Molecular imaging with targeted quantum dot bioconjugates: The need for contrast optimisation studies

International Journal of Nanotechnology

Volumn 6, Issue 5-6, 2009, Pages 442-455

  Roy, Mathieu ^a   Wilson, Brian C ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

Autofluorescence; Contrast agent; Contrast optimisation; Excitation and emission spectra; Fluorescence imaging; Medical imaging; Molecular imaging; Quantum dots; Signal to background; Tissue phantoms

Indexed keywords

DIAGNOSIS; EMISSION SPECTROSCOPY; FLUORESCENCE IMAGING; MEDICAL IMAGING; NANOCRYSTALS; PHANTOMS; SEMICONDUCTOR QUANTUM DOTS; TISSUE;

AUTOFLUORESCENCE; CONTRAST AGENT; EXCITATION AND EMISSION SPECTRA; OPTIMISATIONS; TISSUE PHANTOM;

MOLECULAR IMAGING;

EID: 64649093318     PISSN: 14757435     EISSN: None     Source Type: Journal    
DOI: 10.1504/IJNT.2009.024639     Document Type: Article

References (40)

1. DaCosta, R.S., Wilson, B.C. and Marcon, N.E. (2005) 'Optical techniques for the endoscopic detection of dysplastic colonic lesions', Current Opinion in Gastroenterology, Vol. 21, No. 1, pp.70-79.
2. Ferrari, M. (2005) 'Cancer nanotechnology: opportunities and challenges', Nat. Rev. Cancer, Vol. 5, No.3, pp.161-171.
3. Gao, X., Yang, L., Petros, J.A., Marshall, F.F., Simons, J.W. and Nie, S. (2005) 'In vivo molecular and cellular imaging with quantum dots', Curr. Opin. Biotechnol., Vol. 16, No. 1, pp.63-72.
4. Medintz, I.L., Uyeda, H.T., Goldman, E.R. and Mattoussi, H. (2005) 'Quantum dot bioconjugates for imaging, labelling and sensing', Nat. Mater., Vol. 4, No. 6, pp.435-446.
5. Chan, W.C., Maxwell, D.J., Gao, X., Bailey, R.E., Han, M. and Nie, S. (2002) 'Luminescent quantum dots for multiplexed biological detection and imaging', Curr. Opin. Biotechnol, Vol. 13, No. 1, pp.40-46.
6. Wang, K.K., Liu, N., Radulovich, N., Wigle, D.A., Johnston, M.R., Shepherd, F.A., Minden, M.D. and Tsao, M.S. (2002) 'Novel candidate tumour marker genes for lung adenocarcinoma', Oncogene, Vol. 21, No. 49, pp.7598-7604.
7. Akerman, M.E., Chan, W.C., Laakkonen, P., Bhatia, S.N. and Ruoslahti, E. (2002) 'Nanocrystal targeting in vivo', Proc. Natl. Acad. Sei. USA, Vol. 99, No. 20, pp. 12617-12621.
8. Gao, X., Cui, Y., Levenson, R.M., Chung, L.W. and Nie, S. (2004) 'In vivo cancer targeting and imaging with semiconductor quantum dots', Nat. Biotechnol, Vol. 22, No. 8, pp.969-976.
9. Diagaradjane, P., Orenstein-Cardona, J.M., N, E.C-C., Deorukhkar, A., Shentu, S., Kuno, N., Schwartz, D.L., Gelovani, J.G. and Krishnan, S. (2008) 'Imaging epidermal growth factor receptor expression in vivo: pharmacokinetic and biodistribution characterization of a bioconjugated quantum dot nanoprobe', Clin. Cancer Res., Vol. 14, No. 3, pp.731-741.
10. Diagaradjane, P., Orenstein-Cardona, J.M., Colon-Casasnovas, N.E., Deorukhkar, A., Shentu, S., Kuno, N., Schwartz, D.L., Gelovani, J.G. and Krishnan, S. (2008) 'EGF-conjugated near-infrared quantum dots as nanoprobes for in-vivo imaging of EGFR expression', Proc. SPIE, Vol. 6866, pp.68660R.
11. Cai, W., Shin, D.W., Chen, K., Gheysens, O., Cao, Q., Wang, S.X., Gambhir, S.S. and Chen, X. (2006) 'Peptide-labeled near-infrared quantum dots for imaging tumour vasculature in living subjects', Nano Lett., Vol. 6, No. 4, pp.669-676.
12. Chen, X., Conti, P.S. and Moats, R.A. (2004) 'In vivo near-infrared fluorescence imaging of integrin alphavbeta3 in brain tumour xenografts', Cancer Res., Vol. 64, No. 21, pp.8009-8014.
13. Karwa, A., Papazoglou, E., Pourrezaei, K., Tyagi, S. and Murthy, S. (2007) 'Imaging biomarkers of inflammation in situ with functionalized quantum dots in the dextran sodium sulfate (DSS) model of mouse colitis', Inflamm. Res., Vol. 56, No. 12, pp.502-510.
14. Lee, H.A., Imran, M., Monteiro-Riviere, N.A., Colvin, V.L., Yu, W.W. and Riviere, J.E. (2007) 'Biodistribution of quantum dot nanoparticles in perfused skin: evidence of coating dependency and periodicity in arterial extraction', Nano Lett., Vol. 7, No. 9, pp.2865-2870.
15. Riviere, J.E., Bowman, K.F., Monteiro-Riviere, N.A., Dix, L.P. and Carver, M.P. (1986) 'The isolated perfused porcine skin flap (IPPSF). I. A novel in vitro model for percutaneous absorption and cutaneous toxicology studies', Fundam. Appl Toxicol., Vol. 7, No. 3, pp.444-453.
16. Fibich, G., Hammer, A., Gannot, G., Gandjbakhche, A. and Gannot, I. (2005) 'Modeling and simulations of the pharmacokinetics of fluorophore conjugated antibodies in tumour vicinity for the optimization of fluorescence-based optical imaging', Lasers Surg. Med., Vol. 37, No.2,pp.155-160.
17. Dahan, M., Levi, S., Luccardini, C., Rostaing, P., Riveau, B. and Triller, A. (2003) 'Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking', Science, Vol. 302, No. 5644, pp.442-445.
18. Kaji, N., Tokeshi, M. and Baba, Y. (2007) 'Single-molecule measurements with a single quantum dot', Chem. Rec, Vol. 7, No. 5, pp.295-304.
19. Troy, T., Jekic-McMullen, D., Sambucetti, L. and Rice, B. (2004) 'Quantitative comparison of the sensitivity of detection of fluorescent and bioluminescent reporters in animal models', Mol. Imaging, Vol. 3, No. 1, pp.9-23.
20. Yu, W.W., Qu, L.H., Guo, W.Z. and Peng, X.G. (2003) 'Experimental determination of the extinction coefficient of CdTe, CdSe, and CdS nanocrystals', Chem. Mater., Vol. 15, No. 14, pp.2854-2860.
21. Cademartiri, L., Montanari, E., Calestani, G., Migliori, A., Guagliardi, A. and Ozin, G.A. (2006) 'Size-dependent extinction coefficients of PbS quantum dots', J. Am. Chem. Soc., Vol. 128, No. 31, pp.10337-10346.
22. Zhang, C.Y. and Johnson, L.W. (2008) 'Simple and accurate quantification of quantum dots via single-particle counting', J. Am. Chem. Soc., Vol. 130, No. 12, pp.3750-3751.
23. Lim, Y.T., Kim, S., Nakayama, A., Stott, N.E., Bawendi, M.G. and Frangioni, J.V. (2003) 'Selection of quantum dot wavelengths for biomedical assays and imaging', Mol. Imaging, Vol. 2, No. 1, pp.50-64.
24. Roy, M., DaCosta, R.S., Weersink, R., Netchev, G., Davidson, S.R.H., Chan, W.C.W. and Wilson, B.C. (2007) 'Quantum dots as contrast agents for endoscopy: mathematical modeling and experimental validation of the optimal excitation wavelength', Proc. SPIE, Vol. 6448, pp.644812.
25. Roy, M. and Wilson, B.C. (2008) 'An accurate homogenized tissue phantom for broad spectrum autofluorescence studies: a tool for optimizing quantum dot-based contrast agents', Proc. SPIE, Vol. 6870, pp.68700E.
26. Dahan, M., Laurence, T., Pinaud, F., Chemla, D.S., Alivisatos, A.P., Sauer, M. and Weiss, S. (2001) 'Time-gated biological imaging by use of colloidal quantum dots', Opt. Lett, Vol. 26, No. 11, pp.825-827.
27. Bloch, S., Lesage, F., Mcintosh, L., Gandjbakhche, A., Liang, K. and Achilefu, S. (2005) 'Whole-body fluorescence lifetime imaging of a tumour-targeted near-infrared molecular probe in mice', J. Biomed. Opt, Vol. 10, No. 5, pp.054003.
28. Mansfield, J.R., Gossage, K.W., Hoyt, C.C. and Levenson, R.M. (2005) 'Autofluorescence removal, multiplexing, and automated analysis methods for in-vivo fluorescence imaging', J. Biomed. Opt, Vol. 10, No. 4, pp.41207.
29. Martin, M.E., Wabuyele, M., Panjehpour, M., Overholt, B., DeNovo, R., Kennel, S., Cunningham, G. and Vo-Dinh, T. (2006) 'An AOTF-based dual-modality hyperspectral imaging system (DMHSI) capable of simultaneous fluorescence and reflectance imaging', Medical Engineering and Physics, Vol. 28, No. 2, pp. 149-155.
30. Martin, M.E., Wabuyele, M.B., Chen, K., Kasili, P., Panjehpour, M., Phan, M., Overholt, B., Cunningham, G., Wilson, D., Denovo, R.C. and Vo-Dinh, T. (2006) 'Development of an advanced hyperspectral imaging (HSI) system with applications for cancer detection', Annals of Biomedical Engineering, Vol. 34, No. 6, pp. 1061-1068.
31. Themelis, G., Yoo, J.S. and Ntziachristos, V. (2008) 'Multispectral imaging using multiple-bandpass filters', Opt. Lett, Vol. 33, No. 9, pp.1023-1025.
32. Hsiung, P.L., Hardy, J., Friedland, S., Soetikno, R., Du, C.B., Wu, A.P., Sahbaie, P., Crawford, J.M., Lowe, A.W., Contag, C.H. and Wang, T.D. (2008) 'Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy', Nat. Med., Vol. 14, No. 4, pp.454-458.
33. Myaing, M.T., MacDonald, D.J. and Li, X. (2006) 'Fiber-optic scanning two-photon fluorescence endoscope', Opt. Lett., Vol. 31, No. 8, pp. 1076-1078.
34. Kim, P., Puoris'haag, M., Co Te, D., Lin, C.P. and Yun, S.H. (2008) 'In vivo confocal and multiphoton microendoscopy', J Biomed. Opt, Vol. 13, No. 1, pp.010501.
35. Stroh, M., Zimmer, J.P., Duda, D.G., Levchenko, T.S., Cohen, K.S., Brown, E.B., Scadden, D.T., Torchilin, V.P., Bawendi, M.G., Fukumura, D. and Jain, R.K. (2005) 'Quantum dots spectrally distinguish multiple species within the tumour milieu in vivo', Nat. Med., Vol. 11, No. 6, pp.678-682.
36. Bateman, R.M., Hodgson, K.C., Kohli, K., Knight, D. and Walley, K.R. (2007) 'Endotoxemia increases the clearance of mPEGylated 5000-MW quantum dots as revealed by multiphoton microvascular imaging', J. Biomed. Opt, Vol. 12, No. 6, pp.064005.
37. Flusberg, B.A., Jung, J.C., Cocker, E.D., Anderson, E.P. and Schnitzer, MJ. (2005) 'In vivo brain imaging using a portable 3.9 gram two-photon fluorescence microendoscope', Opt. Lett, Vol. 30, No. 17, pp.2272-2274.
38. Ntziachristos, V., Ripoll, J., Wang, L.V. and Weissleder, R. (2005) 'Looking and listening to light: the evolution of whole-body photonic imaging', Nat Biotechnol, Vol. 23, No. 3, pp.313-320.
39. Montet, X., Ntziachristos, V., Grimm, J. and Weissleder, R. (2005) 'Tomographic fluorescence mapping of tumour targets', Cancer Res., Vol. 65, No. 14, pp.6330-6336.
40. Montet, X., Figueiredo, J.L., Alencar, H., Ntziachristos, V., Mahmood, U. and Weissleder, R. (2007) 'Tomographic fluorescence imaging of tumour vascular volume in mice', Radiology, Vol. 242, No. 3, pp.751-758.