Interleukin 18 (IL-18) and other immunological parameters as markers of severity in acute pancreatitis;Interleucina-18 (IL-18) y otros parámetros inmunológicos como marcadores de gravedad en la pancreatitis aguda

Revista Espanola de Enfermedades Digestivas

Volumn 100, Issue 12, 2008, Pages 768-773

  Martin M A ^a   Saracibar E ^a   Santamaria A ^a   Arranz, E ^b   Garrote, J A ^c   Almaraz, A ^d   Del Olmo, Ma Lourdes ^e,f   Garcia Pajares F ^a   Fernandez Orcajo P ^a   Velicia, R ^a   Blanco Quiros A ^b   Caro Paton A ^a  

^a HOSPITAL UNIVERSITARIO RÍO HORTEGA   (Spain)

^b Instituto de Biología Molecular Y Genética IBGM   (Spain)

^c CSIC   (Spain)

^d Facultad de Medicina   (Spain)

^e UNIVERSITY OF VALLADOLID   (Spain)

^f HOSPITAL CLÍNICO UNIVERSITARIO DE VALLADOLID   (Spain)

Author keywords

Acute pancreatitis; Interleukin 18; Pseudocyst; Severity

Indexed keywords

INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 18; INTERLEUKIN 6; TUMOR NECROSIS FACTOR RECEPTOR; BIOLOGICAL MARKER;

ACUTE PANCREATITIS; ADULT; ARTICLE; BILIARY COLIC; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; FEMALE; HOSPITALIZATION; HUMAN; IMMUNOLOGICAL PARAMETERS; MALE; PANCREAS PSEUDOCYST; PROSPECTIVE STUDY; ACUTE DISEASE; AGED; BLOOD; MIDDLE AGED; PANCREATITIS;

ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; FEMALE; HUMANS; INTERLEUKIN-18; MALE; MIDDLE AGED; PANCREATITIS; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX;

EID: 64749098308     PISSN: 11300108     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Banks PA. Practice guidelines in acute pancreatitis. Am J Gastroenterol 1997; 92: 377-386 (Pubitemid 27108167)
2. Norman J. The role of cytokines in the pathogenesis of acute pancreatitis. Am J Surg 1998; 175: 76-83. (Pubitemid 28047037)
3. Bradley EL. A clinically based classification system for acute pancreatitis. Arch Surg 1993; 128: 586-590
4. Devernis C, Johnson CD, Bassi C, et al. Diagnosis, objective assessment of severity and management of acute pancreatitis. The Santorini Consensus Conference. Int J Pancreatol 1999; 25: 195-210.
5. Taxonera Samsó C. Early assessment of severity in acute pancreatitis. Rev Esp Enferm Dig 2002; 94: 515-518
6. Triester SL, Kowdley KV. Prognostic factors in acute pancreatitis. J Clin Gastroenterol 2002; 34: 167-176 (Pubitemid 15180519)
7. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med 1985; 13: 818-829 (Pubitemid 15250137)
8. Halonen KI, Pettilá V, Leppániemi AK, et al. Multiple organ dysfunctions associated with severe acute pancreatitis. Crit Care Med 2002; 30: 1274-1279
9. Simchuk EJ, Traverso LH, Nukiu Y, et al. Computed tomography severity index is a predictor of outcome for severe pancreatitis. Am J Surg 2000; 179: 352-355
10. Montaño Loza A, Rodríguez Lomelí X, García Correa JE, Dávalos Covien C, Cervantes Guevara G, Medrano Muñoz F, et al. Effect of administration of rectal indomethacin on amylase serum levels alter endoscopic retrograde cholangiopancreatography, and its impact on the development of secondary pancreatitis episodes. Rev Esp Enferm Dig 2007; 99: 330-336
11. Lebel-Binay S, Berger A, Zinzindohoue F, Cugnenc P, Thiounn N, Fridman WH, et al. Interleukin-18: biological properties and clinical implications. Eur Cytokine Netw 2000; 11: 15-26.
12. Puren AJ, Fantuzzi G, Gu Y, et al. Interleukin-18 (IFN-γ inducing factor) induces IL-1β and IL-8 via TNF-α production in from non-CD141 human blood mononuclear cells. J Clin Invest 1998; 101: 711-724
13. Casas M, Mora J, Fort E, Aracil C, Busquets D, Galter S, et al. Total enteral nutrition vs. total parenteral nutrition in patients with severe acute pancreatitis. Rev Esp Enferm Dig 2007; 99: 264-269
14. Gracie JA, Robertson SE, McInnes IB. Interleukin-18. J of Leukocyte Biology 2003; 73: 213-224
15. Norman J, Yang J, Fink G, et al. Severity and mortality of experimental pancreatitis are dependent on interleukin-1 converting enzyme (ICE). J Interferon Cytokine Res 1997; 17: 113-118
16. Biet F, Locht C, Kremer L. Immunoregulatory functions of interleukin 18 and its role in defense against bacterial pathogens. J Mol Med 2002; 80: 147-162 (Pubitemid 34230635)
17. Rau B, Baumgart K, Paszkowski AS, Mayer JM, Beger HG. Clinical relevance of caspase-1 activated cytokines in acute pancreatitis: high correlation of serum interleukin-18 with pancreatic necrosis and systemic complication. Crit Care Med 2001; 29: 1556-1562 (Pubitemid 32762336)
18. Mayer J, Rau B, Gansauge F, Beger HG. Inflammatory mediators in human acute pancreatitis: clinical and pathophysiological implications. Gut 2000; 47: 546-552
19. Endo S, Inoue Y, Fujino Y, Wakabayashi G, Inada K, Sato S. Interleukin 18 levels reflect the severity of acute pancreatitis. Res Commun Mol Pathol Pharmacol 2001; 110: 285-291 (Pubitemid 36896937)
20. Wereszczynska-Siemiatkowska U, Mroczko B, Siemiatkowsky A. Serum profiles of interleukin-18 in different severity forms of human acute pancreatitis. Scand J Gastroenterol 2002; 37: 1097-1102
21. Wereszczynska-Siemiatkowska U, Mroczko B, Siemiatkowsky A, Szmitkowski M, Borawska M, Kosel J. The importance of interleukine 1o, glutathione peroxidase and selenium concentration changes in acute pancreatitis. Dig Dis Sci 2004; 49: 642-650 (Pubitemid 38992556)
22. Yuan BS, Zhu RM, Braddock M, Zhang XH, Shi W, Zheng MH. Interleukin- 18: a pro-inflammatory cytokine that plays an important role in acute pancreatitis. Expert Opin Ther Targets 2007; 11: 1261-1271 (Pubitemid 47604068)
23. Ueda T, Takeyama Y, Yasuda T, Matsumura N, Sawa H, Nakajima T, et al. Significant elevation of serum interleukin-18 levels in patients with acute pancreatitis. J Gastroenterol 2006; 41: 158-165
24. Mozo G, del Olmo ML, Caro-Patón A, Reyes E, Manzano L, Belmonte A, et al. Lung changes and cytokine levels in a model of experimental acute pancreatitis. Rev Esp Enferm Dig 2002; 94: 53-59
25. De Beaux AC, Goldie AS, Ross JA, Carter DC, Fearon KCH. Serum concentrations of inflammatory mediators related to organ failure in patients with acute pancreatitis. Br J Surg 1996; 83: 349-353 (Pubitemid 26083168)
26. Hirota M, Nozawa F, Okabe A, Shibata M, Beppu T, Shimada S, et al. Relationship between plasma cytokine concentration and multiple organ failure in patients with acute pancreatitis. Pancreas 2000; 21: 141-146
27. Kaufmann P, Tilz GP, Lueger A, Demel U. Elevated plasma levels of soluble tumour necrosis factor receptor (sTNFRp60) reflect severity of acute pancreatitis. Intensive Care Med 1997; 23: 841-848 (Pubitemid 27417687)
28. Messmann H, Grüne S, Sitter-Heinisch A, et al. TNF and TNF receptors p55 and p75 in acute mild and severe pancreatitis. Gastroenterology 1997; 112: 464.
29. Hynninen M, Valtonen M, Markkanen H, et al. Interleukin-1 receptor antagonist and E- selectin concentrations: A comparison in patients with severe acute pancreatitis and severe sepsis. J Crit Care 1999; 14: 63-68
30. Heresbach D, Letourneur JP, Bahon I, Pagenault M, Guillou Y-M, Dyard F, et al. Value of early blood Th-1 cytokine determination in predicting severity of acute pancreatitis. Scand J Gastroenterol 1998; 33: 554-560
31. Frossard JL, Hadengue A, Pastor CM. New serum markers for the detection of severe acute pancreatitis in humans. J Respir Crit Care Med 2001; 164: 162-170 (Pubitemid 33151314)
32. Pezzilli R, Billi P, Miniero R, Fiocchi M, Barakat. Serum interleukin- 6, interleukin-8, and beta2-mycroglobulin in early assessment of severity of acute pancreatitis: comparison with serum C-reactive protein. Dig Dis Sci 1995; 40: 2341-2348
33. Brivet FG, Emilie D, Galanaud P. Pro- and anti-inflammatory cytokines during acute severe pancreatitis. An early and sustained response although unpredictable of death. Crit Care Med 1999; 27: 749-755
34. Pezzilli R, Morselli-Labate AM, Miniero R, Barakat B, Fiocchi M, Cappelletti O. Simultaneous serum assays of lipase and interleukin 6 for early diagnosis and prognosis of acute pancreatitis. Clin Chem 1999; 45: 1762-1767 (Pubitemid 29477333)
35. Lipsett P. Serum cytokines, proteins, and receptors in acute pancreatitis: mediators, markers, or more of the same? Crit Care Med 2001; 29: 1640-1648
36. Chen CC, Wang SS, Lee FW, Chang FY, Lee SD. Proinflammatory cytokines in the early assessment of the prognosis of acute pancreatitis. Am J Gastroenterol 1999; 94: 213-218 (Pubitemid 29063471)
37. Leser HG, Gross V, Scheibeanbogen C, Heinisch A, Schölmerich J. Elevation of serum interleukin-6 concentration precedes acute-phase response and reflects severity in acute pancreatitis. Gastroenterology 1991; 101: 782-785
38. Viedma JA, Pérez-Mateo M, Domínguez JE, Caraballo F, Scheibeanbogen C, Heinisch A, et al. Role of interleukin-6 in acute pancreatitis: comparison with C-reactive protein and phospholipase A. Gut 1992; 33: 1264-1267
39. Heath DI, Cruiskshank A, Gudgeon M, Jehanli A, Imrie CW. Role of interleukin-6 in mediating the acute phase protein response and potential as an early means of severity assessment in acute pancreatitis. Gut 1993; 34: 41-45 (Pubitemid 23015948)
40. Mandi Y, Farkas G, Takacs T, Boda K, Lonovics J. Diagnostic relevance of procalcitonin, IL-6, and sICAM-1 in the prediction of infected necrosis in acute pancreatitis. Int J Pancreatol 2000; 28: 41-49
41. Martín Alonso MA, Santamaría A, Saracíbar E, Arranz E, Garrote JA, et al. Cytokines and other immunological parameters as markers of distant organ involvement in acute pancreatitis. Med Clin (Barc) 2007; 128: 401-406
42. Zhang ZH, Zhu RM, Xu WA, Wan HJ, Lu H. Therapeutic effects of caspase-1 inhibitors on acute lung injury in experimental severe acute pancreatitis. World J Gastroenterol 2007; 13: 623-627 (Pubitemid 46210933)
43. Senello JA, Fayad R, Pini M, Gove ME, Ponemone V, Cabay RJ, et al. Interleukin-18, together with interleukin-12, induces severe acute pancreatitis in obese but not in non-obese leptin-deficient mice. PNAS 2008; 105: 8085-8090
44. Kast RE. Ritonavir and Disulfiram may be synergistic in lowering active interleukin-18 levels in acute pancreatitis, and thereby hasten recovery. J Pancreas 2008; 9: 350-353