Augmented brain 5-HT crosses the blood-brain barrier through the 5-HT transporter in rat

European Journal of Neuroscience

Volumn 27, Issue 9, 2008, Pages 2466-2472

  Nakatani, Yasushi ^a   Sato Suzuki, Ikuko ^a   Tsujino, Naohisa ^a   Nakasato, Akane ^a   Seki, Yoshinari ^a   Fumoto, Masaki ^a   Arita, Hideho ^a  

^a TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Blood brain barrier; Microdialysis; Serotonin; SSRI

Indexed keywords

5 HYDROXYTRYPTOPHAN; FLUOXETINE; SEROTONIN; SEROTONIN TRANSPORTER;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; BLOOD SAMPLING; CIRCULATION; CONTROLLED STUDY; GASTROINTESTINAL SURGERY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MICRODIALYSIS; NEPHRECTOMY; NONHUMAN; PRIORITY JOURNAL; RAT;

5-HYDROXYTRYPTOPHAN; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MALE; MICRODIALYSIS; RATS; RATS, WISTAR; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS;

EID: 42549170030     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2008.06201.x     Document Type: Article

References (18)

1. Artigas, F., Sarrias, M.J., Martínez, E. Gelpí, E. (1985) Serotonin in body fluids: characterization of human plasmatic and cerebrospinal fluid pools by means of a new HPLC method. Life Sci., 37, 441 447.
2. Brust, P., Friedrich, A., Krizbai, I.A., Bergmann, R., Roux, F., Ganapathy, V. Johannsen, B. (2000) Functional expression of the serotonin transporter in immortalized rat brain microvessel endothelial cells. J. Neurochem., 74, 1241 1248.
3. Fuxe, K. Agnati, L.F. (1991) Two principal modes of electrochemical communication in the brain: volume versus wiring transmission. In Fuxe, K. Agnati, L.F. (eds), Volume Transmission in the Brain: Novel Mechanisms for Neural Transmission. Raven Press, New York, pp. 1 9.
4. Fuxe, K., Dahlström, A., Höistad, M., Marcellino, D., Jansson, A., Rivera, A., Diaz-Cabiale, Z., Jacobsen, K., Tinner-Staines, B., Hagman, B., Leo, G., Staines, W., Guidolin, D., Kehr, J., Genedani, S., Belluardo, N. Agnati, L.F. (2007) From the Golgi-Cajal mapping to the transmitter-based characterization of the neuronal networks leading to two modes of brain communication: Wiring and volume transmission. Brain Res. Rev., 55, 17 54.
5. Gaginella, T.S. (1995) Serotonin in the intestinal tract: a synopsis. In Gaginella, T.S. Galligan, J.J. (eds), Serotonin and Gastrointestinal Function. CRC Press, Boca Raton, pp. 1 9.
6. Gartside, S.E., Cowen, P.J. Sharp, T. (1992) Effect of 5-hydroxy-L-tryptophan on the release of 5-HT in rat hypothalamus in vivo as measured by microdialysis. Neuropharmacology, 31, 9 14.
7. Gillis, C.N. (1985) Peripheral metabolism of serotonin. In Vanhoutte, P.M. (ed.), Serotonin and the Cardiovascular System. Raven Press, New York, pp. 27 36.
8. Hornung, J.P. (2003) The human raphe nuclei and the serotonergic system. J. Chem. Neuroanat., 26, 331 343.
9. Jacobs, B.L. Azmitia, E.C. (1992) Structure and function of the brain serotonin system. Physiol. Rev., 72, 165 229.
10. Kremer, H.P., Goekoop, J.G. Van Kempen, G.M. (1990) Clinical use of the determination of serotonin in whole blood. J. Clin. Psychopharmacol., 10, 83 87.
11. Löscher, W., Pagliusi, S.R. Müller, F. (1984) L-5-hydroxytryptophan. Correlation between anticonvulsant effect and increases in levels of 5-hydroxyindoles in plasma and brain. Neuropharmacology, 23, 1041 1048.
12. Okada, F., Saito, Y., Fujieda, T. Yamashita, I. (1972) Monoamine changes in the brain of rats injected with L-5-hydroxytryptophan. Nature, 238, 355 356.
13. Ortiz, J., Artigas, F. Gelpí, E. (1988) Serotonergic status in human blood. Life Sci., 43, 983 990.
14. Paxinos, G. Watson, C. (1986) The Rat Brain in Stereotaxic Coordinates, 2nd edn. Academic Press, San Diego.
15. Penalva, R.G., Lancel, M., Flachskamm, C., Reul, J.M., Holsboer, F. Linthorst, A.C. (2003) Effect of sleep and sleep deprivation on serotonergic neurotransmission in the hippocampus: a combined in vivo microdialysis/EEG study in rats. Eur. J. Neurosci., 17, 1896 1906.
16. Stier, C.T. Jr. Itskovitz, H.D. (1985) Formation of serotonin by rat kidneys in vivo. Proc. Soc. Exp. Biol. Med., 180, 550 557.
17. Wakayama, K., Ohtsuki, S., Takanaga, H., Hosoya, K. Terasaki, T. (2002) Localization of norepinephrine and serotonin transporter in mouse brain capillary endothelial cells. Neurosci. Res., 44, 173 180.
18. West, G.B. (1958) Studies on 5-hydroxytryptamine and 5-hydroxytryptophan. J. Pharm. Pharmacol., 10 (Suppl. 92 97.