Diagnostic relevance of procalcitonin, IL-6, and sICAM-1 in the prediction of infected necrosis in acute pancreatitis

International Journal of Gastrointestinal Cancer

Volumn 28, Issue 1, 2000, Pages 43-51

  Mándi, Yvette ^a   Farkas, Gyula ^a   Takács, Tamás ^a   Boda, Krisztina ^a   Lonovics, János ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Endothelial cells; IL 6; Mononuclear cells; Pancreatitis; Procalcitonin; Sepsis; Sicam 1; Western blot

Indexed keywords

EID: 26344477171     PISSN: 15373649     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Gross V, Leser HG, Heinish A, Schölmerich J. Inflammatory mediators and cytokines New aspects of the patophysiology and assessment of severity of acute pancreatitis. Hepato-Gastroenterol 1993; 40: 522-530.
2. Norman J. The role of cytokines in pathogenesis of acute pancreatitis. Am J Surg 1998; 175: 76-83.
3. Formela LJ, Galloway SW, Kingsnorth AN. Inflammatory mediators in acute pancreatitis. Br J Surg 1995; 82: 6-13.
4. Bone RC. Sepsis, sepsis syndrome and the systemic inflammatory response syndrome (SIRS) JAMA 1995; 273: 155-156.
5. Rangel-Frausto M, Pittet D, Costigan M, Hwang T, Davis CS, Wenzel RP. The natural hystory of the systemic inflammatory response syndrome (SIRS) JAMA 1995; 273: 117-123.
6. Ogawa M. Acute pancreatitis and cytokines: "second atack" by septic complication leads to organ failure. Pancreas 1997; 16: 312-315.
7. Rau B, Beger HG. Surgical treatment of infected necrosis. World J Surg 1997; 21: 155-161.
8. Rau B, Pralle U, Uhl W, Schoenberg MH, Nevalien T, Beger HG. Management of sterile necrosis in instances of severe acute pancreatitis. J Am Coll Surg 1995, 181: 279-288.
9. Bradley EL III, Allen K. A prospective longitudinal study of observation versus surgical intervention in the management of necrotizing pancreatitis. Am J Surg 1991; 161: 19-25.
10. Meisner M. PCT, Procalcitonin: a new, innovative infection parameter. Biochemical and clinical aspects. (Monograph) BRAHMS Diagnostica, Berlin, Germany, 1996.
11. Assicot M, Gendrel D, Carsin H, Raymond J, Guilbaud J, Bohun C. High serum procalcitonin concentrations in patients with sepsis and infection. Lancet 1993; 341: 515-518.
12. Al-Navas B, Krammer J, Shah PM. Procalcitonin in diagnosis of severe infections. Eur J Med Res 1996; 1: 331-333.
13. Meisner M, Tschaikowsky K, Schmidt J, Schüttler J. Procalcitonin (PCT) indications for a new diagnostic parameter of severe bacterial infection and sepsis in transplantation, immunosuppression and cardiac assist devices. Cardiovasc Eng 1996; 1: 67-76.
14. Gearing AJH, Newman W. Circulating adhesion molecules in disease. Immunol Today 1993; 14: 506-512.
15. Küster H. Circulating ICAM-1 in neonatal sepsis. Lancet 1993; 341: 506.
16. Mándi Y, Farkas Gy, Ocsovszky I. Inhibition of tumor necrosis factor production and ICAM-1 expression by pentoxifylline, beneficial effects in sepsis syndrome. Res Exp Med 1995; 195: 297-305.
17. Aarden LA, deGroot ER, Shaap OL, Lansdorp PM. Production of hybridoma growth factor by human monocytes. Eur J Immunol 1997; 17: 1411-1416.
18. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-685.
19. Ghillans P, Motte P, Troden F. Identification and measurement of calcitonin and precursor molecules of patients with malignant diseases. Cancer Res 1989; 49: 6845-6851.
20. Dandona P, Nix M, Wilson MF, Aljada A, Love J, Assicot M, Bohuon C. Procalcitonin increase after endotoxin injection in normal subjects. J Clin Endocrinol Metab 1994; 79: 1605-1608.
21. Brunkhorst FM, Forycki ZF, Wagner J. Frühe identifizierung der biliaren akuten pancreatitis durch procalcitonin-immunreaktivitat-vorlaufige Ergebnisse. Chir Gastroenterol 1995; 11(Suppl 2): 42-46.
22. Rau B, Steinbach G, Gansauge F, Mayer JM, Grünert A, Beger HG. The potential role of procalcitonin and interleukin-8 in the prediction of infected necrosis in acute pancreatitis. Gut 1997; 41: 832-840.
23. Becker KL, Monaghan KG, Silva OL. Immunocytochemical localisation of calcitonin in Kultschitzky cells of of human lung. Arch Pathol Lab Med 1980; 104c: 196-198.
24. Monneret G, Laroche B, Bienvenu J. Procalcitonin is not produced by circulating blood cells. Infection 1999; 27: 34-35.
25. Oberhoffer M, Stonans I, Russwurm S, Stonane E, Vogelslang H, Junker U, et al. Procalcitonin expression in human peripheral blood mononuclear cells and its modulation by lipopolysacharides and sepsis related cytokines in vitro. J Lab Clin Med 1999; 134: 49-55.
26. Müller CA, Uhl W, Printzen G, Gloor B, Bischofberger H, Tcholakov O, Büchler MW. Role of procalcitonin and granulocyte colony stimulating factor in the early prediction of infected necrosis in severe acute pancreatitis. Gut 2000; 46: 233-238.