An Exosite-Specific ssDNA Aptamer Inhibits the Anticoagulant Functions of Activated Protein C and Enhances Inhibition by Protein C Inhibitor

Chemistry and Biology

Volumn 16, Issue 4, 2009, Pages 442-451

  Müller, Jens ^a   Isermann, Berend ^b   Dücker, Christina ^a   Salehi, Mohammad ^a   Meyer, Moritz ^a   Friedrich, Max ^a   Madhusudhan, Thati ^b   Oldenburg, Johannes ^a   Mayer, Günter ^c   Pötzsch, Bernd ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

CHEMBIO; DNA

Indexed keywords

ANTICOAGULANT AGENT; APTAMER; ENZYME INHIBITOR; PROTEIN C; THROMBIN;

APOPTOSIS; ARTICLE; COMBINATORIAL CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; HUMAN; METABOLISM; PROTEIN BINDING;

ANTICOAGULANTS; APOPTOSIS; APTAMERS, NUCLEOTIDE; ENZYME INHIBITORS; HUMANS; PROTEIN BINDING; PROTEIN C; SELEX APTAMER TECHNIQUE; THROMBIN;

EID: 64749104065     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2009.03.007     Document Type: Article

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