Differential expression of nuclear receptors in T helper cells

Journal of Microbiology and Biotechnology

Volumn 19, Issue 2, 2009, Pages 208-214

  Hwang, Soo Suk ^a   Kim, Young Uk ^a   Lee, Wonyong ^a   Lee, Gap Ryol ^a  

^a Sogang University   (South Korea)

Author keywords

Coregulator; Differentiation; Nuclear receptor; Th1; Th2; Transcription factor

Indexed keywords

CELL NUCLEUS RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 4; RETINOID X RECEPTOR ALPHA; STEROID HORMONE;

ANIMAL CELL; ARTICLE; CELL MATURATION; CONTROLLED STUDY; GENE EXPRESSION; HELPER CELL; HUMAN; HUMAN CELL; IMMUNE SYSTEM; LEUKEMIA CELL LINE; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TH1 CELL; TH2 CELL;

CELL DIFFERENTIATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-4; JURKAT CELLS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RETINOID X RECEPTOR ALPHA; T-LYMPHOCYTES, HELPER-INDUCER; TH1 CELLS; TH2 CELLS;

EID: 64549099033     PISSN: 10177825     EISSN: 17388872     Source Type: Journal    
DOI: 10.4014/jmb.0811.618     Document Type: Article

References (39)

1. Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383: 787-793.
2. Cantorna, M. T., F. E. Nashold, and C. E. Hayes. 1995. Vitamin A deficiency results in a priming environment conducive for Th1 cell development. Eur. J. Immunol. 25: 1673-1679.
3. Dong, C. and R. A. Flavell. 2001. Th1 and Th2 cells. Curr. Opin. Hematol. 8: 47-51.
4. Du, X., K. Tabeta, N. Mann, K. Crozat, S. Mudd, and B. Beutler. 2005. An essential role for RXRα in the development of Th2 responses. Eur. J. Immunol. 35: 3414-3423.
5. Dzhagalov, I., N. Zhang, and Y. W. He. 2004. The roles of orphan nuclear receptors in the development and function of the immune system. Cell. Mol. Immunol. 1: 401-407.
6. Dzhagalov, I., V. Giguere, and Y. W. He. 2004. Lymphocyte development and function in the absence of retinoic acid-related orphan receptor α. J. Immunol. 173: 2952-2959.
7. Eberl, G. and D. R. Littman. 2004. Thymic origin of intestinal αβ T cells revealed by fate mapping of RORγt+ cells. Science 305: 248-251.
8. Glimcher, L. H. and K. M. Murphy. 2000. Lineage commitment in the immune system: The T helper lymphocyte grows up. Genes Dev. 14: 1693-1711.
9. Grenningoh, R., A. Gho, P. di Lucia, M. Klaus, W. Bollag, I-C. Ho, F. Sinigaglia, and P. Panina-Bordignon. 2006. Inhibition of the retinoid X receptor (RXR) blocks T helper 2 differentiation and prevents allergic lung inflammation. J. Immunol. 176: 5161-5171.
10. Hamilton, B. A., W. N. Frankel, A. W. Kerrebrock, T. L. Hawkins, W. FitzHugh, K. Kusumi, et al. 1996. Disruption of nuclear hormone receptor RORα in staggerer mice. Nature 379: 736-739.
11. He, Y. W. 2002. Orphan nuclear receptors in T lymphocyte development. J. Leukoc. Biol. 72: 440-446.
12. He, Y. W., M. L. Deftos, W. W. Ojala, and M. J. Bevan. 1998. RORγt, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells. Immunity 9: 797-806.
13. Huh, S., K. Lee, H. S. Yun, D. J. Paik, J. M. Kim, and J. Youn. 2007. Functions of metallothionein generating interleukin-10-producing regulatory CD4+ T cells potentiate suppression of collagen-induced arthritis. J. Microbiol. Biotechnol. 17: 348-358.
14. + T helper cells. Cell 126: 1121-1133.
15. Jetten, A. M. and E. Ueda. 2002. Retinoid-related orphan receptors (RORs); roles in cell survival, differentiation and disease. Cell Death Differ. 9: 1167-1171.
16. + T cells. Br. J. Pharmacol. 130: 581-586.
17. Kim, H. Y. and G. E. Ji. 2006. Effect of viability and integrity of Bifidobacterium on suppression of allergy in mice. J. Microbiol. Biotechnol. 16: 1010-1016.
18. Kumar, R. and E. B. Thompson. 1999. The structure of the nuclear hormone receptors. Steroids 64: 310-319.
19. Kurebayashi, S., E. Ueda, M. Sakaue, D. D. Patel, A. Medvedev, F. Zhang, and A. M. Jetten. 2000. Retinoid-related orphan receptor γ (RORγ) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis. Proc. Natl. Acad. Sci. U.S.A. 97: 10132-10137.
20. Lee, G. R. 2007. A minor transactivation effect of GATA-3 on its target sites in the extrachromosomal status. J. Microbiolol. Biotechnol. 17: 2056-2060.
21. Lee, G. R., P. E. Fields, and R. A. Flavell. 2001. Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level. Immunity 14: 447-459.
22. Lee, G. R., S. T. Kim, C. G. Spilianakis, P. E. Fields, and R. A. Flavell. 2006. T helper cell differentiation: Regulation by cis elements and epigenetics. Immunity 24: 369-379.
23. McKenna, N. J. and B. W. O'Malley. 2002. Combinatorial control of gene expression by nuclear receptors and coregulators. Cell 83: 835-839.
24. H17 and regulatory T cell differentiation mediated by retinoic acid. Science 317: 256-260.
25. Na, S. Y., B. Y. Kang, S. W. Chung, S. J. Han, Z. Ma, G. Trinchieri, S. Y. Im, J. W. Lee, and T. S. Kim. 1999. Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NFκB. J. Biol. Chem. 274: 7674-7680.
26. Oh, M. K., M. J. Cha, S. G. Lee, L. Rohlin, and J. C. Liao. 2006. Dynamic gene expression profiling of Escherichia coli in carbon source transition from glucose to acetate. J. Microbiol. Biotechnol. 16: 543-549.
27. Park, S. E., M. J. Lee, M. H. Yang, K. Y. Ahn, S. I. Jang, Y. J. Suh, H. Myung, J. C. You, and J. H. Park. 2007. Expression profiles and pathway analysis in HEK 293 T cells overexpressing HIV-1 Tat and nucleocapsid using cDNA microarray. J. Microbiol. Biotechnol. 17: 154-161.
28. Sidman, R. L., R. W. Lane, and M. M. Dickie. 1962. Staggerer, a new mutation in the mouse affecting the cerebellum. Science 137: 610-612.
29. Spilanakis, C. G., G. R. Lee, and R. A. Flavell. 2005. Twisting the Th1/ Th2 immune response via retinoid X receptor: Lessons from a genetic approach. Eur. J. Immunol. 35: 3400-3404.
30. Stephensen, C. B., A. D. Borowsky, and K. C. K. Lloyd. 2007. Disruption of Rxra gene in thymocytes and T lymphocytes modestly alters lymphocyte frequencies, proliferation, survival and T helper type 1/type 2 balance. Immunology 121: 484-498.
31. Stephensen, C. B., R. Rasooly, J. Xiaowen, M. A. Ceddia, C. T. Weaver, R. A. S. Chandraratna, and R. P. Bucy. 2002. Vitamin A enhances in vitro Th2 development via retinoid X receptor pathway. J. Immunol. 168: 4495-4503.
32. Stockinger, B. and M. Veldhoen. 2007. Differentiation and function of Th17 T cells. Curr. Opin. Immunol. 19: 281-286.
33. Sun, Z., D. Unutmaz, Y. R. Zou, M. J. Sunshine, A. Pierani, S. Brenner-Morton, R. E. Mebius, and D. R. Littman. 2000. Requirement for RORγ in thymocyte survival and lymphoid organ development. Science 288: 2369-2373.
34. Tilley, S. L., M. Jaradat, C. Stapleton, D. Dixon, X. Hua, C. J. Erikson, et al. 2007. Retinoid-related orphan receptor γ controls immunoglobulin production and Th1/Th2 cytokine balance in the adaptive immune response to allergen. J. Immunol. 178: 3208-3218.
35. Trenkner, E. and M. K. Hoffmann. 1986. Defective development of the thymus and immunological abnormalities in the neurological mouse mutation "staggerer". J. Neurosci. 6: 1733-1737.
36. Tsai, M. J. and B. W. O'Malley. 1994. Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu. Rev. Biochem. 63: 451-486.
37. Weaver, C. T., R. D. Hatton, P. R. Mangan, and L. E. Harrington. 2007. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 25: 821-852.
38. Winoto, A. and D. R. Littman. 2002. Nuclear hormone receptors in T lymphocytes. Cell 109: S57-S66.
39. Yang, X. O., B. P. Pappu, R. Nurieva, A. Akimzhanov, H. S. Kang, Y. Chung, et al. 2008. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity 28: 29-39.