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Volumn 379, Issue 6, 2009, Pages 627-636

Analgesic and antiinflammatory effects of cannabinoid receptor agonists in a rat model of neuropathic pain

Author keywords

Allodynia; Chronic treatment; Gliosis; GW405833; Spinal cord; WIN55,212 2

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; CANNABINOID RECEPTOR AGONIST; CATHEPSIN S; CATHEPSIN X; GW 405833; UNCLASSIFIED DRUG; 1-(2,3-DICHLOROBENZOYL)-5-METHOXY-2-METHYL-(2-(MOPHOLIN-4-YL)ETHYL)-1H-INDOLE; ANALGESIC AGENT; BENZOXAZINE DERIVATIVE; CANNABINOID; CANNABINOID RECEPTOR; INDOLE DERIVATIVE; MORPHOLINE DERIVATIVE; NAPHTHALENE DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT;

EID: 64749087048     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-008-0386-4     Document Type: Article
Times cited : (35)

References (57)
  • 1
    • 0032926695 scopus 로고    scopus 로고
    • The effects of cannabinoids on the brain
    • A Ameri 1999 The effects of cannabinoids on the brain Prog Neurobiol 58 315 348
    • (1999) Prog Neurobiol , vol.58 , pp. 315-348
    • Ameri, A.1
  • 3
    • 0032872486 scopus 로고    scopus 로고
    • Adverse effects of cannabis and cannabinoids
    • CH Ashton 1999 Adverse effects of cannabis and cannabinoids Br J Anaesth 83 637 649
    • (1999) Br J Anaesth , vol.83 , pp. 637-649
    • Ashton, C.H.1
  • 5
    • 34548693203 scopus 로고    scopus 로고
    • Reassessment of the role of cannabinoids in the management of pain
    • P Beaulieu M Ware 2007 Reassessment of the role of cannabinoids in the management of pain Curr Opin Anaesthesiol 20 473 477
    • (2007) Curr Opin Anaesthesiol , vol.20 , pp. 473-477
    • Beaulieu, P.1    Ware, M.2
  • 7
    • 34347398083 scopus 로고    scopus 로고
    • Quantification of the rat spinal microglial response to peripheral nerve injury as revealed by immunohistochemical image analysis and flow cytometry
    • J Blackbeard KP O'Dea VC Wallace A Segerdahl T Pheby M Takata MJ Field AS Rice 2007 Quantification of the rat spinal microglial response to peripheral nerve injury as revealed by immunohistochemical image analysis and flow cytometry J Neurosci Methods 164 207 217
    • (2007) J Neurosci Methods , vol.164 , pp. 207-217
    • Blackbeard, J.1    O'Dea, K.P.2    Wallace, V.C.3    Segerdahl, A.4    Pheby, T.5    Takata, M.6    Field, M.J.7    Rice, A.S.8
  • 8
    • 0018154549 scopus 로고
    • A comparison of some pharmacological actions of morphine and delta9-tetrahydrocannabinol in the mouse
    • AS Bloom WL Dewey 1978 A comparison of some pharmacological actions of morphine and delta9-tetrahydrocannabinol in the mouse Psychopharmacology (Berl) 57 243 248
    • (1978) Psychopharmacology (Berl) , vol.57 , pp. 243-248
    • Bloom, A.S.1    Dewey, W.L.2
  • 9
    • 0034951162 scopus 로고    scopus 로고
    • The synthetic cannabinoid WIN55,212-2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain
    • D Bridges K Ahmad AS Rice 2001 The synthetic cannabinoid WIN55,212-2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain Br J Pharmacol 133 586 594
    • (2001) Br J Pharmacol , vol.133 , pp. 586-594
    • Bridges, D.1    Ahmad, K.2    Rice, A.S.3
  • 10
    • 0035822343 scopus 로고    scopus 로고
    • Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review
    • FA Campbell MR Tramer D Carroll DJ Reynolds RA Moore HJ McQuay 2001 Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review BMJ 323 13 16
    • (2001) BMJ , vol.323 , pp. 13-16
    • Campbell, F.A.1    Tramer, M.R.2    Carroll, D.3    Reynolds, D.J.4    Moore, R.A.5
  • 11
    • 34447542824 scopus 로고    scopus 로고
    • Targeting cannabinoid agonists for inflammatory and neuropathic pain
    • Y Cheng SA Hitchcock 2007 Targeting cannabinoid agonists for inflammatory and neuropathic pain Expert Opin Investig Drugs 16 951 965
    • (2007) Expert Opin Investig Drugs , vol.16 , pp. 951-965
    • Cheng, Y.1    Hitchcock, S.A.2
  • 13
    • 1242296234 scopus 로고    scopus 로고
    • Repeated treatment with the synthetic cannabinoid WIN 55,212-2 reduces both hyperalgesia and production of pronociceptive mediators in a rat model of neuropathic pain
    • B Costa M Colleoni S Conti AE Trovato M Bianchi ML Sotgiu G Giagnoni 2004 Repeated treatment with the synthetic cannabinoid WIN 55,212-2 reduces both hyperalgesia and production of pronociceptive mediators in a rat model of neuropathic pain Br J Pharmacol 141 4 8
    • (2004) Br J Pharmacol , vol.141 , pp. 4-8
    • Costa, B.1    Colleoni, M.2    Conti, S.3    Trovato, A.E.4    Bianchi, M.5    Sotgiu, M.L.6    Giagnoni, G.7
  • 14
    • 0037397037 scopus 로고    scopus 로고
    • Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R + WIN55,212
    • JL Croxford SD Miller 2003 Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R + WIN55,212 J Clin Invest 111 1231 1240
    • (2003) J Clin Invest , vol.111 , pp. 1231-1240
    • Croxford, J.L.1    Miller, S.D.2
  • 15
    • 2342446466 scopus 로고    scopus 로고
    • Pharmacological characterization of the chronic constriction injury model of neuropathic pain
    • J De Vry E Kuhl P Franken-Kunkel G Eckel 2004 Pharmacological characterization of the chronic constriction injury model of neuropathic pain Eur J Pharmacol 491 137 148
    • (2004) Eur J Pharmacol , vol.491 , pp. 137-148
    • De Vry, J.1    Kuhl, E.2    Franken-Kunkel, P.3    Eckel, G.4
  • 17
    • 8144229133 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naive rats and in rat models of inflammatory and neuropathic pain
    • SJ Elmes MD Jhaveri D Smart DA Kendall V Chapman 2004 Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naive rats and in rat models of inflammatory and neuropathic pain Eur J Neurosci 20 2311 2320
    • (2004) Eur J Neurosci , vol.20 , pp. 2311-2320
    • Elmes, S.J.1    Jhaveri, M.D.2    Smart, D.3    Kendall, D.A.4    Chapman, V.5
  • 18
    • 0035059241 scopus 로고    scopus 로고
    • The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain
    • A Fox A Kesingland C Gentry K McNair S Patel L Urban I James 2001 The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain Pain 92 91 100
    • (2001) Pain , vol.92 , pp. 91-100
    • Fox, A.1    Kesingland, A.2    Gentry, C.3    Patel, S.4    Urban, L.5    James, I.6
  • 19
    • 38949107918 scopus 로고    scopus 로고
    • Comparison of analgesic effects and patient tolerability of nabilone and dihydrocodeine for chronic neuropathic pain: Randomised, crossover, double blind study
    • B Frank MG Serpell J Hughes JN Matthews D Kapur 2008 Comparison of analgesic effects and patient tolerability of nabilone and dihydrocodeine for chronic neuropathic pain: randomised, crossover, double blind study BMJ 336 199 201
    • (2008) BMJ , vol.336 , pp. 199-201
    • Frank, B.1    Serpell, M.G.2    Hughes, J.3    Matthews, J.N.4    Kapur, D.5
  • 21
    • 38349119715 scopus 로고    scopus 로고
    • Cannabinoid CB(2) receptors: A therapeutic target for the treatment of inflammatory and neuropathic pain
    • J Guindon AG Hohmann 2008 Cannabinoid CB(2) receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain Br J Pharmacol 153 319 334
    • (2008) Br J Pharmacol , vol.153 , pp. 319-334
    • Guindon, J.1    Hohmann, A.G.2
  • 24
    • 0342762087 scopus 로고    scopus 로고
    • The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain
    • U Herzberg E Eliav GJ Bennett IJ Kopin 1997 The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain Neurosci Lett 221 157 160
    • (1997) Neurosci Lett , vol.221 , pp. 157-160
    • Herzberg, U.1    Eliav, E.2    Bennett, G.J.3    Kopin, I.J.4
  • 25
    • 0034130227 scopus 로고    scopus 로고
    • Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons
    • P Honore SD Rogers MJ Schwei JL Salak-Johnson NM Luger MC Sabino DR Clohisy PW Mantyh 2000 Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons Neuroscience 98 585 598
    • (2000) Neuroscience , vol.98 , pp. 585-598
    • Honore, P.1    Rogers, S.D.2    Schwei, M.J.3    Salak-Johnson, J.L.4    Luger, N.M.5    Sabino, M.C.6    Clohisy, D.R.7    Mantyh, P.W.8
  • 27
    • 0026727999 scopus 로고
    • An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat
    • SH Kim JJ Chung 1992 An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat Pain 50 355 363
    • (1992) Pain , vol.50 , pp. 355-363
    • Kim, S.H.1    Chung, J.J.2
  • 28
    • 19344374704 scopus 로고    scopus 로고
    • Pharmacological evaluation of the selective spinal nerve ligation model of neuropathic pain in the rat
    • CJ LaBuda PJ Little 2005 Pharmacological evaluation of the selective spinal nerve ligation model of neuropathic pain in the rat J Neurosci Methods 144 175 181
    • (2005) J Neurosci Methods , vol.144 , pp. 175-181
    • Labuda, C.J.1    Little, P.J.2
  • 31
    • 33751506126 scopus 로고    scopus 로고
    • Effects of a cannabinoid agonist on spinal nociceptive neurons in a rodent model of neuropathic pain
    • C Liu JM Walker 2006 Effects of a cannabinoid agonist on spinal nociceptive neurons in a rodent model of neuropathic pain J Neurophysiol 96 2984 2994
    • (2006) J Neurophysiol , vol.96 , pp. 2984-2994
    • Liu, C.1    Walker, J.M.2
  • 32
    • 0033956629 scopus 로고    scopus 로고
    • Two distinctive antinociceptive systems in rats with pathological pain
    • J Mao DD Price J Lu L Keniston DJ Mayer 2000 Two distinctive antinociceptive systems in rats with pathological pain Neurosci Lett 280 13 16
    • (2000) Neurosci Lett , vol.280 , pp. 13-16
    • Mao, J.1    Price, D.D.2    Lu, J.3    Keniston, L.4    Mayer, D.J.5
  • 33
    • 33846335526 scopus 로고    scopus 로고
    • Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation
    • Y Marchalant S Rosi GL Wenk 2007 Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation Neuroscience 144 1516 1522
    • (2007) Neuroscience , vol.144 , pp. 1516-1522
    • Marchalant, Y.1    Rosi, S.2    Wenk, G.L.3
  • 34
    • 0027492734 scopus 로고
    • Localization of cannabinoid receptor mRNA in rat brain
    • LA Matsuda TI Bonner SJ Lolait 1993 Localization of cannabinoid receptor mRNA in rat brain J Comp Neurol 327 535 550
    • (1993) J Comp Neurol , vol.327 , pp. 535-550
    • Matsuda, L.A.1    Bonner, T.I.2    Lolait, S.J.3
  • 35
    • 14844303420 scopus 로고    scopus 로고
    • Immune and glial cell factors as pain mediators and modulators
    • SB McMahon WB Cafferty F Marchand 2005 Immune and glial cell factors as pain mediators and modulators Exp Neurol 192 444 462
    • (2005) Exp Neurol , vol.192 , pp. 444-462
    • McMahon, S.B.1    Cafferty, W.B.2    Marchand, F.3
  • 36
    • 35648934575 scopus 로고    scopus 로고
    • Meta-analysis of cannabinoid ligand binding affinity and receptor distribution: Interspecies differences
    • JM McPartland M Glass RG Pertwee 2007 Meta-analysis of cannabinoid ligand binding affinity and receptor distribution: interspecies differences Br J Pharmacol 152 583 593
    • (2007) Br J Pharmacol , vol.152 , pp. 583-593
    • McPartland, J.M.1    Glass, M.2    Pertwee, R.G.3
  • 37
    • 33745153343 scopus 로고    scopus 로고
    • Immune and inflammatory mechanisms in neuropathic pain
    • G Moalem DJ Tracey 2006 Immune and inflammatory mechanisms in neuropathic pain Brain Res Rev 51 240 264
    • (2006) Brain Res Rev , vol.51 , pp. 240-264
    • Moalem, G.1    Tracey, D.J.2
  • 38
    • 34247609748 scopus 로고    scopus 로고
    • The biochemical origin of pain-proposing a new law of pain: The origin of all pain is inflammation and the inflammatory response. Part 1 of 3-a unifying law of pain
    • S Omoigui 2007 The biochemical origin of pain-proposing a new law of pain: the origin of all pain is inflammation and the inflammatory response. Part 1 of 3-a unifying law of pain Med Hypotheses 69 70 82
    • (2007) Med Hypotheses , vol.69 , pp. 70-82
    • Omoigui, S.1
  • 40
    • 27844552904 scopus 로고    scopus 로고
    • Effect of anandamide uptake inhibition in the production of nitric oxide and in the release of cytokines in astrocyte cultures
    • S Ortega-Gutierrez E Molina-Holgado C Guaza 2005 Effect of anandamide uptake inhibition in the production of nitric oxide and in the release of cytokines in astrocyte cultures Glia 52 163 168
    • (2005) Glia , vol.52 , pp. 163-168
    • Ortega-Gutierrez, S.1    Molina-Holgado, E.2    Guaza, C.3
  • 42
    • 33748703859 scopus 로고    scopus 로고
    • The endocannabinoid system as an emerging target of pharmacotherapy
    • P Pacher S Batkai G Kunos 2006 The endocannabinoid system as an emerging target of pharmacotherapy Pharmacol Rev 58 389 462
    • (2006) Pharmacol Rev , vol.58 , pp. 389-462
    • Pacher, P.1    Batkai, S.2    Kunos, G.3
  • 43
    • 0033538476 scopus 로고    scopus 로고
    • Presence and functional regulation of cannabinoid receptors in immune cells
    • D Parolaro 1999 Presence and functional regulation of cannabinoid receptors in immune cells Life Sci 65 637 644
    • (1999) Life Sci , vol.65 , pp. 637-644
    • Parolaro, D.1
  • 44
    • 0033020283 scopus 로고    scopus 로고
    • Lumbar sympathectomy failed to reverse mechanical allodynia- and hyperalgesia-like behavior in rats with L5 spinal nerve injury
    • M Ringkamp S Eschenfelder EJ Grethel HJ Habler RA Meyer W Janig SN Raja 1999 Lumbar sympathectomy failed to reverse mechanical allodynia- and hyperalgesia-like behavior in rats with L5 spinal nerve injury Pain 79 143 153
    • (1999) Pain , vol.79 , pp. 143-153
    • Ringkamp, M.1    Eschenfelder, S.2    Grethel, E.J.3    Habler, H.J.4    Meyer, R.A.5    Janig, W.6    Raja, S.N.7
  • 45
    • 34147098441 scopus 로고    scopus 로고
    • Spinal cannabinoid receptor type 2 activation reduces hypersensitivity and spinal cord glial activation after paw incision
    • A Romero-Sandoval JC Eisenach 2007 Spinal cannabinoid receptor type 2 activation reduces hypersensitivity and spinal cord glial activation after paw incision Anesthesiology 106 787 794
    • (2007) Anesthesiology , vol.106 , pp. 787-794
    • Romero-Sandoval, A.1    Eisenach, J.C.2
  • 46
    • 23244444097 scopus 로고    scopus 로고
    • Inhibitory effects of CB1 and CB2 receptor agonists on responses of DRG neurons and dorsal horn neurons in neuropathic rats
    • DR Sagar S Kelly PJ Millns CT O'Shaughnessey DA Kendall V Chapman 2005 Inhibitory effects of CB1 and CB2 receptor agonists on responses of DRG neurons and dorsal horn neurons in neuropathic rats Eur J Neurosci 22 371 379
    • (2005) Eur J Neurosci , vol.22 , pp. 371-379
    • Sagar, D.R.1    Kelly, S.2    Millns, P.J.3    O'Shaughnessey, C.T.4    Kendall, D.A.5    Chapman, V.6
  • 47
    • 13244283049 scopus 로고    scopus 로고
    • Synthetic cannabinoid WIN55,212-2 inhibits generation of inflammatory mediators by IL-1beta-stimulated human astrocytes
    • WS Sheng S Hu X Min GA Cabral JR Lokensgard PK Peterson 2005 Synthetic cannabinoid WIN55,212-2 inhibits generation of inflammatory mediators by IL-1beta-stimulated human astrocytes Glia 49 211 219
    • (2005) Glia , vol.49 , pp. 211-219
    • Sheng, W.S.1    Hu, S.2    Min, X.3    Cabral, G.A.4    Lokensgard, J.R.5    Peterson, P.K.6
  • 48
    • 9644268887 scopus 로고    scopus 로고
    • Cannabinoid signaling in glial cells
    • N Stella 2004 Cannabinoid signaling in glial cells Glia 48 267 277
    • (2004) Glia , vol.48 , pp. 267-277
    • Stella, N.1
  • 52
    • 46049119745 scopus 로고    scopus 로고
    • Adverse effects of medical cannabinoids: A systematic review
    • T Wang JP Collet S Shapiro MA Ware 2008 Adverse effects of medical cannabinoids: a systematic review CMAJ 178 1669 1678
    • (2008) CMAJ , vol.178 , pp. 1669-1678
    • Wang, T.1    Collet, J.P.2    Shapiro, S.3    Ware, M.A.4
  • 53
    • 33845945382 scopus 로고    scopus 로고
    • Norman Cousins Lecture. Glia as the "bad guys": Implications for improving clinical pain control and the clinical utility of opioids
    • LR Watkins MR Hutchinson A Ledeboer J Wieseler-Frank ED Milligan SF Maier 2007 Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids Brain Behav Immun 21 131 146
    • (2007) Brain Behav Immun , vol.21 , pp. 131-146
    • Watkins, L.R.1    Hutchinson, M.R.2    Ledeboer, A.3    Wieseler-Frank, J.4    Milligan, E.D.5    Maier, S.F.6
  • 54
    • 0347169249 scopus 로고    scopus 로고
    • Glia: A novel drug discovery target for clinical pain
    • LR Watkins SF Maier 2003 Glia: a novel drug discovery target for clinical pain Nat Rev Drug Discov 2 973 985
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 973-985
    • Watkins, L.R.1    Maier, S.F.2
  • 57
    • 33847183860 scopus 로고    scopus 로고
    • Association of neural inflammation with hyperalgesia following spinal nerve ligation
    • L Znaor S Lovric Q Hogan D Sapunar 2007 Association of neural inflammation with hyperalgesia following spinal nerve ligation Croat Med J 48 35 42
    • (2007) Croat Med J , vol.48 , pp. 35-42
    • Znaor, L.1    Lovric, S.2    Hogan, Q.3    Sapunar, D.4


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