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Volumn 17, Issue , 2008, Pages 395-411

Chapter 5.2 How effective are current drug treatments for anxiety disorders, and how could they be improved?

Author keywords

cognitive behavioural therapy; combination treatment; generalised anxiety disorder; panic disorder; pharmacotherapy; psychopharmacology; social anxiety disorder (social phobia); treatment efficacy; treatment response

Indexed keywords


EID: 65049087842     PISSN: 15697339     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1569-7339(07)00018-5     Document Type: Review
Times cited : (8)

References (147)
  • 1
    • 4444333450 scopus 로고    scopus 로고
    • Efficacy of venlafaxine ER in patients with social anxiety disorder: a double-blind, placebo-controlled, parallel-group comparison with paroxetine
    • Allgulander C., Mangano R., Zhang J., Dahl A.A., Lepola U., Sjodin I., and Emilien G. Efficacy of venlafaxine ER in patients with social anxiety disorder: a double-blind, placebo-controlled, parallel-group comparison with paroxetine. Hum. Psychopharmacol. 19 (2004) 387-396
    • (2004) Hum. Psychopharmacol. , vol.19 , pp. 387-396
    • Allgulander, C.1    Mangano, R.2    Zhang, J.3    Dahl, A.A.4    Lepola, U.5    Sjodin, I.6    Emilien, G.7
  • 4
    • 4544274763 scopus 로고    scopus 로고
    • Sexual dysfunction associated with antidepressant drugs
    • Baldwin D.S. Sexual dysfunction associated with antidepressant drugs. Exp. Opin. Drug Safe. 3 (2004) 457-470
    • (2004) Exp. Opin. Drug Safe. , vol.3 , pp. 457-470
    • Baldwin, D.S.1
  • 5
    • 34249893069 scopus 로고    scopus 로고
    • The role of pregabalin in the treatment of generalized anxiety disorder
    • Baldwin D.S., and Ajel K. The role of pregabalin in the treatment of generalized anxiety disorder. Neuropsychiatr. Dis. Treat. 3 (2007) 185-191
    • (2007) Neuropsychiatr. Dis. Treat. , vol.3 , pp. 185-191
    • Baldwin, D.S.1    Ajel, K.2
  • 7
    • 33748432736 scopus 로고    scopus 로고
    • Escitalopram and paroxetine in the treatment of generalised anxiety disorder. Randomised, double-blind, placebo-controlled, double-blind study
    • Baldwin D.S., Huusom A.K.T., and Maehlum E. Escitalopram and paroxetine in the treatment of generalised anxiety disorder. Randomised, double-blind, placebo-controlled, double-blind study. Br. J. Psychiatry 189 (2006) 264-272
    • (2006) Br. J. Psychiatry , vol.189 , pp. 264-272
    • Baldwin, D.S.1    Huusom, A.K.T.2    Maehlum, E.3
  • 8
    • 0037620644 scopus 로고    scopus 로고
    • Sexual side effects of antidepressant and antipsychotic drugs
    • Baldwin D.S., and Mayers A.G. Sexual side effects of antidepressant and antipsychotic drugs. Adv. Psychiatr. Treat. 9 (2003) 202-210
    • (2003) Adv. Psychiatr. Treat. , vol.9 , pp. 202-210
    • Baldwin, D.S.1    Mayers, A.G.2
  • 9
    • 20044384075 scopus 로고    scopus 로고
    • Evidence-based pharmacotherapy of generalized anxiety disorder
    • Baldwin D.S., and Polkinghorn C. Evidence-based pharmacotherapy of generalized anxiety disorder. Int. J. Neuropsychopharmacol. 8 (2005) 293-302
    • (2005) Int. J. Neuropsychopharmacol. , vol.8 , pp. 293-302
    • Baldwin, D.S.1    Polkinghorn, C.2
  • 10
    • 17744373871 scopus 로고    scopus 로고
    • The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition: a comparison
    • Ballard T.M., Wolley M.L., Prinssen E., Huwyler J., Porter R., and Spooren W. The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition: a comparison. Psychopharmacology 179 (2005) 218-229
    • (2005) Psychopharmacology , vol.179 , pp. 218-229
    • Ballard, T.M.1    Wolley, M.L.2    Prinssen, E.3    Huwyler, J.4    Porter, R.5    Spooren, W.6
  • 11
    • 0034679102 scopus 로고    scopus 로고
    • Cognitive-behavioral therapy, imipramine, or their combination for panic disorder: a randomized controlled trial
    • Barlow D.H., Gorman J.M., Shear M.K., and Woods S.W. Cognitive-behavioral therapy, imipramine, or their combination for panic disorder: a randomized controlled trial. JAMA 283 (2000) 2529-2536
    • (2000) JAMA , vol.283 , pp. 2529-2536
    • Barlow, D.H.1    Gorman, J.M.2    Shear, M.K.3    Woods, S.W.4
  • 15
    • 0035021701 scopus 로고    scopus 로고
    • Tryptophan depletion and its implications for psychiatry
    • Bell C.J., Abrams J.K., and Nutt D.J. Tryptophan depletion and its implications for psychiatry. Br. J. Psychiatry 178 (2001) 399-405
    • (2001) Br. J. Psychiatry , vol.178 , pp. 399-405
    • Bell, C.J.1    Abrams, J.K.2    Nutt, D.J.3
  • 16
  • 17
    • 33750379476 scopus 로고    scopus 로고
    • Efficacy of combined pharmacotherapy and psychotherapy versus monotherapy in the treatment of anxiety disorders
    • Black D.W. Efficacy of combined pharmacotherapy and psychotherapy versus monotherapy in the treatment of anxiety disorders. CNS Spectrosc. 11 Suppl. (2006) 29-33
    • (2006) CNS Spectrosc. , vol.11 , Issue.SUPPL , pp. 29-33
    • Black, D.W.1
  • 19
    • 0034946458 scopus 로고    scopus 로고
    • Randomised controlled general practice trial of sertraline, exposure therapy and combined treatment in generalised social phobia
    • Blomhoff S., Haug T.T., Hellstrom K., Holme I., Humble M., Madsbu H.P., and Wold J.E. Randomised controlled general practice trial of sertraline, exposure therapy and combined treatment in generalised social phobia. Br. J. Psychiatry 179 (2001) 23-30
    • (2001) Br. J. Psychiatry , vol.179 , pp. 23-30
    • Blomhoff, S.1    Haug, T.T.2    Hellstrom, K.3    Holme, I.4    Humble, M.5    Madsbu, H.P.6    Wold, J.E.7
  • 20
    • 0035220285 scopus 로고    scopus 로고
    • A modern learning theory perspective on the etiology of panic disorder
    • Bouton M.E., Mineka S., and Barlow D.H. A modern learning theory perspective on the etiology of panic disorder. Psychol. Rev. 108 (2001) 4-32
    • (2001) Psychol. Rev. , vol.108 , pp. 4-32
    • Bouton, M.E.1    Mineka, S.2    Barlow, D.H.3
  • 23
    • 29144449785 scopus 로고    scopus 로고
    • The empirical status of cognitive-behavioural therapy: a review of meta-analyses
    • Butler A.C., Chapman J.E., Forman E.M., and Beck A.T. The empirical status of cognitive-behavioural therapy: a review of meta-analyses. Clin. Psychol. Rev. 26 (2006) 17-31
    • (2006) Clin. Psychol. Rev. , vol.26 , pp. 17-31
    • Butler, A.C.1    Chapman, J.E.2    Forman, E.M.3    Beck, A.T.4
  • 26
    • 0141517336 scopus 로고    scopus 로고
    • Neuroanatomical circuits modulating fear and anxiety behaviors
    • Charney D.S. Neuroanatomical circuits modulating fear and anxiety behaviors. Acta Psychiatr. Scand. Suppl. 417 (2003) 38-50
    • (2003) Acta Psychiatr. Scand. Suppl. , vol.417 , pp. 38-50
    • Charney, D.S.1
  • 27
    • 0021249631 scopus 로고
    • Noradrenergic function and panic anxiety effects of yohimbine in healthy subjects and patients with agoraphobia and panic disorder
    • Charney D.S., Heninger G.R., and Breier A. Noradrenergic function and panic anxiety effects of yohimbine in healthy subjects and patients with agoraphobia and panic disorder. Arch. Gen. Psychiatry. 41 (1984) 751-763
    • (1984) Arch. Gen. Psychiatry. , vol.41 , pp. 751-763
    • Charney, D.S.1    Heninger, G.R.2    Breier, A.3
  • 28
    • 0024577109 scopus 로고
    • Noradrenergic function in generalized anxiety disorder: effects of yohimbine in healthy subjects and patients with generalized anxiety disorder
    • Charney D.S., Woods S.W., and Heninger G.R. Noradrenergic function in generalized anxiety disorder: effects of yohimbine in healthy subjects and patients with generalized anxiety disorder. Psychiatry Res. 27 (1989) 173-182
    • (1989) Psychiatry Res. , vol.27 , pp. 173-182
    • Charney, D.S.1    Woods, S.W.2    Heninger, G.R.3
  • 30
    • 13244262698 scopus 로고    scopus 로고
    • The S-enantiomer of R, S-citalopram increases inhibitor binding to the human serotonin transporter by an allosteric mechanism: comparison with other serotonin transporter inhibitors
    • Chen F., Larsen M.B., and Sánchez C. The S-enantiomer of R, S-citalopram increases inhibitor binding to the human serotonin transporter by an allosteric mechanism: comparison with other serotonin transporter inhibitors. Eur. Neuropsychopharmacol. 15 (2005) 193-198
    • (2005) Eur. Neuropsychopharmacol. , vol.15 , pp. 193-198
    • Chen, F.1    Larsen, M.B.2    Sánchez, C.3
  • 32
    • 0036153315 scopus 로고    scopus 로고
    • Information processing in social phobia
    • Clark D.M., and McManus F. Information processing in social phobia. Biol. Psychiatry 51 (2002) 92-100
    • (2002) Biol. Psychiatry , vol.51 , pp. 92-100
    • Clark, D.M.1    McManus, F.2
  • 34
    • 0026508464 scopus 로고
    • Anxiolytic potential of 5-HT3 antagonists
    • Costall B., and Naylor R.J. Anxiolytic potential of 5-HT3 antagonists. Pharmacol. Toxicol. 70 (1993) 157-162
    • (1993) Pharmacol. Toxicol. , vol.70 , pp. 157-162
    • Costall, B.1    Naylor, R.J.2
  • 36
    • 0036381315 scopus 로고    scopus 로고
    • Psychoeducation in panic disorder patients: effect of a self-information booklet in a randomized, masked-rater study
    • Dannon P.N., Iancu I., and Grunhaus L. Psychoeducation in panic disorder patients: effect of a self-information booklet in a randomized, masked-rater study. Depress. Anxiety 16 (2002) 71-76
    • (2002) Depress. Anxiety , vol.16 , pp. 71-76
    • Dannon, P.N.1    Iancu, I.2    Grunhaus, L.3
  • 38
    • 0032900652 scopus 로고    scopus 로고
    • The functional neuroanatomy of emotion and affective style
    • Davidson R.J., and Irwin W. The functional neuroanatomy of emotion and affective style. Trends Cogn. Sci. 3 (1999) 11-21
    • (1999) Trends Cogn. Sci. , vol.3 , pp. 11-21
    • Davidson, R.J.1    Irwin, W.2
  • 39
    • 0027146133 scopus 로고
    • Monoamines and the mechanism of antidepressant action: effects of catecholamine depletion on mood of patients treated with antidepressants
    • Delgado P.L., Miller H.L., Solomon R.M., Licinio J., Heninger G.R., Gelenberg A.J., and Charney D.S. Monoamines and the mechanism of antidepressant action: effects of catecholamine depletion on mood of patients treated with antidepressants. Psychopharmacol. Bull. 29 (1993) 389-396
    • (1993) Psychopharmacol. Bull. , vol.29 , pp. 389-396
    • Delgado, P.L.1    Miller, H.L.2    Solomon, R.M.3    Licinio, J.4    Heninger, G.R.5    Gelenberg, A.J.6    Charney, D.S.7
  • 40
    • 0023672570 scopus 로고
    • Effect of a serotonin and noradrenaline uptake inhibitor in panic disorder; a double-blind comparative study with fluvoxamine and maprotiline
    • Den Boer J.A., and Westenberg H.G. Effect of a serotonin and noradrenaline uptake inhibitor in panic disorder; a double-blind comparative study with fluvoxamine and maprotiline. Int. Clin. Psychopharmacol. 3 (1988) 59-74
    • (1988) Int. Clin. Psychopharmacol. , vol.3 , pp. 59-74
    • Den Boer, J.A.1    Westenberg, H.G.2
  • 44
    • 0023220625 scopus 로고
    • Cognitive therapy versus behaviour therapy in the treatment of chronic generalised anxiety
    • Durham R.C., and Turvey A.A. Cognitive therapy versus behaviour therapy in the treatment of chronic generalised anxiety. Behav. Res. Ther. 25 (1987) 229-234
    • (1987) Behav. Res. Ther. , vol.25 , pp. 229-234
    • Durham, R.C.1    Turvey, A.A.2
  • 45
    • 13844315590 scopus 로고    scopus 로고
    • A multicenter, placebo-controlled study of modafinil augmentation in partial responders to selective serotonin reuptake inhibitors with persistent fatigue and sleepiness
    • Fava M., Thase M.E., and DeBattista C. A multicenter, placebo-controlled study of modafinil augmentation in partial responders to selective serotonin reuptake inhibitors with persistent fatigue and sleepiness. J. Clin. Psychiatr. 66 (2005) 85-93
    • (2005) J. Clin. Psychiatr. , vol.66 , pp. 85-93
    • Fava, M.1    Thase, M.E.2    DeBattista, C.3
  • 46
    • 15244351436 scopus 로고    scopus 로고
    • Evidence-based pharmacotherapy of obsessive-compulsive disorder
    • Fineberg N.A., and Gale T.M. Evidence-based pharmacotherapy of obsessive-compulsive disorder. Int. J. Neuropsychopharmacol. 8 (2005) 107-129
    • (2005) Int. J. Neuropsychopharmacol. , vol.8 , pp. 107-129
    • Fineberg, N.A.1    Gale, T.M.2
  • 48
    • 0037112156 scopus 로고    scopus 로고
    • Context in the clinic: how well do cognitive-behavioural therapies and medications work in combination?
    • Foa E.B., Franklin M.E., and Moser J. Context in the clinic: how well do cognitive-behavioural therapies and medications work in combination?. Biol. Psychiatry 52 (2002) 987-997
    • (2002) Biol. Psychiatry , vol.52 , pp. 987-997
    • Foa, E.B.1    Franklin, M.E.2    Moser, J.3
  • 50
    • 33751009394 scopus 로고    scopus 로고
    • Orienting and maintenance of gaze to facial expressions in social anxiety
    • Garner M., Mogg K., and Bradley B.P. Orienting and maintenance of gaze to facial expressions in social anxiety. J. Abnorm. Psychol. 115 (2006) 760-770
    • (2006) J. Abnorm. Psychol. , vol.115 , pp. 760-770
    • Garner, M.1    Mogg, K.2    Bradley, B.P.3
  • 52
    • 0021082501 scopus 로고
    • Influence of yohimbine on blood pressure, autonomic reflexes and plasma catecholamines in humans
    • Goldberg M.R., Hollister A.S., and Robertson D. Influence of yohimbine on blood pressure, autonomic reflexes and plasma catecholamines in humans. Hypertension 5 (1983) 772-778
    • (1983) Hypertension , vol.5 , pp. 772-778
    • Goldberg, M.R.1    Hollister, A.S.2    Robertson, D.3
  • 53
    • 0029568041 scopus 로고
    • A meta-analysis of treatment outcome for panic disorder
    • Gould R.A., Otto M.W., and Pollack M.H. A meta-analysis of treatment outcome for panic disorder. Clin. Psychol. Rev. 15 (1995) 819-844
    • (1995) Clin. Psychol. Rev. , vol.15 , pp. 819-844
    • Gould, R.A.1    Otto, M.W.2    Pollack, M.H.3
  • 54
    • 0030799724 scopus 로고    scopus 로고
    • Cognitive behavioural and pharmacological treatment of generalised anxiety disorder: a preliminary meta-analysis
    • Gould R.A., Otto M.W., and Pollack M.H. Cognitive behavioural and pharmacological treatment of generalised anxiety disorder: a preliminary meta-analysis. Behav. Ther. 28 (1997) 285-305
    • (1997) Behav. Ther. , vol.28 , pp. 285-305
    • Gould, R.A.1    Otto, M.W.2    Pollack, M.H.3
  • 55
    • 0032929398 scopus 로고    scopus 로고
    • Intracerebral administration of metabotropic glutamate receptor agonists disrupts prepulse inhibition of acoustic startle in Sprague-Dawley rats
    • Grauer S.M., and Marquis K.L. Intracerebral administration of metabotropic glutamate receptor agonists disrupts prepulse inhibition of acoustic startle in Sprague-Dawley rats. Psychopharmacology 141 (1999) 405-412
    • (1999) Psychopharmacology , vol.141 , pp. 405-412
    • Grauer, S.M.1    Marquis, K.L.2
  • 56
    • 0037197989 scopus 로고    scopus 로고
    • 1b receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders
    • 1b receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders. Proc. Natl. Acad. Sci. USA 99 (2002) 6370-6375
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 6370-6375
    • Griebel, G.1
  • 60
    • 0035089147 scopus 로고    scopus 로고
    • Administration of the beta-adrenoceptor blocker propranolol impairs the processing of facial expressions of sadness
    • Harmer C.J., Perrett D.I., Cowen P.J., and Goodwin G.M. Administration of the beta-adrenoceptor blocker propranolol impairs the processing of facial expressions of sadness. Psychopharmacology 154 (2001) 383-389
    • (2001) Psychopharmacology , vol.154 , pp. 383-389
    • Harmer, C.J.1    Perrett, D.I.2    Cowen, P.J.3    Goodwin, G.M.4
  • 61
    • 0038182445 scopus 로고    scopus 로고
    • Toward a neuropsychological theory of antidepressant drug action: increase in positive emotional bias after potentiation of norepinephrine activity
    • Harmer C.J., Hill S.A., Taylor M.J., Cowen P.J., and Goodwin G.M. Toward a neuropsychological theory of antidepressant drug action: increase in positive emotional bias after potentiation of norepinephrine activity. Am. J. Psychiatry 160 (2003) 990-992
    • (2003) Am. J. Psychiatry , vol.160 , pp. 990-992
    • Harmer, C.J.1    Hill, S.A.2    Taylor, M.J.3    Cowen, P.J.4    Goodwin, G.M.5
  • 62
    • 33646087196 scopus 로고    scopus 로고
    • Antidepressant drug treatment modifies the neural processing of nonconscious threat cues
    • Harmer C.J., Mackay C.E., Reid C.B., Cowen P.J., and Goodwin G.M. Antidepressant drug treatment modifies the neural processing of nonconscious threat cues. Biol. Psychiatry 59 (2006) 816-820
    • (2006) Biol. Psychiatry , vol.59 , pp. 816-820
    • Harmer, C.J.1    Mackay, C.E.2    Reid, C.B.3    Cowen, P.J.4    Goodwin, G.M.5
  • 63
    • 33646342001 scopus 로고    scopus 로고
    • 5HT(3) antagonism abolishes the emotion potentiated startle effect in humans
    • Harmer C.J., Reid C.B., Ray M.K., Goodwin G.M., and Cowen P.J. 5HT(3) antagonism abolishes the emotion potentiated startle effect in humans. Psychopharmacology 186 (2006) 18-24
    • (2006) Psychopharmacology , vol.186 , pp. 18-24
    • Harmer, C.J.1    Reid, C.B.2    Ray, M.K.3    Goodwin, G.M.4    Cowen, P.J.5
  • 65
    • 3042739104 scopus 로고    scopus 로고
    • Increased positive versus negative affective perception and memory in healthy volunteers following selective serotonin and norepinephrine reuptake inhibition
    • Harmer C.J., Shelley N.C., Cowen P.J., and Goodwin G.M. Increased positive versus negative affective perception and memory in healthy volunteers following selective serotonin and norepinephrine reuptake inhibition. Am. J. Psychiatry 161 (2004) 1256-1263
    • (2004) Am. J. Psychiatry , vol.161 , pp. 1256-1263
    • Harmer, C.J.1    Shelley, N.C.2    Cowen, P.J.3    Goodwin, G.M.4
  • 66
    • 14644435740 scopus 로고    scopus 로고
    • Low-dose tryptophan depletion in recovered depressed patients induces changes in cognitive processing without depressive symptoms
    • Hayward G., Goodwin G.M., Cowen P.J., and Harmer C.J. Low-dose tryptophan depletion in recovered depressed patients induces changes in cognitive processing without depressive symptoms. Biol. Psychiatry 57 (2005) 517-524
    • (2005) Biol. Psychiatry , vol.57 , pp. 517-524
    • Hayward, G.1    Goodwin, G.M.2    Cowen, P.J.3    Harmer, C.J.4
  • 67
    • 0026463013 scopus 로고
    • Clomipramine, clonazepam and clonidine treatment of obsessive-compulsive disorder
    • Hewlett W.A., Vongradov S., and Agras W.S. Clomipramine, clonazepam and clonidine treatment of obsessive-compulsive disorder. J. Clin. Psychopharmacol. 12 (1992) 420-430
    • (1992) J. Clin. Psychopharmacol. , vol.12 , pp. 420-430
    • Hewlett, W.A.1    Vongradov, S.2    Agras, W.S.3
  • 69
    • 0032978974 scopus 로고    scopus 로고
    • Tiagabine antinocioception in rodents depends on GABA(B) receptor activation: parallel antinocioception testing and medial thalamus GABA microdialysis
    • Ipponi A., Lamberti C., Medica A., Bartolini A., and Malmberg-Aiello P. Tiagabine antinocioception in rodents depends on GABA(B) receptor activation: parallel antinocioception testing and medial thalamus GABA microdialysis. Eur. J. Pharmacol. 368 (1999) 205-211
    • (1999) Eur. J. Pharmacol. , vol.368 , pp. 205-211
    • Ipponi, A.1    Lamberti, C.2    Medica, A.3    Bartolini, A.4    Malmberg-Aiello, P.5
  • 70
    • 0026744274 scopus 로고
    • Effects of benzodiazepine receptor inverse agonists on locomotor activity and exploration in mice
    • Jackson H.C., and Nutt D.J. Effects of benzodiazepine receptor inverse agonists on locomotor activity and exploration in mice. Eur. J. Pharmacol. 221 (1992) 199-204
    • (1992) Eur. J. Pharmacol. , vol.221 , pp. 199-204
    • Jackson, H.C.1    Nutt, D.J.2
  • 71
  • 72
    • 33745399645 scopus 로고    scopus 로고
    • Pregabalin: from molecule to medicine
    • Kavoussi R. Pregabalin: from molecule to medicine. Eur. Neuropsychopharmacol. 16 Suppl. (2006) S128-S133
    • (2006) Eur. Neuropsychopharmacol. , vol.16 , Issue.SUPPL
    • Kavoussi, R.1
  • 73
    • 33645787677 scopus 로고    scopus 로고
    • Efficacy of escitalopram in the treatment of major depressive disorder compared with conventional selective serotonin reuptake inhibitors and venlafaxine XR: a meta-analysis
    • Kennedy S.H., Andersen H.F., and Lam R.W. Efficacy of escitalopram in the treatment of major depressive disorder compared with conventional selective serotonin reuptake inhibitors and venlafaxine XR: a meta-analysis. Rev. Psychiatr. Neurosci. 31 (2006) 122-131
    • (2006) Rev. Psychiatr. Neurosci. , vol.31 , pp. 122-131
    • Kennedy, S.H.1    Andersen, H.F.2    Lam, R.W.3
  • 74
    • 28444445585 scopus 로고    scopus 로고
    • GABA-A receptor subtypes as targets for neuropsychiatric drug development
    • Korpi E.R., and Sinkkonen S.T. GABA-A receptor subtypes as targets for neuropsychiatric drug development. Pharmacol. Ther. 109 (2006) 12-32
    • (2006) Pharmacol. Ther. , vol.109 , pp. 12-32
    • Korpi, E.R.1    Sinkkonen, S.T.2
  • 75
    • 0032508514 scopus 로고    scopus 로고
    • Distinct mechanism for antidepressant activity by blockade of central substance P receptors
    • Kramer M., Cutler N., Feighner J., et al. Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science 281 (1998) 1640-1645
    • (1998) Science , vol.281 , pp. 1640-1645
    • Kramer, M.1    Cutler, N.2    Feighner, J.3
  • 77
    • 0026695552 scopus 로고
    • Dose-response relationship for oral idazoxan effects in healthy human subjects: comparison with oral yohimbine
    • Krystal J.H., McDougle C.J., Woods S.W., Price L.H., Heninger G.R., and Charney D.S. Dose-response relationship for oral idazoxan effects in healthy human subjects: comparison with oral yohimbine. Psychopharmacology 108 (1992) 313-319
    • (1992) Psychopharmacology , vol.108 , pp. 313-319
    • Krystal, J.H.1    McDougle, C.J.2    Woods, S.W.3    Price, L.H.4    Heninger, G.R.5    Charney, D.S.6
  • 78
    • 3543043767 scopus 로고    scopus 로고
    • Efficacy and tolerability of escitalopram in 12- and 24-week treatment of social anxiety disorder: randomised, double-blind, placebo-controlled, fixed-dose study
    • Lader M., Stender K., Burger V., and Nil R. Efficacy and tolerability of escitalopram in 12- and 24-week treatment of social anxiety disorder: randomised, double-blind, placebo-controlled, fixed-dose study. Depress. Anxiety 19 (2004) 241-248
    • (2004) Depress. Anxiety , vol.19 , pp. 241-248
    • Lader, M.1    Stender, K.2    Burger, V.3    Nil, R.4
  • 79
    • 0031862911 scopus 로고    scopus 로고
    • Interaction of pharmacological and psychological treatments of anxiety
    • Lader M.H., and Bond A.J. Interaction of pharmacological and psychological treatments of anxiety. Br. J. Psychiatry 173 Suppl. (1998) 42-48
    • (1998) Br. J. Psychiatry , vol.173 , Issue.SUPPL , pp. 42-48
    • Lader, M.H.1    Bond, A.J.2
  • 80
    • 0027205397 scopus 로고
    • A randomized double-blind placebo-controlled study of tropisetron in the treatment of outpatients with generalized anxiety disorder
    • Lecrubier Y., Puech A.J., Azcona A., Bailey P.E., and Lataste X. A randomized double-blind placebo-controlled study of tropisetron in the treatment of outpatients with generalized anxiety disorder. Psychopharmacology 112 (1993) 129-133
    • (1993) Psychopharmacology , vol.112 , pp. 129-133
    • Lecrubier, Y.1    Puech, A.J.2    Azcona, A.3    Bailey, P.E.4    Lataste, X.5
  • 82
    • 13244255707 scopus 로고    scopus 로고
    • Venlafaxine extended release vs. placebo and paroxetine in social anxiety disorder
    • Liebowitz M.R., Gelenberg A.J., and Munjack D. Venlafaxine extended release vs. placebo and paroxetine in social anxiety disorder. Arch. Gen. Psychiatry 62 (2005) 190-198
    • (2005) Arch. Gen. Psychiatry , vol.62 , pp. 190-198
    • Liebowitz, M.R.1    Gelenberg, A.J.2    Munjack, D.3
  • 83
    • 0030468201 scopus 로고    scopus 로고
    • Venlafaxine or bupropion responders but not nonresponders show baseline prefrontal and paralimbic hypometabolism compared with controls
    • Little J.T., Ketter T.A., Kimbrell T.A., Danielson A., Benson B., Willis M.W., and Post R.M. Venlafaxine or bupropion responders but not nonresponders show baseline prefrontal and paralimbic hypometabolism compared with controls. Psychopharm. Bull. 32 (1996) 629-635
    • (1996) Psychopharm. Bull. , vol.32 , pp. 629-635
    • Little, J.T.1    Ketter, T.A.2    Kimbrell, T.A.3    Danielson, A.4    Benson, B.5    Willis, M.W.6    Post, R.M.7
  • 84
    • 0032775334 scopus 로고    scopus 로고
    • Effects of catecholamine depletion with AMPT (alpha-methyl-para-tyrosine) in obsessive-compulsive disorder
    • Longhurst J.G., Carpenter L.L., Epperson C.N., Price L.H., and McDougle C.J. Effects of catecholamine depletion with AMPT (alpha-methyl-para-tyrosine) in obsessive-compulsive disorder. Biol. Psychiatry 46 (1999) 573-576
    • (1999) Biol. Psychiatry , vol.46 , pp. 573-576
    • Longhurst, J.G.1    Carpenter, L.L.2    Epperson, C.N.3    Price, L.H.4    McDougle, C.J.5
  • 85
    • 0038707200 scopus 로고    scopus 로고
    • Pilot study comparing in blind the therapeutic effect of two doses of agomelatine, melatonin-agonist and selective 5HT2C receptor antagonist, in the treatment of major depressive disorders
    • Loo H., Dalery J., Macher J.P., and Payen A. Pilot study comparing in blind the therapeutic effect of two doses of agomelatine, melatonin-agonist and selective 5HT2C receptor antagonist, in the treatment of major depressive disorders. Encephale 29 (2003) 165-171
    • (2003) Encephale , vol.29 , pp. 165-171
    • Loo, H.1    Dalery, J.2    Macher, J.P.3    Payen, A.4
  • 86
    • 0036738228 scopus 로고    scopus 로고
    • Determination of the dose of agomelatine, a melatonergic agonist and selective 5-HT(2C) antagonist, in the treatment of major depressive disorder: a placebo-controlled dose range study
    • Loo H., Hale A., and D'haenen H. Determination of the dose of agomelatine, a melatonergic agonist and selective 5-HT(2C) antagonist, in the treatment of major depressive disorder: a placebo-controlled dose range study. Int. Clin. Psychopharmacol. 17 (2002) 239-247
    • (2002) Int. Clin. Psychopharmacol. , vol.17 , pp. 239-247
    • Loo, H.1    Hale, A.2    D'haenen, H.3
  • 87
    • 0031902127 scopus 로고    scopus 로고
    • Decreased brain GABA-A -benzodiazepine receptor binding in panic disorder: preliminary results from a quantitative PET study
    • Malizia A.L., Cunningham V.J., Bell C.J., Liddle P.F., Jones T., and Nutt D.J. Decreased brain GABA-A -benzodiazepine receptor binding in panic disorder: preliminary results from a quantitative PET study. Arch. Gen. Psychiatry 55 (1998) 715-720
    • (1998) Arch. Gen. Psychiatry , vol.55 , pp. 715-720
    • Malizia, A.L.1    Cunningham, V.J.2    Bell, C.J.3    Liddle, P.F.4    Jones, T.5    Nutt, D.J.6
  • 89
    • 33644762169 scopus 로고    scopus 로고
    • Cognitive vulnerability to emotional disorders
    • Mathews A., and MacLeod C. Cognitive vulnerability to emotional disorders. Ann. Rev. Clin. Psychol. 1 (2005) 167-195
    • (2005) Ann. Rev. Clin. Psychol. , vol.1 , pp. 167-195
    • Mathews, A.1    MacLeod, C.2
  • 90
    • 0020601263 scopus 로고
    • Pharmacological treatment of agoraphobia: imipramine versus imipramine with programmed practice
    • Mavissakalian M., Michelson L., and Dealy R.S. Pharmacological treatment of agoraphobia: imipramine versus imipramine with programmed practice. Br. J. Psychiatry 143 (1983) 348-355
    • (1983) Br. J. Psychiatry , vol.143 , pp. 348-355
    • Mavissakalian, M.1    Michelson, L.2    Dealy, R.S.3
  • 93
    • 0034005411 scopus 로고    scopus 로고
    • The impact of comorbid mood and personality disorders in the cognitive-behavioral treatment of panic disorder
    • Mennin D.S., and Heimberg R.G. The impact of comorbid mood and personality disorders in the cognitive-behavioral treatment of panic disorder. Clin. Psychol. Rev. 20 (2000) 339-357
    • (2000) Clin. Psychol. Rev. , vol.20 , pp. 339-357
    • Mennin, D.S.1    Heimberg, R.G.2
  • 94
    • 13644250791 scopus 로고    scopus 로고
    • Anxiolytic properties of agomelatine, an antidepressant with melatoninergic and serotonergic properties: role of 5-HT2C receptor blockade
    • Millan M.J., Brocco M., Gobert A., and Dekeyne A. Anxiolytic properties of agomelatine, an antidepressant with melatoninergic and serotonergic properties: role of 5-HT2C receptor blockade. Psychopharmacology 77 (2005) 448-458
    • (2005) Psychopharmacology , vol.77 , pp. 448-458
    • Millan, M.J.1    Brocco, M.2    Gobert, A.3    Dekeyne, A.4
  • 95
    • 15444365574 scopus 로고    scopus 로고
    • A meta-analytic review of the efficacy of drug treatment in generalized anxiety disorder
    • Mitte K., Noack P., Steil R., and Hautzinger M. A meta-analytic review of the efficacy of drug treatment in generalized anxiety disorder. J. Clin. Psychopharmacol. 25 (2005) 141-150
    • (2005) J. Clin. Psychopharmacol. , vol.25 , pp. 141-150
    • Mitte, K.1    Noack, P.2    Steil, R.3    Hautzinger, M.4
  • 96
    • 10944253017 scopus 로고    scopus 로고
    • Effect of short-term SSRI treatment on cognitive bias in generalised anxiety disorder
    • Mogg K., Baldwin D.S., Brodrick P., and Bradley B.P. Effect of short-term SSRI treatment on cognitive bias in generalised anxiety disorder. Psychopharmacology 176 (2004) 466-470
    • (2004) Psychopharmacology , vol.176 , pp. 466-470
    • Mogg, K.1    Baldwin, D.S.2    Brodrick, P.3    Bradley, B.P.4
  • 97
    • 0031815299 scopus 로고    scopus 로고
    • A cognitive-motivational analysis of anxiety
    • Mogg K., and Bradley B. A cognitive-motivational analysis of anxiety. Behav. Res. Ther. 36 (1998) 809-848
    • (1998) Behav. Res. Ther. , vol.36 , pp. 809-848
    • Mogg, K.1    Bradley, B.2
  • 98
    • 33749515230 scopus 로고    scopus 로고
    • Major depressive disorders: clinical efficacy and tolerability of agomelatine, a new melatonergic agonist
    • Montgomery S.A. Major depressive disorders: clinical efficacy and tolerability of agomelatine, a new melatonergic agonist. Eur. Neuropsychopharmacol. 16 Suppl. (2006) S633-S638
    • (2006) Eur. Neuropsychopharmacol. , vol.16 , Issue.SUPPL
    • Montgomery, S.A.1
  • 99
    • 4344715163 scopus 로고    scopus 로고
    • Absence of discontinuation symptoms with agomelatine and occurrence of discontinuation symptoms with paroxetine: a randomized, double-blind, placebo-controlled discontinuation study
    • Montgomery S.A., Kennedy S.H., Burrows G.D., Lejoyeux M., and Hindmarch I. Absence of discontinuation symptoms with agomelatine and occurrence of discontinuation symptoms with paroxetine: a randomized, double-blind, placebo-controlled discontinuation study. Int. Clin. Psychopharmacol. 19 (2004) 271-280
    • (2004) Int. Clin. Psychopharmacol. , vol.19 , pp. 271-280
    • Montgomery, S.A.1    Kennedy, S.H.2    Burrows, G.D.3    Lejoyeux, M.4    Hindmarch, I.5
  • 100
    • 33645216755 scopus 로고    scopus 로고
    • Selective processing of social threat cues following acute tryptophan depletion
    • Munafo M.R., Hayward G., and Harmer C. Selective processing of social threat cues following acute tryptophan depletion. J. Psychopharmacol. 20 (2006) 33-39
    • (2006) J. Psychopharmacol. , vol.20 , pp. 33-39
    • Munafo, M.R.1    Hayward, G.2    Harmer, C.3
  • 101
    • 0036367355 scopus 로고    scopus 로고
    • The effects of tryptophan depletion on cognitive and affective processing in healthy volunteers
    • Murphy F.C., Smith K.A., Cowen P.J., Robbins T.W., and Sahakian B.J. The effects of tryptophan depletion on cognitive and affective processing in healthy volunteers. Psychopharmacology 163 (2002) 42-53
    • (2002) Psychopharmacology , vol.163 , pp. 42-53
    • Murphy, F.C.1    Smith, K.A.2    Cowen, P.J.3    Robbins, T.W.4    Sahakian, B.J.5
  • 102
    • 33745019913 scopus 로고    scopus 로고
    • Tryptophan supplementation induces a positive bias in the processing of emotional material in healthy female volunteers
    • Murphy S.E., Longhitano C., Ayres R.E., Cowen P.J., and Harmer C.J. Tryptophan supplementation induces a positive bias in the processing of emotional material in healthy female volunteers. Psychopharmacology 181 (2006) 121-130
    • (2006) Psychopharmacology , vol.181 , pp. 121-130
    • Murphy, S.E.1    Longhitano, C.2    Ayres, R.E.3    Cowen, P.J.4    Harmer, C.J.5
  • 104
    • 0036089270 scopus 로고    scopus 로고
    • New directions in the development of antidepressants: the interface of neurobiology and psychiatry
    • Nemeroff C. New directions in the development of antidepressants: the interface of neurobiology and psychiatry. Hum. Psychopharmacol. Clin. Exp. 17 (2002) S13-S16
    • (2002) Hum. Psychopharmacol. Clin. Exp. , vol.17
    • Nemeroff, C.1
  • 105
    • 0025049828 scopus 로고
    • Evidence for altered benzodiazepine receptor sensitivity in panic disorder: effects of the benzodiazepine receptor antagonist flumazenil
    • Nutt D.J., Glue P., Lawson C., and Wilson S. Evidence for altered benzodiazepine receptor sensitivity in panic disorder: effects of the benzodiazepine receptor antagonist flumazenil. Arch. Gen. Psychiatry 47 (1990) 917-925
    • (1990) Arch. Gen. Psychiatry , vol.47 , pp. 917-925
    • Nutt, D.J.1    Glue, P.2    Lawson, C.3    Wilson, S.4
  • 106
    • 5644298301 scopus 로고    scopus 로고
    • For better or worse: neural systems supporting the cognitive down- and up-regulation of negative emotion
    • Ochsner K.N., Ray R.D., Cooper J.C., Robertson E.R., Chopra S., Gabrieli J.D., and Gross J.J. For better or worse: neural systems supporting the cognitive down- and up-regulation of negative emotion. Neuroimage 23 (2004) 483-499
    • (2004) Neuroimage , vol.23 , pp. 483-499
    • Ochsner, K.N.1    Ray, R.D.2    Cooper, J.C.3    Robertson, E.R.4    Chopra, S.5    Gabrieli, J.D.6    Gross, J.J.7
  • 108
    • 85047683645 scopus 로고    scopus 로고
    • Fears, phobias, and preparedness: toward an evolved module of fear and fear learning
    • Ohman A., and Mineka S. Fears, phobias, and preparedness: toward an evolved module of fear and fear learning. Psychol. Rev. 108 (2001) 483-522
    • (2001) Psychol. Rev. , vol.108 , pp. 483-522
    • Ohman, A.1    Mineka, S.2
  • 110
    • 0037328427 scopus 로고    scopus 로고
    • "Change the mind and you change the brain": effects of cognitive-behavioral therapy on the neural correlates of spider phobia
    • Paquette V., Levesque J., Mensour B., Leroux J.M., Beaudoin G., Bourgouin P., and Beauregard M. "Change the mind and you change the brain": effects of cognitive-behavioral therapy on the neural correlates of spider phobia. Neuroimage 18 (2003) 401-409
    • (2003) Neuroimage , vol.18 , pp. 401-409
    • Paquette, V.1    Levesque, J.2    Mensour, B.3    Leroux, J.M.4    Beaudoin, G.5    Bourgouin, P.6    Beauregard, M.7
  • 111
    • 34247527031 scopus 로고    scopus 로고
    • Cytochrome P450 genotyping and antidepressants
    • Perlis R.H. Cytochrome P450 genotyping and antidepressants. Br. Med. J. 334 (2007) 759
    • (2007) Br. Med. J. , vol.334 , pp. 759
    • Perlis, R.H.1
  • 112
    • 28844461167 scopus 로고    scopus 로고
    • The selective GABA reuptake inhibitor tiagabine for the treatment of generalized anxiety disorder: results of a placebo-controlled study
    • Pollack M.H., Roy-Byrne P.P., Van Ameringen M., Snyder H., Brown C., Ondrasik J., and Rickels K. The selective GABA reuptake inhibitor tiagabine for the treatment of generalized anxiety disorder: results of a placebo-controlled study. J. Clin. Psychiatry 66 (2005) 1401-1408
    • (2005) J. Clin. Psychiatry , vol.66 , pp. 1401-1408
    • Pollack, M.H.1    Roy-Byrne, P.P.2    Van Ameringen, M.3    Snyder, H.4    Brown, C.5    Ondrasik, J.6    Rickels, K.7
  • 114
    • 0025673910 scopus 로고
    • A controlled comparison of cognitive-behaviour therapy, diazepam, and placebo in the management of generalized anxiety disorder
    • Power K.G., Simpson M.B., Swanson V., and Wallace L.A. A controlled comparison of cognitive-behaviour therapy, diazepam, and placebo in the management of generalized anxiety disorder. J. Anxiety Disord. 4 (1990) 267-292
    • (1990) J. Anxiety Disord. , vol.4 , pp. 267-292
    • Power, K.G.1    Simpson, M.B.2    Swanson, V.3    Wallace, L.A.4
  • 116
    • 23144441853 scopus 로고    scopus 로고
    • The role of 5-HT2C receptor polymorphisms in the pharmacogenetics of antipsychotic drug treatment
    • Reynolds G.P., Templeman L.A., and Zhang Z.J. The role of 5-HT2C receptor polymorphisms in the pharmacogenetics of antipsychotic drug treatment. Prog. Neuropsychopharmacol. Biol. Psychiatry 29 (2005) 1021-1028
    • (2005) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.29 , pp. 1021-1028
    • Reynolds, G.P.1    Templeman, L.A.2    Zhang, Z.J.3
  • 117
    • 1642276857 scopus 로고    scopus 로고
    • Effects of beta-adrenoceptor blockade on components of human decision-making
    • Rogers R.D., Lancaster M., Wakeley J., and Bhagwagar Z. Effects of beta-adrenoceptor blockade on components of human decision-making. Psychopharmacology 172 (2004) 157-164
    • (2004) Psychopharmacology , vol.172 , pp. 157-164
    • Rogers, R.D.1    Lancaster, M.2    Wakeley, J.3    Bhagwagar, Z.4
  • 120
    • 0036850509 scopus 로고    scopus 로고
    • Predictors of fluvoxamine response in contamination-related obsessive compulsive disorder: a PET symptom provocation study
    • Rauch S.L., Shin L.M., Dougherty D.D., Alpert N.M., Fischman A.J., and Jenike M.A. Predictors of fluvoxamine response in contamination-related obsessive compulsive disorder: a PET symptom provocation study. Neuropsychopharmacology 27 (2002) 782-791
    • (2002) Neuropsychopharmacology , vol.27 , pp. 782-791
    • Rauch, S.L.1    Shin, L.M.2    Dougherty, D.D.3    Alpert, N.M.4    Fischman, A.J.5    Jenike, M.A.6
  • 122
    • 0036633359 scopus 로고    scopus 로고
    • Genome-based pharmacogenetics and the pharmaceutical industry
    • Roses A. Genome-based pharmacogenetics and the pharmaceutical industry. Nat. Drug Discov. 1 (2002) 541-549
    • (2002) Nat. Drug Discov. , vol.1 , pp. 541-549
    • Roses, A.1
  • 124
    • 33747033403 scopus 로고    scopus 로고
    • The pharmacology of citalopram enantiomers: the antagonism by R-citalopram on the effect of S-citalopram
    • Sánchez C. The pharmacology of citalopram enantiomers: the antagonism by R-citalopram on the effect of S-citalopram. Basic Clin. Pharmacol. Toxicol. 99 (2006) 91-95
    • (2006) Basic Clin. Pharmacol. Toxicol. , vol.99 , pp. 91-95
    • Sánchez, C.1
  • 125
    • 0031846547 scopus 로고    scopus 로고
    • Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder
    • Saxena S., Brody A.L., Schwartz J.M., and Baxter L.R. Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder. Br. J. Psychiatry 35 (1998) 26-37
    • (1998) Br. J. Psychiatry , vol.35 , pp. 26-37
    • Saxena, S.1    Brody, A.L.2    Schwartz, J.M.3    Baxter, L.R.4
  • 126
    • 0030031439 scopus 로고    scopus 로고
    • Systematic changes in cerebral glucose metabolic rate after successful behavior modification treatment of obsessive-compulsive disorder
    • Schwartz J.M., Stoessel P.W., Baxter L.R., Martin K.M., and Phelps M.E. Systematic changes in cerebral glucose metabolic rate after successful behavior modification treatment of obsessive-compulsive disorder. Arch. Gen. Psychiatry 53 (1996) 109-113
    • (1996) Arch. Gen. Psychiatry , vol.53 , pp. 109-113
    • Schwartz, J.M.1    Stoessel, P.W.2    Baxter, L.R.3    Martin, K.M.4    Phelps, M.E.5
  • 127
    • 0034883568 scopus 로고    scopus 로고
    • Efficacy of venlafaxine extended release in patients with major depressive disorder and comorbid generalized anxiety disorder
    • Silverstone P.H., and Salinas E. Efficacy of venlafaxine extended release in patients with major depressive disorder and comorbid generalized anxiety disorder. J. Clin. Psychiatry 62 (2001) 523-539
    • (2001) J. Clin. Psychiatry , vol.62 , pp. 523-539
    • Silverstone, P.H.1    Salinas, E.2
  • 129
    • 0034796330 scopus 로고    scopus 로고
    • The prediction of nonresponse to pharmacotherapy in panic disorder: a review
    • Slaap B.R., and den Boer J.A. The prediction of nonresponse to pharmacotherapy in panic disorder: a review. Depress. Anxiety 14 (2001) 112-121
    • (2001) Depress. Anxiety , vol.14 , pp. 112-121
    • Slaap, B.R.1    den Boer, J.A.2
  • 130
    • 2442488689 scopus 로고    scopus 로고
    • Anticonvulsants as anxiolytics: Part 2. Pregabalin and gabapentin as alpha(2)delta ligands at voltage-gated calcium channels
    • Stahl S.M. Anticonvulsants as anxiolytics: Part 2. Pregabalin and gabapentin as alpha(2)delta ligands at voltage-gated calcium channels. J. Clin. Psychiatry 65 (2004) 460-461
    • (2004) J. Clin. Psychiatry , vol.65 , pp. 460-461
    • Stahl, S.M.1
  • 131
    • 0345413412 scopus 로고    scopus 로고
    • Escitalopram in the treatment of panic disorder: a randomized, double-blind, placebo-controlled trial
    • Stahl S.M., Gergel I., and Li D. Escitalopram in the treatment of panic disorder: a randomized, double-blind, placebo-controlled trial. J. Clin. Psychiatry 64 (2003) 1322-1327
    • (2003) J. Clin. Psychiatry , vol.64 , pp. 1322-1327
    • Stahl, S.M.1    Gergel, I.2    Li, D.3
  • 132
    • 33845619513 scopus 로고    scopus 로고
    • Which factors predict placebo response in anxiety disorders and major depression? An analysis of placebo-controlled studies of escitalopram
    • Stein D.J., Baldwin D.S., Dolberg O.T., Despiegel N., and Bandelow B. Which factors predict placebo response in anxiety disorders and major depression? An analysis of placebo-controlled studies of escitalopram. J. Clin. Psychiatry 67 (2006) 1741-1746
    • (2006) J. Clin. Psychiatry , vol.67 , pp. 1741-1746
    • Stein, D.J.1    Baldwin, D.S.2    Dolberg, O.T.3    Despiegel, N.4    Bandelow, B.5
  • 133
    • 0342656611 scopus 로고    scopus 로고
    • Do selective serotonin re-uptake inhibitors enhance the efficacy of very brief cognitive behavioral therapy for panic disorder? A pilot study
    • Stein M.B., Ron Norton G., Walker J.R., Chartier M.J., and Graham R. Do selective serotonin re-uptake inhibitors enhance the efficacy of very brief cognitive behavioral therapy for panic disorder? A pilot study. Psychiatry Res. 94 (2000) 191-200
    • (2000) Psychiatry Res. , vol.94 , pp. 191-200
    • Stein, M.B.1    Ron Norton, G.2    Walker, J.R.3    Chartier, M.J.4    Graham, R.5
  • 134
    • 0035042259 scopus 로고    scopus 로고
    • Neurokinin (1) receptor antagonists as potential antidepressants
    • Stout S., Owens M., and Nemeroff C. Neurokinin (1) receptor antagonists as potential antidepressants. Ann. Rev. Pharmacol. Toxicol. 41 (2001) 877-906
    • (2001) Ann. Rev. Pharmacol. Toxicol. , vol.41 , pp. 877-906
    • Stout, S.1    Owens, M.2    Nemeroff, C.3
  • 136
    • 0031669184 scopus 로고    scopus 로고
    • Overlapping genomic sequences: a treasure-trove of single-nucleotide polymorphisms
    • Taillon-Miller P., Gu Z., Li Q., Hillier L., and Kwok P.Y. Overlapping genomic sequences: a treasure-trove of single-nucleotide polymorphisms. Genome Res. 8 (1998) 748-754
    • (1998) Genome Res. , vol.8 , pp. 748-754
    • Taillon-Miller, P.1    Gu, Z.2    Li, Q.3    Hillier, L.4    Kwok, P.Y.5
  • 137
    • 10844224525 scopus 로고    scopus 로고
    • Computerised patient-specific guidelines for management of common mental disorders in primary care: a randomised controlled trial
    • Thomas H.V., Lewis G., Watson M., Bell T., Lyons I., Lloyd K., Weich S., and Sharp D. Computerised patient-specific guidelines for management of common mental disorders in primary care: a randomised controlled trial. Br. J. Gen. Pract. 54 (2004) 832-837
    • (2004) Br. J. Gen. Pract. , vol.54 , pp. 832-837
    • Thomas, H.V.1    Lewis, G.2    Watson, M.3    Bell, T.4    Lyons, I.5    Lloyd, K.6    Weich, S.7    Sharp, D.8
  • 138
    • 33947712686 scopus 로고    scopus 로고
    • Stratified medicine: strategic and economic implications of combining drugs and clinical biomarkers
    • Trusheim M.R., Berndt E.R., and Douglas F.L. Stratified medicine: strategic and economic implications of combining drugs and clinical biomarkers. Nat. Rev. Drug Discov. 6 (2007) 287-293
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 287-293
    • Trusheim, M.R.1    Berndt, E.R.2    Douglas, F.L.3
  • 139
    • 33845450824 scopus 로고    scopus 로고
    • Generalised anxiety disorder
    • Tyrer P.J., and Baldwin D.S. Generalised anxiety disorder. Lancet 368 (2006) 2156-2166
    • (2006) Lancet , vol.368 , pp. 2156-2166
    • Tyrer, P.J.1    Baldwin, D.S.2
  • 140
    • 0030883914 scopus 로고    scopus 로고
    • A meta-analysis of the treatment of panic disorder with or without agoraphobia: a comparison of psychopharmacological, cognitive-behavioral, and combination treatments
    • van Balkom A.J., Bakker A., Spinhoven P., Blaauw B.M., Smeenk S., and Ruesink B. A meta-analysis of the treatment of panic disorder with or without agoraphobia: a comparison of psychopharmacological, cognitive-behavioral, and combination treatments. J. Nerv. Ment. Dis. 185 (1997) 510-516
    • (1997) J. Nerv. Ment. Dis. , vol.185 , pp. 510-516
    • van Balkom, A.J.1    Bakker, A.2    Spinhoven, P.3    Blaauw, B.M.4    Smeenk, S.5    Ruesink, B.6
  • 142
    • 0034177388 scopus 로고    scopus 로고
    • Functional brain imaging and pharmacotherapy in social phobia: single photon emission computed tomography before and after treatment with the selective serotonin reuptake inhibitor citalopram
    • Van der Linden G., van Heerden B., Warwick J., Wessels C., van Kradenburg J., Zungu-Dirwayi N., and Stein D.J. Functional brain imaging and pharmacotherapy in social phobia: single photon emission computed tomography before and after treatment with the selective serotonin reuptake inhibitor citalopram. Prog. Neuropsychopharmacol. Biol. Psychiatry 24 (2000) 419-438
    • (2000) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.24 , pp. 419-438
    • Van der Linden, G.1    van Heerden, B.2    Warwick, J.3    Wessels, C.4    van Kradenburg, J.5    Zungu-Dirwayi, N.6    Stein, D.J.7
  • 143
    • 0035960261 scopus 로고    scopus 로고
    • Improving outcomes in depression
    • Von Korff M., and Goldberg D. Improving outcomes in depression. Br. Med. J. 323 (2001) 948-949
    • (2001) Br. Med. J. , vol.323 , pp. 948-949
    • Von Korff, M.1    Goldberg, D.2
  • 146
    • 1242263295 scopus 로고    scopus 로고
    • From monoamines to genomic targets: a paradigm shift for drug discovery in depression
    • Wong M.L., and Licinio J. From monoamines to genomic targets: a paradigm shift for drug discovery in depression. Nat. Rev. Drug Discov. 3 (2004) 136-151
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 136-151
    • Wong, M.L.1    Licinio, J.2
  • 147
    • 0034193881 scopus 로고    scopus 로고
    • Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated
    • Zobel A., Nickel T., Kunzel H., Ackl N., Sonntag A., Ising M., and Holsboer F. Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated. J. Psychiatr. Res. 34 (2000) 171-181
    • (2000) J. Psychiatr. Res. , vol.34 , pp. 171-181
    • Zobel, A.1    Nickel, T.2    Kunzel, H.3    Ackl, N.4    Sonntag, A.5    Ising, M.6    Holsboer, F.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.