Ritonavir and disulfiram may be synergistic in lowering active interleukin-18 levels in acute pancreatitis, and thereby hasten recovery

Journal of the Pancreas

Volumn 9, Issue 3, 2008, Pages 350-353

  Kast, Richard Eric ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

Captopril; Caspase 1; Disulfiram; Inflammation; Interleukin 18; Pancreatitis; Ritonavir

Indexed keywords

CAPTOPRIL; DISULFIRAM; INTERLEUKIN 18; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEINASE; RITONAVIR;

ACUTE PANCREATITIS; ARTICLE; CATALYSIS; CYTOKINE PRODUCTION; DRUG HALF LIFE; DRUG POTENCY; DRUG POTENTIATION; DRUG TOLERABILITY; ENZYME INHIBITION; HUMAN; HYPOTENSION; MORBIDITY; MORTALITY; MULTIPLE ORGAN FAILURE; NONHUMAN; PANCREAS INJURY; PROTEIN DEGRADATION; SHORT COURSE THERAPY;

ACUTE DISEASE; ANIMALS; ANTIHYPERTENSIVE AGENTS; CAPTOPRIL; CASPASE 1; DISULFIRAM; DRUG SYNERGISM; ENZYME INHIBITORS; HUMANS; INTERLEUKIN-18; MODELS, BIOLOGICAL; PANCREATITIS; REMISSION INDUCTION; RITONAVIR; TIME FACTORS;

EID: 45749119205     PISSN: None     EISSN: 15908577     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Frossard JL, Steer ML, Pastor CM. Acute pancreatitis. Lancet 2008; 371:143-52.
2. Elfar M, Gaber LW, Sabek O, Fischer CP, Gaber AO. The inflammatory cascade in acute pancreatitis: relevance to clinical disease. Surg Clin North Am 2007;87:1325-40.
3. Matute-Bello G. Targeting caspase-1 in sepsis: a novel approach to an old problem. Intensive Care Med 2007; 33:755-7.
4. Yuan BS, Zhu RM, Braddock M, Zhang XH, Shi W, Zheng MH. Interleukin-18: a pro-inflammatory cytokine that plays an important role in acute pancreatitis. Expert Opin Ther Targets 2007; 11:1261-71.
5. Schneider A, Haas SL, Hildenbrand R, Siegmund S, Reinhard I, Nakovics H, et al. Enhanced expression of interleukin-18 in serum and pancreas of patients with chronic pancreatitis. World J Gastroenterol 2006; 12:6507-14.
6. Hirota M, Shibata M, Baba H. Significance of elevated serum IL-18 levels in patients with acute pancreatitis. J Gastroenterol 2006; 41:182-3.
7. Ueda T, Takeyama Y, Yasuda T, Matsumura N, Sawa H, Nakajima T, et al. Significant elevation of serum interleukin-18 levels in patients with acute pancreatitis. J Gastroenterol 2006; 41:158-65.
8. Endo S, Inoue Y, Fujino Y, Wakabayashi G, Inada K, Sato S. Interleukin 18 levels reflect the severity of acute pancreatitis. Res Commun Mol Pathol Pharmacol 2001;110:285-91.
9. Wereszczynska-Siemiatkowska U, Mroczko B, Siemiatkowski A, Szmitkowski M, Borawska M, Kosel J. The importance of interleukin 18, glutathione peroxidase, and selenium concentration changes in acute pancreatitis. Dig Dis Sci 2004; 49:642-50.
10. Boraschi D, Dinarello CA. IL-18 in autoimmunity: review. Eur Cytokine Netw 2006; 17:224-52.
11. Bombardieri M, McInnes IB, Pitzalis C. Interleukin-18 as a potential therapeutic target in chronic autoimmune/inflammatory conditions. Expert Opin Biol Ther 2007; 7:31-40.
12. Lotito AP, Silva CA, Mello SB. Interleukin-18 in chronic joint diseases. Autoimmun Rev 2007; 6:253-6.
13. Zhang XH, Zhu RM, Xu WA, Wan HJ, Lu H. Therapeutic effects of caspase-1 inhibitors on acute lung injury in experimental severe acute pancreatitis. World J Gastroenterol 2007; 13:623-7.
14. Rau B, Baumgart K, Paszkowski AS, Mayer JM, Beger HG. Clinical relevance of caspase-1 activated cytokines in acute pancreatitis: high correlation of serum interleukin-18 with pancreatic necrosis and systemic complications. Crit Care Med 2001; 29:1556-62,
15. Sloand EM, Maciejewski J, Kumar P, Kim S, Chaudhuri A, Young N. Protease inhibitors stimulate and decrease apoptosis and ICE expression in CD34(+) cells. Blood 2000; 96:2735-9.
16. Weichold FF, Bryant JL, Pati S. Barabitskaya 0, Gallo RC., Reitz MS Jr. HIV-1 protease inhibitor ritonavir modulates susceptibility to apoptosis of uninfected T cells. J Hum Virol 1999; 2:261-9.
17. Sloand EM, Kumar PN, Kim S, Chaudhuri A, Weichold FF, Young NS. Human immunodeficiency virus type 1 protease inhibitor modulates activation of peripheral blood CD4(+) T cells and decreases their susceptibility to apoptosis in vitro and in vivo. Blood 1999; 94:1021-7.
18. Nobel CS, Kimland M, Nicholson DW, Orrenius S, Slater AF. Disulfiram is a potent inhibitor of proteases of the caspase family. Chem Res Toxicol 1997; 10:1319-24.
19. Uhal BD, Gidea C, Bargout R, Bifero A, Ibarra-Sunga O, Papp M, et al. Captopril inhibits apoptosis in human lung epithelial cells: a potential antifibrotic mechanism. Am J Physiol 1998; 275:L1013-7.