Dissociation of activated protein C functions by elimination of protein S cofactor enhancement

Journal of Biological Chemistry

Volumn 283, Issue 45, 2008, Pages 30531-30539

  Harmon, Shona ^a   Preston, Roger J S ^a   Ainle, Fionnuala Ni ^a   Johnson, Jennifer A ^a   Cunningham, Moya S ^a   Smith, Owen P ^a   White, Barry ^b   O'Donnell, James S ^a,b  

^a ST JAMES S HOSPITAL   (Ireland)

^b OUR LADY S CHILDREN S HOSPITAL   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINATION; AMINES; AMINO ACIDS; BINDING SITES; BLOOD VESSEL PROSTHESES; ENDOTHELIAL CELLS; FUNCTIONS; GLYCOPROTEINS; ORGANIC ACIDS; PROBABILITY DENSITY FUNCTION; SELF ASSEMBLY;

ACTIVATED PROTEIN C; ACTIVATED PROTEINS; ACTIVATED RECEPTORS; AMINO ACID SUBSTITUTIONS; ANTICOAGULANT ACTIVITIES; ANTICOAGULANT FUNCTIONS; C FUNCTIONS; COFACTOR; DEPENDENT FACTORS; DO-MAINS; IN-VIVO; PURIFIED PROTEINS; PUTATIVE PROTEINS; THROMBIN GENERATIONS; WILD TYPES;

CHEMICAL PLANTS;

ACTIVATED PROTEIN C; AMINO ACID; LEUCINE; PROTEIN S; PROTEINASE ACTIVATED RECEPTOR 1;

AMINO ACID SUBSTITUTION; ANTICOAGULATION; ARTICLE; CELL PROTECTION; DISSOCIATION; HUMAN; HUMAN CELL; PLASMA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PURIFICATION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; WILD TYPE;

AMINO ACID SUBSTITUTION; ANTIGENS, CD; BINDING SITES; CELL LINE; COENZYMES; ENDOTHELIAL CELLS; FACTOR VA; FACTOR VIIIA; HUMANS; MUTAGENESIS, SITE-DIRECTED; PEPTIDE MAPPING; PROTEIN C; PROTEIN S; RECEPTOR, PAR-1; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION;

EID: 57649198486     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M802338200     Document Type: Article

References (42)

1. Esmon, C. T. (1989) J. Biol. Chem. 264, 4743-4746
2. Stearns-Kurosawa, D. J., Kurosawa, S., Mollica, J. S., Ferrell, G. L., and Esmon, C. T. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 10212-10216
3. Walker, F. J., Sexton, P. W., and Esmon, C. T. (1979) Biochim. Biophys. Acta 571, 333-342
4. Fay, P. J., Smudzin, T. M., and Walker, F. J. (1991) J. Biol. Chem. 266, 20139-20145
5. Seligsohn, U., Berger, A., Abend, M., Rubin, L., Attias, D., Zivelin, A., and Rapaport, S. I. (1984) N. Engl. J. Med. 310, 559-562
6. Reitsma, P. H., Poort, S. R., Bernardi, F., Gandrille, S., Long, G. L., Sala, N., and Cooper, D. N. (1993) Thromb. Haemostasis 69, 77-84
7. Riewald, M., Petrovan, R. J., Donner, A., Mueller, B. M., and Ruf, W. (2002) Science 296, 1880-1882
8. Kerschen, E. J., Fernandez, J. A., Cooley, B. C., Yang, X. V., Sood, R., Mosnier, L. O., Castellino, F. J., Mackman, N., Griffin, J. H., and Weiler, H. (2007) J. Exp. Med. 204, 2439-2448
9. Joyce, D. E., Gelbert, L., Ciaccia, A., DeHoff, B., and Grinnell, B. W. (2001) J. Biol. Chem. 276, 11199-11203
10. Riewald, M., and Ruf, W. (2005) J. Biol. Chem. 280, 19808-19814
11. White, B., Schmidt, M., Murphy, C., Livingstone, W., O'Toole, D., Lawler, M., O'Neill, L., Kelleher, D., Schwarz, H. P., and Smith, O. P. (2000) Br. J. Haematol. 110, 130-134
12. Feistritzer, C., Lenta, R., and Riewald, M. (2005) J. Thromb. Haemost. 3, 2798-2805
13. Feistritzer, C., and Riewald, M. (2005) Blood 105, 3178-3184
14. Domotor, E., Benzakour, O., Griffin, J. H., Yule, D., Fukudome, K., and Zlokovic, B. V. (2003) Blood 101, 4797-4801
15. Cheng, T., Liu, D., Griffin, J. H., Fernandez, J. A., Castellino, F., Rosen, E. D., Fukudome, K., and Zlokovic, B. V. (2003) Nat. Med. 9, 338-342
16. Griffin, J. H., Zlokovic, B., and Fernandez, J. A. (2002) Semin. Hematol. 39, 197-205
17. Han, M. H., Hwang, S. I., Roy, D. B., Lundgren, D. H., Price, J. V., Ousman, S. S., Fernald, G. H., Gerlitz, B., Robinson, W. H., Baranzini, S. E., Grinnell, B. W., Raine, C. S., Sobel, R. A., Han, D. K., and Steinman, L. (2008) Nature 451, 1076-1081
18. Isermann, B., Vinnikov, I. A., Madhusudhan, T., Herzog, S., Kashif, M., Blautzik, J., Corat, M. A., Zeier, M., Blessing, E., Oh, J., Gerlitz, B., Berg, D. T., Grinnell, B. W., Chavakis, T., Esmon, C. T., Weiler, H., Bierhaus, A., and Nawroth, P. P. (2007) Nat. Med. 13, 1349-1358
19. Bernard, G. R., Vincent, J. L., Laterre, P. F., LaRosa, S. P., Dhainaut, J. F., Lopez-Rodriguez, A., Steingrub, J. S., Garber, G. E., Helterbrand, J. D., Ely, E. W., and Fisher, C. J., Jr. (2001) N. Engl. J. Med. 344, 699-709
20. Warren, B. L., Eid, A., Singer, P., Pillay, S. S., Carl, P., Novak, I., Chalupa, P., Atherstone, A., Penzes, I., Kubler, A., Knaub, S., Keinecke, H. O., Heinrichs, H., Schindel, F., Juers, M., Bone, R. C., and Opal, S. M. (2001) J. Am. Med. Assoc. 286, 1869-1878
21. Abraham, E., Reinhart, K., Opal, S., Demeyer, I., Doig, C., Rodriguez, A. L., Beale, R., Svoboda, P., Laterre, P. F., Simon, S., Light, B., Spapen, H., Stone, J., Seibert, A., Peckelsen, C., De Deyne, C., Postier, R., Pettila, V., Artigas, A., Percell, S. R., Shu, V., Zwingelstein, C., Tobias, J., Poole, L., Stolzenbach, J. C., and Creasey, A. A. (2003) J. Am. Med. Assoc. 290, 238-247
22. Bertolini, G., Rossi, C., Anghileri, A., Livigni, S., Addis, A., and Poole, D. (2007) Intensive Care Med. 33, 426-434
23. Kanji, S., Perreault, M. M., Chant, C., Williamson, D., and Burry, L. (2007) Intensive Care Med. 33, 517-523
24. Bae, J. S., Yang, L., Manithody, C., and Rezaie, A. R. (2007) J. Biol. Chem. 282, 9251-9259
25. Mosnier, L. O., Gale, A. J., Yegneswaran, S., and Griffin, J. H. (2004) Blood 104, 1740-1744
26. Mosnier, L. O., Yang, X. V., and Griffin, J. H. (2007) J. Biol. Chem. 282, 33022-33033
27. Walker, F. J. (1984) Semin. Thromb. Hemostasis 10, 131-138
28. Yegneswaran, S., Smirnov, M. D., Safa, O., Esmon, N. L., Esmon, C. T., and Johnson, A. E. (1999) J. Biol. Chem. 274, 5462-5468
29. Nicolaes, G. A., Tans, G., Thomassen, M. C., Hemker, H. C., Pabinger, I., Varadi, K., Schwarz, H. P., and Rosing, J. (1995) J. Biol. Chem. 270, 21158-21166
30. Preston, R. J., Ajzner, E., Razzari, C., Karageorgi, S., Dua, S., Dahlback, B., and Lane, D. A. (2006) J. Biol. Chem. 281, 28850-28857
31. Preston, R. J., Villegas-Mendez, A., Sun, Y. H., Hermida, J., Simioni, P., Philippou, H., Dahlback, B., and Lane, D. A. (2005) FEBS J. 272, 97-108
32. Berg, D. T., Gerlitz, B., Shang, J., Smith, T., Santa, P., Richardson, M. A., Kurz, K. D., Grinnell, B. W., Mace, K., and Jones, B. E. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 4423-4428
33. Hackeng, T. M., Sere, K. M., Tans, G., and Rosing, J. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 3106-3111
34. Dahlback, B., Hildebrand, B., and Malm, J. (1990) J. Biol. Chem. 265, 8127-8135
35. Giri, T. K., de Frutos, P. G., Yamazaki, T., Villoutreix, B. O., and Dahlback, B. (1999) Thromb. Haemostasis 82, 1627-1633
36. He, X., Shen, L., and Dahlback, B. (1995) Eur. J. Biochem. 227, 433-440
37. He, X., Shen, L., Villoutreix, B. O., and Dahlback, B. (1998) J. Biol. Chem. 273, 27449-27458
38. Mille-Baker, B., Rezende, S. M., Simmonds, R. E., Mason, P. J., Lane, D. A., and Laffan, M. A. (2003) Blood 101, 1416-1418
39. Saller, F., Kaabache, T., Aiach, M., Gandrille, S., and Borgel, D. (2006) J. Thromb. Haemost. 4, 704-706
40. Saller, F., Villoutreix, B. O., Amelot, A., Kaabache, T., Le Bonniec, B. F., Aiach, M., Gandrille, S., and Borgel, D. (2005) Blood 105, 122-130
41. Smirnov, M. D., Safa, O., Regan, L., Mather, T., Stearns-Kurosawa, D. J., Kurosawa, S., Rezaie, A. R., Esmon, N. L., and Esmon, C. T. (1998) J. Biol. Chem. 273, 9031-9040
42. Scaldaferri, F., Sans, M., Vetrano, S., Graziani, C., De Cristofaro, R., Gerlitz, B., Repici, A., Arena, V., Malesci, A., Panes, J., Grinnell, B. W., and Danese, S. (2007) J. Clin. Investig. 117, 1951-1960