Influenza virus and poly(I:C) inhibit MHC class I-restricted presentation of cell-associated antigens derived from infected dead cells captured by human dendritic cells

Journal of Immunology

Volumn 182, Issue 5, 2009, Pages 2766-2776

  Frleta, Davor ^a   Yu, Chun I ^a   Klechevsky, Eynav ^a   Flamar, Anne Laure ^a   Zurawski, Gerard ^a   Banchereau, Jacques ^a   Palucka, A Karolina ^a  

^a BAYLOR INSTITUTE FOR IMMUNOLOGY RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; POLYINOSINIC POLYCYTIDYLIC ACID; TOLL LIKE RECEPTOR 3; GROWTH INHIBITOR; HLA A2 ANTIGEN; TUMOR ANTIGEN;

ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; HUMAN CELL; INFLUENZA VIRUS; PRIORITY JOURNAL; CELL CULTURE; COCULTURE; CROSS PRESENTATION; CYTOTOXIC T LYMPHOCYTE; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; INFLUENZA VIRUS A; LYMPHOCYTE ACTIVATION; MELANOMA; METABOLISM; METHODOLOGY; NECROSIS; PATHOLOGY; TUMOR CELL LINE; VIROLOGY;

ANTIGENS, NEOPLASM; CELL LINE, TUMOR; CELLS, CULTURED; COCULTURE TECHNIQUES; CROSS-PRIMING; DENDRITIC CELLS; GROWTH INHIBITORS; HLA-A2 ANTIGEN; HUMANS; IMMUNOSUPPRESSION; INFLUENZA A VIRUS; LYMPHOCYTE ACTIVATION; MELANOMA; NECROSIS; POLY I-C; T-LYMPHOCYTES, CYTOTOXIC;

EID: 64849110817     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0801720     Document Type: Article

References (41)

1. Brossart, P., and M. J. Bevan. 1997. Presentation of exogenous protein antigens on major histocompatibility complex class I molecules by dendritic cells: pathway of presentation and regulation by cytokines. Blood 90: 1594-1599.
2. Albert, M. L., B. Sauter, and N. Bhardwaj. 1998. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 392: 86-89.
3. Bevan, M. J. 2006. Cross-priming. Nat. Immunol. 7: 363-365.
4. + T cells: cross-priming in infectious diseases. Curr. Opin. Immunol. 13: 437-441.
5. + T cells by viral and tumor antigens is a robust phenomenon. Eur. J. Immunol. 34: 194-199.
6. Hawiger, D., K. Inaba, Y. Dorsett, M. Guo, K. Mahnke, M. Rivera, J. V. Ravetch, R. M. Steinman, and M. C. Nussenzweig. 2001. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J. Exp. Med. 194: 769-779.
7. Inaba, K., S. Turley, F. Yamaide, T. Iyoda, K. Mahnke, M. Inaba, M. Pack, M. Subklewe, B. Sauter, D. Sheff, et al. 1998. Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells. J. Exp. Med. 188: 2163-2173.
8. Liu, K., T. Iyoda, M. Saternus, Y. Kimura, K. Inaba, and R. M. Steinman. 2002. Immune tolerance after delivery of dying cells to dendritic cells in situ. J. Exp. Med. 196: 1091-1097.
9. Steinman, R. M., S. Turley, I. Mellman, and K. Inaba. 2000. The induction of tolerance by dendritic cells that have captured apoptotic cells. J. Exp. Med. 191: 411-416.
10. + T cell tolerance. J. Exp. Med. 196: 1627-1638.
11. Steinman, R. M., and M. C. Nussenzweig. 2002. Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc. Natl. Acad. Sci. USA 99: 351-358.
12. Van den Eynde, B. J., and S. Morel. 2001. Differential processing of class-I-restricted epitopes by the standard proteasome and the immunoproteasome. Curr. Opin. Immunol. 13: 147-153.
13. Roncarolo, M. G., M. K. Levings, and C. Traversari. 2001. Differentiation of T regulatory cells by immature dendritic cells. J. Exp. Med. 193: F5-F9.
14. Blander, J. M., and R. Medzhitov. 2006. Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature 440: 808-812.
15. Schulz, O., S. S. Diebold, M. Chen, T. I. Naslund, M. A. Nolte, L. Alexopoulou, Y. T. Azuma, R. A. Flavell, P. Liljestrom, and C. Reis e Sousa. 2005. Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature 433: 887-892.
16. Berard, F., P. Blanco, J. Davoust, E. M. Neidhart-Berard, M. Nouri-Shirazi, N. Taquet, D. Rimoldi, J. C. Cerottini, J. Banchereau, and A. K. Palucka. 2000. Cross-priming of naive CD8 T cells against melanoma antigens using dendritic cells loaded with killed allogeneic melanoma cells. J. Exp. Med. 192: 1535-1544.
17. + T-cell immunity. J. Immunother. 29: 545-557.
18. Shi, H., T. Cao, J. E. Connolly, L. Monnet, L. Bennett, S. Chapel, C. Bagnis, P. Mannoni, J. Davoust, A. K. Palucka, and J. Banchereau. 2006. Hyperthermia enhances CTL cross-priming. J. Immunol. 176: 2134-2141.
19. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260: 547-549.
20. Le Bon, A., and D. F. Tough. 2002. Links between innate and adaptive immunity via type I interferon. Curr. Opin. Immunol. 14: 432-436.
21. + T cells. J. Immunol. 154: 5071-5079.
22. O'Garra, A., and K. Murphy. 1994. Role of cytokines in determining T-lymphocyte function. Curr. Opin. Immunol. 6: 458-466.
23. + T cell help. J. Exp. Med. 186: 65-70.
24. Bennett, S. R., F. R. Carbone, F. Karamalis, R. A. Flavell, J. F. Miller, and W. R. Heath. 1998. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature 393: 478-480.
25. Longman, R. S., D. Braun, S. Pellegrini, C. M. Rice, R. B. Darnell, and M. L. Albert. 2007. Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-α/β on antigen cross-presentation. Blood 109: 1113-1122.
26. Bates, E. E., N. Fournier, E. Garcia, J. Valladeau, I. Durand, J. J. Pin, S. M. Zurawski, S. Patel, J. S. Abrams, S. Lebecque, P. Garrone, and S. Saeland. 1999. APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif. J. Immunol. 163: 1973-1983.
27. Kanazawa, N. 2007. Dendritic cell immunoreceptors: C-type lectin receptors for pattern-recognition and signaling on antigen-presenting cells. J. Dermatol. Sci. 45: 77-86.
28. Yee, C., P. A. Savage, P. P. Lee, M. M. Davis, and P. D. Greenberg. 1999. Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers. J. Immunol. 162: 2227-2234.
29. de Bouteiller, O., E. Merck, U. A. Hasan, S. Hubac, B. Benguigui, G. Trinchieri, E. E. Bates, and C. Caux. 2005. Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH. J. Biol. Chem.. 280: 38133-38145.
30. Matsumoto, M., K. Funami, M. Tanabe, H. Oshiumi, M. Shingai, Y. Seto, A. Yamamoto, and T. Seya. 2003. Subcellular localization of Toll-like receptor 3 in human dendritic cells. J. Immunol. 171: 3154-3162.
31. Blander, J. M., and R. Medzhitov. 2004. Regulation of phagosome maturation by signals from toll-like receptors. Science 304: 1014-1018.
32. Blander, J. M., and R. Medzhitov. 2006. On regulation of phagosome maturation and antigen presentation. Nat. Immunol. 7: 1029-1035.
33. Burgdorf, S., C. Scholz, A. Kautz, R. Tampe, and C. Kurts. 2008. Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation. Nat. Immunol. 9: 558-566.
34. Burgdorf, S., A. Kautz, V. Bohnert, P. A. Knolle, and C. Kurts. 2007. Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation. Science 316: 612-616.
35. Cui, Z., U. M. Le, F. Qiu, and D. S. Shaker. 2007. Learning from viruses: the necrotic bodies of tumor cells with intracellular synthetic dsRNA induced strong anti-tumor immune responses. Pharm. Res. 24: 1645-1652.
36. Cui, Z., and F. Qiu. 2006. Synthetic double-stranded RNA poly(I:C) as a potent peptide vaccine adjuvant: therapeutic activity against human cervical cancer in a rodent model. Cancer Immunol. Immunother. 55: 1267-1279.
37. - dendritic cells in vivo. J. Exp. Med. 196: 817-827.
38. - dendritic cells cross-prime cytotoxic T cells in vivo. J. Exp. Med. 192: 1685-1696.
39. + dendritic cells are generally involved in priming CTL immunity to viruses. J. Immunol. 172: 1996-2000.
40. Allan, R. S., J. Waithman, S. Bedoui, C. M. Jones, J. A. Villadangos, Y. Zhan, A. M. Lew, K. Shortman, W. R. Heath, and F. R. Carbone. 2006. Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming. Immunity 25: 153-162.
41. Qu, H., V. Nguyen, M. Merad, and G. J. Randolph. 2009. MCH I/peptide transfer between dendritic cells overcomes poor cross-presentation by monocyte-derived antigen-presenting cells that engulf dying cells. J. Immunol. In press.