R Mader T Kocher J Haier G Wieczorek HJ Pfannkuche M Ito, Eur J Gastroenterol Hepatol 2006 18 945 950 10.1097/01.meg.0000228975.87645.27 16894306
41. Brief Report: Normal intestinal permeability at elevated platelet serotonin levels in a subgroup of children with pervasive developmental disorders in Curacao (The Netherlands Antilles). RFJ Kemperman FD Muskiet AI Boutier IP Kema FAJ Muskiet, J Autism Dev Disord 2008 38 401 406 17661166 10.1007/s10803-007-0399-8
42. H Gray, Gray's Anatomy New York, NY: Barnes & Noble, Inc 15 1995
43. The pre-nervous serotonergic system of developing sea urchin embryos and larvae: Pharmacologic and immnocytochemical evidence. GA Buznikov RE Peterson LA Nikitina VV Bezuglov JM Lauder, Neurochem Res 2005 30 825 837 10.1007/s11064-005-6876-6 16187217
44. Serotonin and serotonin-like substances as regulators of early embryogenesis and morphogenesis. GA Buznikov HW Lambert JM Lauder, Cell Tissue Res 2001 305 177 186 10.1007/s004410100408 11545255
45. Paleoanthropology: Food for thought. A Gibbons, Science 2007 316 1558 1560 10.1126/science.316.5831.1558 17569838
46. Interactions between integrin αIIbβ3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. AMD Carneiro EH Cook DL Murphy RD Blakely, J Clin Invest 2008 118 1544 1552 18317590 10.1172/JCI33374
47. TC Ruch JF Fulton, Medical Physiology and Biophysics Philadelphia, PA: W. B. Saunders Company 18 1960
48. IP Herman, Physics of the Human Body New York, NY: Springer-Verlag 2007
49. MH Ross LJ Romrell GI Kaye, Histology: A Text and Atlas Baltimore, MD: Williams & Wilkins 3 1995
50. Protein content in various regions of rat brain and adult and aging human brains. M Banay-Schwartz A Kenessey T DeGuzman A Lajtha M Palkovits, Age 1992 15 51 54 10.1007/BF02435024
51. SM Blinkov II Glezer, The Human Brain in Figures and Tables New York, NY: Plenum Press 1968
52. Function, expression, and characterization of the human serotonin transporter in the native human intestine. RK Gill N Pant S Saksena A Singla TM Nazir L Vohwinkel JR Turner J Goldstein WA Alrefai PK Dudeja, Am J Physiol Gastrointest Liver Physiol 2008 294 G254 G262 10.1152/ajpgi.00354.2007 17991706
53. Three-dimensional capillary geometry in gut tissue. S Bosan T Kareco D Ruehlmann KY Chen KR Walley, Microsc Res Tech 2003 61 428 437 10.1002/jemt.10352 12845569