Clinical relevance of caspase-1 activated cytokines in acute pancreatitis: High correlation of serum interleukin-18 with pancreatic necrosis and systemic complications

Critical Care Medicine

Volumn 29, Issue 8, 2001, Pages 1556-1562

  Rau, Bettina ^a   Baumgart, Katja ^a   Paszkowski, Adam S ^a   Mayer, Jens M ^a   Beger, Hans G ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

Acute pancreatitis; Caspase 1 necrosis; Cytokines; Interferon ; Interleukin 18; Organ failure; Prognosis

Indexed keywords

CYTOKINE; INTERLEUKIN 18; INTERLEUKIN 1BETA CONVERTING ENZYME;

ACUTE PANCREATITIS; ADOLESCENT; ADULT; AGED; ARTICLE; ASCITES; CHILD; COHORT ANALYSIS; CORRELATION FUNCTION; CYTOKINE PRODUCTION; FEMALE; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; NEEDLE BIOPSY; PANCREAS NECROSIS; PATHOGENESIS; PRIORITY JOURNAL; SYSTEMIC DISEASE; ULTRASOUND;

EID: 0034893790     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200108000-00010     Document Type: Article

References (31)

1. Bacterial contamination of pancreatic necrosis
2. Incidence of necrotizing pancreatitis and factors related to mortality
3. Prevalence and prediction of multiple organ system failure and mortality in acute pancreatitis
4. Bacterial infection and extent of necrosis are determinants of organ failure in patients with acute necrotizing pancreatitis
5. Multicentre audit of death from acute pancreatitis
6. Inflammatory mediators in acute pancreatitis
7. Cytokines and acute pancreatitis
8. The role of cytokines in the pathogenesis of acute pancreatitis
9. Local and systemic cytokines in human acute pancreatitis: Clinical and pathophysiological implications
10. Gene targeting demonstrates additive detrimental effects of interleukin-1 and tumor necrosis factor during pancreatitis
11. Amelioration of the physiologic and biochemical changes of acute pancreatitis using an anti-TNF-α polyclonal antibody
12. Anti-TNF therapy improves survival and ameliorates the pathophysiologic sequelae in acute pancreatitis in the rat
13. Interleukin-1 receptor antagonist modifies the changes in vital organs induced by acute pancreatitis in a rat experimental model
14. Decreased mortality of severe acute pancreatitis after proximal cytokine blockade
15. Intrapancreatic interleukin-1β gene expression by specific leukocyte populations during acute pancreatitis
16. Severity and mortality of experimental pancreatitis are dependent on interleukin-1 converting enzyme (ICE)
17. Identification of a monocyte specific pre-interleukin 1 β convertase activity
18. IL-18: A Th1-inducing, proinflammatory cytokine and new member of the IL-1 family
19. Interleukin-18 (IFN-γ inducing factor) induces IL-1β and IL-8 via TNF-α production in from non-CD14+ human blood mononuclear cells
20. The potential role of procalcitonin and interleukin-8 in the prediction of infected necrosis in acute pancreatitis
21. MedCalc: A new computer program for medical statistics
22. Pro- and anti-inflammatory cytokines during acute severe pancreatitis: An early and sustained response, although unpredictable of death
23. Proinflammatory cytokines in early assessment of the prognosis of acute pancreatitis
24. Therapeutic application of interleukin-1β-converting enzyme (ICE) inhibitor decreases mortality of severe acute pancreatitis
25. Interleukin-12: A proinflammatory cytokine with immuno-regulatory functions that bridge innate resistance and antigen-specific adaptive immunity
26. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-γ production and activates IRAK and NFκB
27. Behaviour of serum interleukin-12 in human acute pancreatitis
28. Systemic lymphocyte activation modulates the severity of diet-induced acute pancreatitis in mice
29. Prevention of early pancreatitis-associated complications by immunomodulatory drugs used in organ transplantation
30. Interferon-γ receptor deficient mice are resistant to endotoxic shock
31. Cellular responses to interferon-gamma